Publikationen

2026
A Multivalent TAT–Arginine-Biodynamer Conjugate Targeting the Bacterial Cell Envelope via Specific Membrane Interactions. Kamal, M. A. M.; Metwally, W. M.; Bassil, J.; Niebuur, B. J.; Kraus, T.; Herrmann, J.; Koch, M.; Hirsch, A. K. H.; Loretz, B.; Lee, S.; Lehr, C.-M. Biomedicine & Pharmacotherapy. 2026, 198, 119304. https://doi.org/10.1016/j.biopha.2026.119304
The Role of Biofunctional Polymers in Polymer–Drug Conjugates: From Passive Carriers to Therapeutically Active Platforms. Passi, C.; Novak, A. N.; Schneider, M.; Lee, S. Pharmaceutics. 2026, 18(4), 419. https://doi.org/10.3390/pharmaceutics18040419
Design of Poly-Catechol Biodynamers for Potentiation of Antibiotic Efficacy against Drug-Resistant Bacteria. Zeroug-Metz, L.; Shehu, K.; Bassil, J.; Podlecki, J.; Sonntag, P.; Koch, M.; Christoulaki, A.; Buhler, E.; Hirsch, A. K. H.; Kraegeloh, A.; Schneider, M.; Lee, S. Biomacromolecules. 2026, 27(3), 1949–1968. https://doi.org/10.1021/acs.biomac.5c02130
Biodynamers as Prodrugs with Controlled Uptake and Activity. Nguyen, T. T.; Hemmer, J.; Kiemer, A. K.; Diesel, B.; Lee, S. Journal of Controlled Release. 2026, 390, 114538. https://doi.org/10.1016/j.jconrel.2025.114538
pH-Responsive Isoprenoid-Antitumoral Polymer Conjugates for Superior Drug Loading via Self-Assembly and Endosomal-Targeted Anticancer Activity. Passi, C.; Neu, T.; Schneider-Daum, N.; Lehr, C.-M.; Schneider, M.; Lee, S. ChemMedChem. 2026, 21(2), e202500810. https://doi.org/10.1002/cmdc.202500810
2025
Development of Probiotic Microencapsulated Limosilactobacillus reuteri Films Using Mucoadhesive Polymers as a Delivery System – Strategies to Improve Bacterial Viability. Eckermann, C.; Klein, C. J.; Lasch, C.; Lee, S.; Luzhetskyy, A.; Schneider, M. Next Research. 2025, 2(3), 100643. https://doi.org/10.1016/j.nexres.2025.100643
Direct Monitoring of Intracellular Polymer Degradation via BODIPY Dynamic Dequenching. Bassil, J.; Kamal, M. A. M.; Gabelmann, A.; Christoulaki, A.; Koch, M.; Hamed, M. M.; Loretz, B.; Gallei, M.; Buhler, E.; Lehr, C.-M.; Hirsch, A. K. H.; Lee, S. Materials & Design. 2025, 256, 114240. https://doi.org/10.1016/j.matdes.2025.114240
Tobramycin Crosslinking Improves the Colloidal Stability of Arginine Chitosan Biodynamers for Safe and Efficient siRNA Delivery. Liu, Y.; Biesel, A.; Kamal, M. A. M.; Latta, L.; Loretz, B.; Hirsch, A. K. H.; Lee, S.; Lehr, C.-M. International Journal of Biological Macromolecules. 2025, 311, 143420. https://doi.org/10.1016/j.ijbiomac.2025.143420
Protometabolically Generated NADH Mediates Material Properties of Aqueous Dispersions to Coacervate Microdroplets. Bose, R.; Tomar, A.; Rossetto, D.; Mansy, S. S.; Tang, T.-Y. D. Synthetic Biology. 2025. https://doi.org/10.1101/2025.03.13.642830

 

2024
Fluorescent Histidine-Derived Biodynamers as Biocompatible and Highly Water-Soluble Copper(II)-Sensors. Zeroug-Metz, L.; Kamal, M. A. M.; Bassil, J.; Elamaldeniya, K.; Ryu, B. H.; Buhler, E.; Lee, S. RSC Applied Polymers. 2024. https://doi.org/10.1039/D4LP00126E
Biodynamers: Applications of Dynamic Covalent Chemistry in Single-Chain Polymer Nanoparticles. Zeroug-Metz, L.; Lee, S. Drug Delivery and Translational Research. 2024. https://doi.org/10.1007/s13346-024-01665-z
Arg-Biodynamers as Antibiotic Potentiators through Interacting with Gram-Negative Outer Membrane Lipopolysaccharides. Kamal, M. A. M.; Bassil, J.; Loretz, B.; Hirsch, A. K. H.; Lee, S.; Lehr, C.-M. European Journal of Pharmaceutics and Biopharmaceutics. 2024, 200, 114336. https://doi.org/10.1016/j.ejpb.2024.114336
Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery. Liu, Y.; Hamm, T.; Eichinger, T.; Kamm, W.; Wieland, H.; Loretz, B.; Hirsch, A.; Lee, S.; Lehr, C.-M. International Journal of Nanomedicine. 2024, 19, 4429–4449. https://doi.org/10.2147/IJN.S448578

 

2023
pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA. Liu, Y.; Ashmawy, S.; Latta, L.; Weiss, A.-V.; Kiefer, A. F.; Nasr, S.; Loretz, B.; Hirsch, A. K. H.; Lee, S.; Lehr, C.-M. Biomacromolecules. 2023, 24(8), 3742–3754. https://doi.org/10.1021/acs.biomac.3c00424
PLGA-Based Nanoparticles for Treatment of Infectious Diseases. Buescher, J.; Novak, A. W.; Khan, S. A.; Weiss, A.-V.; Lee, S.; Schneider, M. In Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery. 2023, pp. 303–333. Elsevier. https://doi.org/10.1016/B978-0-323-91215-0.00014-5
Proteoid Biodynamers for Safe mRNA Transfection via pH-Responsive Nanorods Enabling Endosomal Escape. Lee, S.; Nasr, S.; Rasheed, S.; Liu, Y.; Hartwig, O.; Kaya, C.; Boese, A.; Koch, M.; Herrmann, J.; Müller, R.; Loretz, B.; Buhler, E.; Hirsch, A. K. H.; Lehr, C.-M. Journal of Controlled Release. 2023, 353, 915–929. https://doi.org/10.1016/j.jconrel.2022.12.018

 

2021
Co-Delivery of mRNA and pDNA Using Thermally Stabilized Coacervate-Based Core-Shell Nanosystems. Nasr, S. S.; Lee, S.; Thiyagarajan, D.; Boese, A.; Loretz, B.; Lehr, C.-M. Pharmaceutics. 2021, 13(11), 1924. https://doi.org/10.3390/pharmaceutics13111924

 

vor 2021
pH-Dependent Morphology and Optical Properties of Lysine-Derived Molecular Biodynamers. Lee, S.; Kaya, C.; Jang, H.; Koch, M.; Loretz, B.; Buhler, E.; Lehr, C.-M.; Hirsch, A. K. H. Materials Chemistry Frontiers. 2020, 4(3), 905–909. https://doi.org/10.1039/C9QM00651F
Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases. Christmann, R.; Ho, D.-K.; Wilzopolski, J.; Lee, S.; Koch, M.; Loretz, B.; Vogt, T.; Bäumer, W.; Schaefer, U. F.; Lehr, C.-M. Pharmaceutics. 2020, 12(12), 1131. https://doi.org/10.3390/pharmaceutics12121131
The Chemistry of Boronic Acids in Nanomaterials for Drug Delivery. Stubelius, A.; Lee, S.; Almutairi, A. Accounts of Chemical Research. 2019, 52(11), 3108–3119. https://doi.org/10.1021/acs.accounts.9b00292
Disease-Triggered Drug Release Effectively Prevents Acute Inflammatory Flare-Ups, Achieving Reduced Dosing. Stubelius, A.; Sheng, W.; Lee, S.; Olejniczak, J.; Guma, M.; Almutairi, A. Small. 2018, 14(32), 1800703. https://doi.org/10.1002/smll.201800703
Chemical Amplification Accelerates Reactive Oxygen Species Triggered Polymeric Degradation. Lee, S.; Stubelius, A.; Olejniczak, J.; Jang, H.; Huu, V. A. N.; Almutairi, A. Biomaterials Science. 2018, 6(1), 107–114. https://doi.org/10.1039/C7BM00758B
Inflammation-Responsive Drug-Conjugated Dextran Nanoparticles Enhance Anti-Inflammatory Drug Efficacy. Lee, S.; Stubelius, A.; Hamelmann, N.; Tran, V.; Almutairi, A. ACS Applied Materials & Interfaces. 2018, 10(47), 40378–40387. https://doi.org/10.1021/acsami.8b08254
Delivery of Cargo with a Bioelectronic Trigger. Hemmatian, Z.; Jalilian, E.; Lee, S.; Strakosas, X.; Khademhosseini, A.; Almutairi, A.; Shin, S. R.; Rolandi, M. ACS Applied Materials & Interfaces. 2018, 10(26), 21782–21787. https://doi.org/10.1021/acsami.8b02724
Biorthogonal Click Chemistry on Poly(Lactic-Co-Glycolic Acid)-Polymeric Particles. Olejniczak, J.; Collet, G.; Nguyen Huu, V. A.; Chan, M.; Lee, S.; Almutairi, A. Biomaterials Science. 2017, 5(2), 211–215. https://doi.org/10.1039/C6BM00721J
Bioactive Polymeric Metallosomes Self-Assembled through Block Copolymer–Metal Complexation. Osada, K.; Cabral, H.; Mochida, Y.; Lee, S.; Nagata, K.; Matsuura, T.; Yamamoto, M.; Anraku, Y.; Kishimura, A.; Nishiyama, N.; Kataoka, K. Journal of the American Chemical Society. 2012, 134(32), 13172–13175. https://doi.org/10.1021/ja304615y
Strong Binding Affinity of a Zinc-Porphyrin-Based Receptor for Halides through the Cooperative Effects of Quadruple C–H Hydrogen Bonds and Axial Ligation. Lee, C.-H.; Lee, S.; Yoon, H.; Jang, W.-D. Chemistry – A European Journal. 2011, 17(49), 13898–13903. https://doi.org/10.1002/chem.201101884