V. Hintze, M. Schnabelrauch, S. Rother. Chemical Modification of Hyaluronan and Their Biomedical Applications. Frontiers in Chemistry 2022; 10.  

D. Scharnweber, L. Hübner, S. Rother, U. Hempel, U. Anderegg, S. A. Samsonov, M. T. Pisabarro, L. Hofbauer, M. Schnabelrauch, S. Franz, J. Simon, V. Hintze. Glycosaminoglycan derivatives: promising candidates for the design of functional biomaterials. J Mater Sci Mater Med. 2015; 26(9):232.


Original papers


G. Ruiz-Gómez, J. Salbach-Hirsch, J.N. Dürig, L. Köhler, K. Balamurugan, S. Rother, S.L. Heidig, S. Moeller, M. Schnabelrauch, G. Furesi, S. Pählig, P.M. Guillem-Gloria, C. Hofbauer, V. Hintze, M.T. Pisabarro, J. Rademann, L.C. Hofbauer. Rational engineering of glycosaminoglycan-based Dickkopf-1 scavengers to improve bone regeneration. Biomaterials. 2023 Jun;297:122105.

D. Kilian, A. Poddar, V. Desrochers, C. Heinemann, N. Halfter, S. Liu, S. Rother, M. Gelinsky, V. Hintze, A. Lode. Cellular adhesion and chondrogenic differentiation inside an alginate-based bioink in response to tailorable artificial matrices and tannic acid treatment. Biomater Adv. 2023 Apr;147:213319.



A.K. Bains, L. Behrens Wu, J. Rivière, S. Rother, V. Magno, J. Friedrichs, C. Werner, M. Bornhauser, K. Götze, M. Cross, U. Platzbecker, M. Wobus. Bone marrow mesenchymal stromal cell-derived extracellular matrix displays altered glycosaminoglycan structure and impaired functionality in Myelodysplastic Syndromes. Front Oncol. 2022 Sep 8;12:961473.



R.J. Weiss, P.N. Spahn, A.W.T. Chiang, Q. Liu, J. Li, K.M. Hamill, S. Rother, T.M. Clausen, M.A. Hoeksema, B.M. Timm, K. Godula, C.K. Glass, Y. Tor, P.L.S.M. Gordts, N.E. Lewis, J.D. Esko. Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate. Nat Chem Biol. 2021;17(6):684-692.

S. Al-Maawi*, S. Rother*, N. Halfter, K.M. Fiebig, J. Moritz, S. Moeller, M. Schnabelrauch, C.J. Kirkpatrick, R. Sader, H.P. Wiesmann, D. Scharnweber, V. Hintze, S. Ghanaati. Covalent linkage of sulfated hyaluronan to the collagen scaffold Mucograft® enhances scaffold stability and reduces proinflammatory macrophage activation in vivo. Bioact Mater. 2021;8:420-434. *contributed equally

S. Hauck, P. Zager, N. Halfter, E. Wandel, M. Torregrossa, A. Kakpenova, S. Rother, M. Ordieres, S. Räthel, A. Berg, S. Möller, M. Schnabelrauch, J.C. Simon, V. Hintze, S. Franz. Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity. Bioact Mater. 2021;6(12):4342-4359.

S. Rother, G. Ruiz-Gómez, K. Balamurugan, L. Koehler, K.M. Fiebig, V.D. Galiazzo, U. Hempel, S. Moeller, M. Schnabelrauch, J. Waltenberger, M.T. Pisabarro, D. Scharnweber, V. Hintze. Hyaluronan/Collagen Hydrogels with Sulfated Glycosaminoglycans Maintain VEGF165 Activity and Fine-Tune Endothelial Cell Response. ACS Applied Bio Materials 2021;4(1):494-506.

L.M. Kroschwald, F. Allerdt, A. Bernhardt, S. Rother, K. Zheng, I. Maqsood, N. Halfter, C. Heinemann, S. Möller, M. Schnabelrauch, M.C. Hacker, S. Rammelt, A.R. Boccaccini, V. Hintze. Artificial Extracellular Matrices Containing Bioactive Glass Nanoparticles Promote Osteogenic Differentiation in Human Mesenchymal Stem Cells. Int J Mol Sci. 2021;22(23):12819.



M. Gronbach, F. Mitrach, S. Möller, S. Rother, S. Friebe, S.G. Mayr, M. Schnabelrauch, V. Hintze, M.C. Hacker, M. Schulz-Siegmund. A Versatile Macromer-Based Glycosaminoglycan (sHA3) Decorated Biomaterial for Pro-Osteogenic Scavenging of Wnt Antagonists. Pharmaceutics. 2020 Oct 29;12(11):1037.



J. Krieghoff, A. K. Picke, J. Salbach-Hirsch, S. Rother, C. Heinemann, R. Bernhardt, C. Kascholke, S. Möller, M. Rauner, M. Schnabelrauch, V. Hintze, D. Scharnweber, M. Schulz-Siegmund, M. C. Hacker, L. C. Hofbauer, C. Hofbauer. Increased pore size of scaffolds improves coating efficiency with sulfated hyaluronan and mineralization capacity of osteoblasts. Biomater Res. 2019, 23:26.

L. Koehler, G. Ruiz-Gómez, K. Balamurugan, S. Rother, J. Freyse, S. Möller, M. Schnabelrauch, S. Köhling, S. Djordjevic, D. Scharnweber, J. Rademann, M. T. Pisabarro, V. Hintze. Dual action of sulfated hyaluronan on angiogenic processes in relation to vascular endothelial growth factor-A. Sci Rep. 2019, 9(1):18143.

S. Rother, V. Krönert, N. Hauck, A. Berg, S. Moeller, M. Schnabelrauch, J. Thiele, D. Scharnweber, V. Hintze. Hyaluronan/collagen hydrogel matrices containing high-sulfated hyaluronan microgels for regulating transforming growth factor-β1. J Mater Sci Mater Med. 2019, 30(6):65.

M. Schneider, S. Rother, S. Möller, M. Schnabelrauch, D. Scharnweber, J. C. Simon, V. Hintze, V. Savkovic. Sulfated hyaluronan-containing artificial extracellular matrices promote proliferation of keratinocytes and melanotic phenotype of melanocytes from the outer root sheath of hair follicles. J Biomed Mater Res A. 2019, 107(8):1640-1653.

S. Thönes*, S. Rother*, T. Wippold*, J. Blaszkiewicz, K. Balamurugan, S. Moeller, G. Ruiz-Gómez, M. Schnabelrauch, D. Scharnweber, J. Rademann, A. Saalbach, M. T. Pisabarro, Vera Hintze, Ulf Anderegg. Hyaluronan/collagen hydrogels containing sulfated hyaluronan improve wound healing by sustained release of heparin-binding EGF-like growth factor. Acta Biomater. 2019, 86:135-147. *contributed equally

M. Rauner, U. Baschant, A. Roetto, R. M. Pellegrino, S. Rother, J. Salbach-Hirsch, H. Weidner, V. Hintze, G. Campbell, A. Petzold, R. Lemaitre, I. Henry, T. Bellido, I. Theurl, S. Altamura, S. Colucci, M. U. Muckenthaler, G. Schett, D. K. Ebri, J. H. D. Bassett, G. R. Williams, U. Platzbecker, Lorenz C. Hofbauer. Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling. Nature Metabolism. 2019; 1:111-124.

I. Kratochvil, T. Hofmann, S. Rother, R. Schlichting, R. Moretti, D. Scharnweber, V. Hintze, B. I. Escher, J. Meiler, S. Kalkhof, M. von Bergen. MEHP and MEOHP but not DEHP bind productively to the peroxisome proliferator-activated receptor γ. Rapid Commun. Mass Spectrom, 2019; 33 Suppl 1:75-85.



S. Thiele, A. Zimmer, A. Göbel, T. Rachner, S. Rother, S. Füssel, M. Froehner, M. Wirth, M. Muders, G. Baretton, F. Jakob, M. Rauner, L. Hofbauer. Role of WNT5A receptors FZD5 and RYK in prostate cancer cells. Oncotarget. 2018; 9:27293-27304.

S. Bhowmick, A. V. Thanusha, A. Kumar, D. Scharnweber, S. Rother, V. Koul: Nanofibrous artificial skin substitute composed of mPEG-PCL grafted gelatin/hyaluronan/chondroitin sulfate/sericin for 2nd degree burn care: in vitro and in vivo study. RSC Adv. 2018; 8: 16420.

L. Corsuto*, S. Rother*, L. Koehler, E. Bedini, S. Moeller, M. Schnabelrauch, V. Hintze, C. Schiraldi, D. Scharnweber. Sulfation degree not origin of chondroitin sulfate derivatives modulates keratinocyte response. Carbohydrate Polymers. 2018; 191:53-64. *contributed equally



S. Bhowmick, S. Rother, H. Zimmermann, P. S. Lee, S. Moeller, M. Schnabelrauch, V. Koul, R. Jordan, V. Hintze, D. Scharnweber. Reciprocal influence of hMSCs / HaCaT cultivated on electrospun scaffolds. J Mater Sci Mater Med. 2017; 28(8):128.

S. Rother, V. D. Galiazzo, D. Kilian, K. M. Fiebig, J. Becher, S. Möller, U. Hempel, M. Schnabelrauch, J. Waltenberger, D. Scharnweber, V. Hintze. Hyaluronan/collagen hydrogels with sulfated hyaluronan for improved repair of vascularized tissue tune the binding of proteins and promote endothelial cell growth. Macromol Biosci. 2017;17(11).

S. Bhowmick, S. Rother, H. Zimmermann, P. S. Lee, S. Moeller, M. Schnabelrauch, V. Koul, R. Jordan, V. Hintze, D. Scharnweber. Biomimetic electrospun scaffolds from main extracellular matrix components for skin tissue engineering application – The role of chondroitin sulfate and sulfated hyaluronan. Mater Sci Eng C Mater Biol Appl. 2017; 79:15-22.

L. Koehler, S. A. Samsonov, S. Rother, S. Vogel, S. Köhling, S. Moeller, M. Schnabelrauch, J. Rademann, U. Hempel, M. T. Pisabarro, D. Scharnweber, V. Hintze. Sulfated hyaluronan derivatives modulate TGF-β1:receptor complex formation: possible consequences for TGF-β1 signaling. Sci Rep. 2017; 7(1):1210.

S. Rother, S. A. Samsonov, S. Moeller, M. Schnabelrauch, J. Rademann, J. Blaszkiewicz, S. Köhling, J. Waltenberger, M. T. Pisabarro, D. Scharnweber, V. Hintze. Sulfate hyaluronan alters endothelial cell activation in vitro by controlling the biological activity of the angiogenic factors vascular endothelial growth factor-A and tissue inhibitor of metalloproteinase-3. ACS Appl Mater Interfaces. 2017; 9(11):9539-9550.

W. Metzger, S. Rother, T. Pohlemann, S. Möller, M. Schnabelrauch, V. Hintze, D. Scharnweber. Evaluation of cell-surface interaction using a 3D spheroid cell culture model on artificial extracellular matrices. Mater Sci Eng C Mater Biol Appl. 2017; 73:310-318.



S. Rother, S. A. Samsonov, U. Hempel, S. Vogel, S. Moeller, J. Blaszkiewicz, S. Köhling, M. Schnabelrauch, J. Rademann, M. T. Pisabarro, V. Hintze, D. Scharnweber. Sulfated hyaluronan alters the interaction profile of TIMP-3 with the endocytic receptor LRP-1 cluster II and IV and increases the extracellular TIMP-3 level of human bone marrow stromal cells. Biomacromolecules. 2016; 17(10):3252-3261.

S. Rother, S. A. Samsonov, T. Hofmann, J. Blaszkiewicz, S. Köhling, S. Moeller, M. Schnabelrauch, J. Rademann, S. Kalkhof, M. von Bergen, M. T. Pisabarro, D. Scharnweber, V. Hintze. Structural and functional insights into the interaction of sulfated glycosaminoglycans with tissue inhibitor of metalloproteinase-3 – a possible regulatory role on extracellular matrix homeostasis. Acta Biomater. 2016; 45:143-154.

A. K. Picke, J. Salbach-Hirsch, V. Hintze, S. Rother, M. Rauner, C. Kascholke, S. Möller, R. Bernhardt, S. Rammelt, M. Schnabelrauch, M. Schulz-Siegmund, M. C. Hacker, D. Scharnweber, C. Hofbauer, L. C. Hofbauer. Sulfated hyaluronan improves bone regeneration of diabetic rats by scavenging sclerostin and enhancing osteoblast function. Biomaterials. 2016; 96:11-23.

M. Hellwig, M. Kiessling, S. Rother, T. Henle. Quantification of the glycation compound 6-(3-hydroxy-4-oxo-2-methyl-4(1H)-pyridin-1-yl)-l-norleucine (maltosine) in model systems and food samples. Eur Food Res Technol. 2016; 242(4):547-557.



S. Rother, J. Salbach-Hirsch, S. Möller, T. Seemann, M. Schnabelrauch, L. Hofbauer, V. Hintze, D. Scharnweber. Bioinspired collagen/glycosaminoglycan-based cellular microenvironments for tuning osteoclastogenesis. ACS Appl Mater Interfaces. 2015; 7(42):23787-97.  



A. Miron, S. Rother, L. Huebner, U. Hempel, I. Käppler, S. Moeller, M. Schnabelrauch, D. Scharnweber, V. Hintze: Sulfated hyaluronan influences the formation of artificial extracellular matrices and the adhesion of osteogenic cells. Macromol Biosci. 2014; 14(12):1783-94.