ZHMB-Kolloquium - Vortrag von Jun.Prof. Dr. Luis Linares-Otoya

KolloquiumBeyond canonical disulfide-bond formation: the DSP pathway

Disulfide-bonded peptides (DSPs) play essential roles in immunity, metabolism, and chemical defense across living organisms. In bacteria, their biosynthesis was assumed to rely
 on “canonical” protein disulfide-bond formation systems. However, large proportion of bacteria lack these systems, suggesting that they should have evolved alternative mechanisms
 to form disulfide bonds.In this seminar, I will present the discovery of the DSP pathway, which introduces a unprecedent logic for disulfide-bond formation.
 This system is widely distributed across Bacteroidota, a bacterial phylum whose members include prevalent human gut commensals and bacteria from diverse environmental habitats
 where we found evidence of the biological roles of these secreted DSP effectors.This presentation will cover our preliminary findings about this unique bacterial disulfide-bond formation 
system and will highlight our ideas for new avenues for exploring the ecological roles and biotechnological potential of DSPs.