PBPK Resources

OSP Software, User Forum, Documentation, News Video Tutorials Selected Saarland University PBPK Publications
  • Physiologically based pharmacokinetic models for prediction of complex CYP2C8 and OATP1B1 (SLCO1B1) drug-drug-gene interactions: a modeling network of gemfibrozilrepaglinidepioglitazone, rifampicin, clarithromycin and itraconazole. 
  • A comprehensive whole-body physiologically based pharmacokinetic model of dabigatran etexilatedabigatran and dabigatran glucuronide in healthy adults and renally impaired patients.
  • Physiologically-based pharmacokinetic models for CYP1A2 drug-drug interaction prediction: a modeling network of fluvoxaminetheophyllinecaffeine, rifampicin, and midazolam.
  • A quantitative systems pharmacology kidney model of diabetes associated renal hyperfiltration and the effects of SGLT inhibitors
  • PBPK models for CYP3A4 and P‐gp DDI prediction: a modeling network of rifampicinitraconazoleclarithromycinmidazolamalfentanil, and digoxin
  • A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model of the histone deacetylase (HDAC) inhibitor vorinostat for pediatric and adult patients and its application for dose specification.