Denise Türk

Forschungsgebiet

Physiologie-basierte Pharmakokinetik (PBPK) Modellierung

Lebenslauf

Seit 12/2017: Doktorandin in der Klinischen Pharmazie

11/2017: Approbation als Apothekerin

05/2017 – 10/2017: Praktisches Jahr, Landmann Apotheke Oliver Blank, Völklingen

11/2016 – 04/2017: Praktisches Jahr und Diplom, Klinischen Pharmazie, Universität des Saarlandes, Saarbrücken

10/2012 – 09/2016: Studium der Pharmazie, Universität des Saarlandes, Saarbrücken

06/2012: Allgemeine Hochschulreife, Warndtgymnasium, Völklingen

Publikationen

Hanke N, Türk D, Selzer D, Wiebe S, Fernandez É, Stopfer P, Nock V, Lehr T. A mechanistic, enantioselective, physiologically based pharmacokinetic model of verapamil and norverapamil, built and evaluated for drug-drug interaction studies. Pharmaceutics 2020;12(6):556.

Hanke N, Türk D, Selzer D, Ishiguro N, Ebner T, Wiebe S, Müller F, Stopfer P, Nock V, Lehr T. A comprehensive whole-body physiologically based pharmacokinetic drug-drug-gene interaction model of metformin and cimetidine in healthy adults and renally impaired individuals. Clin Pharmacokinet 2020;Epub:10.1007/s40262-020-00896-w.

Türk D, Hanke N, Wolf S, Frechen S, Eissing T, Wendl T, Schwab M, Lehr T. Physiologically based pharmacokinetic models for prediction of complex CYP2C8 and OATP1B1 (SLCO1B1) drug-drug-gene interactions: a modeling network of gemfibrozil, repaglinide, pioglitazone, rifampicin, clarithromycin and itraconazole. Clin Pharmacokinet 2019;58(12):1595-1607.

Poster

Türk D, Hanke N, Lehr T. Physiologically-based pharmacokinetic modeling of trimethoprim drug-drug interactions with the CYP2C8 victim drugs repaglinide and pioglitazone. DPhG Annual Meeting, 2019, Heidelberg, Germany.

Türk D, Hanke N, Lehr T. Physiologically-based pharmacokinetic modeling of the CYP2C8 perpetrator trimethoprim. 28th Population Approach Group Europe (PAGE) meeting, 2019, Stockholm, Sweden.

Türk D, Hanke N, Lehr T. Physiologically-based pharmacokinetic modeling of gemfibrozil drug-drug interactions with the CYP2C8 victim drugs repaglinide and pioglitazone. 27th Population Approach Group Europe (PAGE) meeting, 2018, Montreux, Switzerland.

Türk D, Hanke N, Lehr T. Physiologically-based pharmacokinetic (PBPK) modeling of the CYP2C8 substrate pioglitazone. 26th Population Approach Group Europe (PAGE) meeting, 2017, Budapest, Hungary.

Kontakt

Denise Türk

Klinische Pharmazie
Universität des Saarlandes
Campus C4 1, Zimmer -1.08
66123 Saarbrücken 

T: +49/681/302-70254
F: +49/681/302-70258

denise.tuerk[at]uni-saarland.de