Dr. Simeon Rüdesheim

Field of research

Physiologically based pharmacokinetic (PBPK) modeling

Curriculum vitae

Since 01/2024: Postdoctoral researcher Clinical Pharmacy, Saarland University, Saarbrücken

06/2019 – 01/2024: Doctoral student Clinical Pharmacy, Saarland University, Saarbrücken

06/2019: Licensed as pharmacist

11/2018 – 04/2019: Practical year, Paulus Apotheke, Saarbrücken

05/2018 – 10/2018: Master student Clinical Pharmacy, Saarland University, Saarbrücken

04/2014 – 03/2018: Pharmacy studies Clinical Pharmacy, Saarland University, Saarbrücken

08/2013 – 01/2014: PTA trainee, Rochus Vital Apotheke, Gensingen

08/2011 – 01/2014: Training as a pharmaceutical technical assistant (PTA), PTA-Schule des Internationalen Bundes, Mainz-Hechtsheim

03/2011: Abitur, Bischöflichen Willigis Gymnasium, Mainz

Publications

Manuscripts

Kovar C, Loer HLH, Rüdesheim S, Fuhr LM, Marok FZ, Selzer D, Schwab M, Lehr T. A physiologically-based pharmacokinetic precision dosing approach to manage dasatinib drug-drug interactions. CPT Pharmacometrics Syst Pharmacol. 2024. doi:10.1002/psp4.13146

Loer HLH, Kovar C, Rüdesheim S, Marok FZ, Fuhr LM, Selzer D, Schwab M, Lehr T. Physiologically based pharmacokinetic modeling of imatinib and N-desmethyl imatinib for drug-drug interaction predictions. CPT Pharmacometrics Syst Pharmacol. 2024;00:1-15.

Feick D, Rüdesheim S, Marok FZ, Selzer D, Loer HLH, Teutonico D, Frechen S, van der Lee M, Moes DJAR, Swen JJ, Schwab M, Lehr T. Physiologically-based pharmacokinetic modeling of quinidine to establish a CYP3A4, P-gp, and CYP2D6 drug–drug–gene interaction network. CPT Pharmacometrics Syst Pharmacol 2023;00:1-14

Loer HLH, Feick D, Rüdesheim S, Selzer D, Schwab M, Teutonico D, Frechen S, van der Lee M, Moes DJAR, Swen JJ, Lehr T. Physiologically based pharmacokinetic modeling of tacrolimus for food-drug and CYP3A drug-drug-gene interaction predictions. CPT Pharmacometrics Syst Pharmacol 2023;00:1-15.

Kovar C, Kovar L, Rüdesheim S, Selzer D, Ganchev B, Kröner P, Igel S, Kerb R, Schaeffeler E, Mürdter TE, Schwab M, Lehr T. Prediction of drug–drug–gene interaction scenarios of (E)-clomiphene and its metabolites using physiologically based pharmacokinetic modeling. Pharmaceutics 2022;14(12):2604.

Rüdesheim S, Selzer D, Mürdter T, Igel S, Kerb R, Schwab M, Lehr T. Physiologically based pharmacokinetic modeling to describe the CYP2D6 activity score-dependent metabolism of paroxetine, atomoxetine and risperidone. Pharmaceutics 2022;14(8):1734.

Rüdesheim S, Selzer D, Fuhr U, Schwab M, Lehr T. Physiologically-based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups. CPT Pharmacometrics Syst Pharmacol 2022;11:494-511.

Türk D, Fuhr LM, Marok FZ, Rüdesheim S, Kühn A, Selzer D, Schwab M, Lehr T. Novel models for the prediction of drug-gene interactions. Expert Opin on Drug Metab Toxicol 2021;17(11):1293-1310.

Rüdesheim S, Wojtyniak JG, Selzer D, Hanke N, Mahfoud F, Schwab M, Lehr T. Physiologically based pharmacokinetic modeling of metoprolol enantiomers and α-hydroxymetoprolol to describe CYP2D6 drug-gene interactions. Pharmaceutics 2020;12(12):1200.