Publications

Postdoctoral, Graduate and Undergraduate Research

13. Ribosomal peptides with polycyclic isoprenoid moieties
F. Hubrich, S. K. Kandy, C. Chepkirui, C. Padhi, S. Mordhorst, P. Moosmann, T. Zhu, M. Gugger, J. R. Chekan, and J. Piel
Chem, 2024, 10, 3224–2342, doi: 10.1016/j.chempr.2024.07.026.

12. Widespread microbial utilization of ribosomal β-amino acid-containing peptides and proteins
T. A. Scott, M. Verest, J. Farnung, C. C. Forneris, S. L. Robinson, X. Ji, F. Hubrich, C. Chepkirui, D. U. Richter, S. Huber, P. Rust, A. B. Streiff, Q. Zhang, J. W. Bode and J. Piel
Chem, 2022, 8, 2659–2677, doi: 10.1016/j.chempr.2022.09.017.

11. Biosynthesis of menaquinone in E. coli: identification of an elusive isomer of SEPHCHC
A. Fries*, L. Mazzaferro*, P. Bisel*, F. Hubrich*, J. N. Andexer* and M. Müller*
ChemBioChem, 2022, e202200181. doi: 10.1002/cbic.202200181.

10. Biosynthetic potential of the global ocean microbiome
L. Paoli, H.-J. Ruscheweyh^§, C. C. Forneris^§, F. Hubrich^§, S. Kautsar, Q. Clayssen, A. Bhushan, G. Salazar, A. Milanese, D. Gehrig, A. Lotti, M. Larralde, L. M. Carroll, P. Sánchez, A. A. Zayed, D. R. Cronin, S. G. Acinas, P. Bork, C. Bowler, T. O. Delmont, M. B. Sullivan, P. Wincker, G. Zeller, S. L. Robinson, J. Piel and S. Sunagawa
Nature, 2022, 607, 111–118, doi: 10.1038/s41586-022-04862-3.

9. Ribosomally derived lipopeptides containing distinct fatty acyl moieties
F. Hubrich^§, N. M. Bösch^§, C. Chepkirui, B. I. Morinaka, M. Rust, M. Gugger, S. L. Robinson, A. L. Vagstad and J. Piel
Proc. Natl. Acad. Sci. U.S.A., 2022, 119, e2113120119, doi: 10.1073/pnas.2113120119.

8. Uncovering novel peptide chemistry from bacterial natural products
F. Hubrich^§, A. Lotti^§, T. A. Scott^§ and J. Piel
Chimia (Aarau), 2021, 75, 543–547, doi: 10.2533/chimia.2021.543.

7. Chorismate and isochorismate converting enzymes: versatile catalysts acting on an important metabolic node
F. Hubrich*, M. Müller and J. N. Andexer*
Chem. Commun. (Camb.), 2021, 57, 2441–2463, doi: 10.1039/D0CC08078K.

6. Chorismatases – the family is growing
M. J. Grüninger, P. C. F. Buchholz, S. Mordhorst, P. Strack, M. Müller, F. Hubrich, J. Pleiss and J. N. Andexer
Org. Biomol. Chem., 2019, 17, 2092–2098, doi: 10.1039/c8ob03038c.

5. Chorismatase mechanisms reveal fundamentally different types of reaction in a single conserved protein fold
F. Hubrich, P. Juneja, K. Diederichs, M. Müller, W. Welte and J. N. Andexer
J. Am. Chem. Soc., 2015, 137, 11032–11037, doi: 10.1021/jacs.5b05559.

4. In vitro production and purification of isochorismate using a two-enzyme cascade
F. Hubrich, M. Müller and J. N. Andexer
 J. Biotechnol., 2014, 191, 93–98, doi: 10.1016/j.jbiotec.2014.06.003.

3. Mechanistic implications for the chorismatase FkbO based on the crystal structure
P. Juneja^§, F. Hubrich^§, K. Diederichs, W. Welte and J. N. Andexer
J. Mol. Biol., 2014, 426, 105–115, doi: 10.1016/j.jmb.2013.09.006.

2. Cinnamic acid derivatives as inhibitors for chorismatases and isochorismatases
F. Hubrich, S. Mordhorst and J. N. Andexer
Bioorg. Med. Chem. Lett., 2013, 23, 1477‒1481, doi: 10.1016/j.bmcl.2012.12.059.

1. Engineering the respiratory complex I to energy-converting NADPH:ubiquinone oxidoreductase
K. Morina, M. Schulte, F. Hubrich, K. Dörner, S. Steimle, S. Stolpe and T. Friedrich
J. Biol. Chem., 2011, 286, 34627–34634, doi: 10.1074/jbc.M111.274571.

^§equal contribution, *corresponding author(s)