Helena Loer

Field of research

Physiologically based pharmacokinetic (PBPK) modeling

Curriculum vitae

Since 12/2021: Doctoral student Clinical Pharmacy, Saarland University, Saarbrücken and external doctoral student in the Graduate Research Training Program „PharMetrX - Pharmacometrics & Computational Disease Modelling“

04/2021 – 11/2021: Master student Clinical Pharmacy, Saarland University, Saarbrücken

01/2021: Licensed as pharmacist

05/2020 – 10/2020: Practical year, Schloss Apotheke, Bergisch Gladbach

11/2019 – 04/2020: Practical year, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß

10/2015 – 09/2019: Pharmacy studies, Rheinische Friedrich-Wilhelms-Universität, Bonn

07/2014 – 07/2015: Voluntary social year, Tansania

06/2014: Abitur, Friedrich-Wilhelm-Gymnasium, Köln

Publications

Manuscripts

Kovar C, Loer HLH, Rüdesheim S, Fuhr LM, Marok FZ, Selzer D, Schwab M, Lehr T. A physiologically-based pharmacokinetic precision dosing approach to manage dasatinib drug-drug interactions. CPT Pharmacometrics Syst Pharmacol. 2024. doi:10.1002/psp4.13146

Loer HLH, Kovar C, Rüdesheim S, Marok FZ, Fuhr LM, Selzer D, Schwab M, Lehr T. Physiologically based pharmacokinetic modeling of imatinib and N-desmethyl imatinib for drug-drug interaction predictions. CPT Pharmacometrics Syst Pharmacol. 2024;00:1-15.

Feick D, Rüdesheim S, Marok FZ, Selzer D, Loer HLH, Teutonico D, Frechen S, van der Lee M, Moes DJAR, Swen JJ, Schwab M, Lehr T. Physiologically-based pharmacokinetic modeling of quinidine to establish a CYP3A4, P-gp, and CYP2D6 drug–drug–gene interaction network. CPT Pharmacometrics Syst Pharmacol 2023;00:1-14.

Loer HLH, Feick D, Rüdesheim S, Selzer D, Schwab M, Teutonico D, Frechen S, van der Lee M, Moes DJAR, Swen JJ, Lehr T. Physiologically based pharmacokinetic modeling of tacrolimus for food-drug and CYP3A drug-drug-gene interaction predictions. CPT Pharmacometrics Syst Pharmacol 2023;00:1-15.

Loer HLH, Türk D, Gómez-Mantilla JD, Selzer D, Lehr T. Physiologically based pharmakokinetic (PBPK) modeling of clopidogrel and its four relevant metabolites for CYP2B6, CYP2C8, CYP2C19 and CYP3A4 drug-drug-gene interaction predictions. Pharmaceutics 2022;14(5):915.

Posters

Loer HLH, Kovar C, Schwab M, Lehr T. Physiologically based pharmacokinetic modeling of imatinib and its main metabolite for drug-drug interaction predictions. 31st Population Approach Group Europe (PAGE) meeting, 2023, A Coruña, Spain.

Loer HLH, Feick D, Lehr T. Physiologically based pharmacokinetic (PBPK) modeling of tacrolimus for CYP3A drug-drug-gene interaction predictions. Annual Meeting of the German Pharmaceutical Society (DPhG), 2022, Marburg, Germany.

Loer HLH, Türk D, Selzer D, Lehr T. Dose adaptations for drug-gene and drug-drug interactions involving clopidogrel – A physiologically based pharmacokinetic (PBPK) modeling approach. 30th Population Approach Group Europe (PAGE) meeting, 2022, Ljubljana, Slovenia.