Bottromycins were isolated from the fermentation broth of Streptomyces bottropensis and Streptomyces No. 3668-L2. This antibiotic inhibits the growth of a wide range of microorganisms by interfering with their protein biosynthesis. The unusual structure was determined correctly very recently.
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Thio-Ugi reactions were found to be an excellent synthetic tool for the synthesis of sterically highly hindered endothiopeptides. S-Methylation and subsequent amidine formation can be carried out in an inter- as well as in an intramolecular fashion. The intramolecular approach allows the synthesis of the bottromycin ring system in a straightforward manner.
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