Publications

2024
Zeroug-Metz, L.; Lee, S. Biodynamers: Applications of Dynamic Covalent Chemistry in Single-Chain Polymer Nanoparticles. Drug Deliv. and Transl. Res.2024. doi.org/10.1007/s13346-024-01665-z.
Kamal, M. A. M.; Bassil, J.; Loretz, B.; Hirsch, A. K. H.; Lee, S.; Lehr, C.-M. Arg-Biodynamers as Antibiotic Potentiators through Interacting with Gram-Negative Outer Membrane Lipopolysaccharides. European Journal of Pharmaceutics and Biopharmaceutics2024, 200, 114336. doi.org/10.1016/j.ejpb.2024.114336.
Liu, Y.; Hamm, T.; Eichinger, T.; Kamm, W.; Wieland, H.; Loretz, B.; Hirsch, A.; Lee, S.; Lehr, C.-M. Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery. IJN2024, Volume 19, 4429–4449. doi.org/10.2147/IJN.S448578.

 

2023
Liu, Y.; Ashmawy, S.; Latta, L.; Weiss, A.-V.; Kiefer, A. F.; Nasr, S.; Loretz, B.; Hirsch, A. K. H.; Lee, S.; Lehr, C.-M. pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA. Biomacromolecules2023, 24 (8), 3742–3754. doi.org/10.1021/acs.biomac.3c00424.
Buescher, J.; Novak, A. W.; Khan, S. A.; Weiss, A.-V.; Lee, S.; Schneider, M. PLGA-Based Nanoparticles for Treatment of Infectious Diseases. In Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery; Elsevier, 2023; pp 303–333. doi.org/10.1016/B978-0-323-91215-0.00014-5.
Lee, S.; Nasr, S.; Rasheed, S.; Liu, Y.; Hartwig, O.; Kaya, C.; Boese, A.; Koch, M.; Herrmann, J.; Müller, R.; Loretz, B.; Buhler, E.; Hirsch, A. K. H.; Lehr, C.-M. Proteoid Biodynamers for Safe mRNA Transfection via pH-Responsive Nanorods Enabling Endosomal Escape. Journal of Controlled Release2023, 353, 915–929. doi.org/10.1016/j.jconrel.2022.12.018.

 

2021
Nasr, S. S.; Lee, S.; Thiyagarajan, D.; Boese, A.; Loretz, B.; Lehr, C.-M. Co-Delivery of mRNA and pDNA Using Thermally Stabilized Coacervate-Based Core-Shell Nanosystems. Pharmaceutics2021, 13 (11), 1924. doi.org/10.3390/pharmaceutics13111924.

 

vor 2021
Lee, S.; Kaya, C.; Jang, H.; Koch, M.; Loretz, B.; Buhler, E.; Lehr, C.-M.; Hirsch, A. K. H. pH-Dependent Morphology and Optical Properties of Lysine-Derived Molecular Biodynamers. Mater. Chem. Front.2020, 4 (3), 905–909. doi.org/10.1039/C9QM00651F.
Christmann, R.; Ho, D.-K.; Wilzopolski, J.; Lee, S.; Koch, M.; Loretz, B.; Vogt, T.; Bäumer, W.; Schaefer, U. F.; Lehr, C.-M. Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases. Pharmaceutics2020, 12 (12), 1131. doi.org/10.3390/pharmaceutics12121131.
Stubelius, A.; Lee, S.; Almutairi, A. The Chemistry of Boronic Acids in Nanomaterials for Drug Delivery. Acc. Chem. Res.2019, 52 (11), 3108–3119. doi.org/10.1021/acs.accounts.9b00292.
Stubelius, A.; Sheng, W.; Lee, S.; Olejniczak, J.; Guma, M.; Almutairi, A. Disease‐Triggered Drug Release Effectively Prevents Acute Inflammatory Flare‐Ups, Achieving Reduced Dosing. Small2018, 14 (32), 1800703. doi.org/10.1002/smll.201800703.
Lee, S.; Stubelius, A.; Olejniczak, J.; Jang, H.; Huu, V. A. N.; Almutairi, A. Chemical Amplification Accelerates Reactive Oxygen Species Triggered Polymeric Degradation. Biomater. Sci.2018, 6 (1), 107–114. doi.org/10.1039/C7BM00758B.
Lee, S.; Stubelius, A.; Hamelmann, N.; Tran, V.; Almutairi, A. Inflammation-Responsive Drug-Conjugated Dextran Nanoparticles Enhance Anti-Inflammatory Drug Efficacy. ACS Appl. Mater. Interfaces2018, 10 (47), 40378–40387. doi.org/10.1021/acsami.8b08254.
Hemmatian, Z.; Jalilian, E.; Lee, S.; Strakosas, X.; Khademhosseini, A.; Almutairi, A.; Shin, S. R.; Rolandi, M. Delivery of Cargo with a Bioelectronic Trigger. ACS Appl. Mater. Interfaces2018, 10 (26), 21782–21787. doi.org/10.1021/acsami.8b02724.
Olejniczak, J.; Collet, G.; Nguyen Huu, V. A.; Chan, M.; Lee, S.; Almutairi, A. Biorthogonal Click Chemistry on Poly(Lactic-Co-Glycolic Acid)-Polymeric Particles. Biomater. Sci.2017, 5 (2), 211–215. doi.org/10.1039/C6BM00721J.
Osada, K.; Cabral, H.; Mochida, Y.; Lee, S.; Nagata, K.; Matsuura, T.; Yamamoto, M.; Anraku, Y.; Kishimura, A.; Nishiyama, N.; Kataoka, K. Bioactive Polymeric Metallosomes Self-Assembled through Block Copolymer–Metal Complexation. J. Am. Chem. Soc.2012, 134 (32), 13172–13175. doi.org/10.1021/ja304615y.
Lee, C.-H.; Lee, S.; Yoon, H.; Jang, W.-D. Strong Binding Affinity of a Zinc-Porphyrin-Based Receptor for Halides through the Cooperative Effects of Quadruple C-H Hydrogen Bonds and Axial Ligation. Chem. Eur. J.2011, 17 (49), 13898–13903. doi.org/10.1002/chem.201101884.