Ullrich, Angelika

Dr. Angelika Ullrich

Gebäude C4 2, Büro 3.05/Labor 3.09
Tel.: +49 681 302-64835/-64181
Fax: +49 681 302-64834



Synthese peptidischer Naturstoffe


21   T. F. Primke, R. Ingelfinger, M. A. F. Elewa, I. Macinkovic, A. Weigert, M. P. Fabritius, C. A. Reichel, A. Ullrich, U. Kazmaier, L. D. Burgers, R. Fürst, " The Microtubule-Targeting Agent Pretubulysin Impairs the Inflammatory Response in Endothelial Cells by a JNK-Dependent Deregulation of the Histone Acetyltransferase Brd4", Cells 2023, 12, 2112. https://doi.org/10.3390/cells12162112

20   A. Ullrich, U. Kazmaier, "A Half-Century of the Ugi Reaction: Modified Variants", in Organic Reactions (Hrsg.: P. A. Evans), Wiley, 2023, Vol. 112, Part B. https://doi.org/10.1002/0471264180.or112.02

19   A. Ullrich, U. Kazmaier, "A Half-Century of the Ugi Reaction: Classic Variant", in Organic Reactions (Hrsg.: P. A. Evans), Wiley, 2023, Vol. 112, Part A. https://doi.org/10.1002/0471264180.or112.01

18   L. Junk, A. Ullrich, U. Kazmaier, "Synthesis of Modified Tryptophan Derivatives" in Targets in Heterocyclic Systems - Chemistry and Properties (Hrsg.: O. A. Attanasi, B. Gabriele, P. Merino, D. Spinelli), Italian Chemical Society, 202225, 342-364.

17   A. Ullrich, L. Junk, U. Kazmaier, "Three Methods for the Solution Phase Synthesis of Cyclic Peptides" in Methods in Molecular Biology - Peptide Macrocycles (Hrsg.: M. B. Coppock , A. J. Winton), Humana, New York, NY, 2022, 2371, 43-61. https://doi.org/10.1007/978-1-0716-1689-5_4.

16   R. Schwenk, T. Stehning, I. Bischoff, A. Ullrich, U. Kazmaier, R. Fürst, "The anti-metastatic action of the microtubule-targeting agent pretubulysin is associated with the trapping of tumor cells to the endothelium", Oncotarget 2017, 77622-77633.

15   U. Kazmaier, T. Doroshenko, K. Bauer, I. Filbrich, A. Grueter, G. Jung, A. Ullrich, "Coumaryl triflates, versatile building blocks for the modification of coumarins and for fluorescence labelling", Synthesis 2017, 49, 2743–2748.

14   M. A. Rather, D. P. Pandey, R. P. Singh, Y. Singh, A. Ullrich, "Phytochemical analysis and antimicrobial activity of Pleurospermum brunonis", World J. Pharm. Res. 2016, 5, 1320-1331.

13   R. Kubisch, M. von Gamm, S. Braig, A. Ullrich, J. L Burkhart, L. Colling, J. Hermann, O. Scherer, R. Müller, O. Werz, U. Kazmaier, A. M. Vollmar, "Simplified pretubulysin-derivatives and their biological effects on cancer cells", J. Nat. Prod. 2014, 77, 536–542.

12   V. K. Kretzschmann, D. Gellrich, A. Ullrich, S. Zahler, A. M. Vollmar, U. Kazmaier, R. Fürst, "The novel tubulin antagonist pretubulysin exhibits profound tumor vessel disrupting properties in vitro and in vivo", Arterioscl. Thromb. Vasc. Biol. 2014, 34, 294–303.

11   J. Gorges, A. Ullrich, U. Kazmaier, "A Straightforward Approach towards Ferrocenyl Amino Acids and Peptides via Allylic Alkylation", Eur. J. Org. Chem. 2013, 4372–4378.

10   U. Kazmaier, A. Ullrich, J. Hoffmann, "Synthetic Approaches towards Tubulysins and their Derivatives", Open Nat. Prod. J. 2013, 6, 12−30.

9   S. Ackermann, H.-G. Lerchen, D. Häbich, A. Ullrich, U. Kazmaier, "Synthetic studies towards Bottromycin", Beilstein J. Org. Chem. 2012, 8, 1652–1656.

8   S. Rath, J. Liebl, R. Fürst, A. Ullrich, J. L. Burkhart, U. Kazmaier, J. Herrmann, R. Müller, M. Günther, L. Schreiner, E. Wagner, A. M. Vollmar, S. Zahler, "Anti-angiogenic effects of the tubulysin precursor pretubulysin and of simplified pretubulysin derivatives", Brit. J. Pharmacol. 2012, 167, 1048–1061.

7   F. Maurer, V. Huch, A. Ullrich, U. Kazmaier, "Development of catalysts for the stereoselective hydrogenation of α,β-unsaturated ketones", J. Org. Chem. 2012, 77, 5139−5143. 

6   J. Eirich, J. L. Burkhart, A. Ullrich, A. Vollmar, S. Zahler, U. Kazmaier, S. A. Sieber, "Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy", Mol. BioSyst. 2012, 8, 2067–2075.

5   J. Herrmann, R. M. Wiedmann, Y. A. Elnakady, A. Ullrich, M. Rohde, U. Kazmaier, A. M. Vollmar, R. Müller, "Pretubulysins: from a hypothetical biosynthetic intermediate to potential lead in tumor therapie", PLoS One 2012, 7, e37416, 1–12. 

4   D. Pistorius, A. Ullrich, S. Lucas, R. W. Hartmann, U. Kazmaier, R. Müller, "Biosynthesis of 2-alkyl-4(1H)-quinolones in Pseudomonas auruginosa: Potential for interference with pathogenicity", ChemBioChem 2011, 850–853.

3   Y. Chai, D. Pistorius, A. Ullrich, K. J. Weissman, U. Kazmaier, R. Müller, "Discovery of 23 Novel Natural Tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004", Chem. Biol. 2010, 17, 296–309.

2   A. Ullrich, J. Herrmann, R. Müller, U. Kazmaier, "Synthesis and biological evaluation of pretubulysin and derivatives", Eur. J. Org. Chem. 2009, 6367–6378.

1   A. Ullrich, Y. Chai, D. Pistorius, Y. A. Elnakady, J. E. Herrmann, K. J. Weissman, U. Kazmaier, and R. Müller, "Pretubulysin, a potent and chemically-accessible tubulysin precursor from Angiococcus disciformis", Angew. Chem. 2009, 121, 4486–4489; Angew. Chem. Int. Ed. 2009, 47, 4422–4425.