Denise Feick

Forschungsgebiet

  • Physiologie-basierte Pharmakokinetik (PBPK) Modellierung                                                         

Lebenslauf

Seit 12/2017: Doktorandin in der Klinischen Pharmazie

11/2017: Approbation als Apothekerin

05/2017 – 10/2017: Praktisches Jahr, Landmann Apotheke Oliver Blank, Völklingen

11/2016 – 04/2017: Praktisches Jahr und Diplom, Klinischen Pharmazie, Universität des Saarlandes, Saarbrücken

10/2012 – 09/2016: Studium der Pharmazie, Universität des Saarlandes, Saarbrücken

06/2012: Allgemeine Hochschulreife, Warndtgymnasium, Völklingen

Publikationen

Manuskripte

Türk D, Müller F, Fromm MF, Selzer D, Dallmann R, Lehr T. Renal transporter-mediated drug-biomarker interactions of the endogenous substrates creatinine and N1-methylnicotinamide: a PBPK modeling approach. Clin Pharmacol Ther 2022, Epub: doi.org/10.1002/cpt.2636.

Loer HLH, Türk D, Gómez-Mantilla JD, Selzer D, Lehr T. Physiologically based pharmakokinetic (PBPK) modeling of clopidogrel and its four relevant metabolites for CYP2B6, CYP2C8, CYP2C19 and CYP3A4 drug-drug-gene interaction predictions. Pharmaceutics 2022;14(5):915.

Türk D, Fuhr LM, Marok FZ, Rüdesheim S, Kühn A, Selzer D, Schwab M, Lehr T. Novel models for the prediction of drug-gene interactions. Expert Opin on Drug Metab Toxicol 2021;17(11):1293-1310.

Türk D, Hanke N, Lehr T. A physiologically-based pharmacokinetic model of trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 drug-drug-gene interaction predictions. Pharmaceutics 2020;12(11):1074.

Hanke N, Türk D, Selzer D, Wiebe S, Fernandez É, Stopfer P, Nock V, Lehr T. A mechanistic, enantioselective, physiologically based pharmacokinetic model of verapamil and norverapamil, built and evaluated for drug-drug interaction studies. Pharmaceutics 2020;12(6):556.

Hanke N, Türk D, Selzer D, Ishiguro N, Ebner T, Wiebe S, Müller F, Stopfer P, Nock V, Lehr T. A comprehensive whole-body physiologically based pharmacokinetic drug-drug-gene interaction model of metformin and cimetidine in healthy adults and renally impaired individuals. Clin Pharmacokinet 2020;59:1419-1431.

Türk D, Hanke N, Wolf S, Frechen S, Eissing T, Wendl T, Schwab M, Lehr T. Physiologically based pharmacokinetic models for prediction of complex CYP2C8 and OATP1B1 (SLCO1B1) drug-drug-gene interactions: a modeling network of gemfibrozil, repaglinide, pioglitazone, rifampicin, clarithromycin and itraconazole. Clin Pharmacokinet 2019;58(12):1595-1607.

Poster

Türk D, Hanke N, Lehr T. Physiologically-based pharmacokinetic models to predict CYP2C8 drug-drug interactions: a modeling network of trimethoprim, repaglinide, pioglitazone and rifampicin. International PhD Student & Postdoc Meeting of the German Pharmaceutical Society (DPhG) 2021, Virtual Meeting, Germany.

Türk D, Hanke N, Lehr T. Physiologically-based pharmacokinetic modeling of the CYP2C8 perpetrator trimethoprim. 28th Population Approach Group Europe (PAGE) meeting, 2019, Stockholm, Sweden.

Türk D, Hanke N, Lehr T. Physiologically-based pharmacokinetic modeling of gemfibrozil drug-drug interactions with the CYP2C8 victim drugs repaglinide and pioglitazone. 27th Population Approach Group Europe (PAGE) meeting, 2018, Montreux, Switzerland.

Türk D, Hanke N, Lehr T. Physiologically-based pharmacokinetic (PBPK) modeling of the CYP2C8 substrate pioglitazone. 26th Population Approach Group Europe (PAGE) meeting, 2017, Budapest, Hungary.

Preise

Posterpreis. International PhD Student & Postdoc Meeting of the German Pharmaceutical Society (DPhG) 2021, Virtual Meeting, Germany.                      

Kontakt

Denise Feick, geb. Türk

Klinische Pharmazie
Universität des Saarlandes
Campus C4 1, Zimmer -1.08
66123 Saarbrücken 

T: +49/681/302-70254
F: +49/681/302-70258

denise.tuerk[at]uni-saarland.de