From soil samples of japanese halophilic myxobacterium of the species Paraliomyxa miuraensis SMH-27-4 miuraenamides were isolated, cyclodepsipeptides closely related to the jasplakinolides and chondramides. The miuraenamides show antimicrobial activity and inhibit NADH-oxidase. First studies also indicate, that the miuraena­mides also stabilize the actin filaments.

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The miuraenamides can easily be obtained by the flexible concept of peptide modification. A combination of aldol reaction/oxidation/methylation on a glycine subunit allows the incorporation of the unusual α,β-unsaturated dehydro amino acid in one of the last steps of the synthesis.

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