Publications

Recent Publications

* joint first author
# joint corresponding author
 

2024

  • Present and future of synthetic cell development.

    Katarzyna P Adamala#, Marileen Dogterom#, Yuval Elani#, Petra Schwille#, Masahiro Takinoue#, T-Y Dora Tang#

    Nat Rev Mol Cell Biol DOI 

     

     

  • Cell Free Expression in Proteinosomes Prepared from Native Protein-PNIPAAm Conjugates.

    Mengfei Gao, Dishi Wang, Michaela Wilsch-Bräuninger, Weihua Leng, Jonathan Schulte, Nina Morgner, Dietmar Appelhans, T-Y Dora Tang

    Macromol Biosci  DOI

     

2023

  • Protocells Capable of Generating a Cytoskeleton-like Structure from intracellular Membrane-active Artificial Organelles.

    Dishi Wang, Silvia Moreno#, Mengfei Gao, Jiaqi Guo, Bing Xu, Brigitte I Voit, Dietmar Appelhans#

    Adv Funct Mater  DOI 

     

  • Artificial Cells: From Basic Assembly to Directed Functionality.

    T-Y Dora Tang#, Xin Huang#

    Small Methods DOI 

     

  • Bidirectional Communication between Droplet Interface Bilayers Driven by Cell-Free Quorum Sensing Gene Circuits.

    David Thomas Gonzales, Surased Suraritdechachai, Christoph Zechner, T-Y Dora Tang

    ChemSystemsChem DOI 

  • Ribozyme activity modulates the physical properties of RNA-peptide coacervates.

    Kristian Le Vay✳︎#, Elia Salibi✳︎, Basusree Ghosh, T Y Dora Tang#, Hannes Mutschler#

    Elife DOI 

  • Compartmentalized Cell-Free Expression Systems for Building Synthetic Cells.

    David Thomas Gonzales, Surased Suraritdechachai, T Y Dora Tang

    Adv Biochem Eng Biotechnol DOI 

     

  • Statistical mechanics of biomolecular condensates via cavity methods.

    Nino Lauber, Ondrej Tichacek, Rudrarup Bose, Christoph Flamm, Luca Leuzzi, T-Y Dora Tang, Kepa Ruiz-Mirazo, Daniele De Martino

    iScience DOI 

  • Frontiers in biomolecular condensate research.

    Christine Mayr, Tanja Mittag, T-Y Dora Tang, Wenyu Wen, Hong Zhang, Huaiying Zhang

    Nat Cell Biol DOI 

     

     

2022

  • Engineering strategies for sustainable synthetic cells.

    Xuejing Wang, Shuqi Wu, T-Y Dora Tang, Liangfei Tian

    Trends in Chemistry

     

     

  • Programmable synthetic cell networks regulated by tuneable reaction rates.

    Adrian Zambrano✳︎, Giorgio Fracasso✳︎, Mengfei Gao✳︎, Martina Ugrinic, Dishi Wang, Dietmar Appelhans, Andrew deMello, T-Y Dora Tang

    Nat Commun DOI

  • Characterization of RNA content in individual phase-separated coacervate microdroplets.

    Damian Wollny#, Benjamin Vernot, Jie Wang, Maria Hondele, Aram Safrastyan, Franziska Aron, Julia Micheel, Zhisong He, Anthony Hyman, Karsten Weis, J Gray Camp, T-Y Dora Tang#, Barbara Treutlein#

    Nat Commun DOI 

  • Charge-density reduction promotes ribozyme activity in RNA-peptide coacervates via RNA fluidization and magnesium partitioning.

    Juan M Iglesias-Artola, Björn Drobot, Mrityunjoy Kar, Anatol Fritsch, Hannes Mutschler, T-Y Dora Tang, Moritz Kreysing

    Nat Chem DOI 

  • Cell scientist to watch - Dora Tang.

    Dora Tang

    J Cell Sci DOI 

     

  • Cell-Free Gene Expression Dynamics in Synthetic Cell Populations.

    David Thomas Gonzales, Naresh Yandrapalli, Tom Robinson, Christoph Zechner#, T-Y Dora Tang#

    ACS Synth Biol DOI 

  • Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells.

    Alan Ianeselli, Damla Tetiker, Julian Stein, Alexandra Kühnlein, Christof Mast, Dieter Braun#, T-Y Dora Tang#

    Nat Chem DOI 

2021

  • Enhanced Ribozyme-Catalyzed Recombination and Oligonucleotide Assembly in Peptide-RNA Condensates.

    Kristian Le Vay✳︎#, Emilie Yeonwha Song✳︎, Basusree Ghosh, T-Y Dora Tang#, Hannes Mutschler#

    Angew Chem Int Ed Engl DOI 

  • Quantitative theory for the diffusive dynamics of liquid condensates.

    Lars Hubatsch, Louise Jawerth, Celina Love, Jonathan Bauermann, Ty Dora Tang, Stefano Bo, Anthony Hyman, Christoph A. Weber

    Elife DOI 

  • Can coacervation unify disparate hypotheses in the origin of cellular life?

    Basusree Ghosh✳︎, Rudrarup Bose✳︎, T-Y Dora Tang

    Curr Opin Colloid Interface Sci DOI 

     

2020

  • Controlling Protein Nanocage Assembly with Hydrostatic Pressure.

    Kristian Le Vay, Ben M Carter, Daniel W Watkins, T-Y Dora Tang, Valeska P Ting, Helmut Cölfen, Robert P Rambo, Andrew J Smith, J L Ross Anderson, Adam W Perriman

    J Am Chem Soc DOI 

     

  • Spontaneous membrane-less multi-compartmentalization via aqueous two-phase separation in complex coacervate micro-droplets.

    Nicolette G Moreau, Nicolas Martin, Pierangelo Gobbo, T-Y Dora Tang, Stephen Mann

    Chem Commun (Camb) DOI 

     

  • Building synthetic multicellular systems using bottom–up approaches.

    David Thomas Gonzales, Christoph Zechner, T-Y Dora Tang

    Curr Opin Syst Biol DOI 

  • Toward Engineering Biosystems With Emergent Collective Functions.

    Thomas E. Gorochowski, Sabine Hauert, Jan-Ulrich Kreft, Lucia Marucci, Namid R. Stillman, T-Y Dora Tang, Lucia Bandiera, Vittorio Bartoli, Daniel O.R. Dixon, Alex J.H. Fedorec, Harold Fellermann, Alexander G. Fletcher, Tim Foster, Luca Giuggioli, Antoni Matyjaszkiewicz, Scott McCormick, Sandra Montes Olivas, Jonathan Naylor, Ana Rubio Denniss, Daniel Ward

    Front Bioeng Biotechnol DOI 

  • High-Throughput Synthesis and Screening of Functional Coacervates Using Microfluidics.

    Thomas Beneyton✳︎, Celina Love✳︎, Mathias Girault, T-Y Dora Tang#, Jean-Christophe Baret#

    ChemSystemsChem DOI 

  • Reversible pH-Responsive Coacervate Formation in Lipid Vesicles Activates Dormant Enzymatic Reactions.

    Celina Love, Jan Steinkühler, David Thomas Gonzales, Naresh Yandrapalli, Tom Robinson, Rumiana Dimova, T-Y Dora Tang

    Angew Chem Int Ed Engl DOI 

2019

  • Moment-based analysis of biochemical networks in a heterogeneous population of communicating cells.

    David Thomas Gonzales, T-Y Dora Tang, Christoph Zechner

    2019 IEEE 58th Conference on Decision and Control (CDC) DOI 

     

  • Special Issue on Bottom-Up Synthetic Biology.

    Hannes Mutschler, Tom Robinson, T-Y Dora Tang, Seraphine Wegner

    Chembiochem  DOI 

  • Microfluidic Tools for Bottom-Up Synthetic Cellularity.

    Martina Ugrinic, Andrew deMello#, T-Y Dora Tang#

    Chem  DOI 

     

     

  • In vitro gene expression and detergent-free reconstitution of active proteorhodopsin in lipid vesicles.

    Giorgio Fracasso, Yvonne Körner, David Thomas Gonzales, T-Y Dora Tang

    Exp Biol Med  DOI 

     

  • Directed Growth of Biomimetic Microcompartments.

    Ivan Ivanov#, Rafael B. Lira, T-Y Dora Tang, Titus Franzmann, Adam Klosin, Lucas Caire da Silva, Anthony Hyman, Katharina Landfester, Reinhard Lipowsky, Kai Sundmacher, Rumiana Dimova#

    Adv Biosys  DOI 

     

     

2018

  • MaxSynBio: Avenues Towards Creating Cells from the Bottom Up.

    Petra Schwille, Joachim P. Spatz, Katharina Landfester, Eberhard Bodenschatz, Stephan Herminghaus, Victor Sourjik, Tobias Erb, Philippe Bastiaens, Reinhard Lipowsky, Anthony Hyman, Peter Dabrock, Jean-Christophe Baret, Tanja Vidakovic-Koch, Peter Bieling, Rumiana Dimova, Hannes Mutschler, Tom Robinson, T-Y Dora Tang, Seraphine Wegner, Kai Sundmacher

    Angew Chem Int Ed Engl  DOI 

     

  • Compartmentalised RNA catalysis in membrane-free coacervate protocells.

    Björn Drobot, Juan M Iglesias-Artola, Kristian Le Vay, Viktoria Mayr, Mrityunjoy Kar, Moritz Kreysing#, Hannes Mutschler#, T-Y Dora Tang#

    Nat Commun  DOI 

     

  • Ultrafast Transient Absorption Spectroscopy of UO22+ and [UO2Cl].

    Toni Haubitz, Satoru Tsushima, Robin Steudtner, Björn Drobot, Gerhard Geipel, Thorsten Stumpf, Michael U. Kumke

    J Phys Chem A  DOI 

     

  • Gene-Mediated Chemical Communication in Synthetic Protocell Communities.

    T-Y Dora Tang, Dario Cecchi, Giorgio Fracasso, Davide Accardi, Angelique Coutable-Pennarun, Sheref S Mansy, Adam W Perriman, J L Ross Anderson, Stephen Mann

    ACS Synth Biol  DOI 

     

  • Microfluidic formation of proteinosomes.

    Martina Ugrinic, Adrian Zambrano, Simon Berger, Stephen Mann, T-Y Dora Tang, Andrew deMello

    Chem Commun DOI 

     

2016

  • Polynucleotides in cellular mimics: Coacervates and lipid vesicles

    Jeffrey R Vieregg, T-Y Dora Tang

    Curr Opin Colloid Interface Sci  DOI 

     

2015

  • Hydrophobic nanoparticles promote lamellar to inverted hexagonal transition in phospholipid mesophases.

    Jennifer M Bulpett, Tim Snow, Benoit Quignon, Charlotte M Beddoes, T-Y D Tang, Stephen Mann, Olga Shebanova, Claire L Pizzey, Nicholas J Terrill, Sean A Davis, Wuge H Briscoe

    Soft Matter  DOI 

     

  • In vitro gene expression within membrane-free coacervate protocells.

    T-Y Dora Tang, Dirk van Swaay, Andrew deMello, J L Ross Anderson, Stephen Mann

    Chem Commun  DOI 

  • Microfluidic Formation of Membrane-Free Aqueous Coacervate Droplets in Water.

    Dirk van Swaay, T-Y Dora Tang, Stephen Mann, Andrew de Mello

    Angew Chem Int Ed Engl  DOI  

     

  • Structural studies of the lamellar to bicontinuous gyroid cubic (Q(G)(II)) phase transitions under limited hydration conditions.

    T-Y Dora Tang, Nicholas J Brooks, Oscar Ces, John M Seddon, Richard H Templer

    Soft Matter  DOI 

2014

  • Synthetic cellularity based on non-lipid micro-compartments and protocell models.

    Mei Li, Xin Huang, T-Y Dora Tang, Stephen Mann

    Curr Opin Chem Biol  DOI 

  • Fatty acid membrane assembly on coacervate microdroplets as a step towards a hybrid protocell model.

    T-Y Dora Tang, C Rohaida Che Hak, Alexander J Thompson, Marina K Kuimova, D S Williams, Adam W Perriman, Stephen Mann

    Nat Chem  DOI

  • The effects of pressure and temperature on the energetics and pivotal surface in a monoacylglycerol/water gyroid inverse bicontinuous cubic phase.

    T-Y Dora Tang, Annela M Seddon, Christoph Jeworrek, Roland Winter, Oscar Ces, John M Seddon, Richard H Templer

    Soft Matter  DOI 

     

2013

  • Small-molecule uptake in membrane-free peptide/nucleotide protocells

    T-Y Dora Tang, Massimo Antognozzi, James A. Vicary, Adam W Perriman, Stephen Mann

    Soft Matter

     

     

2012

  • Hydrostatic pressure effects on the lamellar to gyroid cubic phase transition of monolinolein at limited hydration.

    T-Y Dora Tang, Nicholas J Brooks, Christoph Jeworrek, Oscar Ces, Nicholas J Terrill, Roland Winter, Richard H Templer, John M Seddon

    Langmuir DOI 

     

2010

  • Engineering bicontinuous cubic structures at the nanoscale—the role of chain splay

    Chandrashekhar V. Kulkarni, T-Y Dora Tang, Annela M Seddon, John M Seddon, Oscar Ces, Richard H Templer

    Soft Matter