Publications

Linares-Otoya L., Shirkey JD., Chhetri BK., Mira A., Biswas A., Neff SL., Linares-Otoya MV., Chen Y., Campos-Florian JV., Ganoza-Yupanqui ML., Jeffrey PD., Hughson FM., Donia MS.*
Discovery of a widespread chemical signalling pathway in the Bacteroidota. Nature 646, 423–432 (2025). https://doi.org/10.1038/s41586-025-09418-9

Linares-Otoya L.*†, Linares-Otoya V.†, Galliani-Huamanchumo G., Carrion-Zavaleta T., Condor-Goytizolo J., Schäberle TF., Ganoza-Yupanqui ML., Campos-Florian J.*
Carbon-Source Effects on Growth and Secondary Metabolism in the Marine Bacteroidota Tenacibaculum mesophilum and Fulvivirga kasyanovii. Marine Drugs 23, 394 (2025). https://doi.org/10.3390/md23100394

Liu Y.†, Linares-Otoya L.†, Kersten C., Marner M., Mihajlovic S., Abdeldayem MH., Semmler S., Bletz MC., Vences M., Spohn M., Zumkeller CM., Schäberle TF.
A genetically tractable branch of environmental Pedobacter from the phylum Bacteroidota represents a hotspot for natural product discovery. Scientific Reports 15, 20106 (2025). https://doi.org/10.1038/s41598-025-03955-z

Wang L., Linares-Otoya V., Liu Y., Mettal U., Marner M., Armas-Mantilla L., Willbold S., Kurtán T.,Linares-Otoya L., Schäberle TF.*
Discovery and Biosynthesis of Antimicrobial Phenethylamine Alkaloids from the Marine Flavobacterium Tenacibaculum discolor sv11. Journal of Natural Products 85, 1039–1051 (2022). https://doi.org/10.1021/acs.jnatprod.1c01173

Kresna IDM., Wuisan ZG., Pohl JM., Mettal U., Linares Otoya V., Gand M., Marner M., Linares Otoya L., Böhringer N., Vilcinskas A., Schäberle TF.
Genome-Mining-Guided Discovery and Characterization of the PKS-NRPS-Hybrid Polyoxyperuin Produced by a Marine-Derived Streptomycete. Journal of Natural Products 85, 888–898 (2022). https://doi.org/10.1021/acs.jnatprod.1c01018

Kresna IDM., Linares-Otoya L., Milzarek TM., Duell ER., Mir Mohseni M., Mettal U., König GM., Gulder TAM., Schäberle TF.*
In vitro characterization of 3-chloro-4-hydroxybenzoic acid building block formation in ambigol biosynthesis. Organic & Biomolecular Chemistry 19, 2302–2311 (2021). https://doi.org/10.1039/D0OB02372H

Duell ER.†, Milzarek TM.†, El Omari M., Linares-Otoya L., Schäberle TF., König GM., Gulder TAM.*
Identification, cloning, expression and functional interrogation of the biosynthetic pathway of the polychlorinated triphenyls ambigol A–C from Fischerella ambigua 108b. Organic Chemistry Frontiers 7, 3193–3201 (2020). https://doi.org/10.1039/D0QO00707B

Imai Y.†, Meyer KJ.†, Iinishi A., Favre-Godal Q., Green R., Manuse S., Caboni M., Mori M., Niles S., Ghiglieri M., Honrao C., Ma X., Guo JJ., Makriyannis A., Linares-Otoya L., Böhringer N., Wuisan ZG., Kaur H., Wu R., Mateus A., Typas A., Savitski MM., Espinoza JL., O’Rourke A., Nelson KE., Hiller S., Noinaj N., Schäberle TF., D’Onofrio A., Lewis K.*
A new antibiotic selectively kills Gram-negative pathogens. Nature 576, 459–464 (2019). https://doi.org/10.1038/s41586-019-1791-1

Linares-Otoya L., Liu Y., Linares-Otoya V., Armas-Mantilla L., Crüsemann M., Ganoza-Yupanqui ML., Campos-Florian J., König GM., Schäberle TF.*
Biosynthetic Basis for Structural Diversity of Aminophenylpyrrole-Derived Alkaloids. ACS Chemical Biology 14, 176–181 (2019). https://doi.org/10.1021/acschembio.8b00993

Nasfi Z., Busch H., Kehraus S., Linares-Otoya L., König GM., Schäberle TF.*, Bachoual R.
Soil Bacteria Isolated From Tunisian Arid Areas Show Promising Antimicrobial Activities Against Gram-Negatives. Frontiers in Microbiology 9, 2742 (2018). https://doi.org/10.3389/fmicb.2018.02742

Sohel MMH., Amin A., Prastowo S., Linares-Otoya L., Hoelker M., Schellander K., Tesfaye D.*
Sulforaphane protects granulosa cells against oxidative stress via activation of NRF2-ARE pathway. Cell and Tissue Research 374, 629–641 (2018). https://doi.org/10.1007/s00441-018-2877-z

Linares-Otoya L., Linares-Otoya V., Armas-Mantilla L., Blanco-Olano C., Crüsemann M., Ganoza-Yupanqui ML., Campos-Florian J., König GM., Schäberle TF.*
Diversity and Antimicrobial Potential of Predatory Bacteria from the Peruvian Coastline. Marine Drugs 15, 308 (2017). https://doi.org/10.3390/md15100308

Linares-Otoya L., Linares-Otoya V., Armas-Mantilla L., Blanco-Olano C., Crüsemann M., Ganoza-Yupanqui ML., Campos-Florian J., König GM., Schäberle TF.*
Identification and heterologous expression of the kocurin biosynthetic gene cluster. Microbiology 163, 1409–1414 (2017). https://doi.org/10.1099/mic.0.000538

† Equal contribution
* Corresponding author