Publikationen

Burkhart JL, Diehl B,Schmitt MJ, Kazmaier U (2012). A Straightforward Approach to MMP-2 and MMP-9 Inhibitors Based on Chelate Claisen Rearrangements. Eur. J. Org. Chem. 2012:567-575

Diehl B, Hoffmann TM, Mueller NC, Burkhart JL, Kazmaier U, Schmitt MJ(2011). A novel yeast bioassay for high-throughput screening of matrix metalloproteinase inhibitors. Appl Environ Microbiol.77(24):8573-7.

Walch B, Breinig T, Schmitt MJ, Breinig F. (2011). Delivery of functional DNA and messenger RNA to mammalian phagocytic cells by recombinant yeast. Gene Ther. [Epub ahead of print]

Bazan SB, Geginat G, Breinig T, Schmitt MJ, Breinig F. (2011). Uptake of various yeast genera by antigen-presenting cells and influence of subcellular antigen localization on the activation of ovalbumin-specific CD8 T lymphocytes. Vaccine 29:8165-73

Becker B, Schmitt MJ (2011). Adapting Yeast as Model to Study Ricin Toxin A Uptake and Trafficking. Toxins 3:834-47.

Walch B, Breinig T, Geginat G, Schmitt MJ, Breinig F. (2011). Yeast-based protein delivery to mammalian phagocytic cells is increased by coexpression of bacterial listeriolysin. Microbes Infect. 13:908-13

Li S, Spooner RA, Allen SC, Guise CP, Ladds G, Schnöder T, Schmitt MJ, Lord JM, Roberts LM (2010). Folding-competent and Folding-defective Forms of Ricin A Chain have Different Fates Following Retrotranslocation from the Endoplasmic Reticulum. Mol Biol Cell. 21:2543-54.

Kanno T, Bucher E, Daxinger L, Huettel B, Kreil DP, Breinig F, Lind M, Schmitt MJ, Simon SA, Gurazada SGR, Meyers BC, Lorkovic ZJ, Matzke AJM & Matzke M (2010). RNA-directed DNA methylation and plant development require an IWR1-type transcription factor. EMBO Rep. 11: 65-71.

Carroll SY, Stirling PC, Stimpson HE, Giesselmann E, Schmitt MJ (2009). Drubin DGA yeast killer toxin screen provides insights into a/b toxin entry, trafficking, and killing mechanisms. Dev Cell 17(4): 552-60.

Schmitt MJ, Sao-José C, Santos MA (2009). Phages of yeast and bacteria. In: Biology of Microorganisms on Grapes, in Must and in Wine, König H et al. (eds.), Springer-Verlag Berlin Heidelberg, 89-109.

Schmitt MJ, Reiter J (2008). Viral induced yeast apoptosis. Biochim. Biophys. Acta Mol. Cell Res. 1783, 1413-1417.

Schmitt MJ (2008). Viral killer toxins. In: Encyclopedia of Virology, 3rd ed., Volume 5, Mahy BWJ, van Regenmortel MHV (eds.), Elsevier Oxford, pp. 299-308.

Schmitt MJ, Powilleit F (2008). Chimäre Hefevirus-Capside: Eine innovative Plattform zur Herstellung von Impfstoffen und Fremdproteinen. BIOforum 5: 42-44.

Powilleit F, Breinig T, Schmitt MJ (2007). Exploiting the yeast L-A viral capsid for the in vivo assembly of chimeric VLPs as platform in vaccine development and foreign protein expression. PLoS One 2(5), e415.

Breinig F, Schmitt MJ (2007). Killertoxine aus Hefen. Biologie in unserer Zeit 37: 104-111.

Schmitt MJ, Breinig F (2006). Yeast viral killer toxins: lethality and self-protection. Nat. Rev. Microbiol. 4: 212-221.

Heiligenstein S, Eisfeld K, Sendzik T, Breinig F, Jimenez-Becker N, Schmitt MJ (2006). Retro-tranlocation of a viral A/B toxin from the yeast endoplasmic reticulum is independent of ubiquitination and ERAD. EMBO J. 25: 4717-4727.

Breinig F, Diehl B, Rau S, Zimmer C, Schwab H, Schmitt MJ (2006). Yeast cell surface expression of bacterial esterase A and its enhancement by activation of the unfolded protein response. Appl. Environ. Microbiol. 72: 7140-7147.

Breinig F, Sendzik T, Eisfeld K, Schmitt MJ (2006). Dissecting toxin immunity in virus-infected killer yeast uncovers an intrinsic strategy of self protection. Proc. Natl. Acad. Sci. USA 103: 3810-3815.

Reiter J, Herker E, Madeo F, Schmitt MJ (2005). Viral killer toxins induce caspase-mediated apoptosis in yeast. J. Cell Biol. 168: 353-358.

Weiler F, Schmitt MJ (2005). Zygocin - a monomeric protein toxin secreted by virus-infected Zygosaccharomyces bailii. In: Microbial Protein Toxins. Schmitt MJ, Schaffrath R (eds). Springer-Verlag, pp. 175-187.

Leis S, Spindler J, Reiter J, Breinig F, Schmitt MJ (2005).S. cerevisiae K28 toxin - a secreted virus toxin of the A/B family of protein toxins. In: Microbial Protein Toxins. Schmitt MJ, Schaffrath R (eds). Springer-Verlag, pp. 111-132.

Breinig F, Schleinkofer K, Schmitt MJ (2004). Yeast Kre1p is GPI-anchored and involved in both cell wall assembly and architecture. Microbiology 150: 3209-3218.

Petrova V, Drescher D, Kujumdzieva A, Schmitt MJ (2004). Dual targeting of yeast catalase A to peroxisomes and mitochondria. Biochem. J. 380: 393-400.

Eiden-Plach A, Zagorc T, Heintel T, Carius Y, Breinig F, Schmitt MJ (2004). A viral preprotoxin signal sequence allows efficient secretion of green fluorescent protein by Candida glabrata, Pichia pastoris, Saccharomyces cerevisiae and Schizosaccharomyces pombe. Appl. Environ. Microbiol. 70: 961-966.

Leis S, Reiter J, Sendzik T, Schmitt MJ (2004). Virale Killertoxine der Hefe und deren Wirkung auf Zellzyklus und DNA-Synthese. BIOspektrum 4: 387-388.

Breinig F, Eiden-Plach A, Breinig T, Schmitt MJ (2004). Ein virales Killertoxin-Sekretionssignal zur effizienten Proteinsekretion. Laborwelt 5: 6-9.

Schmitt MJ (2004). Foreign proteins targeted to successful secretion in yeast species. ASM News 70 (4): 185.

Breinig F, Heintel T, Schumacher A, Meyerhans A, Schmitt MJ (2003). Specific activation of CMV-primed human T lymphocytes by cytomegalovirus pp65 expressed in fission yeast. FEMS Immunol. Med. Microbiol. 38: 231-239.

Heintel T, Breinig F, Schmitt MJ, Meyerhans A (2003). Extensive MHC class I-restricted CD8 T lymphocyte responses against various yeast genera in humans. FEMS Immunol. Med. Microbiol. 39: 279-286.

Weiler F, Schmitt MJ (2003). Zygocin, a secreted antifungal toxin of the yeast Zygosaccharomyces bailii and its effect on sensitive fungal cells. FEMS Yeast Res. 3: 69-76.

Weiler F, Schmitt MJ (2003). Transfection of yeast with toxin-coding dsRNA viruses of Zygosaccharomyces bailii and toxin purification by receptor-mediated affinity chromatography. In: Lab Manual on Non-conventional Yeasts: Genetics, Biochemistry, Molecular Biology, and Biotechnology. Wolf K, Breunig K, Barth E (eds.), Springer-Verlag, pp. 417-425.

Breinig F, Tipper DJ, Schmitt MJ (2002). Kre1p, the plasma membrane receptor for the yeast K1 viral toxin. Cell 108: 395-405.

Weiler F, Rehfeldt K, Bautz F, Schmitt MJ (2002) The Zygosaccharomyces bailii antifungal virus toxin zygocin: cloning and expression in a heterologous fungal host. Mol. Microbiol. 46: 1095-1105.

Breinig F, Schmitt MJ (2002). Spacer-elongated cell wall fusion proteins improve cell surface expression in the yeast Saccharomyces cerevisiae. Appl. Microbiol. Biotechnol. 58: 637-644.

Riffer F, Eisfeld K, Breinig F, Schmitt MJ (2002). Mutational analysis of K28 preprotoxin processing in the yeast Saccharomyces cerevisiae. Microbiology 148: 1317-28.

Schmitt MJ, Breinig F (2002). The viral killer system in yeast: from molecular biology to application. FEMS Microbiol. Rev. 26: 257-276.

Schmitt MJ, Eisfeld K, Leis S (2002). „Intelligente“ Strategien zur Abtötung eukaryonter Zielzellen: Die Rolle mikrobieller A/B-Toxine. BIOforum 7-8: 487-489.

Eisfeld K, Leis S, Schmitt MJ (2001). Ubiquitination and ER-to-cytosol export of the ??? heterodimeric K28 toxin in yeast. Yeast 18: S1-354.

Schmitt MJ (2001). Biotechnology of yeasts. In: Innovative Aspects in Biotechnology of Eukaryotes, Schmitt MJ, Blanc P (eds.), pp. 83-126, BioINEP Series, Invest-Press ISBN 954785001-6.

Heintel T, Zagorc T, Schmitt MJ (2001). Expression, processing and high level secretion of a virus toxin in fission yeast. Appl. Microbiol. Biotechnol. 56: 165-172.

Eisfeld K, Riffer F, Mentges J, Schmitt MJ (2000). Endocytotic uptake and retrograde transport of a virally encoded killer toxin in yeast. Mol. Microbiol. 37: 926-940.

Theisen S, Molkenau E, Schmitt MJ (2000). Wicaltin, a new protein toxin secreted by the yeast Williopsis californica and its broad-spectrum antimycotic potential. J. Microbiol. Biotechnol. 10: 547-550.

Schmitt MJ (2000). Molekulare Grundlagen und Anwendungspotential von 'Killer'-Hefen. Mathematisch-Naturwissenschaftlicher Unterricht MNU 53: 392-401.

Schmitt MJ (1998). Weinhefen und Gentechnik: Entwicklungen gegen Ende des 20. Jahrhunderts. Deutsches Weinbau Jahrbuch 50: 181-190.

Schmitt MJ, Eisfeld K (1999). Killer viruses in Saccharomyces cerevisiae and their general importance in understanding eukaryotic cell biology. Recent Res. Devel. Virol. 1: 525-545.

Schmitt MJ (1998). Yeast killer viruses: tracers in eukaryotic cell biology and useful vehicles in gene technology. Eur. J. Cell Biol. 75: 16-17.

Schmitt MJ, Eisfeld K (1997). Construction and possible use of recombinant M-dsRNA satellite viruses in heterologous gene expression in yeast. Yeast 13: 237.

Schmitt MJ, Poravou O, Trenz K, Rehfeldt K (1997). Unique double-stranded RNAs responsible for the anti-Candida-activity of the yeast Hanseniaspora uvarum. J. Virol. 71: 8852-8855.

Schmitt MJ, Schernikau G (1997). Construction of a cDNA-based K1/K2/K28 triple killer strain of Saccharomyces cerevisiae. Food Techn. Biotechnol. 35: 281-285.

Schmitt MJ (1997). „Killerviren“: Tödlich für Hefen - nützlich in Gentechnik und Medizin? Magazin Forschung 2: 16-22.

Schmitt MJ, Klavehn P, Wang C, Schönig I, Tipper DJ (1996). Cell cycle studies on the mode of action of yeast killer toxin K28. Microbiology 142: 2655-2662.

Neuhausen F, Schmitt MJ (1996). Transgenic expression of a toxin-coding killer virus of the yeast Zygosaccharomyces bailii in Saccharomyces cerevisiae: genetic evidence for a possible function of "cryptic" mycoviruses in the evolution of their hosts. In: Biosafety: Stability of DNA, Horizontal Gene Transfer and Expression of Transgenes. Schmidt ER, Hankeln T (eds.), Springer Verlag, pp.117-124.

Schmitt MJ, Radler F (1996). dsRNA-Viren codieren Killertoxine bei der Hefe Saccharomyces. BIOspektrum 2: 30-34.

Schmitt MJ (1995). Cloning and expression of a cDNA copy of the viral K28 killer toxin gene in yeast. Mol. Gen. Genet. 246: 236-246.

Schmitt MJ, Tipper DJ (1995). Sequence of the M28-dsRNA: Preprotoxin is processed to an ???-heterodimeric protein toxin. Virology 213: 341-351.

Schmitt MJ, Compain P (1995). Killer toxin resistant kre12 mutants of Saccharomyces cerevisiae: Biochemical and genetic evidence for a secondary K1 membrane receptor. Arch. Microbiol. 164: 435-443.

Schmitt MJ (1995). Konstruktion und möglicher Einsatz gentechnisch veränderter Weinhefen. Deutsches Weinbau Jahrbuch 47: 177-186.

Schmitt MJ, Radler F (1995). Mycoviren und Hefe-Killertoxine erlauben Einblicke in die Zellbiologie. Forschungsmagazin 2: 86-96.

Tipper DJ, Schmitt MJ (1995). The Saccharomyces cerevisiae K28 killer virus. In: The Proceedings of the International Workshop on Viruses of Fungi and Lower Eukaryotes. Leibowitz M, Rubio V, Koltin Y (eds.), Wilmington, Delaware Press, pp. 284-292.

Schmitt MJ, Neuhausen F (1994). Killer toxin secreting double-stranded RNA mycoviruses in the yeasts Hanseniaspora uvarum and Zygosaccharomyces bailii. J. Virol. 68: 1765-1772.

Schmitt MJ, Tipper DJ (1992). Genetic analysis of maintenance and expression of L and M double-stranded RNAs from yeast killer virus K28. Yeast 8: 373-384.

Radler F, Schmitt MJ (1992). Welche Bedeutung haben Killerhefen bei der Weinbereitung? Deutsches Weinbau Jahrbuch 44: 229-238.

Tipper DJ, Schmitt MJ (1991). Yeast dsRNA viruses: replication and killer phenotypes. Mol. Microbiol. 5: 2331-2338.

Schmitt MJ, Radler F (1990). Blockage of cell wall receptors for yeast killer toxin K28 with antimannoprotein antibodies. Antimicr. Agents Chemoth. 34: 1615-1618.

Schmitt MJ, Tipper DJ (1990). K28, a unique double-stranded RNA killer virus of Saccharomyces cerevisiae. Mol. Cell. Biol. 10: 4807-4815.

Schmitt MJ, Pfeiffer PC (1990). Immunochemical analysis of the carbohydrate mojety of yeast killer toxin K28. Antonie van Leeuwenhoek 58: 277-282.

Radler F, Schmitt MJ, Meyer B (1990). Killer toxin of Hanseniaspora uvarum. Arch. Microbiol. 154: 175-178. Schmitt MJ, Brendel M, Schwarz R, Radler F (1989). Inhibition of DNA synthesis in S. cerevisiae by yeast killer toxin KT28. J. Gen. Microbiol. 135: 1529-1535.

Schmitt MJ, Radler F (1989). Purification of yeast killer toxin KT28 by receptor-mediated affinity chromatography. J. Chromat. 469: 448-452.

Schmitt MJ, Radler F (1988). Molecular structure of the cell wall receptor for killer toxin KT28 in Saccharomyces cerevisiae. J. Bacteriol. 170: 2192-2196.

Schmitt MJ, Radler F (1987). Mannoprotein of the yeast cell wall as primary receptor for the killer toxin of Saccharomyces cerevisiae strain 28. J. Gen. Microbiol. 133: 3347-54.

Radler F, Schmitt MJ (1987). Killer toxins of yeasts: inhibitors of fermentation and their adsorption. J. Food Protec. 50: 234-238.

Diehl B, Schmitt MJ (2008). Hefezellbasierter Bioassay zur Testung spezifischer Inhibitoren gegen humane tumorrelevante Matrix-Metalloproteasen (MMPs). Patentschrift Nr. 102008 054494.9, Deutsches Patent- und Markenamt, S. 1-49.

Powilleit F, Schmitt MJ (2004). Rekombinante ScV-Partikel, ihre kodierenden Nukleinsäuren und ihre Verwendungen. Patentschrift DE 10 2004 032 888.9, Deutsches Patent- und Markenamt, S. 1-147.

Schmitt MJ, Theisen S, Wagner P (2002). Novel antimycotics and fungicides, processes for their preparation and their use. U.S. Patent Application No. 10/019963.

Zagorc T, Heintel T, Schmitt MJ (2000). Sekretionssignalpeptide, deren DNA-Sequenzen, damit herstellbare Expressionsvektoren für eukaryotische Zellen und deren Verwendung zur biotechnologischen Herstellung von Proteinen. Patentschrift Nr. 10062 302.6, Deutsches Patent- und Markenamt, S. 1-26.

Schmitt MJ, Theisen S, Wagner P (1999). Neue Antimykotika und Fungizide: Verfahren zu deren Herstellung und Anwendung. Deutsches Patent- und Markenamt, Patentschrift Nr. DPA 199 30 959.0, S. 1-41.

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