About the Project

The UdS-HIPS-TANDEM initiative aims to characterize, modulate and model specific microbiota from patient cohorts with regard to their relevance for infection processes.  The long-term goal is to lay the foundation for an early and rapid diagnosis of infection processes and their therapeutic influence and to evaluate them in various preclinical models. This will be based on a fundamental microbiological and cell biological understanding of the pro and eukaryotic single cells and cell populations involved, as well as their cellular signals and molecular interactions.

 

Within the framework of this strategic research alliance between the Saarland University (UdS) and the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), joint research projects in the field of therapeutic modelling and modulation of cellular signals in infections, are facilitated in order to provide targeted support for interdisciplinary cooperation between the top research areas of the university's NanoBioMed and the non-university partner HIPS. To this end, scientists from HIPS and the faculties NT and MI at the Saarbrücken site in particular will be brought together with scientists from clinical medicine and basic medicine at the faculty M in Homburg.

 

Projects, Principal Investigators, and Students

1. ADAM-basierte Therapiemöglichkeiten bei infektiösen Lungenerkrankungen
2. Charakterisierung und Validierung von Immunzell-Wirkstoffen aus Myxobakterien im Ganztiermodell
3. Einfluss des Lektins EclA auf die Virulenz von Enterobacter cloacae
4. Therapeutische Modellierung und Modulation zellulärer Signale bei Infektions­ getriggerter Autoinflammation und Autoimmunität in der Haut: Charakterisier­ung, Modellierung und Modulation der Mikrobiotika bei destruierenden Erkrankungen der Haarfollikel
5. Extracellular vesicles in infectious diseases: (patho)physiological mediators and drug vehicles
6. Charakterisierung von zellulären Veränderungen in Zebrafischembryo-Infektionsmodellen mittels Metabolomics, Proteomics und bildgebender Massen­ spektrometrie
7. / 8. Identification of microbial antibiotics to protect the physiologic microbiota at body surfaces (IMAGINE) 9. Bacterial infections targeting synaptic adhesion molecules: effects of bacterial adhesin binding to adhesive components of photoreceptor/retina synapses
Identifizierung und Charakterisierung natürlicher Produkte aus Myxobakterien und Aktinomyceten, welche die Zytotoxizität humaner Immunzellen beeinflussen
10. Pharmakologische Modulation der Aktivität Bakterien schmeckender chemosensorischer Epithelzellen zur Steigerung der angeborenen Immunabwehr der Lunge
11. Struktur-Aktivitäts-Beziehungen für die Entwicklung von Nucleosid-Antibiotika zu präklinischen Wirkstoff-Kandidaten
12. Bio-engineering mucosal in vitro-tissues for dissecting transkingdom micro- biota-host crosstalk in infection-associated carcinogenesis and identification of novel therapeutic approaches
13. Impact of natural and synthetic antibiotics on innate and adaptive immunity throughout life
14. Therapeutic approach to improve migration of Cytotoxic T lymphocytes in 3D
15. In vitro and in vivo evaluation of novel inhibitors targeting Pseudomonas aeru­ginosa LasB
16. Pharmaceutical manipulation of ciliary GPCRs
17. Einfluss antibiobiotisch wirksamer Naturstoffe auf die Ca2+-Homöostase der Zelle
18. Modulation zellulärer Infektionssignale durch bakterielle Signalpeptide

Members of the Organisation Team

Prof. Dr. Claus-Michael Lehr

Head of the department “Drug Delivery” at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)

Coordinator for the campus Saarbrücken

 

 

 

Dr. Brigitta Loretz

Senior scientist at the department “Drug Delivery” at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)

Assisting coordinator for the campus Saarbrücken

 

Sarah Müller

Multilingual secretary at the department “Drug Delivery” at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)

Secretary at the campus Saarbrücken

E-Mail: tandem-sb(at)uni-saarland.de

 

Prof. Dr. Markus R. Meyer

Head of the department "Experimental and Clinical Toxicology" at the Saarland University

Coordinator for the campus Homburg

 

Sascha K. Manier

Research assistant at the department "Experimental and Clinical Toxicology" at the Saarland University

Assisting Coordinator for the campus Homburg

E-Mail: tandem-hom(at)uni-saarland.de