Picture: Portrait of Dr. Martin Frotscher

Dr. Martin Frotscher
Chemist

Building C2 3 EG, Room 0.30
Phone: +49 - 681 302 70330
Email: m.frotscher@mx.uni-saarland.de

Curriculum vitae

  Diploma in Chemistry at the University of the Saarland.
93 - 97 Research assistant in the group of Professor Dr. R. W. Hartmann at the Institute of Pharmaceutical and Medicinal Chemistry of the University of the Saarland

Thesis: Imidazolyl-substituted pyridines and quinolines: Novel, dual inhibitors of P450 arom and P450 TxA2 as potential drugs for the treatment of mammacarcinoma and the prophylaxis of metastasis.

Promotion to a Dr. rer. nat.
98 - 99 Postdoc in the group of Professor Dr. J. Hüttermann at the Institute of Biophysics und Physical Fundamentals of Medicinal Sciences of the University of the Saarland.

Elucidation of structure-function-relationships of metalloproteins using ESR- and ENDOR-spektroscopie.
99-00 Research Associate at A. Menarini s.p.a., Florence (Italy).

Development of a stereoselective synthesis for a chiral scaffold molecule as a core structure for libraries; Design and synthesis of NK-2 receptor antagonists.
3/01 – 8/01 Coworker of ChemCon GmbH, Freiburg i. Br.

R&D; Custom synthesis and contract research; Project management.
since 9/01 Lecturer and scientific coworker in the group of Professor Dr. R. W. Hartmann at the Institute of Pharmaceutical and Medicinal Chemistry of the University of the Saarland.

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Publications

  • Jacobs, C.; Frotscher, M.; Dannhardt, G.; Hartmann, R. W. 1-Imidazolyl(alkyl)-Substituted Di- and Tetrahydroquinolines and Analogues: Syntheses and Evaluation of Dual Inhibitors of Thromboxane A2 Synthase and Aromatase. J. Med. Chem.2000, 43, 1841-1851.

  • Hartmann, R. W.; Frotscher, M. 1-Imidazolylcarbonyloxy-substituted Tetrahydroquinolines and Pyridines: Synthesis and Evaluation of P450 TxA2 Inhibition. Arch. Pharm. Pharm. Med. Chem. 1999, 332, 358-362.

  • Frotscher, M.; Cullmann, C. Kappl, R.; Hüttermann, J.; Eltis, L.D.; Ciurli, S.; Luchinat, C. EPR and ENDOR Studies on High-Potential Iron Sulfur Proteins: Electronic and Structural Aspects. Deutsche Gesellschaft für Biophysik, Jahrestagung 1998, Frankfurt/Main, Abstract S. 46.

  • Ledergerber, D.; Frotscher, M.; Hartmann, R. W. Novel Highly Active Thromboxane A2 Synthase Inhibitors Devoid of Carboxylic Groups. Arch. Pharm. Pharm. Med. Chem. 1997, 1-2, 3-5.

  • Hartmann, R. W.; Frotscher, M.; Ledergerber, D.; Wächter, G. A.; Grün, G. L.; Sergejew, T. F. Synthesis and Evaluation of Azole-Substituted Tetrahydronaphthalenes as Inhibitors of P450 arom, P450 17, and P450 TxA2. Arch. Pharm. Pharm. Med. Chem. 1996, 329, 251-261.

  • Frotscher, M.; Ledergerber, D.; Hartmann, R. W. Dual Inhibitors of Thromboxane-A2-Synthase and Aromatase as Potential Drugs in the Prophylaxis of Tumor Metastases and Therapy of Breast Cancer. XIVth International Symposium on Medicinal Chemistry; Maastricht, the Netherlands 1996, Abstract No. P-5.18.

  • Frotscher, M.; Wächter, G.; Hartmann, R. W. Imidazolyl- and 1,2,4-Triazolyl-substituted Benzocyclohexenes as Potent and Selective Inhibitors of Cytochrome P-450 Enzymes. Second European Congress of Pharmaceutical Sciences, Berlin, Germany 1994, Abstract No. FC24.

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Tasks

Lectures and courses

For students of pharmacy

  • Lecture: Introduction to Instrumental Analysis (8065)
    For students of the third and fourth term; 3 semester periods per week

  • Seminar: Stereochemistry (8063)
    For students in the second and third term; 1 semester period per week; Winter term only

  • Seminar: Nomenclature of organic compounds (8067)
    For students in the second and third term; 1 semester period per week; Summer term only

  • Lecture and exercise: Mathematical and statistical methods (8059, 8069)
    For students in the first and second term; 1 semester period per week; Part I: Winter term, Part II: Summer term

For students of chemistry with elective subject “Medicinal Chemistry”:

  • Lecture and exercise: Medicinal Chemistry for Chemists
    1 semester period per week; summer term only

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Research

  • Rational design of inhibitors of steroid biosynthesis (industrial cooperation programme)

Further tasks

  • Security administrator

  • Selection of new research equipment

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