Jahresbibliographie - Kumulierte Ausgabe (1993- )

Veröffentlichungen von
Angehörigen der Hochschulen des Saarlandes

Pharmazeutische und Medizinische Chemie (09.02.10)

Angotti, Marc
2005
- The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of aldosterone 
synthase (CYP11B2) inhibitors and their potential side effects / Müller-Vieira, Ursula ; Angotti, Marc 
; Hartmann, Rolf W.. - In: J. Steroid Biochem. Mol. Biol., 96 (2005) , 259-270

- Effect of 2-(4-aminophenylmethyl)-6-hydroxy-3,4-dihydronaphthalen-1(2H)-one on all-trans and 13-cis-retinoic 
acid levels in plasma quantified by high performance liquid chromatography coupled to tandem mass spectrometry 
/ Angotti, Marc ; Hartmann, Rolf W. ; Kirby, Andrew J. ; Simons, Claire ; Nicholls, Paul J. ; Sewell 
Robert D.E. ; Smith, H. John. - In: J. Enz. Inhib. Med. Chem., 20 (2005) , 219-226

Batzl-Hartmann, Christine

2004
- [1,2-Bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]platinum(II) Complexes, Compounds for the Endocrine 
Therapy of Breast Cancer - Mode of Action II / Schertl, Sabine ; Hartmann, Rolf W. ; Batzl-Hartmann, 
Christine ; Bernhardt, Günther ; Spruß, Thilo ; Beckenlehner, Karin ; Koch, Marion ; Krauser, Rudolf 
; Schlemmer, Richard ; Gust, Ronald ; Schönenberger, Helmut. - In: Arch. Pharm. Pharm. Med. Chem., , 
337 (2004) , 349-359

- [1,2-Bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes, compounds for the endocrine 
therapy of breast cancer - Mode of action I: antitumor activity due to the reduction of the endogenous 
estrogen level / Schertl, Sabine ; Hartmann, Rolf W. ; Batzl-Hartmann, Christine ; Bernhardt, Günther 
; Spruß, Thilo ; Beckenlehner, Karin ; Koch, Marion ; Krauser, Rudolf ; Schlemmer, Richard ; Gust, Ronald 
; Schönenberger, Helmut. - In: Arch. Pharm. Pharm. Med. Chem., 337 (2004) , 335-348

2003
- Effects of novel 17alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis 
in vitro and in vivo / Haidar, Samer ; Ehmer, Peter B. ; Barassin, Stephan ; Batzl-Hartmann, Christine 
; Hartmann, Rolf W.. - In: J. Steroid. Biochem. Mol. Biol., 84 (2003) , 555-562

2001
- 1-(2,6-Dichloro-4-hydroxyphenyl)-2-phenylethanes - new biological response modifiers for the therapy 
of breast cancer. Synthesis and evalulation of estrogenic/antiestrogenic properties / Schertl, S. ; Hartmann, 
Rolf W. ; Batzl-Hartmann, Christine ; Schlemmer, R. ; Spruß, T. ; Bernhardt, G. ; Gust, R. ; Schönenberger, 
H.. - In: Arch. Pharm. Pharm. Med. Chem., 334 (2001) , 125-137

Betscheider, Dirk

2003
- New inhbitors of human cathepsin G identified by surface display library screening and peptide-protein 
docking / Jose, Joachim ; Betscheider, Dirk ; Ray, Somak ; Lengauer, Thomas ; Zangen, D.. - In: 7th International 
symposium on Pharmaceutical Sciences (ISOPS-7), Ankara, Turkey, June, 24 - June, 27, Faculty of Pharmacy, 
Ankara University, Ankara, 2003, 46-49

- New inhibitors of human cathepsin G by bacterial surface display library screening and peptide-protein 
docking / Jose, Joachim ; Betscheider, Dirk ; Ray, Somak ; Lengauer, Thomas ; Zangen, Dirk. - In: Proceedings 
of the 7th International Symposium on Pharmaceutical Sciences ISOPS7 / Ed.: Akin, Ahmet et al.. - Ankara 
: Tasarim Basim. 2003, 46-49

Bild, Thomas

2004
- Discovery of inhibitors of the MCF-7 tumor cell adhesion to endothelium cells and investigation of their 
mode of action / Bild, Thomas ; Jose, Joachim ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 
337 (2004) , 617-712

Dossou, Ulrich

2004
- Evaluation of cell permeation of a potent 5á-reductase inhibitor using MALDI-TOF MS / Mathur, Sonal ; 
Picard, Franck ; Dossou, Ulrich ; Barassin, Catherine ; Seidel, Stefanie ; Kang, Min-Jung ; Hartmann, 
Rolf W.. - In: J. Enz. Inhib. Med. Chem., 19 (2004) , 425-429

Ehmer Peter

2001
- Novel Steroidal Pyrimidyl Inhibitors of P450 17 (17alpha-Hydroxylase/C17- se) / Haidar, Samer ; Ehmer 
Peter ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem, 334 (2001) , 373-374

Ehmer, Peter

2004
- Synthesis of hydroxy derivatives of highly potent non-steroidal CYP 17 inhibitors as potential metabolites 
and evaluation of their activity by a non cellular assay using recombinant human enzyme / Hutschenreuter, 
Tilmann ; Ehmer, Peter ; Hartmann, Rolf W.. - In: J. Enz. Inhib. Med. Chem., 19 (2004) , 17-32

2002
- Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission 
yeast and evaluation of selectivity / Ehmer, Peter ; Bureik, Matthias ; Bernhardt, Rita ; Müller, Ursula 
; Hartmann, Rolf W.. - In: J. Steroid Biochem. Mol. Biol., 81 (2002) , 173-179

- Inhibition of CYP 17, A new strategy for the treatment of prostate cancer / Hartmann, Rolf W. ; Ehmer, 
Peter ; Haidar, Samer ; Hector, Markus ; Jose, Joachim ; istian ; Seidel, Stefanie ; Sergejew, Tom ; 
Wachall, Bertil Gero ; Wächter, Gerald A. ; Zhuang Yan. - In: Arch. Pharm. Pharm. Med. Chem., 4 (2002) 
, 119-128

2000
- Development of a simple and rapid assay for the evaluation of inhibitors of human 17alpha-hydroxylase-
C17,20-lyase (P450c17) by coexpression of P450c17 with NADPH-cytochrome-P450-reductase in Escherichia 
coli / Ehmer, Peter ; Jose, Joachim ; Hartmann, Rolf W.. - In: J. Steroid Biochem. Mol. Biol., 75 (2000) 
, 57-63

- Development of a simple and rapid test assay for inhibitors of human 17a- hydroxylase-C17,20-lyase by 
coexpression of cytochrome P450c17 and NADPH- cytochrome-P450 reductase in Escherichia coli / Ehmer, 
Peter ; Jose, Joachim ; Hartmann, Rolf W.. - In: Journal of Steroid Biochemistry and Molecular Biology, 
75 (2000) , 1, 57-63

- Synthesis and evaluation of novel steroidal oximes as inhibitors of P450 17 (17alpha-hydroxylase / C17-
20-lyase) and . - a-reductase 1 and 2 / Hartmann, Rolf W. ; Hector, Markus ; Haidar, Samer ; Ehmer, Peter 
; Jose, Joachim. - In: J. Med. Chem., 43 (2000) , 4266-4277

1999
- Development of a simple and rapid test assay for inhibitors of human 17a- hydroxylase-C17,20-lyase by 
coexpression of cytochrome P450c17 and NADPH- cytochrome-P450 reductase in Escherichia coli / Ehmer, 
Peter ; Hartmann, Rolf W. ; Jose, Joachim. - In: Arch. Pharm. Pharm. Med Chem., 332 (1999) , Suppl. 2, 
9

Haidar, Samer

2003
- Effects of novel 17alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis 
in vitro and in vivo / Haidar, Samer ; Ehmer, Peter B. ; Barassin, Stephan ; Batzl-Hartmann, Christine 
; Hartmann, Rolf W.. - In: J. Steroid. Biochem. Mol. Biol., 84 (2003) , 555-562

2002
- C16 and C17 substituted derivatives of pregnenolone and progesterone as inhibitors of 17alpha-hydroxylase-
C17,20-lyase: synthesis and biological evaluation / Haidar, Samer ; Hartmann, Rolf W.. - In: Arch. Pharm. 
Pharm. Med. Chem., 335 (2002) , 526-534 

- Inhibition of CYP 17, A new strategy for the treatment of prostate cancer / Hartmann, Rolf W. ; Ehmer, 
Peter ; Haidar, Samer ; Hector, Markus ; Jose, Joachim ; istian ; Seidel, Stefanie ; Sergejew, Tom ; 
Wachall, Bertil Gero ; Wächter, Gerald A. ; Zhuang Yan. - In: Arch. Pharm. Pharm. Med. Chem., 4 (2002) 
, 119-128

2001
- Novel Steroidal Pyrimidyl Inhibitors of P450 17 (17alpha-Hydroxylase/C17- se) / Haidar, Samer ; Ehmer 
Peter ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem, 334 (2001) , 373-374

- Synthesis and evaluation of steroidal hydroxamic acids as inhibitors of P450 17 (17alpha-hydroxylase/C17-
20-lyase) / Haidar, Samer ; Klein, Christian ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 
334 (2001) , 138-140

2000
- Synthesis and evaluation of novel steroidal oximes as inhibitors of P450 17 (17alpha-hydroxylase / C17-
20-lyase) and . - a-reductase 1 and 2 / Hartmann, Rolf W. ; Hector, Markus ; Haidar, Samer ; Ehmer, Peter 
; Jose, Joachim. - In: J. Med. Chem., 43 (2000) , 4266-4277

Handel, Steffen

2003
- Monitoring the surface display of recombinant proteins by cysteine labeling and flow cytometry / Jose, 
Joachim ; Handel, Steffen. - In: ChemBioChem, 4 (2003) , 5, 396-405

Hartmann, Rolf W.

2005
- 5alpha-reductase in human embryonic kidney cell line HEK293 : evidence for type II enzyme expression 
and activity / Panter, Bärbel Ursula ; Jose, Joachim ; Hartmann, Rolf W.. - In: Mol. Cell. Biochem., 
270 (2005) , 201-208

- The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of aldosterone 
synthase (CYP11B2) inhibitors and their potential side effects / Müller-Vieira, Ursula ; Angotti, Marc 
; Hartmann, Rolf W.. - In: J. Steroid Biochem. Mol. Biol., 96 (2005) , 259-270

- Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2) 
/ Ulmschneider, Sarah ; Negri, Matthias ; Voets, Marieke ; Hartmann, Rolf W.. - In: Bioorg. Med. Chem. 
Lett., 16 (2005) , 25-30

- Effect of 2-(4-aminophenylmethyl)-6-hydroxy-3,4-dihydronaphthalen-1(2H)-one on all-trans and 13-cis-retinoic 
acid levels in plasma quantified by high performance liquid chromatography coupled to tandem mass spectrometry 
/ Angotti, Marc ; Hartmann, Rolf W. ; Kirby, Andrew J. ; Simons, Claire ; Nicholls, Paul J. ; Sewell 
Robert D.E. ; Smith, H. John. - In: J. Enz. Inhib. Med. Chem., 20 (2005) , 219-226

- Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry 
approach / Cavalli, Andrea ; Bisi, Alessandra ; Bertucci, Carlo ; Rosini, Carlo ; Palusczak, Anja ; Gobbi, 
Silvia ; Giorgio, Egidio ; Rampa, Angela ; Belluti, Federica ; Piazzi, Lorna ; Valenti, Piero ; Hartmann, 
Rolf W. ; Recanatini, Maurizio. - In: J. Med. Chem., 48 (2005) , 7282-7289

- Enzyme inhibitors for the treatment of prostate tumor. Enzyme inhibitor examples for the treatment of 
prostate tumor / Haider, Samer ; Hartmann, Rolf W.. - In: Enzyme and their inhibition: drug development 
/ Ed.: Smith, H. John; Simons, Claire. - Florida : CRC Press. 2005, 241-253 (CRC Enzyme Inhibitors Series)

- Heteroaryl substituted naphthalenes and structurally modified derivatives : selective inhibitors of CYP11B2 
for the treatment of congestive heart failure and myocardial fibrosis / Voets, Marieke ; Antes, Iris 
; Scherer, Christiane ; Biemel, Klaus ; Barassin, Catherine ; Marchais-Oberwinkler, Sandrine ; Hartmann, 
Rolf W.. - In: J. Med. Chem., 48 (2005) , 6632-6642

- A Method for Screening Enzyme Inhibitors Using Size Exclusion Chromatography and ESI-LC-MS/MS / Mathur, 
Sonal ; Park, Jung Dae ; Kim, Dong H. ; Hartmann, Rolf W.. - In: J. Biomol. Screening. 2005 , 10, 30-
35

- Methyl Esters of N-(Dicyclohexyl)acetyl-piperidine-4-(benzylidene-4-carboxylic acids) as Drugs and Prodrugs 
– a New Strategy for Dual Inhibition of 5á-Reductase Type 1 and Type 2 / Streiber, Martina ; Picard, 
Franck ; Seidel, Stefanie ; Scherer, Christiane ; Hartmann, Rolf W.. - In: J. Pharm. Sci., 94 (2005) 
, 473-480

- Synthesis and Evaluation of Imidazolylmethylene-tetrahydronaphthalenes and -indanes: Potent Inhibitors 
of Aldosterone Synthase (CYP11B2) / Ulmschneider, Sarah ; Müller-Vieira, Ursula ; Mitrenga, Markus ; 
Hartmann, Rolf W. ; Marchais-Oberwinkler, Sandrine ; Klein, Christian ; Bureik, Matthias ; Bernhardt, 
Rita ; Antes, Iris ; Lengauer, Thomas. - In: J. Med. Chem.. 2005 , 48, 1796-1805

- Synthesis and study of some new N-substituted imide derivatives as potential anticancer agents / Jindal, 
Dharam Paul ; Bedi, Vikas ; Jit, Birinder ; Karkra, Nalin ; Guleria, Sheetal ; Bansal, Ranju ; Palusczak, 
Anja ; Hartmann, Rolf W.. - In: Il Farmaco, 60 (2005) , 283-290

- Three-dimensional model of cytochrome P450 human aromatase and docking studies in to the active site 
/ Logé, Cedric ; Le Borgne, Marc ; Marchand, Pascal ; Robert, Jean-Michel ; Palzer, Martina ; Hartmann, 
Rolf W.. - In: Bioorg. Med. Chem., 20 (2005) , 581-585

2004
- [1,2-Bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]platinum(II) Complexes, Compounds for the Endocrine 
Therapy of Breast Cancer - Mode of Action II / Schertl, Sabine ; Hartmann, Rolf W. ; Batzl-Hartmann, 
Christine ; Bernhardt, Günther ; Spruß, Thilo ; Beckenlehner, Karin ; Koch, Marion ; Krauser, Rudolf 
; Schlemmer, Richard ; Gust, Ronald ; Schönenberger, Helmut. - In: Arch. Pharm. Pharm. Med. Chem., , 
337 (2004) , 349-359

- [1,2-Bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes, compounds for the endocrine 
therapy of breast cancer - Mode of action I: antitumor activity due to the reduction of the endogenous 
estrogen level / Schertl, Sabine ; Hartmann, Rolf W. ; Batzl-Hartmann, Christine ; Bernhardt, Günther 
; Spruß, Thilo ; Beckenlehner, Karin ; Koch, Marion ; Krauser, Rudolf ; Schlemmer, Richard ; Gust, Ronald 
; Schönenberger, Helmut. - In: Arch. Pharm. Pharm. Med. Chem., 337 (2004) , 335-348

- 2- and 3-[(Aryl)(azolyl)methyl]indoles as Potential Non-steroidal Aromatase Inhibitors / Lézé, Marie-
Pierre ; Le Borgne, Marc ; Marchand, Pascal ; Loquet, Denis ; Kogler, Manuela ; Le Baut, Guillaume ; 
Palusczak, Anja ; Hartmann, Rolf W.. - In: J. Enz. Inhib. Med. Chem., 19 (2004) , 549-557

- CYP 17 and CYP 19 Inhibitors. Evaluation of Fluorine Effects on the Inhibiting Activity of Regioselectively 
Fluorinated 1-(Naphthalen-2-ylmethyl)imidazoles / Hartmann, Rolf W. ; Palusczak, Anja ; Lacan, F. ; Ricci, 
G. ; Ruzziconi, R.. - In: J. Enz. Inhib. Med. Chem., 19 (2004) , 2, 145-155

- Design, Synthesis and 3D QSAR of Novel Potent and Selective Aromatase Inhibitors / Leonetti, Francesco 
; Favia, Angelo ; Rao, Angela ; Aliano, Rosaria ; Paluszcak, Anja ; Hartmann, Rolf W. ; Carotti, Angelo. 
- In: J. Med. Chem.. 2004 , 47, 6792-6803

- Discovery of inhibitors of the MCF-7 tumor cell adhesion to endothelium cells and investigation of their 
mode of action / Bild, Thomas ; Jose, Joachim ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 
337 (2004) , 617-712

- Evaluation of cell permeation of a potent 5á-reductase inhibitor using MALDI-TOF MS / Mathur, Sonal ; 
Picard, Franck ; Dossou, Ulrich ; Barassin, Catherine ; Seidel, Stefanie ; Kang, Min-Jung ; Hartmann, 
Rolf W.. - In: J. Enz. Inhib. Med. Chem., 19 (2004) , 425-429

- Identification of monohydroxy progesterones produced by CYP106A2 using comparative HPLC and electrospray 
ionisation collision-induced dissociation mass spectrometry / Lisurek, Michael ; Kang, Min-Jung ; Hartmann, 
Rolf W. ; Bernhardt, Rita. - In: Biochem. Biophys. Res. Comm., 319 (2004) , 677-682

- Inhibition of CYP 17. Potential Treatment of Prostate Cancer / Haider, Samer ; Hartmann, Rolf W.. - In: 
Arab J. Pharm. Sci., 2 (2004) , 59-76

- The pro-oxidant and antioxidant action of 4-(4-phenoxybenzoyl)benzoic acid derivatives / Aboul-Enein, 
Hassan Y. ; Kladna, Alexandra ; Kruk, Irena ; Lichszteld, Krzystof ; Marchlewicz, Mariola ; Michalska, 
Teresa ; Salem, Ola Ibrahim Abdel ; Hartmann, Rolf W.. - In: Biopolymers, 73 (2004) , 631-639

- Protein-Dynamics of the Putative HCV Receptor CD81 Large Extracellular Loop / Neugebauer, Alexander ; 
Klein, Christian ; Hartmann, Rolf W.. - In: Bioorg. Med. Chem.Lett., 14 (2004) , 1765-1769

- QSAR of Human Steroid 5 á-Reductase Inhibitors: Where are the differences between isoenzyme type 1 and 
2? / Hutter, Michael ; Hartmann, Rolf W.. - In: QSAR Combinatorial Science, 23 (2004) , 6, 406-415

- QSAR of Human Steroid 5#945;-Reductase Inhibitors: Where are the differences between isoenzyme type 1 
and  / Hutter, Michael ; Hartmann, Rolf W.. - In: QSAR Comb. Sci.. 2004 , 23, 406-415

- Quantitative analysis of 5á-reductase inhibitors permeated in DU145 cells using MALDI-TOF MS and HPLC-
MS/MS / Kang, Min-Jung ; Mathur, Sonal ; Hartmann, Rolf W.. - In: J. Mass Spectrometry, 39 (2004) , 762-
769

- Synthesis and evaluation of a dimer of 2-(4-pyridylmethyl)-1-indanone as a novel nonsteroidal aromatase 
inhibitor / Gupta, Ranju ; Jindal, Dharam Paul ; Jit, Birinder ; Narang, Gaurav ; Palusczak, Anja ; Hartmann, 
Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 337 (2004) , 398-401

- Synthesis of Amidinohydrazones and Evaluation of Their Inhibitory Effect towards Aldosterone Synthase 
(CYP11B2) and the Formation of Selected Steroids / Voets, Marieke ; Müller-Vieira, Ursula ; Marchais-
Oberwinkler, Sandrine ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 337 (2004) , 411-416

- Synthesis of hydroxy derivatives of highly potent non-steroidal CYP 17 inhibitors as potential metabolites 
and evaluation of their activity by a non cellular assay using recombinant human enzyme / Hutschenreuter, 
Tilmann ; Ehmer, Peter ; Hartmann, Rolf W.. - In: J. Enz. Inhib. Med. Chem., 19 (2004) , 17-32

- Use of HPLC-ESI-CID mass spectrometry for structural identification of monohydroxylated progesterones 
/ Kang, Min-Jung ; Lisurek, Michael ; Bernhardt, Rita ; Hartmann, Rolf W.. - In: Rapid Comm. in Mass 
Spec., 18 (2004) , 2795-2800

2003
- Cyclohex-1-ene Carboxylic Acids: Synthesis and Biological Evaluation of Novel Inhibitors of Human 5a 
Reductase / Baston, Eckhard ; Salem, Ola Ibrahim Abdel ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. 
Med. Chem., 336 (2003) , 31-38

- Cyclohex-1-ene Carboxylic Acids: Synthesis and Biological Evaluation of Novel Inhibitors of Human 5alpha 
Reductase / Baston, Eckhardt ; Salem, Ola Ibrahim Abdel Razek ; Hartmann, Rolf W.. - In: Arch. Pharm. 
Pharm. Med. Chem., 336 (2003) , 1, 31-38

- Development of a New Approach for Screening Combinatorial Libraries Using MALDI-TOF MS and HPLC-MS/MS 
/ Steiner, Frank ; Hassel, Marc ; Hollemeyer, Klaus ; Hartmann, Rolf W. ; Sonal, Mathur. - In: Journal 
of Biomolecular Screening, 8 (2003) , 136-148

- Discovery of selective CYP11B2 (aldosterone synthase) inhibitors for the therapy of congestive heart 
failure and myocardial fibrosis / Hartmann, Rolf W. ; Müller, Ursula ; Ehmer, Peter B.. - In: Eur. J. 
Med. Chem., 38 (2003) , 363-366

- Effects of novel 17alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis 
in vitro and in vivo / Haidar, Samer ; Ehmer, Peter B. ; Barassin, Stephan ; Batzl-Hartmann, Christine 
; Hartmann, Rolf W.. - In: J. Steroid. Biochem. Mol. Biol., 84 (2003) , 555-562

- Enantiomeric resolution of some human aldosterone synthase[CYP 11 B2]inhibitors on derivatized chiral 
stationary phases / Aboul-Enein, Hassan Y. ; Hefnawy, Mohamed M. ; Ehmer, Peter B. ; Hartmann, Rolf W.. 
- In: J. Sep. Sci., 26 (2003) , 1455-1458

- N-(4-Biphenylmethyl)imidazoles as potential therapeutics for the treatment of prostate cancer: metabolic 
robustness due to fluorine substition? / Leroux, Frédéric ; Hutschenreuter, Tilmann ; Charrière, Céline 
; Scopelliti, Rosario ; Hartmann, Rolf W.. - In: Helv. Chim. Act., 86 (2003) , 2671-2686

- Preparation and pharmacological profile of 7-(alpha-Azolylbenzyl)-1H-Indoles and indolines as new aromatase 
inhibitors / Marchand, Pascal ; Le Borgne, Marc ; Palzer, Martina ; Le Baut, Guillaume ; Hartmann, Rolf 
W.. - In: Bioorg. Med. Chem. Lett., 13 (2003) , 1553-1555

- Three Dimensional Pharmacophore Modeling of Human CYP17 inhibitors. Potential Agents for Prostate Cancer 
Therapy / Clement, Omoshile O. ; Freeman, Clive M. ; Hartmann, Rolf W. ; Handratta, Venkatesh D. ; Vasaitis, 
Tadas S. ; Brodie, Angela M.H. ; Njar, Vincent C.O.. - In: J. Med. Chem., 46 (2003) , 12, 2345-2351

2002
- 5-Phenyl substituted 1-methyl-2-pyridones and 4'-substituted biphenyl-4- carboxylic acids. Synthesis 
and evaluation as inhibitors of steroid-5alpha- reductase type 1 and 2 / Picard, Franck ; Schulz, Tobias 
; Hartmann, Rolf W.. - In: Bioorg. Med. Chem, 10 (2002) , 437-448

- 6-substituted 3,4-Dihydro-naphthalene-2-carboxylic acids: synthesis and structure-activity studies in 
a novel class of human 5a reductase inhibitors / Baston, Eckhardt ; Salem, Ola Ibrahim Abdel Razek ; 
Hartmann, Rolf W.. - In: J. Enzym. Inhib. Med. Chem., 17 (2002) , 303-320

- C16 and C17 substituted derivatives of pregnenolone and progesterone as inhibitors of 17alpha-hydroxylase-
C17,20-lyase: synthesis and biological evaluation / Haidar, Samer ; Hartmann, Rolf W.. - In: Arch. Pharm. 
Pharm. Med. Chem., 335 (2002) , 526-534 

- Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission 
yeast and evaluation of selectivity / Ehmer, Peter ; Bureik, Matthias ; Bernhardt, Rita ; Müller, Ursula 
; Hartmann, Rolf W.. - In: J. Steroid Biochem. Mol. Biol., 81 (2002) , 173-179

- Inhibition of CYP 17, A new strategy for the treatment of prostate cancer / Hartmann, Rolf W. ; Ehmer, 
Peter ; Haidar, Samer ; Hector, Markus ; Jose, Joachim ; istian ; Seidel, Stefanie ; Sergejew, Tom ; 
Wachall, Bertil Gero ; Wächter, Gerald A. ; Zhuang Yan. - In: Arch. Pharm. Pharm. Med. Chem., 4 (2002) 
, 119-128

- N-substituted 4-(4-carboxyphenoxy)benzamides. Synthesis and evaluation as inhibitors of steroid-5alpha-
reductase type 1 and 2 / Picard, Franck ; Hartmann, Rolf W.. - In: J. Enzym. Inhib. Med. Chem., 17 (2002) 
, 187-196

- Synthesis and biological evaluation of 4-(4- alkyl- and Phenylaminocarbonyl)benzoyl)benzoic acid derivatives 
as nonsteroidal inhibitors of steroid 5alpha-reductase isozymes 1 and 2 / Salem, Ola Ibrahim Abdel Razek 
; Schulz, Tobias ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 335 (2002) , 83-88

- Synthesis and biological evaluation of 4-(4-alkyl- and Phenylaminocarbonyl)benzoyl)benzoic acid derivatives 
as nonsteroidal inhibitors of steroid 5a-reductase isozymes 1 and 2 / Salem, Ola Ibrahim Abdelrazek ; 
Schulz, Tobias ; Hartmann, Rolf W.. - Saarbrücken : Arch. Pharm. Pharm. Med. Chem., 335 (2002), 2

- Synthesis and evaluation of 2'-substituted 4-(4'-carboxy- or 4'- carboxymethylbenzylidene)-N-acylpiperidines: 
highly potent and In Vivo active steroid-5alpha-reductase type 2 inhibitors / Picard, Franck ; Barassin, 
Stephan ; Mokhtarian, Armand ; Hartmann, Rolf W.. - In: J. Med. Chem., 45 (2002) , 3406-17

2001
- 1-(2,6-Dichloro-4-hydroxyphenyl)-2-phenylethanes - new biological response modifiers for the therapy 
of breast cancer. Synthesis and evalulation of estrogenic/antiestrogenic properties / Schertl, S. ; Hartmann, 
Rolf W. ; Batzl-Hartmann, Christine ; Schlemmer, R. ; Spruß, T. ; Bernhardt, G. ; Gust, R. ; Schönenberger, 
H.. - In: Arch. Pharm. Pharm. Med. Chem., 334 (2001) , 125-137

- CYP-17-Inhibitoren: Steroidomimetika zur Behandlung des Prostatakarzinoms / Hartmann, Rolf W.. - In: 
Pharm. Ztg., 146 (2001) , 27, 2285-2289

- A new class of non steroidal aromatase inhibitors: Design and synthesis of chromone and xanthone derivatives, 
and inhibition of P450 enzymes aromatase and 17alpha-hydroxylase/C17,20-lyase / Recanatini, M. ; Bisi, 
A. ; Cavalli, A. ; Belluti, F. ; Gobbi, S. ; Rampa, A. ; Valenti, P. ; Palzer, M. ; Palusczak, Anja ; 
Hartmann, Rolf W.. - In: J. Med. Chem., 44 (2001) , 672-680

- No effect of thromboxane A2 on the attachment of tumor cell lines MDA MB U145, and U937 to the basement 
membrane in an in-vitro model / Kleber, Alice ; Hartmann, Rolf W. ; Jose, Joachim. - In: J. Cancer Res. 
Clin. Oncol, 127 (2001) , 751-754

- Novel Steroidal Pyrimidyl Inhibitors of P450 17 (17alpha-Hydroxylase/C17- se) / Haidar, Samer ; Ehmer 
Peter ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem, 334 (2001) , 373-374

- Die rationale Entwicklung eines Hemmstoffs von CYP 17, einem neuartigen Target zur Behandlung des Prostatacarcinoms 
/ Hartmann, Rolf W.. - In: Magazin Forschung, UdS, 2 (2001) , 2-9

- Stable expression of human 5alpha-reductase type II in COS1 cells due to chromosomal gene integration: 
a novel tool for inhibitor identification / Reichert, Wolfgang ; Michel, Armin ; Hartmann, Rolf W. ; 
Jose, Joachim. - In: J. Steroid Biochem. Mol. Biol., 78 (2001) , 275-284

- Stable expression of the human 5alpha-reductase - isoenzymes type I and type II in HEK293 cells to identify 
dual and selective inhibitors / Reichert, Wolfgang ; Hartmann, Rolf W. ; Jose, Joachim. - In: J. Enz. 
Inhib., 16 (2001) , 47-53

- Synthesis and evaluation of steroidal hydroxamic acids as inhibitors of P450 17 (17alpha-hydroxylase/C17-
20-lyase) / Haidar, Samer ; Klein, Christian ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 
334 (2001) , 138-140

- Synthesis, evaluation and QSAR studies of highly potent aromatase inhibitors of the piperidinedione type 
/ Baston, Eckhard ; Klein, Christian ; Grimminger, Wolf ; Hebecker, Norbert ; Hartmann, Rolf W.. - In: 
Anti Cancer Drug Des, 16 (2001) , 37-47

- Das virtuelle Biolabor / Lehr, Claus-Michael ; Hartmann, Rolf W. ; Lenhof, Hans-Peter. - In: Pharm. Ztg., 
146 (2001) , 29, 2541-2543

2000
- 1-Imidazolyl(alkyl) substituted di- and tetrahydroquinolines and analogs. Synthesis and evaluation of 
dual inhibitors of P450 TxA2 and P450arom / Jacobs, C. ; Frotscher, Martin ; Dannhardt, G. ; Hartmann, 
Rolf W.. - In: J. Med. Chem., 43 (2000) , 1841-1851

- 5alpha-reductase in intact DU145 cells: Evidence for isozyme I and evaluation of novel inhibitors / Reichert, 
Wolfgang ; Jose, Joachim ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 333 (2000) , 201-
204

- 6-Substituted 1H-quinolin-2-ones and 2-methoxy-quinolines: Synthesis and evaluation as inhibitors of 
steroid 5alpha-reductases type 1 and 2 / Baston, E. ; Palusczak, Anja ; Hartmann, Rolf W.. - In: Eur. 
J. Med. Chem., 35 (2000) , 931-940

- Development of a simple and rapid assay for the evaluation of inhibitors of human 17alpha-hydroxylase-
C17,20-lyase (P450c17) by coexpression of P450c17 with NADPH-cytochrome-P450-reductase in Escherichia 
coli / Ehmer, Peter ; Jose, Joachim ; Hartmann, Rolf W.. - In: J. Steroid Biochem. Mol. Biol., 75 (2000) 
, 57-63

- Development of a simple and rapid test assay for inhibitors of human 17a- hydroxylase-C17,20-lyase by 
coexpression of cytochrome P450c17 and NADPH- cytochrome-P450 reductase in Escherichia coli / Ehmer, 
Peter ; Jose, Joachim ; Hartmann, Rolf W.. - In: Journal of Steroid Biochemistry and Molecular Biology, 
75 (2000) , 1, 57-63

- Development of an improved in vitro model to study the adhesion of tumor cells to the basement membrane 
/ Kleber, Alice ; Hartmann, Rolf W. ; Jose, Joachim. - In: Pharm. Pharmcol. Lett., 10 (2000) , 2, 55-
58

- New nonsteroidal steroid 5alpha-reductase inhibitors. Syntheses and structure-activity-studies on carboxamide 
phenylalkyl-substituted pyridones and piperidones / Hartmann, Rolf W. ; Reichert, Martin. - In: Arch. 
Pharm. Pharm. Med. Chem., 333 (2000) , 145-153

- Novel imidazolyl and triazolyl substituted biphenyl compounds: Synthesis and evaluation as nonsteroidal 
inhibitors of human 17a-hydroxylase-C17,20- lyase(P450 17) / Zhuang, Y. ; Wachall, B.G. ; Hartmann, Rolf 
W.. - In: Bioorg. Med. Chem., 8 (2000) , 1245-1252

- Synthesis and biological evaluation of indole derivatives acting as anti- inflammatory or antitumoral 
drugs / Le Brogne, M. ; Duflos, M. ; Le Baut, G. ; Nicholls, P.J. ; Hartmann, Rolf W.. - In: Ann. Pharm. 
Fr., 58 (2000) , 316-320

- Synthesis and evaluation of 17-aliphatic heterocycle substituted steroidal inhibitors of 17alpha-hydroxylase/C17-
20-lyase(P450 17) / Hartmann, Rolf W. ; Hector, Markus ; Wachall, B.G. ; Palusczak, Anja ; Palzer, M. 
; Huch, Volker ; Veith, Michael. - In: J. Med. Chem., 43 (2000) , 4437-4445

- Synthesis and evaluation of novel steroidal oximes as inhibitors of P450 17 (17alpha-hydroxylase / C17-
20-lyase) and . - a-reductase 1 and 2 / Hartmann, Rolf W. ; Hector, Markus ; Haidar, Samer ; Ehmer, Peter 
; Jose, Joachim. - In: J. Med. Chem., 43 (2000) , 4266-4277

- Synthesis of N-substitued piperidine-4-(benzylidene-4-carboxylic acids) and evaluation as inhibitors 
of steroid-5 alpha-reductase type 1 and 2 / Picard, F. ; Baston, E. ; Reichert, Wolfgang ; Hartmann, 
Rolf W.. - In: Bioorg. Med. Chem., 8 (2000) , 1479-1487

1999
- 1-Imidazolylcarbonyloxy-substituted tetrahydro-quinolines and pyridines Synthesis and evaluation of P450 
TxA2 inhibition / Hartmann, Rolf W. ; Frotscher, Martin. - In: Arch. Pharm. Pharm. Med. Chem., 332 (1999) 
, 358-362

- Development of a simple and rapid test assay for inhibitors of human 17a- hydroxylase-C17,20-lyase by 
coexpression of cytochrome P450c17 and NADPH- cytochrome-P450 reductase in Escherichia coli / Ehmer, 
Peter ; Hartmann, Rolf W. ; Jose, Joachim. - In: Arch. Pharm. Pharm. Med Chem., 332 (1999) , Suppl. 2, 
9

- Imidazole substituted biphenyls - a new class of highly potent and in vivo active inhibitors of P450 
17 as potential therapeutics for treatment of prostate cancer / Wachall, B.G. ; Hector, Markus ; Zhuang, 
Y. ; Hartmann, Rolf W.. - In: Bioorg. Med. Chem., 7 (1999) , 1913-1924

- New selective nonsteroidal aromatase inhibitors: Synthesis and inhibitory activity of 2,3 or 5-(alpha-
azolybenzyl)-1H-indoles / Hartmann, Rolf W. ; Le Borgne, M. ; Marchand, P. ; Delovoye-Seiller, B. ; Robert, 
J.-M. ; Robert-Piessard, S. ; Le Baut, G. ; Palzer, M.. - In: Bioorg. Med. Chem. Lett., 9 (1999) , 333-
336

- N-substituted 4-(5-indolyl)benzoic acids. Synthesis and evaluation of steroid 5alpha-reductase type I 
and II inhibitory activity / Hartmann, Rolf W. ; Baston, Eckhard. - In: Bioorg. Med. Chem. Lett., 9 (1999) 
, 1601-1606

- Stable expression of human 5a-reductase isoenzymes type 1 and type 2 in HEK293 cells to identify dual 
and selective inhibitors / Reichert, Wolfgang ; Hartmann, Rolf W. ; Jose, Joachim. - In: Arch. Pharm. 
Pharm. Med Chem., 332 (1999) , Suppl. 2, 38

- Synthesis and evaluation of azole-substituted 2-aryl-6-methoxy- 3,4- dihydronaphthalenes and -naphthalenes 
as inhibitors of 17 alpha-hydroxylase- C17,20-lyase (P450 17) / Hartmann, Rolf W. ; Yan, Zhuang. - In: 
Arch. Pharm. Pharm. Med. Chem., 332 (1999) , 25-30

- Synthesis of 2-(2-(1-imidazolyl)ethyl(-4-phenylcycloalka(g(phthalazin- 1(2H)-ones as thromboxane A2 synthase 
inhibitors / Haider, N. ; Hartmann, Rolf W. ; Steinwender, A.. - In: Arch. Pharm. Pharm. Med. Chem., 
332 (1999) , 408-409

1998
- 3-(azolylmethyl)-1H-idoles as selective P450 aromatase inhibitors / Hartmann, Rolf W. ; Marchand, P. 
; Le Borgne, M. ; Duflos, M. ; Robert-Piessard, S. ; Le Baut, G. ; Ahmadi, M. ; Palzer, M.. - In: Pharm. 
Pharmacol. Commun., 4 (1998) , 211-218

- Development of a cell culture assay to identify dual and selective inhibitors of human type 1 and type 
2 5alpha-reductase / Reichert, Wolfgang ; Jose, Joachim ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. 
Med. Chem., 331 (1998) , (Suppl. 2), 37

- Development of an in-vitro model to study the effect of Thromboxan-A2- Synthetase on tumor cell adhesion 
/ Kleber, Alice ; Jose, Joachim ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 331 (1998) 
, (Suppl. 2), 31

- The improved preparation of 7,8-Dihydro-quinoline5(6H)-one and 6,7- Dihydro-5H-1-pyrindin-5-one / Hartmann, 
Rolf W. ; Huang, Y.. - In: Synth. Comm., 28 (1998) , 1197-1200

- A new route to 6-aryl-substituted 3,4-dihydronaphthalene derivatives via Pd(O)-catalyzed cross-coupling 
reaction of aryl zinc chlorides with an aryl triflate / Hartmann, Rolf W. ; Baston, E.. - In: Synth. 
Comm., 28 (1998) , 2725-2729

- Slow absorption and fast metabolism are major reasons for low in-vivo activity of in-vitro potent aromatase 
inhibitor HB 63 / SCHROEDER, Joachim ; Maurer, Hans H. ; Hartmann, Rolf W.. - In: Pharmazie, 53 (1998) 
, 34

- Spectrofluorimetral quantification of malondialdehyde for evaluation of cyclooxygenase-1/thromboxane 
synthase inhibition / Hartmann, Rolf W. ; Dannhardt, G. ; Flemmer, L. ; Kleber, A. ; Schulze, E.. - In: 
Arch. Pharm. Pharm. Med. Chem., 331 (1998) , 359-364

- Synthesis of novel oximes of 2-aryl-6-methoxy-3,4-dihydronaphthalene and evaluation as inhibitors of 
17[alpha]-hydroxylase-C17,10-lyase (P450 17) / Hartmann, Rolf W. ; Zhuang, Y.. - In: Arch. Pharm. Med. 
Chem., 331 (1998) , 36-40

1997
- Comparison of the in vitro aromatase inhibitor activity for 3- (azolylmethyl)-1H-indoles / Hartmann, 
Rolf W. ; Le Borgne, M. ; Marchand, P. ; Duflos, M. ; Le Baut, G. ; Piessard-Robert, S. ; Le Baut, G. 
; Palzer, Martina. - In: Pharm. Sci., 3 (1997) , 279-281

- Inhibition of 5[alpha]-reductase and aromatase by the ellagitannins oenothein A and oenothein B from 
epilobium species / Hartmann, Rolf W. ; Ducrey, B. ; Marston, A. ; Göhring, Sigrid. - In: Planta Med., 
63 (1997) , 111-114

- Metabolism of endobiotics and therapeutic aspects of P450 inhibitors / Hartmann, Rolf W. ; Wächter, Gerald 
A. ; Sergejew, T. ; Grün, Gertrud ; Ledergerber, Dorothea ; Frotscher, Martin ; Mitrenga, Markus ; Hector, 
Markus. - In: Proceedings, 14th Internat. Sympos. for Medicinal Chemistry /Ed.: F. Awouters. - Amsterdam 
: Elsevier Scientific Publishers. 1997, 109-116

- Novel highly active thromboxane A2 synthase inhibitors void of carboxylic groups / Hartmann, Rolf W. 
; Ledergerber, Dorothea ; Frotscher, Martin. - In: Arch. Pharm. Pharm. Med. Chem., 330 (1997) , 3-5

- Synthesis and in vitro evaluation of 3-(1-azolylmethyl)-1H-indoles and 3- (1-azolyl-1-phenylmenthyl)-
1H-indoles as inhibitors of P 450 arom / Hartmann, Rolf W. ; Le Borgne, M. ; Marchand, P. ; Duflos, M. 
; Delevoye-Seiller, B. ; Piessard-Robert, S. ; Le Baut, G. ; Palzer, Martina. - In: Arch. Pharm. Pharm. 
Med. Chem., 330 (1997) , 141-145

- Synthesis of Z- and E-1-methyl-2-(1-hydroximinoethyl)-6-methoxy-3,4- dihydronaphthalene and evaluation 
as inhibitors of 17[alpha]-hydroxylase- C17,10-lyase (P450 17) / Hartmann, Rolf W. ; Zhuang, Y. ; Zapp, 
Josef. - In: Arch. Pharm. Med. Chem., 330 (1997) , 359-361

1996
- 20-Amino- and 20,21-aziridinyl pregnene steroids: development of potent inhibitors of 17[alpha]hydroxylase/C17,20-
lyase (P450 17) / Hartmann, Rolf W. ; Njar, Vincent C. O. ; Hector, Markus. - In: Bioorganic & Medicinal 
Chemistry, 4 (1996) , 1447-1453

- Effect of a diphenylethylenediamine platinum complex on steroidogenesis in rats / Hartmann, Rolf W. ; 
Sergejew, Thomas F.. - In: The Journal of Steroid Biochemistry & Molecular Biology, 58 (1996) , 243-248

- Inhibition of 5 [alpha]-reductase and aromatase by PHL-00801 (Prostatonin(R)), a combination of PY102 
(Pygeum africanum) and UR102 (Urtica dioica) extracts / Hartmann, Rolf W. ; Mark, M. ; Soldati, F.. -
 In: Phytomedicine, 3 (1996) , 2, 121-128

- Pyridinium dichromate: A novel reagent for the oxidation of steroidal [delta]5-3ß-alcohols to the corresponding 
[delta]4-3,6-diketones / Hartmann, Rolf W. ; Hector, Markus ; Njar, V. C. O.. - In: Synthetic Communications, 
26 (1996) , 1075-1082

- Synthesis and evaluation of azole-substituted tetrahydronaphthalenes as inhibitors of P450 arom, P450 
17 and P450 TxA2 / Hartmann, Rolf W. ; Wächter, Gerald A. ; Sergejew, T. ; Grün, Gertrud ; Ledergerber, 
Dorothea ; Frotscher, Martin. - In: Archiv der Pharmazie - Pharmaceutical and Medicinal Chemistry, 329 
(1996) , 251-261

- Synthesis of 10ß-(1'-azirinyl)estr-4-en-3,17-dione as an aromatase inhibitor / Hartmann, Rolf W. ; Njar, 
Vincent C. O. ; Dürkop, Jörg. - In: Steroids, 61 (1996) , 138-143

- Tetrahydronaphthalenes: Influence of heterocyclicsubstituents on inhibition of steroidogenic enzymes 
P450 arom and P450 17 / Hartmann, Rolf W. ; Wächter, Gerald A. ; Sergejew, T. ; Grün, Gertrud ; Ledergerber, 
Dorothea. - In: Journal of Medicinal Chemistry, 39 (1996) , 834-841

1995
- 4,5-Dihydro-3-(2-pyrazinyl)naphto-(1,2-c)pyrazole : A potent and selective inhibitor of steroid-17a-hydroxylase-
C17, se (P 450 17) / Hartmann, Rolf W. ; Sergejew, Thomas ; Würtz, Rieka ; Dürkop, Jörg ; Wächter, Gerald 
Anton. - In: Archiv der Pharmazie (Weinheim), 328 (1995) , 573-575

- Development of a screening assay for the in vitro evaluation of thromboxane A2 synthase inhibitors / 
Hartmann, Rolf W. ; Ledergerber, Dorothea. - In: Journal of Enzyme Inhibition, 9 (1995) , 253-261

- Evaluation of 6,7-aziridinyl steroids and related compounds as inhibitors of aromatase (P450 arom) / 
Hartmann, Rolf W. ; Njar, Vincent C. O. ; Grün, Gertrud. - In: Journal of Enzyme Inhibition, 9 (1995) 
, 195-202

- Novel 19-(cyclopropylamino)-androst-4-en-3,17-dione : A mechanism-based inhibitor of aromatase / Hartmann, 
Rolf W. ; Dürkop, Jörg ; Njar, Vincent C.0.. - In: Journal of Enzyme Inhibition, 10 (1995) , 47-56

- N-Oxide formation causes loss of aromatase inhibitory activity of pyridyl substituted tetrahydronaphthalenes 
/ Hartmann, Rolf W. ; Mitrenga, Markus. - In: European Journal of Medicinal Chemistry, 30 (1995) , 241-
244

- Pyridyl-substituted tetrahydrocyclopropa(a)naphtalenes: Highly active and selective inhibitors of P450 
arom / Hartmann, Rolf W. ; Sergejew, Thomas ; Mitrenga, Markus ; Bayer, Herbert ; Grün, Gertrud ; Bartz, 
Ulrike. - In: Journal of Medicinal Chemistry, 38 (1995) , 2103-2111

- Synthesis and biochemical evaluation of (carbamoylalkenyl)phenyloxy carboxylic acid derivatives as non-
steroidal 5alpha-reductase inhibitors / Hartmann, Rolf W. ; Kattner, Lars ; Göhring, Sigrid. - In: Arviv 
der Pharmazie, 328 (1995) , 239-245

- Synthesis of 6alpha, 7a- and 6ß, 7ß-aziridino-androst-4-ene-3, 17-diones and related compounds: potential 
aromatase inhibitors / Hartmann, Rolf W. ; Njar, Vincent C. O. ; Robinson, Cecil H.. - In: Journal of 
the Chemical Society Perkin Transactions I. 1995 , 985-991

1994
- Aromatase inhibitors : syntheses and structure-activity studies of novel pyridyl-substituted indanones, 
indans, and tetralines / Hartmann, Rolf W. ; Grün, Gertrud. - In: Journal of medicinal chemistry, 37 
(1994), 1275-1281

- Novel 5[alpha]-reductase inhibitors : synthesis and structure-activity studies of 5-substituted 1-methyl-
2-piperidones / Hartmann, Rolf W. ; Reichert, Martin ; Göhring, Sigrid. - In: European journal of medicinal 
chemistry, 29 (1994), S. 807-817.

- Preparation of (pyridylmethyl) tetralol derivatives as aromatase inhibitors / Hartmann, Rolf W. ; Wächter, 
Gerald A.. - In: Chemical abstracts, 121 (1994), Patent SP 06,166,674 (94,166,674)

- Preparation of imidazolylmethylenetetralones and analogs as aromatase inhibitors / Hartmann, Rolf W. 
; Wächter, Gerald A.. - In: Chemical abstracts, 121 (1994), Patent WO 9407,866

- Pyridyl substituted benzocycloalkenes : new inhibitors of 17[alpha]-hydroxylase/17,20-lyase (P450 17[alpha]) 
/ Hartmann, Rolf W. ; Sergejew, Thomas. - In: Journal of enzyme inhibition, 8 (1994), S. 113-122.

- Selective inhibition of steroidogenic P450 enzymes : current status and future perspectives / Hartmann, 
Rolf W.. - In: European journal of pharmaceutical sciences, 2 (1994), S. 15-16.

1993
- Synthesis and evaluation of sulfur-containing glutethimide derivatives for aromatase and desmolase inhibitor 
activity / Hartmann, Rolf W.. - In: Archiv der Pharmazie, 326 (1993), S. 391-394.

Hutschenreuter, Tilmann

2004
- Synthesis of hydroxy derivatives of highly potent non-steroidal CYP 17 inhibitors as potential metabolites 
and evaluation of their activity by a non cellular assay using recombinant human enzyme / Hutschenreuter, 
Tilmann ; Ehmer, Peter ; Hartmann, Rolf W.. - In: J. Enz. Inhib. Med. Chem., 19 (2004) , 17-32

2003
- N-(4-Biphenylmethyl)imidazoles as potential therapeutics for the treatment of prostate cancer: metabolic 
robustness due to fluorine substition? / Leroux, Frédéric ; Hutschenreuter, Tilmann ; Charrière, Céline 
; Scopelliti, Rosario ; Hartmann, Rolf W.. - In: Helv. Chim. Act., 86 (2003) , 2671-2686

istian

2002
- Inhibition of CYP 17, A new strategy for the treatment of prostate cancer / Hartmann, Rolf W. ; Ehmer, 
Peter ; Haidar, Samer ; Hector, Markus ; Jose, Joachim ; istian ; Seidel, Stefanie ; Sergejew, Tom ; 
Wachall, Bertil Gero ; Wächter, Gerald A. ; Zhuang Yan. - In: Arch. Pharm. Pharm. Med. Chem., 4 (2002) 
, 119-128

Jose, Joachim

2005
- 5alpha-reductase in human embryonic kidney cell line HEK293 : evidence for type II enzyme expression 
and activity / Panter, Bärbel Ursula ; Jose, Joachim ; Hartmann, Rolf W.. - In: Mol. Cell. Biochem., 
270 (2005) , 201-208

2004
- Autodisplay of active sorbitol dehydrogenase (SDH) from Rhodobacter sphaeroides yields a whole cell biocatalyst 
for the synthesis of rare sugars / Jose, Joachim ; von Schwichow, Steffen. - In: ChemBioChem, 5 (2004) 
, 100-108

- "Cystope tagging" for labelling and detection of recombinant protein expression / Jose, Joachim ; von 
Schwichow, Steffen. - In: Analytical Biochemistry, 331 (2004) , 2, 267-274

- Discovery of inhibitors of the MCF-7 tumor cell adhesion to endothelium cells and investigation of their 
mode of action / Bild, Thomas ; Jose, Joachim ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 
337 (2004) , 617-712

2003
- Esterase EstE from Xanthomonas vesicatoria ( Xv_EstE) is an outer membrane protein capable of hydrolyzing 
long-chain polar esters / Talker-Huiber, Daniela ; Jose, Joachim ; Glieder, Anton ; Pressnig, Michael 
; Stubenrauch, Gerhard ; Schwab, Helmut. - In: Appl Microbiol Biotechnol, 61 (2003) , 6-6, 479-487

- The integration site of the iga gene in commensal Neisseria sp. / Jose, Joachim ; Otto, Georg Wilhelm 
; Meyer, Thomas F.. - In: Mol Genet Genomics, 269 (2003) , 2, 197-204

- Mikrotiterplatten-Reaktoren mit integrierten pH-Sensoren und Autodisplay in E. coli zur evolutiven Enzymentwicklung 
/ Heinzle, Elmar ; Weiss, Svenja ; Wolfbeis, Otto ; Arain, Sarina ; Klimant, Ingo ; John, Gernot ; Räbiger, 
Thomas ; Müller, Günther ; Waltenberger, Harald ; Schultheiss, Eva ; Jose, Joachim. - In: Transkript, 
9 (2003) , 10, 59-62

- Monitoring the surface display of recombinant proteins by cysteine labeling and flow cytometry / Jose, 
Joachim ; Handel, Steffen. - In: ChemBioChem, 4 (2003) , 5, 396-405

- New inhbitors of human cathepsin G identified by surface display library screening and peptide-protein 
docking / Jose, Joachim ; Betscheider, Dirk ; Ray, Somak ; Lengauer, Thomas ; Zangen, D.. - In: 7th International 
symposium on Pharmaceutical Sciences (ISOPS-7), Ankara, Turkey, June, 24 - June, 27, Faculty of Pharmacy, 
Ankara University, Ankara, 2003, 46-49

- New inhibitors of human cathepsin G by bacterial surface display library screening and peptide-protein 
docking / Jose, Joachim ; Betscheider, Dirk ; Ray, Somak ; Lengauer, Thomas ; Zangen, Dirk. - In: Proceedings 
of the 7th International Symposium on Pharmaceutical Sciences ISOPS7 / Ed.: Akin, Ahmet et al.. - Ankara 
: Tasarim Basim. 2003, 46-49

2002
- Cellular surface display of dimeric Adx and whole cell P450- mediated steroid synthesis on E. coli / 
Jose, Joachim ; Bernhardt, Rita ; Hannemann, Frank. - In: Journal of Biotechnology, 95 (2002) , 257-268

- Functional esterase surface display by the autotransporter pathway in Escherichia coli / Schultheiss, 
Eva ; Paar, Christine ; Schwab, Helmut ; Jose, Joachim. - In: Journal of Molecular Catalysis B. Enzymatic, 
18 (2002) , 1-3, 83-91

- Inhibition of CYP 17, A new strategy for the treatment of prostate cancer / Hartmann, Rolf W. ; Ehmer, 
Peter ; Haidar, Samer ; Hector, Markus ; Jose, Joachim ; istian ; Seidel, Stefanie ; Sergejew, Tom ; 
Wachall, Bertil Gero ; Wächter, Gerald A. ; Zhuang Yan. - In: Arch. Pharm. Pharm. Med. Chem., 4 (2002) 
, 119-128

- Selection of protease inhibitors by cellular surface display, enzyme labeling and flow cytometry / Jose, 
Joachim ; Zangen, Dirk. - In: Arch Pharm Pharm Med Chem, 335 (2002) , Suppl. 1, 50

2001
- Functional Display of Active Bovine Adrenodoxin on the Surface of E. coli by Chemical Incorporation of 
the [2Fe-2S] Cluster / Jose, Joachim ; Bernhardt, Rita ; Hannemann, Frank. - In: ChemBioChem, 2 (2001) 
, 695-701

- No effect of thromboxane A2 on the attachment of tumor cell lines MDA MB U145, and U937 to the basement 
membrane in an in-vitro model / Kleber, Alice ; Hartmann, Rolf W. ; Jose, Joachim. - In: J. Cancer Res. 
Clin. Oncol, 127 (2001) , 751-754

- Screening von Biokatalysatoren mit Sauerstoff- und pH - Mikrotiterplatten / Weiß, Svenja ; John, Gottfried 
T ; Heinzle, Elmar ; Schultheiss, Eva ; Jose, Joachim ; Arain, S ; Krause, T ; Klimant, Ingo ; Waltenberger, 
H ; Maier, J ; Räbiger, T. - In: Biospektrum, Sonderband Biokatalyse (2001) , 54-60

- Site-directed mutagenesis of cysteine to threonine in Proteus vulgaris urease active site increases enzyme 
activity and stability / Jose, Joachim ; Lauter, Sven ; Stein, Martin. - In: Biotechnology Letters, 23 
(2001) , 1263-1267

- Stable expression of human 5alpha-reductase type II in COS1 cells due to chromosomal gene integration: 
a novel tool for inhibitor identification / Reichert, Wolfgang ; Michel, Armin ; Hartmann, Rolf W. ; 
Jose, Joachim. - In: J. Steroid Biochem. Mol. Biol., 78 (2001) , 275-284

- Stable expression of the human 5alpha-reductase - isoenzymes type I and type II in HEK293 cells to identify 
dual and selective inhibitors / Reichert, Wolfgang ; Hartmann, Rolf W. ; Jose, Joachim. - In: J. Enz. 
Inhib., 16 (2001) , 47-53

2000
- 5alpha-reductase in intact DU145 cells: Evidence for isozyme I and evaluation of novel inhibitors / Reichert, 
Wolfgang ; Jose, Joachim ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 333 (2000) , 201-
204

- Development of a simple and rapid assay for the evaluation of inhibitors of human 17alpha-hydroxylase-
C17,20-lyase (P450c17) by coexpression of P450c17 with NADPH-cytochrome-P450-reductase in Escherichia 
coli / Ehmer, Peter ; Jose, Joachim ; Hartmann, Rolf W.. - In: J. Steroid Biochem. Mol. Biol., 75 (2000) 
, 57-63

- Development of a simple and rapid test assay for inhibitors of human 17a- hydroxylase-C17,20-lyase by 
coexpression of cytochrome P450c17 and NADPH- cytochrome-P450 reductase in Escherichia coli / Ehmer, 
Peter ; Jose, Joachim ; Hartmann, Rolf W.. - In: Journal of Steroid Biochemistry and Molecular Biology, 
75 (2000) , 1, 57-63

- Development of an improved in vitro model to study the adhesion of tumor cells to the basement membrane 
/ Kleber, Alice ; Hartmann, Rolf W. ; Jose, Joachim. - In: Pharm. Pharmcol. Lett., 10 (2000) , 2, 55-
58

- Human T cell response to meningococcal IgA 1 protease associated alpha- proteins / Jose, Joachim ; Wölk, 
Uwe ; Lorenzen, Dirk ; Wenschuh, Holger ; Meyer, Thomas F.. - In: Scandinavian Journal of Immunology, 
51 (2000) , 176-184

- Synthesis and evaluation of novel steroidal oximes as inhibitors of P450 17 (17alpha-hydroxylase / C17-
20-lyase) and . - a-reductase 1 and 2 / Hartmann, Rolf W. ; Hector, Markus ; Haidar, Samer ; Ehmer, Peter 
; Jose, Joachim. - In: J. Med. Chem., 43 (2000) , 4266-4277

1999
- Characterization of the essential transport function of the AIDA-I autotransporter and evidence supporting 
structural predictions / Maurer, Jochen ; Jose, Joachim ; Meyer, Thomas F.. - In: Journal of Bacteriology, 
181 (1999) , 22, 7014-7020

- Development of a simple and rapid test assay for inhibitors of human 17a- hydroxylase-C17,20-lyase by 
coexpression of cytochrome P450c17 and NADPH- cytochrome-P450 reductase in Escherichia coli / Ehmer, 
Peter ; Hartmann, Rolf W. ; Jose, Joachim. - In: Arch. Pharm. Pharm. Med Chem., 332 (1999) , Suppl. 2, 
9

- MHC-Feintypisierung mit Hilfe von Sequenz-spezifischen Oligonukleotiden (II. Auflage, ELPHA-Detektion) 
/ Jose, Joachim. - Saarbruecken. 1999, 16 S. 

- Stable expression of human 5a-reductase isoenzymes type 1 and type 2 in HEK293 cells to identify dual 
and selective inhibitors / Reichert, Wolfgang ; Hartmann, Rolf W. ; Jose, Joachim. - In: Arch. Pharm. 
Pharm. Med Chem., 332 (1999) , Suppl. 2, 38

1998
- Development of a cell culture assay to identify dual and selective inhibitors of human type 1 and type 
2 5alpha-reductase / Reichert, Wolfgang ; Jose, Joachim ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. 
Med. Chem., 331 (1998) , (Suppl. 2), 37

- Development of an in-vitro model to study the effect of Thromboxan-A2- Synthetase on tumor cell adhesion 
/ Kleber, Alice ; Jose, Joachim ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 331 (1998) 
, (Suppl. 2), 31

1997
- Autodisplay: efficient surface display of recombinant proteins in Escherichia coli and future applications 
in evolutive strategies to study receptor-ligand interactions / Jose, Joachim ; Maurer, J. ; Lattemann. 
C. ; Meyer, TF. - In: Biospektrum, 3 Sonderband (1997) , 140

- Autodisplay: One-component-system for efficient surface display and release of soluble recombinant proteins 
from Escherichia coli / Maurer J ; Jose, Joachim ; Meyer, TF. - In: Journal of Bacteriology, 179 (1997) 
, 794-804

- Bacterial vectors offer new options / Maurer, J. ; Jose, Joachim ; Meyer, TF. - In: ASM News, 63 (1997) 
, 206

- MHC-Feintypisierung mit Hilfe Sequenz-spezifischer Oligonukleotide / Jose, Joachim. - Saarbruecken. 1997 
(Praktikum Grundlegende Molekularbiologische Methoden)

- The Neisseria gonorrhoeae gene aniA encodes an inducible nitrite reductase / Mellies, J ; Jose, Joachim 
; Meyer, TF. - In: Molecular and General Genetics, 256 (1997) , 525-532

1996
- Absence of periplasmic DsbA oxidoreductase facilitates export of cysteine-containing passenger proteins 
to the Escherichia coli surface via the Iga-beta autotransporter pathway / Jose, Joachim ; Krämer, J 
; Klauser, T. ; Pohlner, J. ; Meyer, TF. - In: Gene, 178 (1996) , 107-110

- Virulence associated determinant (iga) of pathogenic Neisseriae completely deleted in commensal species 
/ Jose, Joachim ; Otto, G. ; Meyer, TF. - In: Biospektrum, 2 Sonderband (1996) , 58

1995
- Common structural features of IgA1-protease-like outer membrane protein autotransporters / Jose, Joachim 
; Jähnig, F. ; Meyer, TF. - In: Molecular Microbiology, 18 (1995) , 378-382

1994
- Threonine is present instead of cysteine at the active site of urease from Staphylococcus xylosus / Jose, 
Joachim ; Schäfer, Udo Klaus ; Kaltwasser, Heinrich. - In: Arch. Microbiol., 161 (1994) , 384-392

1993
- Complete nucleotide sequence of the structural urease genes from Staphylococcus xylosus / Jose, Joachim 
; Kaltwasser, Heinrich. - In: Bioengeneering, 9 (1993) , 102

- Purification and characterization of recombinant Staphylococcus xylosus urease expressed by Staphylococcus 
carnosus / Siersdorfer, Christof ; Jose, Joachim ; Schaefer, Udo ; Kaltwasser, Heinrich. - In: Bioengeneering, 
9 (1993) , 85

Kallmayer, Hans-Jörg

2003
- Die Reaktion des Iminodibenzyls mit 2,6-Dichlor-1,4-benzochinon-4-chlorimid / Kallmayer, Hans-Jörg ; 
Thierfelder, Bernd. - In: Pharmazie, 58 (2003) , 218-219

- Reaktionen einiger Isopropyl-alkylamine mit 2,3-Dichlor-1,4-naphthochinon und 2,3-Dichlor-1,4-naphthochinon/Acetaldehyd 
/ Kallmayer, Hans-Jörg ; Thierfelder, Bernd. - In: Pharmazie, 58 (2003) , 104-107

2002
- Die Benzidinblau-Reaktion in der pharmazeutischen Analytik / Kallmayer, Hans-Jörg ; Trojan, Birgit. -
 In: Scientia Pharmaceutica, 70 (2002) , 1-14

- Farbreaktionen zwischen Trialkylaminen und Naphthochinonen / Kallmayer, Hans-Jörg ; Thierfelder, Bernd. 
- In: Pharmazie, 57 (2002) , 456-459

- Umsetzungen einiger Dialkylamin-Arzneistoffe mit 2,3-Dichlor-1,4-naphthochinon und Acetaldehyd / Kallmayer, 
Hans-Jörg ; Thierfelder, Bernd. - In: Pharmazie, 57 (2002) , 530-534

- Umsetzungen einiger Trialkylamin-Arzneistoffe mit 2,3-Dichlor-1,4-naphthochinon / Kallmayer, Hans-Jörg 
; Thierfelder, Bernd. - In: Pharmazie, 57 (2002) , 648-649

2001
- Kondensation eines Dihydro-1,4-benzochinon-Derivates mit 1,2-Arylendiaminen / Kallmayer, Hans-Jörg ; 
Doerr, Martin. - In: Pharmazie, 56 (2001) , 2, 183-184

- Umsetzung von 2-/4-Amino-benzensulfonamid-Strukturen mit Thymol/Natriumhypochlorit / Kallmayer, Hans-
Jörg ; Bender, Roger. - In: Pharmazie, 56 (2001) , 5, 423-424

2000
- 2-Amino-5,6-dihydro-1,4-benzochinon-Derivate / Kallmayer, Hans-Jörg ; Doerr, Martin. - In: Scientia Pharmaceutica, 
68 (2000) , 87-100

- Die Reaktion des 2,3,4a,8a-Tetrachlor-6,7-dimethyl-4a,5,8,8a-tetrahydro- 1,4-naphthochinons mit Aminen 
/ Kallmayer, Hans-Jörg ; Doerr, Martin. - In: Scientia Pharmazeutica, 68 (2000) , 129-139

- Die Umsetzung des 1,2-Naphthochinons mit Arylhydrazinen / Kallmayer, Hans-Jörg ; Kruppert, Claudia. -
 In: Pharmazie, 55 (2000) , 11, 817-820

- Umsetzung von 2,6-Dibromsulfanilamid mit Thymol und Natriumhypochlorit / Kallmayer, Hans-Jörg ; Bender, 
Roger. - In: Pharmazie, 55 (2000) , 10, 781-782

- Die Umsetzung von Furosemid, Quimethazin und Hydrochlorothiazid mit Thymol und Natriumhypochlorit / Kallmayer, 
Hans-Jörg ; Bender, Roger. - In: Pharmazie, 55 (2000) , 320-321

1999
- 4-Alkylamino-1,2-anthrachinone / Kallmayer, Hans-Jörg ; Bock, Udo. - In: Pharmazie, 54 (1999) , 467-468

- 4-Dialkylamino-1,2-anthrachinon-1/2-arylhydrazone / Kallmayer, Hans-Jörg ; Bock, Udo. - In: Pharmazie, 
54 (1999) , 3, 166-170

- 4-Methoxy-5,6,7,8-tetrahydro-1,2-naphthochinon-1-arylhydrazone / Kallmayer, Hans-Jörg ; Bock, Udo. - 
In: Pharmazie, 54 (1999) , 355-358

- 6-/7-Methoxy-1,2-naphthochinon-Chromophore / Kallmayer, Hans-Jörg ; Bock, Udo. - In: Pharmazie, 54 (1999) 
, 6, 422-425

1998
- 4-N-Alkyl-arylamino-1,2-naphthochinon-1/2-dinitrophenylhydrazone - Struktur und Farbe / Kallmayer, Hans-
Jörg ; Bock, Udo. - In: Pharmazie, 53 (1998) , 5, 307-310

- Bichromophore Indikatoren des Deutschen Arzneibuches / Kallmayer, Hans-Jörg ; Lenze, Uwe. - In: Pharmazie 
in unserer Zeit, 27 (1998) , 1, 7-11

- Dihydro-1,4-benzochinon-1-arylhydrazone / Kallmayer, Hans-Jörg ; Doerr, Martin. - In: Scientia Pharmaceutica, 
66 (1998) , 297-307

- Kondensation des 4-Di-n-propylamino-1,2-anthrachinons mit Arylhydrazinen in Methanol/Schwefelsaeure / 
Kallmayer, Hans-Jörg ; Bock, Udo. - In: Pharmazie, 53 (1998) , 418-420

- Zum Ablauf der Farbreaktion zwischen 4-Nitrobenzensulfonamid, Natriumhypochlorit und Thymol / Kallmayer, 
Hans-Jörg ; Bender, Roger. - In: Pharmazie, 53 (1998) , 3, 161-163

- Zum Nachweis der Glykolsäure mit hydroxynaphthalin / Kallmayer, Hans-Jörg ; Schröder-Mann, Stephanie. 
- In: Scientia Pharmaceutica, 66 (1998) , 1-8

1997
- Zum Ablauf der Farbreaktion zwischen Sulfanilamid, Natriumhypochlorit und Thymol / Kallmayer, Hans-Jörg 
; Bender, Roger. - In: Pharmazie, 52 (1997) , 3, 210-212

- Zur Farbreaktion zwischen 1,4-Chinonen und Acylhydrazinen / Kallmayer, Hans-Jörg ; Brandenburg, Jörg. 
- In: Scientia Pharmaceutica, 65 (1997) , 213-233

1996
- Alkylierung von 2-Arylamino-6-tert-butyl-1,4-benzochinonen / Kallmayer, Hans-Jörg ; Burgardt, Silke. 
- In: Scientia Pharmaceutica, 64 (1996) , 17-23

- Bromierung von 2-/4-Arylamino-1,4-/1,2-naphthochinonen mit Ethylbromid und DMSO / Kallmayer, Hans-Jörg 
; Doerr, Martin. - In: Scientia Pharmaceutica, 64 (1996) , 117-124

- Halogenierung von 2-Arylamino-6-tert-butyl-1,4-benzochinonen mit Alkylhalogeniden und DMSO / Kallmayer, 
Hans-Jörg ; Burgardt, Silke ; Doerr, Martin. - In: Scientia Pharmaceutica, 64 (1996) , 25-30

- Iodierung und Chlorierung von 2-/4-Arylamino-1,4-/1,2-naphthochinonen mit Alkylhalogeniden und DMSO / 
Kallmayer, Hans-Jörg ; Doerr, Martin. - In: Scientia Pharmaceutica, 64 (1996) , 479-485

- Phenol-naphthol-benzeine - Darstellung und chromophore Eigenschaften : 5. Mitteilung: Benzeine / Kallmayer, 
Hans-Jörg ; Lenze, Uwe. - In: Pharmazie, 51 (1996) , 534-536

- Zur Farbe des alpha-Naphtholbenzeins und deren pH-Abhängigkeit; 4. Mitteilung: Benzeine / Kallmayer, 
Hans-Jörg ; Lenze, Uwe. - In: Pharmazie, 51 (1996) , 89-92

- Zur Farbe des Benzaurins und der seiner alkylsubstituierten Derivate : 6. Mitteilung: Benzeine / Kallmayer, 
Hans-Jörg ; Lenze, Uwe. - In: Pharmazie, 51 (1996) , 11, 827-831

1995
- 2-Arylamino-6-tert-butyl-1,4-benzochinone; Ein chemischer Strukturbeweis / Kallmayer, Hans-Jörg ; Burgardt, 
Silke. - In: Scientia Pharmaceutica, 63 (1995) , 1, 1-6

- 4-[(4-Hydroxy-1-naphthyl)phenylmethylen]-1(4H)-naphthalinon - die Indikatorsubstanz des "alpha-Naphtholbenzeins"; 
1. Mitteilung: Benzeine / Kallmayer, Hans-Jörg ; Lenze, Uwe. - In: Pharmazie, 50 (1995) , 36-38

- 5-Oxo-14-phenyl-5H-dibenzo[a,h]xanthen - Bestandteil des Indikators "o- Naphtholbenzein"; 3. Mitteilung: 
Benzeine / Kallmayer, Hans-Jörg ; Lenze, Uwe. - In: Pharmazie, 50 (1995) , 6, 393-395

- Ein chemischer Strukturbeweis des o-Naphtholbenzeins; 2. Mitteilung: Benzeine / Kallmayer, Hans-Jörg 
; Lenze, Uwe. - In: Pharmazie, 50 (1995) , 4, 296-297

- Zur Umsetzung von 1,4-Naphtho- und 1,4-Anthrachinon mit N,N- Dialkylhydrazinen / Kallmayer, Hans-Jörg 
; Kruppert, Claudia ; Brandenburg, Jörg. - In: Pharmazie, 50 (1995) , 7, 506-507

- Zur Umsetzung von 4-Amino-1,2-naphthochinonen mit nitrophenylhydrazin / Kallmayer, Hans-Jörg ; Bock, 
Udo. - In: Pharmazie, 50 (1995) , 2, 112-114

1994
- 2-Arylamino-6-tert-butyl-1,4-benzochinone / Kallmayer, Hans-Jörg ; Burgardt, Silke. - In: Scientia pharmaceutica, 
62 (1994), 207-214

- Aminierung von 2,3,5,6-Tetrachlor/brom-1,4-benzochinonen mit Carbonsäureamiden / Kallmayer, Hans-Jörg 
; Fritzen, Wolfgang. - In: Pharmazie, 49 (1994), 284

- Photoreaktivität einiger lthio/Phenylthio-3,5,6-trichlor/brom-1,4- benzochinone / Kallmayer, Hans-Jörg 
; Fritzen, Wolfgang. - In: Pharmazie, 49 (1994), S. 412-415.

- Photoreaktivität einiger xy/Phenoxy-3,5,6-trichlor/brom-1,4-benzochinone / Kallmayer, Hans-Jörg ; Fritzen, 
Wolfgang. - In: Pharmazie, 49 (1994), S. 235-238.

Kang, Min-Jung

2004
- Evaluation of cell permeation of a potent 5á-reductase inhibitor using MALDI-TOF MS / Mathur, Sonal ; 
Picard, Franck ; Dossou, Ulrich ; Barassin, Catherine ; Seidel, Stefanie ; Kang, Min-Jung ; Hartmann, 
Rolf W.. - In: J. Enz. Inhib. Med. Chem., 19 (2004) , 425-429

- Identification of monohydroxy progesterones produced by CYP106A2 using comparative HPLC and electrospray 
ionisation collision-induced dissociation mass spectrometry / Lisurek, Michael ; Kang, Min-Jung ; Hartmann, 
Rolf W. ; Bernhardt, Rita. - In: Biochem. Biophys. Res. Comm., 319 (2004) , 677-682

- Quantitative analysis of 5á-reductase inhibitors permeated in DU145 cells using MALDI-TOF MS and HPLC-
MS/MS / Kang, Min-Jung ; Mathur, Sonal ; Hartmann, Rolf W.. - In: J. Mass Spectrometry, 39 (2004) , 762-
769

Kleber, Alice

2001
- No effect of thromboxane A2 on the attachment of tumor cell lines MDA MB U145, and U937 to the basement 
membrane in an in-vitro model / Kleber, Alice ; Hartmann, Rolf W. ; Jose, Joachim. - In: J. Cancer Res. 
Clin. Oncol, 127 (2001) , 751-754

2000
- Development of an improved in vitro model to study the adhesion of tumor cells to the basement membrane 
/ Kleber, Alice ; Hartmann, Rolf W. ; Jose, Joachim. - In: Pharm. Pharmcol. Lett., 10 (2000) , 2, 55-
58

1998
- Development of an in-vitro model to study the effect of Thromboxan-A2- Synthetase on tumor cell adhesion 
/ Kleber, Alice ; Jose, Joachim ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 331 (1998) 
, (Suppl. 2), 31

Klein, Christian

2005
- Metal ions as cofactors for ligand binding at methionine aminopeptidase : a critical view on the relevance 
of in vitro metalloenzyme assays / Schiffmann, Rolf ; Heine, Andreas ; Klebe, Gerhard ; Klein, Christian. 
- In: Angewandte Chemie / International edition. 2005 , 44, 3620-3623

- Synthesis and Evaluation of Imidazolylmethylene-tetrahydronaphthalenes and -indanes: Potent Inhibitors 
of Aldosterone Synthase (CYP11B2) / Ulmschneider, Sarah ; Müller-Vieira, Ursula ; Mitrenga, Markus ; 
Hartmann, Rolf W. ; Marchais-Oberwinkler, Sandrine ; Klein, Christian ; Bureik, Matthias ; Bernhardt, 
Rita ; Antes, Iris ; Lengauer, Thomas. - In: J. Med. Chem.. 2005 , 48, 1796-1805

- Synthesis and Evaluation of Pyridylmethylene-tetrahydronaphthalenes / -indanes and Structurally Modified 
Derivatives: Potent and Selective Inhibitors of Aldosterone Synthase (CYP11B2) / Ulmschneider, Sarah 
; Müller-Vieira, Ursula ; Klein, Christian ; Antes, Iris ; Lengauer, Thomas ; Bernhardt, Rita. - In: 
J. Med. Chem.. 2005 , 48, 1563-1575

2004
- Protein-Dynamics of the Putative HCV Receptor CD81 Large Extracellular Loop / Neugebauer, Alexander ; 
Klein, Christian ; Hartmann, Rolf W.. - In: Bioorg. Med. Chem.Lett., 14 (2004) , 1765-1769

2001
- Synthesis and evaluation of steroidal hydroxamic acids as inhibitors of P450 17 (17alpha-hydroxylase/C17-
20-lyase) / Haidar, Samer ; Klein, Christian ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 
334 (2001) , 138-140

- Synthesis, evaluation and QSAR studies of highly potent aromatase inhibitors of the piperidinedione type 
/ Baston, Eckhard ; Klein, Christian ; Grimminger, Wolf ; Hebecker, Norbert ; Hartmann, Rolf W.. - In: 
Anti Cancer Drug Des, 16 (2001) , 37-47

Knabe, Joachim

1996
- Stereoselective Binding of the Enantiomers of Four Closely Related N- Methyl-Barbiturates to Human, Bovine, 
and Rat Serum Albumin / Büch, Horst Paul ; Krug, Regina ; Knabe, Joachim. - In: Archiv der Pharmazie 
- Pharmaceitical and Medicinical Chemistry, 329 (1996) , 399-402

1995
- 1,5-Benzodiazepine, 2.Mitt : Entgegengesetzte zentralnervöse Wirkungen der Enantiomere von zwei 3,3-Dialkyl-
1,5-benzodiazepin-2,4-dionen / Knabe, Joachim ; Büch, Horst Paul ; Bender, Susanne. - In: Archiv der 
Pharmazie (Weinheim), 328 (1995) , 1, 59-66

- Entgegengesetzte zentralnervöse Wirkungen der Enantiomere von zwei 3,3- Dialkyl-1,5-benzodiazepin-2,4-
dionen / Büch, Horst Paul ; Knabe, Joachim ; Bender, Susanne. - In: Archiv für Pharmazie, 328 (1995) 
, 59-66

- Influence of albumin concentration, albumin species, pH and temperature on the stereoselectively different 
binding of (S)- (+)- and (R)-(-)-1 methyl- . - enyl-5 propyl barbiturate to serum albumin / Büch, Horst 
Paul ; Knabe, Joachim ; Krug, Regina. - In: Arzneimittel-Forschung/Drug Research, 45 (II) (11995) , 10, 
1049-1053

- Synthetische Enantiomere als Arzneistoffe / Knabe, Joachim. - In: Pharmazie in unserer Zeit, 24 (1995) 
, 6, 324-330

1994
- Lehrbuch der pharmazeutischen Chemie . - 13. Aufl / Knabe, Joachim. - Stuttgart : Wiss. Verl.-Ges.. 1994, 
XVIII, 893 S. : Ill., graph. Darst.

- Racemate und Enantiomere von 5,5-disubstituierten Hexahydropyrimidinen / Knabe, Joachim. - In: Archiv 
der Pharmazie, 327 (1994), S. 31-32.

1993
- On the metabolism of the enantiomers of cyclic ureas in rats / Maurer, Hans H. ; Biwersi, Joachim ; Knabe, 
Joachim. - In: Archiv der Pharmazie, 326 (1993), S. 535-538

- Racemate und Enantiomere von Hexahydropyrimidin-2-onen : Synthese, Konfiguration und sedativ-hypnotische 
Wirkung / Büch, Horst Paul ; Knabe, Joachim ; Biwersi, Joachim. - In: Archiv für Pharmazie, 326 (1993), 
S. 79-84

- Racemate und Enantiomere von Imidazolidin-2-onen : Synthese, Konfiguration und sedativ-hypnotische Wirkung 
/ Büch, Horst Paul ; Knabe, Joachim ; Biwersi, Joachim. - In: Archiv für Pharmazie, 326 (1993), S. 331-
334

Marchais-Oberwinkler, Sandrine

2005
- Heteroaryl substituted naphthalenes and structurally modified derivatives : selective inhibitors of CYP11B2 
for the treatment of congestive heart failure and myocardial fibrosis / Voets, Marieke ; Antes, Iris 
; Scherer, Christiane ; Biemel, Klaus ; Barassin, Catherine ; Marchais-Oberwinkler, Sandrine ; Hartmann, 
Rolf W.. - In: J. Med. Chem., 48 (2005) , 6632-6642

Mathur, Sonal

2005
- A Method for Screening Enzyme Inhibitors Using Size Exclusion Chromatography and ESI-LC-MS/MS / Mathur, 
Sonal ; Park, Jung Dae ; Kim, Dong H. ; Hartmann, Rolf W.. - In: J. Biomol. Screening. 2005 , 10, 30-
35

2004
- Evaluation of cell permeation of a potent 5á-reductase inhibitor using MALDI-TOF MS / Mathur, Sonal ; 
Picard, Franck ; Dossou, Ulrich ; Barassin, Catherine ; Seidel, Stefanie ; Kang, Min-Jung ; Hartmann, 
Rolf W.. - In: J. Enz. Inhib. Med. Chem., 19 (2004) , 425-429

- Quantitative analysis of 5á-reductase inhibitors permeated in DU145 cells using MALDI-TOF MS and HPLC-
MS/MS / Kang, Min-Jung ; Mathur, Sonal ; Hartmann, Rolf W.. - In: J. Mass Spectrometry, 39 (2004) , 762-
769

Müller, Ursula

2003
- Discovery of selective CYP11B2 (aldosterone synthase) inhibitors for the therapy of congestive heart 
failure and myocardial fibrosis / Hartmann, Rolf W. ; Müller, Ursula ; Ehmer, Peter B.. - In: Eur. J. 
Med. Chem., 38 (2003) , 363-366

2002
- Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission 
yeast and evaluation of selectivity / Ehmer, Peter ; Bureik, Matthias ; Bernhardt, Rita ; Müller, Ursula 
; Hartmann, Rolf W.. - In: J. Steroid Biochem. Mol. Biol., 81 (2002) , 173-179

Müller-Vieira, Ursula

2005
- The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of aldosterone 
synthase (CYP11B2) inhibitors and their potential side effects / Müller-Vieira, Ursula ; Angotti, Marc 
; Hartmann, Rolf W.. - In: J. Steroid Biochem. Mol. Biol., 96 (2005) , 259-270

- Synthesis and Evaluation of Imidazolylmethylene-tetrahydronaphthalenes and -indanes: Potent Inhibitors 
of Aldosterone Synthase (CYP11B2) / Ulmschneider, Sarah ; Müller-Vieira, Ursula ; Mitrenga, Markus ; 
Hartmann, Rolf W. ; Marchais-Oberwinkler, Sandrine ; Klein, Christian ; Bureik, Matthias ; Bernhardt, 
Rita ; Antes, Iris ; Lengauer, Thomas. - In: J. Med. Chem.. 2005 , 48, 1796-1805

- Synthesis and Evaluation of Pyridylmethylene-tetrahydronaphthalenes / -indanes and Structurally Modified 
Derivatives: Potent and Selective Inhibitors of Aldosterone Synthase (CYP11B2) / Ulmschneider, Sarah 
; Müller-Vieira, Ursula ; Klein, Christian ; Antes, Iris ; Lengauer, Thomas ; Bernhardt, Rita. - In: 
J. Med. Chem.. 2005 , 48, 1563-1575

Neugebauer, Alexander

2004
- Protein-Dynamics of the Putative HCV Receptor CD81 Large Extracellular Loop / Neugebauer, Alexander ; 
Klein, Christian ; Hartmann, Rolf W.. - In: Bioorg. Med. Chem.Lett., 14 (2004) , 1765-1769

Palusczak, Anja

2005
- Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry 
approach / Cavalli, Andrea ; Bisi, Alessandra ; Bertucci, Carlo ; Rosini, Carlo ; Palusczak, Anja ; Gobbi, 
Silvia ; Giorgio, Egidio ; Rampa, Angela ; Belluti, Federica ; Piazzi, Lorna ; Valenti, Piero ; Hartmann, 
Rolf W. ; Recanatini, Maurizio. - In: J. Med. Chem., 48 (2005) , 7282-7289

- Synthesis and study of some new N-substituted imide derivatives as potential anticancer agents / Jindal, 
Dharam Paul ; Bedi, Vikas ; Jit, Birinder ; Karkra, Nalin ; Guleria, Sheetal ; Bansal, Ranju ; Palusczak, 
Anja ; Hartmann, Rolf W.. - In: Il Farmaco, 60 (2005) , 283-290

2004
- 2- and 3-[(Aryl)(azolyl)methyl]indoles as Potential Non-steroidal Aromatase Inhibitors / Lézé, Marie-
Pierre ; Le Borgne, Marc ; Marchand, Pascal ; Loquet, Denis ; Kogler, Manuela ; Le Baut, Guillaume ; 
Palusczak, Anja ; Hartmann, Rolf W.. - In: J. Enz. Inhib. Med. Chem., 19 (2004) , 549-557

- CYP 17 and CYP 19 Inhibitors. Evaluation of Fluorine Effects on the Inhibiting Activity of Regioselectively 
Fluorinated 1-(Naphthalen-2-ylmethyl)imidazoles / Hartmann, Rolf W. ; Palusczak, Anja ; Lacan, F. ; Ricci, 
G. ; Ruzziconi, R.. - In: J. Enz. Inhib. Med. Chem., 19 (2004) , 2, 145-155

- Synthesis and evaluation of a dimer of 2-(4-pyridylmethyl)-1-indanone as a novel nonsteroidal aromatase 
inhibitor / Gupta, Ranju ; Jindal, Dharam Paul ; Jit, Birinder ; Narang, Gaurav ; Palusczak, Anja ; Hartmann, 
Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 337 (2004) , 398-401

2001
- A new class of non steroidal aromatase inhibitors: Design and synthesis of chromone and xanthone derivatives, 
and inhibition of P450 enzymes aromatase and 17alpha-hydroxylase/C17,20-lyase / Recanatini, M. ; Bisi, 
A. ; Cavalli, A. ; Belluti, F. ; Gobbi, S. ; Rampa, A. ; Valenti, P. ; Palzer, M. ; Palusczak, Anja ; 
Hartmann, Rolf W.. - In: J. Med. Chem., 44 (2001) , 672-680

2000
- 6-Substituted 1H-quinolin-2-ones and 2-methoxy-quinolines: Synthesis and evaluation as inhibitors of 
steroid 5alpha-reductases type 1 and 2 / Baston, E. ; Palusczak, Anja ; Hartmann, Rolf W.. - In: Eur. 
J. Med. Chem., 35 (2000) , 931-940

- Synthesis and evaluation of 17-aliphatic heterocycle substituted steroidal inhibitors of 17alpha-hydroxylase/C17-
20-lyase(P450 17) / Hartmann, Rolf W. ; Hector, Markus ; Wachall, B.G. ; Palusczak, Anja ; Palzer, M. 
; Huch, Volker ; Veith, Michael. - In: J. Med. Chem., 43 (2000) , 4437-4445

Palzer, Martina

2005
- Three-dimensional model of cytochrome P450 human aromatase and docking studies in to the active site 
/ Logé, Cedric ; Le Borgne, Marc ; Marchand, Pascal ; Robert, Jean-Michel ; Palzer, Martina ; Hartmann, 
Rolf W.. - In: Bioorg. Med. Chem., 20 (2005) , 581-585

2003
- Preparation and pharmacological profile of 7-(alpha-Azolylbenzyl)-1H-Indoles and indolines as new aromatase 
inhibitors / Marchand, Pascal ; Le Borgne, Marc ; Palzer, Martina ; Le Baut, Guillaume ; Hartmann, Rolf 
W.. - In: Bioorg. Med. Chem. Lett., 13 (2003) , 1553-1555

1997
- Comparison of the in vitro aromatase inhibitor activity for 3- (azolylmethyl)-1H-indoles / Hartmann, 
Rolf W. ; Le Borgne, M. ; Marchand, P. ; Duflos, M. ; Le Baut, G. ; Piessard-Robert, S. ; Le Baut, G. 
; Palzer, Martina. - In: Pharm. Sci., 3 (1997) , 279-281

- Synthesis and in vitro evaluation of 3-(1-azolylmethyl)-1H-indoles and 3- (1-azolyl-1-phenylmenthyl)-
1H-indoles as inhibitors of P 450 arom / Hartmann, Rolf W. ; Le Borgne, M. ; Marchand, P. ; Duflos, M. 
; Delevoye-Seiller, B. ; Piessard-Robert, S. ; Le Baut, G. ; Palzer, Martina. - In: Arch. Pharm. Pharm. 
Med. Chem., 330 (1997) , 141-145

Panter, Bärbel Ursula

2005
- 5alpha-reductase in human embryonic kidney cell line HEK293 : evidence for type II enzyme expression 
and activity / Panter, Bärbel Ursula ; Jose, Joachim ; Hartmann, Rolf W.. - In: Mol. Cell. Biochem., 
270 (2005) , 201-208

Reichert, Wolfgang

2001
- Stable expression of human 5alpha-reductase type II in COS1 cells due to chromosomal gene integration: 
a novel tool for inhibitor identification / Reichert, Wolfgang ; Michel, Armin ; Hartmann, Rolf W. ; 
Jose, Joachim. - In: J. Steroid Biochem. Mol. Biol., 78 (2001) , 275-284

- Stable expression of the human 5alpha-reductase - isoenzymes type I and type II in HEK293 cells to identify 
dual and selective inhibitors / Reichert, Wolfgang ; Hartmann, Rolf W. ; Jose, Joachim. - In: J. Enz. 
Inhib., 16 (2001) , 47-53

2000
- 5alpha-reductase in intact DU145 cells: Evidence for isozyme I and evaluation of novel inhibitors / Reichert, 
Wolfgang ; Jose, Joachim ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 333 (2000) , 201-
204

- Synthesis of N-substitued piperidine-4-(benzylidene-4-carboxylic acids) and evaluation as inhibitors 
of steroid-5 alpha-reductase type 1 and 2 / Picard, F. ; Baston, E. ; Reichert, Wolfgang ; Hartmann, 
Rolf W.. - In: Bioorg. Med. Chem., 8 (2000) , 1479-1487

1999
- Stable expression of human 5a-reductase isoenzymes type 1 and type 2 in HEK293 cells to identify dual 
and selective inhibitors / Reichert, Wolfgang ; Hartmann, Rolf W. ; Jose, Joachim. - In: Arch. Pharm. 
Pharm. Med Chem., 332 (1999) , Suppl. 2, 38

1998
- Development of a cell culture assay to identify dual and selective inhibitors of human type 1 and type 
2 5alpha-reductase / Reichert, Wolfgang ; Jose, Joachim ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. 
Med. Chem., 331 (1998) , (Suppl. 2), 37

Reinhard, Bernd

1994
- Regioselective acetylations of sialic acid [alpha]-ketosides / Faillard, Hans ; Reinhard, Bernd. - In: 
Liebigs Annalen der Chemie, 1994, S. 193-203.

Scherer, Christiane

2005
- Heteroaryl substituted naphthalenes and structurally modified derivatives : selective inhibitors of CYP11B2 
for the treatment of congestive heart failure and myocardial fibrosis / Voets, Marieke ; Antes, Iris 
; Scherer, Christiane ; Biemel, Klaus ; Barassin, Catherine ; Marchais-Oberwinkler, Sandrine ; Hartmann, 
Rolf W.. - In: J. Med. Chem., 48 (2005) , 6632-6642

- Methyl Esters of N-(Dicyclohexyl)acetyl-piperidine-4-(benzylidene-4-carboxylic acids) as Drugs and Prodrugs 
– a New Strategy for Dual Inhibition of 5á-Reductase Type 1 and Type 2 / Streiber, Martina ; Picard, 
Franck ; Seidel, Stefanie ; Scherer, Christiane ; Hartmann, Rolf W.. - In: J. Pharm. Sci., 94 (2005) 
, 473-480

Schiffmann, Rolf

2005
- Metal ions as cofactors for ligand binding at methionine aminopeptidase : a critical view on the relevance 
of in vitro metalloenzyme assays / Schiffmann, Rolf ; Heine, Andreas ; Klebe, Gerhard ; Klein, Christian. 
- In: Angewandte Chemie / International edition. 2005 , 44, 3620-3623

Seidel, Stefanie

2005
- Methyl Esters of N-(Dicyclohexyl)acetyl-piperidine-4-(benzylidene-4-carboxylic acids) as Drugs and Prodrugs 
– a New Strategy for Dual Inhibition of 5á-Reductase Type 1 and Type 2 / Streiber, Martina ; Picard, 
Franck ; Seidel, Stefanie ; Scherer, Christiane ; Hartmann, Rolf W.. - In: J. Pharm. Sci., 94 (2005) 
, 473-480

2004
- Evaluation of cell permeation of a potent 5á-reductase inhibitor using MALDI-TOF MS / Mathur, Sonal ; 
Picard, Franck ; Dossou, Ulrich ; Barassin, Catherine ; Seidel, Stefanie ; Kang, Min-Jung ; Hartmann, 
Rolf W.. - In: J. Enz. Inhib. Med. Chem., 19 (2004) , 425-429

2002
- Inhibition of CYP 17, A new strategy for the treatment of prostate cancer / Hartmann, Rolf W. ; Ehmer, 
Peter ; Haidar, Samer ; Hector, Markus ; Jose, Joachim ; istian ; Seidel, Stefanie ; Sergejew, Tom ; 
Wachall, Bertil Gero ; Wächter, Gerald A. ; Zhuang Yan. - In: Arch. Pharm. Pharm. Med. Chem., 4 (2002) 
, 119-128

Streiber, Martina

2005
- Methyl Esters of N-(Dicyclohexyl)acetyl-piperidine-4-(benzylidene-4-carboxylic acids) as Drugs and Prodrugs 
– a New Strategy for Dual Inhibition of 5á-Reductase Type 1 and Type 2 / Streiber, Martina ; Picard, 
Franck ; Seidel, Stefanie ; Scherer, Christiane ; Hartmann, Rolf W.. - In: J. Pharm. Sci., 94 (2005) 
, 473-480

Ulmschneider, Sarah

2005
- Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2) 
/ Ulmschneider, Sarah ; Negri, Matthias ; Voets, Marieke ; Hartmann, Rolf W.. - In: Bioorg. Med. Chem. 
Lett., 16 (2005) , 25-30

- Synthesis and Evaluation of Imidazolylmethylene-tetrahydronaphthalenes and -indanes: Potent Inhibitors 
of Aldosterone Synthase (CYP11B2) / Ulmschneider, Sarah ; Müller-Vieira, Ursula ; Mitrenga, Markus ; 
Hartmann, Rolf W. ; Marchais-Oberwinkler, Sandrine ; Klein, Christian ; Bureik, Matthias ; Bernhardt, 
Rita ; Antes, Iris ; Lengauer, Thomas. - In: J. Med. Chem.. 2005 , 48, 1796-1805

- Synthesis and Evaluation of Pyridylmethylene-tetrahydronaphthalenes / -indanes and Structurally Modified 
Derivatives: Potent and Selective Inhibitors of Aldosterone Synthase (CYP11B2) / Ulmschneider, Sarah 
; Müller-Vieira, Ursula ; Klein, Christian ; Antes, Iris ; Lengauer, Thomas ; Bernhardt, Rita. - In: 
J. Med. Chem.. 2005 , 48, 1563-1575

Voets, Marieke

2005
- Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2) 
/ Ulmschneider, Sarah ; Negri, Matthias ; Voets, Marieke ; Hartmann, Rolf W.. - In: Bioorg. Med. Chem. 
Lett., 16 (2005) , 25-30

- Heteroaryl substituted naphthalenes and structurally modified derivatives : selective inhibitors of CYP11B2 
for the treatment of congestive heart failure and myocardial fibrosis / Voets, Marieke ; Antes, Iris 
; Scherer, Christiane ; Biemel, Klaus ; Barassin, Catherine ; Marchais-Oberwinkler, Sandrine ; Hartmann, 
Rolf W.. - In: J. Med. Chem., 48 (2005) , 6632-6642

2004
- Synthesis of Amidinohydrazones and Evaluation of Their Inhibitory Effect towards Aldosterone Synthase 
(CYP11B2) and the Formation of Selected Steroids / Voets, Marieke ; Müller-Vieira, Ursula ; Marchais-
Oberwinkler, Sandrine ; Hartmann, Rolf W.. - In: Arch. Pharm. Pharm. Med. Chem., 337 (2004) , 411-416

Zangen, Dirk

2003
- New inhibitors of human cathepsin G by bacterial surface display library screening and peptide-protein 
docking / Jose, Joachim ; Betscheider, Dirk ; Ray, Somak ; Lengauer, Thomas ; Zangen, Dirk. - In: Proceedings 
of the 7th International Symposium on Pharmaceutical Sciences ISOPS7 / Ed.: Akin, Ahmet et al.. - Ankara 
: Tasarim Basim. 2003, 46-49

2002
- Selection of protease inhibitors by cellular surface display, enzyme labeling and flow cytometry / Jose, 
Joachim ; Zangen, Dirk. - In: Arch Pharm Pharm Med Chem, 335 (2002) , Suppl. 1, 50