Publikationen / Originalartikel

2019

Kessler SM, Hoppstädter J, Hosseini K, Laggai S, Haybaeck J, Kiemer AK. 2019. Lack of Kupffer cell depletion in diethylnitrosamine-induced hepatic inflammation. J Hepatol JHEPAT7170

 

Hoppstädter J, Diesel B, Hachenthal N, Minet M, Leidinger P, Backes C, Grässer F, Meese E, Brucoli S, Riccardi C, Huwer H, Kiemer AK. 2019. Amplified host defense by Toll-like receptor-mediated downregulation of the glucocorticoid-induced leucine zipper (GILZ) in macrophages. Front Immunol 9:3111

 

Kessler SM, Hosseini K, Hussein UK, Kim KM, List M, Schultheiss CS, Schulz MH, Laggai S, Jang KY, Kiemer AK. 2019. Hepatocellular carcinoma and nuclear paraspeckles: induction in chemoresistance and prediction for poor survival. Cell Physiol Biochem, in press

 

Golob-Schwarzl N, Bettermann K, Mehta AK, Kessler SM, Unterluggauer J, Krassnig S, Kojima K, Chen X, Hoshida Y, Bardeesy NM, Müller H, Svendova V, Schimek MG, Diwoky C, Lipfert A, Mahajan V, Stumptner C, Thüringer A, Fröhlich LF, Stojakovic T, Nilsson KPR, Kolbe T, Rülicke T, Magin TM, Strnad P, Kiemer AK, Moriggl R, Haybaeck J. 2019. High keratin 8/18 ratio predicts aggressive hepatocellular cancer phenotype. Translat Oncol 12:256-268

2018

Levada K, Guldiken N, Vella G, James LP, Haybaeck J, Kessler SM, Kiemer AK, Ott T, Trautwein C, Strnad P. 2018. Hsp72 overexpression protects from liver injury via attenuation of hepatocellular death, oxidative stress and JNK-signaling. J Hepatol 68:966-1005

 

Tran HV, Kiemer AK, Helms V. 2018. Copy number alterations in tumor genomes deleting antineoplastic drug targets partially compensated by complementary amplifications. Cancer Genom Proteom 15:365-378

 

Dehghani Amirabad A, Ramasamy P, Wierz M, Nordström K, Kessler SM, Schulz MH, Simon M. 2018. Transgenic expression of the RNA binding protein IMP2 stabilizes miRNA targets in murine microsteatosis. BBA - Mol Basis Dis 1896:3099-3108

 

Sen-Utsukarci B, Zapp J, Kiemer AK, Mericli AH. 2018. A reinvestigation of norditerpenoid alkaloids from the roots of Delphinium formosum. Chem Natl Compd 54:405-406

2017

Schultheiss CS, Laggei S, Czepukojc B, Hussein UK, List M, Barghash A, Tierling S, Hosseini K, Golob-Schwarzl N, Pokorny J, Hachenthal N, Schulz M, Helms V, Walter J, Zimmer V, Lammert F, Bohle RM, Dandolo L, Haybaeck J, Kiemer AK, Kessler SM. 2017. The long non-conding RNA H19 suppresses carcinogenesis and chemoresistance in hepatocellular carcinoma. Cell Stress 1:37-57

 

Kessler SM, Lederer E, Laggai S, Golob-Schwarzl N, Hosseini K, Petzold J, Schweiger C, Reihs R, Keil M, Hoffmann J, Christian Mayr, Kiesslich T, Pilcher M, Kim KS, Rhee H, Park YN, Lax S, Obrist P, Kiemer AK, Haybaeck J. 2017. IMP2/IGF2BP2 expression, but not IMP1 and IMP3, predicts poor outcome in patients and high tumor growth rate in xenograft models of gallbladder cancer. Oncotarget 8:89736-89745

 

Seif M, Hoppstädter J, Breinig F, Kiemer AK. 2017. Yeast-mediated mRNA delivery polarizes immuno-suppressive macrophages towards an immuno-stimulatory phenotype. Eur J Pharm Biopharm 117:1-13

 

Dembek A, Laggai S, Kessler SM, Czepukojc B, Simon Y, Kiemer AK, Hoppstädter J. 2017. Hepatic interleukin-6 production is maintained during endotoxin tolerance and facilitates lipid accumulation.  Immunobiology 222:786-796

 

Philippi F, Rauber D, Zapp J, Hempelmann R. 2017. Transport properties and ionicity of phosphonium ionic liquids. Phys Chem Chem Phys 19:23015-23023

 

Neunzig J, Milhim M, Schiffer L, Zapp J, Sanchez-Guijo A, Hartmann MF, Wudy SA, Bernhardt R. 2017. The steroid metabolite 16(ß)-OH-androstenedione generated by CYP21A2 serves as a substrate for CYP19A1. Steroid Biochem Mol Biol 167:182-191

 

Abdulmughni A, Jozwik IK, Putkaradze N, Brill E, Zapp J, Thunnissen, Andy-Mark WH, Hannemann F, Bernhardt R. 2017. Characterization of cytochrome P450 CYP109E1 from Bacillus megaterium as a novel vitamin D3 hydroxylase. Biotechnol 243:38-47

 

Putkaradze N, Kiss FM, Schmitz D, Zapp J, Hutter MC, Bernhardt R. 2017. Biotransformation of prednisone and dexamethasone by cytochrome P450 based systems - Identification of new potential drug candidates. J Biotechnol 242:101-110

2016

Hoppstädter J, Hachenthal N, Valbuena-Perez JV, Lampe S, Astanina K, Kunze MM, Bruscoli S, Riccardi C, Schmid T, Diesel B, Kiemer AK. 2016. Induction of glucocorticoid-induced leucine zipper (GILZ) contributes to anti-inflammatory effects of the natural product curcumin in macrophages. J Biol Chem 291:22949-22960

 

Kessler SM, Laggai S, van Wonterghem E, Gemperlein K, Müller R, Haybaeck J, Vandenbroucke RE, Ogris M, Libert C, Kiemer AK. 2016. Transient hepatic overexpression of IGF2 induces free cholesterol and lipid droplet formation. Front Physiol 7:147

 

Seif M, Philippi A, Breinig F, Kiemer AK, Hoppstädter J. 2016. Yeast (Saccharomyces cerevisiae) polarizes both M-CSF and GM-CSF differentiated macrophages towards an M1-like phenotype. Inflammation 39:1690-1703

 

Barghash A, Golob-Schwarzl N, Helms V, Haybaeck J, Kessler SM. 2016. Elevated expression of the IGF2 mRNA binding protein 2 (IGF2BP2/IMP2) is linked to short survival and metastasis in esophageal adenocarcinoma. Oncotarget 7:49743-49750

 

Fengler VHI, Macheiner T, Kessler SM, Czepukojc B, Gemperlein K, Müller R, Kiemer AK, Magnes C, Haybaeck J, Lackner C, Sargsyan K. 2016. Susceptibility of different mouse wild type strains to develop diet-induced NAFLD/AFLD-associated liver disease. PLOS One 11:e0155163

 

Abdel-Halim M, Darwish SS, Elhady A, Hoppstädter J, Abadi AA, Hartmann RW, Kiemer AK, Engel M. 2016. Pharmacological inhibition of protein kinase C (PKC)zeta downregulates the expression of cytokines involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Eur J Pharm Sci 93:405-409

 

Schiffer L, Brixius-Anderko S, Hannemann F, Zapp J, Neunzig J, Thevis M, Bernhardt R. 2016. Metabolism of oral turinabol by human steroid hormone-synthesizing cytochrome P450 enzymes. Drug Metab & Dispos 44:227-237

 

Huynh AM, Müller A, Kessler SM, Henrikus S, Hoffmann C, Kiemer AK, Bücker A, Jung G. 2016. Small BODIPY probes for combined dual 19F-MRI and fluorescence imaging. ChemMedChem 1568-1575

 

Jozwik IK, Kiss FM, Gricman L, Abdulmughni A, Brill E, Zapp J, Pleiss J, Bernhardt R, Thunnissen, A-MWH. 2016. Structural basis of steroid binding and oxidation by the cytochrome P 450 CYP109E1 from Bacillus megaterium. FEBS J 283:4128-4148

 

Wink CSD, Michely JA, Jacobsen-Bauer A, Zapp J, Maurer HH. 2016. Diphenidine, a new psychoactive substance: metabolic fate elucidated with rat urine and human liver preparations and detectability in urine using GC-MS, LC-MSn, and LC-HR-MSn, Drug Test Anal 8:1005-1014

 

Schiffer L, Mueller A-R, Hobler A, Brixius-Anderko S, Zapp J, Hannemann F, Bernhardt R. 2016. Biotransformation of the mineralocorticoid receptor antagonists spironolactone and canrenone by human CYP11B1 and CYP11B2: Characterization of the products and their influence on mineralocorticoid receptor transactivation. Biochem Mol Biol 163:68-76

 

Ehrhardt M, Gerber A, Zapp J, Hannemann F, Bernhardt R. 2016. Human CYP27A1 catalyzes hydroxylation of ß-sitosterol and ergosterol. Biol Chem 397:513-518

 

Gerber A, Milhim M, Hartz P, Zapp J, Bernhardt R. 2016. Genetic engineering of Bacillus megaterium for high-yield production of the major teleost progrestogens 17a,20ß-di- and 17a,20ß,21a-trihydroxy-4-pregnen-3-one. Metab Eng 36:19-27

 

Khatri Y, Ringle M, Lisurek M, von Kries JP, Zapp J, Bernhardt R. 2016. Substrate hunting for the myxobacterial CYP260A1 revealed new 1a-hydroxylated products from C-19 steroids. ChemBioChem 17:90-101

2015

Hoppstaedter J, Kiemer AK. 2015. Glucocorticoid-induced leucine zipper (GILZ) in immuno suppression: master regulator or bystander? Oncotarget 6:38446-38457


Kessler SM, Laggai S, Barghash A, Schultheiß CS, Lederer E, Art M, Helms V, Haybaeck J, Kiemer AK. 2015. IMP2/p62 induces genomic instability and an aggressive HCC phenotype. Cell Death Dis 6:e1894

 

Hoppstädter J, Kessler SM, Bruscoli S, Huwer H, Riccardi C, Kiemer AK. 2015. Glucocorticoid-induced leucine zipper (GILZ): a critical factor in macrophage endotoxin tolerance. J Immunol 194:6057-6067

 

Astanina K, Koch M, Jüngst C, Zumbusch A, Kiemer AK. 2015. Lipid droplets as a novel cargo of tunneling nanotubles in endothelial celles. Sci Rep 5:11453

 

Kessler SM, Barghash A, Laggai S, Helms V, Kiemer AK. 2015. Hepatic hepcidin expression is decreased in cirrhosis and HCC. J Hepatol 62:977-979

 

Hoppstädter J, Seif M, Dembek A, Cavelus C, Huwer H, Kraegeloh A, Kiemer AK. 2015. M2 polarization enhances silica nanoparticle uptake by macrophages. Front Pharmacol 6:55

 

Barghash A, Helms V, Kessler SM.2015. Overexpression of IGF2 mRNA-Binding Protein 2 (IMP2/p62) as a feature of basal-like breast cancer correlates with short survival. Scand J Immunol 82:142-143

 

Ziaei A, Hoppstädter J, Kiemer AK, Ramezani M, Amirghofran Z, Diesel B. 2015. Inhibitory effects of teuclatriol, a sesquiterpene from Salvia mirzayanii, on nuclear factor-kappaB activation and expression of inflammatory mediators. J Ethnopharmacol 160:94-100

 

Stiedl P, McMahon R, Blaas L, Stanek V, Svinka J, Grabner B, Zollner G, Kessler SM, Claudel T, Müller M, Mikulits W, Bilban M, Esterbauer H, Eferl R, Haybaeck J, Trauner M, Casanova E. 2015. Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis. Hepatology 61:613-626

 

Lepeltier E, Loretz B, Desmaele D, Zapp J, Herrmann J, Couvreur P, Lehr C-M. 2015. Squalenoylation of chitosan: a platform for drug delivery? Biomacromolecules 16:2930-2939

 

Kiss FM, Khatri Y, Schmitz D, Zapp J, Bernhardt R. 2015. Identification of new substrates for the CYP106A1-​mediated 11-​oxidation and investigation of the reaction mechanism. FEBS Lett 589:2320-2326

 

Mosa A, Hutter MC, Zapp J, Bernhardt R. Hannemann F. 2015. Regioselective acetylation of C21 hydroxysteroids by the bacterial chloramphenicol acetyltransferase I. ChemBioChem 16:1670-1679

 

Kiss FM, Schmitz D, Zapp J, Dier TKF, Volmer DA, Bernhardt R. 2015. Comparison of CYP106A1 and CYP106A2 from Bacillus megaterium - identification of a novel 11-​oxidase activity. App Microbiol Biotechnol 99:8495-8514

 

Meyer GMJ, Wink CSD, Zapp J, Maurer HH. 2015 GC-MS, LC-MSn, LC-high resolution-MSn, and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkalois of the legal high "Kanna" isolated from Sceletium tortuosum. Anal Bioanal Chem 407:761-778

 

Wink CSD, Meyer GMJ, Zapp J, Maurer HH. 2015. Lefetamine, a controlled drug and pharmaceutical lead of new designer drugs: synthesis, metabolism, and detectability in urine and human liver preparations using GC-MS, LC-MSn, and LC-high resolution-MS/MS. Anal Bioanal Chem 407:1545-1557

 

Kiss FM, Lundemo MT, Zapp J, Woodley JM, Bernhardt R. 2015. Process develoment for the production of 15ß-hydroxycyproterone acetate using Bacillus megaterium expressing CYP106A2 as whole-cell biocatalyst. Microb Cell Fact 14:1-13

 

Mosa A, Neunzig J, Gerber A, Zapp J, Hannemann F, Pilak P, Bernhardt R. 2015. 2ß- and 16ß-hydroxylase activity of CYP11A1 and direct stimulatory effect of estrogens on pregnenolone formation. Steroid Biochem 150:1-10

 

Schifrin A, Ly TTB, Guennewich N, Zapp J, Thiel V, Schulz S, Hannemann F, Khatri Y, Bernhardt R. 2015. Chraracterization of the gene cluster CYP264B1-geoA from Sorangium cellulosum So ce56: Biosynthesis of (+)-Eremophilene and its hydroxylation. ChemBioChem 16: 337-344

2014

Kessler SM, Laggai S, Barghash A, Helms V, Kiemer AK. 2014. Lipid metabolism signatures in NASH-associated HCC - Letter. Cancer Res 74:2903-2904

 

Simon Y, Kessler SM, Bohle RM, Haybaeck J, Kiemer AK. 2014. The insulin-like growth factor 2 (IGF2) mRNA binding protein p62/IMP2-2/ IGF2BP2-2 as a promoter of NAFLD and HCC? Gut 63:861-863

 

Laggai S, Kessler SM, Boettcher S, Lebrun V, Gemperlein K, Lederer E, Leclercq IA, Mueller R, Hartmann RW, Haybaeck J, Kiemer AK. 2014. The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis. J Lipid Res 55:1087-1097

 

Hahn RT, Hoppstädter J, Hirschfelder K, Hachenthal N, Diesel B, Kessler SM, Huwer H, Kiemer AK. 2014. Downregulation of the glucocorticoid-induced leucine zipper (GILZ) promotes vascular inflammation. Atherosclerosis 234:391-400

 

Astanina K, Simon Y, Cavelius C, Petry S, Kraegeloh A, Kiemer AK. 2014. Superparamagnetic iron oxide nanoparticles impair endothelial integrity and inhibit nitric oxide production. Acta Biomater 10:4896-4911

 

Abdel-Halim M, Diesel B, Kiemer AK, Abadi A, Hartmann RW, Engel M. 2014. Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C zeta. J Med Chem 57:6513-6530

 

Simon Y, Kessler SM, Gemperlein K, Bohle RM, Müller R, Haybaeck J, Kiemer AK. 2014. Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis. World J Gastroenterol 20:17839-178350

 

Kessler SM, Simon Y, Gemperlein K, Gianmoena K, Cadenas C, Zimmer V, Pokorny J, Barghash A, Helms V, van Rooijen N, Bohle RM, Lammert F, Hengstler JG, Müller R, Haybaeck J, Kiemer AK. 2014. Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma. Int J Mol Sci 15:5762-5773

 

Du P, Viswanathan UM, Khairan K, Buric T, Saidu NEB, Xu Z, Hanf B, Bazukyan I, Trchounian A, Hannemann F, Bernhardt B, Burkholz T, Diesel B, Kiemer AK, Schäfer K-H, Montenarh M, Kirsch G, Jacob C. 2014. Synthesis of amphiphilic, chalcogen-based redox modulators with in vitro cytotoxic activity against cancer celles, macrophages and microbes. Med Chem Commun 5:25-31

 

Schmitz D, Zapp J, Bernhardt R. 2014. Steroid conversion with CYP106A2-production of pharmaceutically interesting DHEA metabolites. Microbial Cell Fact 13:1-13

 

Böse K, Koch M, Cavelius C, Kiemer AK, Kraegeloh A. 2014. Correlative analysis of gold nanoparticles internalized by A549 cells. Part Part Syst Char 31:439-448

 

Trierbach S, Bui N, Zapp J, Chhabra SR, Kappl R, Fetzner S. 2014 Substrate-assisted O2 activation in a cofactor-independent dioxygenese. Chem Biol 21:217-225.

 

Brill E, Hannemann F, Zapp J, Bruening G, Jauch J, Bernhardt R. 2014. A new cytochrome P450 system from Bacillus megaterium DSM319 for the hydroxylation of 11-keto-ß-boswellic acid (KBA) Appl Microbiol Biotechnol 98:1703-1717.

2013

Kessler SM, Pokorny J, Zimmer V, Laggai S, Lammert F, Bohle RM, Kiemer AK. 2013. The lgf2-mRNA binding protein p62 in hepatocellular carcinoma: anti-apoptotic action is independent of lgf2/PI3-K signalling. Am J Physiol Gastrointest Liver Physiol 304:G328-G336

 

Diesel B, Hoppstädter J, Hachenthal N, Zarboc R, Cavelius C, Wahl B, Thewes N, Jacobs K, Kraegeloh A, Kiemer AK. 2013. Activation of Rac1 GTPase by nanoparticulate structures in human macrophages. Eur J Pharm Biopharm 84:315-324

 

Laggai L, Simon Y, Ranssweiler T, Kiemer AK, Kessler SM. 2013. Rapid chromatographic method to decipher distinct alterations in lipid classes in NAFLD/NASH. World J Hepatol 304:G328-G336

 

Janocha S, Zapp J, Hutter M, Kleser M, Bohlmann J, Bernhardt R. 2013. Resin Acid Conversion with CYP105A1: An Enzyme with potenial for the production of pharmaceutically relevant diterpenoids. ChemBioChem 14:467-473

 

Meyer GMJ, Meyer MR, Wink CSD, Zapp J, Maurer HH. 2014. Studies on the in vivo contribution of human cytochrome P450s to the hepatic metabolism of glaucine, a new drug of abuse. Biochem Pharmacol 86:1497-1506.

 

Ringle M, Khatri Y, Zapp J, Hannemann F, Bernhardt R. 2014. Application of a new versatile electron transfer system for cytochrome P450-based Escherichia coli whole-cell bioconversions. Appl Microbiol Biotechnol 97:7741-7754.

 

Pirildar S, Unsal Gurer C, Kocyigit M, Zapp J, Kiemer AK, Meriçli AH. 2013. Alkaloids from the roots of Aconitum anthora and aerial parts of Delphinium kurdicum. Chem Natl Compd 48:1-2

2012

Hoppstädter J, Diesel B, Eifler LK, Schmid T, Brüne B, Kiemer AK. 2012. Glucocorticoid-induced leucine zipper is downregulated in human alveolar macrophages upon Toll-like receotor activation. Eur J Immunol 42:1282-1293

 

Diesel B, Ripoche N, Risch RT, Tierling S, Walter J, Kiemer AK. 2012. Inflammation-induced upregulation of TLR2 expression in human endothelial cells is independent of differential methylation in the TLR2 promoter CpG island. Innate Immun 18:112-123

 

Doering M, Diesel B, Gruhlke M, viswanathan UM, Mániková D, Chovanec M, Burkholz T, Slusarenko A, Kiemer AK, Jacob C. 2012. Selenium- and Tellurium- containing redox modulators with distinct activity against macrophages: possible implications for the treatment of inflammatory diseases. Tetrahedron 68:10577-10585

 

Pirildar S, Ünsal-Gürer C, Koçyigit M, Kiemer AK, Meriçli AH. 2012. Norditerpenoid alkaloids from Delphinium flexuosum Bieb. Z Naturforsch C 67C:541-544

 

Meriçli AH, Yazici S, Eroglu- Ozkan E, Sen B, Kurtoglu S, Ozcelik H, Zapp J, Kiemer AK, Meriçli F. 2012. Nodditerpeniod alkaloids from Consolida thirkeana and Consolida sulpuhurea. Chem Nat Compd 48:525-526

 

Ardzivian-El Nar A, Diesel B, Desor F, Bouayed J, Kiemer AK, Soulimani R. 2012. Neurodevelopmental and behavioral toxicity of lactational exposure to the sum of six indicator non-dioxin-like-polychlorobiphenyls (∑6 NDL-PCBs) in offspring mice. Toxicology 299:44-54

 

Kurtoǧlu S, Şen B, Meligoǧlu G, Becker H, Zapp J, Kiemer AK, Meriçli F, Meriçli AH. 2012. Diterdenoid alkaloids of Aconitum vulparia Rchb. Z Naturforsch C 67:103-107

 

Bouayed J, Bohn T, Tybl E, Kiemer AK, Soulimani R. 2012. Benzo(α)pyrene -induced antidepressive-like behaviour in adult female mice: role of monoaminergic systems. Basic Clin Pharmacol Toxicol 110:544-550

 

Meriçli AH, Çağal-Yurdusever N, Özçelik H, Zapp J, Kiemer AK. 2012. A new diterpenoid alkaloid from the roots of a white-flowering Aconitum orientale sample. Helv Chim Acta 95:314-319

 

Ly TTB, Khatri Y, Zapp J, Hutter MC, Bernhardt R. 2012. CYP264B1 from Sorangium cellulosum So ce56: a fascinating norisoprenoid and sesquiterpene hydroxylase. App Microbiol Biotechnol 95:123-133

 

Schmitz D, Zapp J, Bernhardt R. 2012 Hydroxylation of the triterpenoid dipterocarpol with CYP106A2 from Bacillus megaterium.
FEBS J 279:1663-1674

 

Schwaninger AE, Meyer MR, Zapp J, Maurer HH. 2012. Investigations on the stereoselectivity of the phase II metabolism of the 3,4-methylenedioxyethylamphetaminem (MDEA) metabolites 3,4-dihydroxyethylamphetamine (DHEA) and 4-hydroxy-3-methoxyethylamphetamine (HMEA). Toxicol Lett 212:38-47.

 

Kleser M, Hannemann F, Hutter M, Zapp J, Bernhardt R. 2012. CYP105A1 mediated 3-hydroxylation of glimepiride and glibenclamide using a recombinant Bacillus megaterium whole-cell catalyst. Biotechnol 157:405– 412

 

Bleif, S, Hannemann F, Zapp, J, Hartmann, D, Jauch, J, Bernhardt, R. 2012. A new Bacillus megaterium whole-cell catalyst for the hydroxylation of the pentacyclic triterpene 11-keto-β-boswellic acid (KBA) based on a recombinant cytochrome P450 system. Appl Microbiol and Biotechnol 93:1135-1146

  

Ly TTB, Khatri Y, Zapp J., Hutter MC, Bernhardt R. 2012. CYP264B1 from Sorangium cellulosum So ce56: a fascinating norisoprenoid and sesquiterpene hydroxylase. Appl Microbiol Biotechnol 95:123-133

 

Meyer MR, Dinger J, Schwaninger AE, Wissenbach DK, Zapp J, Fritschi G, Maurer HH. 2012. Qualitative studies on the metabolism and the toxicological detection of the fentanyl-derived designer drugs 3-methylfentanyl and isofentanyl in rats using liquid chromatography-linear ion trap-mass spectrometry (LC-MSn). Anal Bioanal Chem 402:1249-1255

2011

Tybl E, Shi F-D, Kessler SM, Tierling S, Walter J, Bohle RM, Wieland S, Zhang J, Tan EM, Kiemer AK. 2011. Overexpression of the lgf2-mRNA binding protein p62 in transgenic mice induces a steatotic phenotype. J Hepatol 54:994-1001

 

Mohammed HA, Baa LA, Burkholz T, Schumann E, Diesel B, Zapp J, Kiemer AK, Ries C, Hartmann RW, Hosny M, Jacob C. 2011. Facile Synthesis of Chrysin-derivatives with Promising Activities as Aromatase Inhibitors. Nat Prod Commun 6:31-34

 

Ziaei A, Amirghofran Z, Zapp J, Ramezani M. 2011. Immunoinhibitory effect of teuclatriol a guaiane sesquiterpene from Salvia mirzayanii. Iran J lmmunol 8:226-235

 

Philipp AA, Wissenbach DK, Weber AA, Zapp J, Maurer HH. 2011. Metabolism studies of the Kratom alkaloids mitraciliatine and isopaynantheine, diastereomers of the main alkaloids mitragynine and paynantheine, in rat and human urine using liquid chromatography-linear ion trap-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 879:1049-1055

 

Parr MK, Opfermann G, Geyer H, Westphal F, Soennichsen FD, Zapp J, Kwiatkowska, D, Schaenzer W. 2011. Seized designer supplement named "1-Androsterone": Identification as 3β-hydroxy-5α-androst-1-en-17-one and its urinary elimination. Steroids 76:540-547

 

Schwaninger AE, Meyer MR, Zapp J, Maurer HH. 2011. Sulfation of the 3,4-methylenedioxymethamphetamine (MDMA) metabolites 3,4-dihydroxymethamphetamine (DHMA) and 4-hydroxy-3-methoxymethamphetamine (HMMA) and their capability to inhibit human sulfotransferases. Toxicol Lett 202:120-128

 

Dragan C-A, Peters FT, Bour P, Schwaninger AE, Schwaan SM, Neunzig I, Widjaja M, Zapp J, Kraemer T, Maurer HH. 2011. Convenient gram-scale metabolite Synthesis by Engineered Fission Yeast Strains Expressing Functional Human P450 Systems. Appl Biochem Biotechnol 163:965-980

 

Bleif S, Hannemann F, Lisurek M, von Kries JP, Zapp J, Dietzen M, Antes I, Bernhart R. 2011. Identification of CYP106A2 as a Regioselective Allylic Bacteriadl Diterpene Hydroxylase. ChemBioChem 12:576-582

 

Philipp AA, Wissenbach DK, Weber AA, Zapp J, Maurer HH, 2011, Metabolism studies of the Kratom alkaloid speciociliatine, a diastereomer of the main alkaloid mitragynime, in rat and human urine using liquid chromatography-linear ion trap mass spectrometry. Anal Bioanal Chem 399(8), 2747-2753

2010

Hoppstädter J, Diesel B, Zarbock R, Breinig T, Monz D, Koch M, Meyerhans A, Gortner L, Lehr CM, Huwer H, Kiemer AK. 2010. Differential cell reaction upon Toll-like receptor 4 and 9 activation in human alveolar and lung interstitial macrophages. Resp Res 11:124

 

Friedl AM, Oedendorfer K, Kitzer S, Reznicek G, Sladek G, Heuberger E. 2010. Comparison of liquid-liquid partition, HS-SPME and static HS GC/MS analysis for the quantification of (–)-linalool in human whole blood samples. Nat Prod Commun 5:1447-1452

 

Scher JM, Andreas Schinkovitz A, Zapp J, Wang Y, Franzblau SG, Becker H, Lankin DC, Pauli GF. 2010. Structure and Anti-TB Activity of Trachylobanes from the Liverwort Jungermannia exsertifolia ssp. Cordifolia. J Nat Prod 73:656-663

 

Philipp AA, Wissenbach DK, Weber AA, Zapp J, Zoerntlein SW, Kanogsunthornrat J, Maurer HH 2010. Use of liquid chromatography coupled to low- and high-resolution linear ion trap mass spectrometry for studying the metabolism of paynantheine, an alkaloid of the herbal drug Kratom in rat and human urine. Anal Bioanal Chem 396:2379-2391

2009

Kiemer AK, Senaratne RH, Hoppstädter J, Diesel B, Riley LW, Tabeta K, Bauer S, Beutler B, Zuraw BL. 2009. Attenuated activation of macrophage TLR9 by DNA from virulent mycobacteria. J Innate Immun 1:29-45

 

Mecklenburg S, Shaaban S, Ba LA, Burkholz T, Schneider T, Diesel B, Kiemer AK, Röseler A, Becker K, Reichrath J, Stark A, Tilgen W, Abbas M, Wessjohann LA, Jacob C. 2009. Exploring synthetic avenues for the effective synthesis of selenium and tellurium containing multifunctional redox agents. Org Biomol Chem 7:4753-4762

 

Bouayed J, Desor F, Rammal H, Kiemer AK, Tybl E, Schroeder H, Rychen G, Soulimani R. 2009. Effects of lactational exposure to benzo[α]pyrene (B[α]P) on postnatal neurodevelopment, neuronal receptor gene expression and behaviour in mice. Toxicology 259:97-106

 

Schwaninger AE, Meyer MR, Zapp J, Maurer HH. 2009. The role of human UDP-glucuronyltransferases on the formation of the methylenedioxymethamphetamine (ecstasy) phase II metabolites R- and S-3-methoxymethamphetamine 4-O-glucuronides. Drug Metab Dispos 37:2212-2220

 

Speicher A, Groh M, Zapp J, Schaumloeffel A, Knauer M, Bringmann G. 2009. A synthesis-driven structure revision of plagiochin E, a highly bioactive bisbibenzyl. Synlett 11:1852-1858

 

Suzgec S, Bitiş L, Sozer U, Ozcelik H, Zapp J, Kiemer AK, Meriçli F, Meriçli AH. 2009. Alkaloids from the aerial parts of Consolida anthoroidea and Delphinium linearilobumChem Nat Compd 45:287-289

 

Peters FT, Dragan CA, Kauffels A, Schwaninger AE, Zapp J, Bureik M, Maurer HH. 2009. Biotechnological synthesis of the designer drug metabolite 4'-hydroxymethyl-ALPHA-pyrrolidinohexanophenone in fission yeast heterologously expressing human cytochrome P450 2D6-A versatile alternative to multistep hemical synthesis. J Anal Toxicol 33:190-197

 

Kroll U, Reif K, Lederer I, Foerster G, Zapp J. 2009. Kaempferol-3,4'-di-O-b-glucopyranoside-7-O-alpha-rhamnopyranoside as a new flavonoid from Iberis amara L. Pharmazie 64:142-144

 

Peters FT, Dragan CA, Schwaninger AE, Sauer C, Zapp J, Bureik M, Maurer HH. 2009. Use of fission yeast heterologously expressing human cytochrome P450 2B6 in biotechnological synthesis of the designer drug metabolite N-(1-phenylcyclohexyl)-2-hydroxyethanamine. Forensic Sci Int. 184:69-73

2008

Dünschede F, Tybl E, Kiemer AK, Dutkowski P, Erbes K, Kircher A, Gockel I, Zechner U, Schad A, Lang H, Junginger T, Kempski O. 2008. Bcl-2 upregulation after 3-nitropropionic acid preconditioning in warm rat liver ischemia. Shock 30:699-704

 

Bohr G, Klimo K, Zapp J, Becker H, Gerhaeuser C. 2008. Cancer chemopreventive potential of humulones and isohumulones (hops alpha- and iso- alpha -acids): induction of NAD(P)H:quinone reductase as a novel mechanism. Nat Prod Commun 3:1971-1976

 

Zapp H, Orth K, Zapp J, Connolly JD, Becker H. 2008. 21, 28-epoxy-18b, 21b-dihydroxbaccharan-3-one and other terpenoids from the liverwort Lepidozia chordulifera T. Taylor. Nat Prod Commun 3:1755-1758

 

Taetz S, Muerdter TE, Zapp J, Boettcher S, Baldes C, Kleideiter E, Piotrowska K, Schaefer UF, Klotz U, Lehr C-M. 2008. Decomposition of the telomere-targeting agent BRACO19 in physiological media results in products with decreased inhibitory potential. Int J Pharm 357:6-14

2007

Diesel B, Kulhanek-Heinze S, Höltje M, Brandt B, Höltje H-D, Vollmar AM, Kiemer AK. 2007. alpha-lipoic acid as a directly binding activator of the insulin receptor - protection from hepatocyte apoptosis. Biochemistry 46:2146-2155

 

Ladetzki-Baehs K, Keller M, Kiemer AK, Koch E, Zahler S, Wendel A, Vollmar AM. 2007. Atrial Natriuretic Peptide (ANP) - a regulator of NF-kappaB activation in vivoEndocrinology 148:332-336

 

Fürst R, Schroeder T, Eilken HM, Bubik MF, Kiemer AK, Zahler S, Vollmar AM. 2007. MAPK phosphatase-1 represents a novel anti-inflammatory target of glucocorticoids in the human endothelium. FASEB J 21:74-80s

 

Bitiş L, Suzgec S, Sozer U, Ozcelik H, Zapp J, Kiemer AK, Meriçli F, Meriçli AH. Diterpenoid alkaloids of Delphinium buschianum. 2007. GROSSH. Helvetica Chimica Acta 90:2217-2221

 

Duenschede F, Erbes K, Kircher A, Westermann S, Schad A, Riegler N, Ewald P, Dutkowski P, Kiemer AK, Kempski O, Junginger T. 2007. Protection from hepatic ischemia/reperfusion injury and improvement of liver regeneration by alpha-lipoic acid. Shock 27:644-651

 

Duenschede F, Westermann S, Miesner I, Albrecht-Schock S, Kneist W, Korenkov M, Schad A, Dutkowski P, Kiemer AK, Junginger T. 2007. Hepatocellular injury of non-ischemic liver tissue after selective clamping in rats - protective action by pharmacological pretreatment with lipoic acid. Eur Surg Res 9:325-331

 

Duenschede F, Erbes K, Riegler N, Ewald P, Kircher A, Westermann S, Schad A, Miesmer I, Albrecht-Schöck A, Gockel I, Kiemer AK, Junginger T. 2007. Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 minutes of hepatic ischemia in a rat model. World J Gastroenterol 13:3692-3698

 

Szwajgier D, Wasko A, Zapp J, Targonski Z. 2007. An attempt to identify the low molecular feruloylated oligosaccharides in beer. J Inst Brew 113:185-195

 

Meriçli AH, Ulusoylu DM, Meriçli F, Ozcelik H, Zapp J, Becker H. 2007. Norditerpenoid alkaloids from Delphinium cinereum. Chem Nat Compd 43:364-366

 

Peters FT, Dragan CA, Wilde DR, Meyer MR, Zapp J, Bureik M, Maurer HH. 2007. Biotechnological synthesis of drug metabolites using human cytochrome P450 2D6 heterologously expressed in fission yeast exemplified for the designer drug metabolite 4'-hydroxymethyl-alpha -pyrrolidinobutyrophenone. Biochem Pharmacol 74:511-520

 

Parr MK, Zapp J, Becker M, Opfermann G, Bartz U, Schaenzer W. 2007. Steroidal isomers with uniform mass spectra of their per-TMS derivatives: Synthesis of 17-hydroxyandrostan-3-ones, androst-1-, and -4-ene-3,17-diols. Steroids 72:545-551

2006

Fürst R, Blumenthal SB, Kiemer AK, Zahler S, Vollmar AM. 2006. Nuclear Factor kappaB-independent anti-inflammatory action of salicylate in human endothelial cells: induction of heme oxygenase by the JNK/AP-1 pathway. J Pharmacol Exp Ther 318: 389-394

 

Dünschede F, Erbes K, Kircher A, Westermann S, Seifert J, Schad A, Kempski O, Kiemer AK, Junginger T. 2006. Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by alpha-lipoic acid in humans. World J Gastroenterol 12:6812-6817

 

Dünschede F, Westermann S, Riegler N, Miesner I, Erbes K, Ewald P, Kircher A, Schaefer H, Schneider J, Schad A, Dutkowski P, Kiemer AK, Junginger T. 2006. Different protection mechanisms after pretreatment with glycine or alpha-lipoic acid in a rat model of warm hepatic ischemia. Eur Surg Res 38:503-512

 

Grützner U, Keller M, Bach M, Kiemer AK, Meißner H, Bilzer M, Zahler S, Gerbes AL, Vollmar AM. 2006. PI 3-kinase-pathway is responsible for antiapoptotic effects of Atrial Natriuretic Peptide (ANP) in rat liver transplantation. World J Gastroenterol 12:1049-1055

 

Arroniz-Crespo M, Nunez-Olivera E, Martinez-Abaigar J, Becker H. Scher J, Zapp J, Tomas R, Beaucourt N. 2006. Physiological changes and UV protection in the aquatic liverwort Jungermannia exsertifolia subsp. cordifolia along an altitudinal gradient of UV-B radiation. Funct Plant Biol 33:1025-1036

 

Weiss B, Schaefer UF, Zapp J, Lamprecht A, Stallmach A, Lehr CM. 2006. Nanoparticles made of fluorescence-labelled poly(L-lactide-co-glycolide): preparation, stability and biocompatibility. J Nanosci Nanotechnol 6:3048-3056

 

Simunovic V, Zapp J, Rachid S, Krug D, Meiser P, Mueller R. 2006. Myxovirescin A biosynthesis is directed by hybrid polyketide synthases/nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl-CoA synthases, and trans-acting acyl-transferases. ChemBioChem 7:1206-1220

 

Bitiş L, Suzgec S, Meriçli F, Ozcelik H, Zapp J, Becker H, Meriçli A. H. 2006. Alkaloids from Consolida olopetala. Pharm Biol 44:244-246

 

Meriçli AH, Süzgec S, Bitis L, Meriçli F, Oczelik H, Zapp J, Becker H. 2006. Diterpenoid alkaloids from the roots of Aconitum cochlearePharmazie 61:483-485

 

Suzgec S, Bitis L, Pirildar S, Ozcelik H, Zapp J, Becker H, Meriçli F, Meriçli AH. 2006. Diterpenoid alkaloids of Delphinium schmalhausenii. Chem Nat Compd 42:75-78

 

Meriçli AH, Pirildar S, Suzgec S, Bitis L, Meriçli F, Ozcelik H, Zapp J, Becker H. 2006. Norditerpenoid alkaloids from the aerial parts of Aconitum cochleare WoroschinHelv Chim Acta 89:210-217

 

Radermacher J, Diesel B, Seifert M, Tilgen W, Reichrath J, Fischer U, Meese E. 2006. Expression analysis of CYP27B1 in tumor biopsies and cell cultures. Anticancer Res 26:2683-2686

2005

Fürst R, Kuebler WM, Brueckl C, Zahler S, Krötz F, Görlach A, Vollmar AM, Kiemer AK. 2005. Atrial Natriuretic Peptide induces mitogen-activated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD(P)H oxidase/Nox2 activation. Circ Res 96:43-53

 

Blumenthal SB, Kiemer AK, Tiegs G, Seyfried S, Höltje M, Brandt B, Höltje H-D, Zahler S, Vollmar AM. 2005. Metalloporphyrins inactivate caspase-3 and -8. FASEB J 19:1272-1279

 

Kable EPW, Kiemer AK. 2005. Non-invasive live cell measurement of changes in macrophage NAD(P)H by two-photon microscopy. Immunol Lett 96:33-38

 

Keller M, Gerbes AL, Kulhanek-Heinze S, Gerwig T, Grützner U, Vollmar AM, Kiemer AK. 2005. The hepatocyte cytoskeleton during ischemia and reperfusion – influence of ANP-mediated p38 MAPK activation. World J Gastroenterol 11:7418-7429

 

Bohr G, Gerhaeuser C, Knauft J, Zapp J, Becker H. 2005. Anti-inflammatory acyl­phloroglucinol derivatives from hops (Humulus lupulus). J Nat Prod 68:1545-1548

 

Becker H, Scher JM, Speakman JB, Zapp J. 2005. Bioactivity guided isolation of antimicrobial compounds from Lythrum salicariaFitoterapia 76:580-584

 

Berwanger S, Zapp J, Becker H. 2005. 13C-labelling of xanthohumol in hop cones (Humulus lupulus). Planta Med 71:530-534

 

Feld H, Hertewich UM, Zapp J, Becker H. 2005. Sacculatane diterpenoids from axenic cultures of the liverwort Fossombronia wondraczekiiPhytochemistry 66:1094-1099

 

Diesel B, Radermacher J, Bureik M, Bernhardt R, Seifert M, Reichrath J, Fischer U, Meese E. 2005. Vitamin D3 Metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol and effect of calcitriol. Clin Cancer Res 11: 5370-5380

2004

Kulhanek-Heinze S, Gerbes AL, Gerwig T, Vollmar AM, Kiemer AK. 2004. Protein kinase A signalling mediates anti-apoptotic effects of the Atrial Natriuretic Peptide in ischemia reperfusion injury. J Hepatol 41:414-420

 

Kiemer AK, Förnges AC, Pantopoulos K, Bilzer M, Andriopoulos B, Gerwig T, Kenngott S, Gerbes AL, Vollmar AM. 2004. ANP-induced decrease of iron regulatory protein activity is independent of HO-1 induction. Am J Physiol Gastrointest Liver Physiol 287:G518-G526

 

Scher JM, Zapp J, Becker H, Kather N, Kolz J, Speicher A, Dreyer M, Maksimenka K, Bringmann G. 2004. Optically active bisbibenzyls from Bazzania trilobata: isolation and stereochemical analysis by chromatographic, chiroptical, and computational methods. Tetrahedron 60:9877-9881

 

Scher JM, Speakman JB, Zapp J, Becker H. 2004. Bioactivity guided isolation of antifungal compounds from the liverwort Bazzania trilobata (L.) S. F. Gray. Phytochemistry 65:2583-2588

 

Umlauf D, Zapp J, Becker H, Adam KP. 2004. Biosynthesis of the irregular monoterpene artemisia ketone, the sesquiterpene germacrene D and other isoprenoids in Tanacetum vulgare L. (Asteraceae). Phytochemistry 65:2463-2470

 

Feld H, Zapp J, Connolly JD, Becker, H. 2004. Terpenoids from the liverwort Blepharostoma trichophyllumPhytochemistry 65:2357-2362

 

Feld H, Rycroft DS, Zapp J. 2004. Chromenes and prenylated benzoic acid derivatives from the liverwort Pedinophyllum interruptumZeitschrift fuer Naturforschung. B: Chemical Sciences 59:825-828

 

Hillenbrand M, Zapp J, Becker H. 2004. Depsides from the petals of Papaver rhoeasPlanta Med 70:380-382

 

Blaes B, Zapp J, Becker H. 2004. Ent-Clerodane diterpenes and other constituents from the liverwort Adelanthus lindenbergianus (Lehm.) Mitt. Phytochemistry 65:127-137

 

Mitschele T, Diesel B, Friedrich M, Meineke V, Maas RM, Gärtner BC, Kamradt J, Meese E, Tilgen W, Reichrath J. 2004. Analysis of the vitamin D system in basal cell carcinomas (BCC`s). Lab Invest 84: 693-702

2003

Kiemer AK, Hartung T, Huber C, Vollmar AM. 2003. Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kappaB pathway. J Hepatol 38:289-297

 

Kiemer AK, Bildner N, Weber NC, Vollmar AM. 2003. Characterization of heme oxygenase 1 (hsp 32) induction by the Atrial Natriuretic Peptide in human endothelial cellsEndocrinology 144:802-812

 

Schümann J, Mühlen K, Kiemer AK, Vollmar AM, Tiegs G. 2003. Parenchymal, but not leukocyte, TNF receptor 2 mediates T cell-dependent hepatitis in mice. J Immunol 170:2129-2137

 

Bang R, Sass G, Kiemer AK, Vollmar AM, Neuhuber WL, Tiegs G. 2003. Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. J Pharmacol Exp Ther 305:31-39

 

Schümann J, Prockl J, Kiemer AK, Vollmar AM, Bang R, Tiegs G. 2003. Silibinin protects mice from T cell-dependent liver injury. J Hepatol 39:333-340

 

Gerwig T, Meißner H, Bilzer M, Kiemer AK, Arnholdt H, Vollmar AM, Gerbes AL. 2003. ANP preconditioning protects against hepatic preservation injury by attenuating apoptotic and necrotic cell death. J Hepatol 39:341-348

 

Kiemer AK, Gerwig T, Gerbes AL, Meißner H, Bilzer M, Vollmar AM. 2003. Kupffer-cell specific induction of heme oxygenase 1 (HSP32) by the Atrial Natriuretic Peptide – role of cGMP. J Hepatol 38:490-498

 

Müller C, Dünschede F, Koch E, Vollmar AM, Kiemer AK. 2003. alpha-lipoic acid preconditioning reduces ischemia/reperfusion injury of the rat liver via the PI-3 kinase/Akt pathway. Am J Physiol Gastrointest Liver Physiol 285:G769-G778

 

Weber NC, Blumenthal SB, Hartung T, Vollmar AM, Kiemer AK. 2003. ANP inhibits TNF-alpha-induced endothelial MCP-1 expression – involvement of p38 MAPK and MKP-1. J Leukoc Biol 74:932-941

 

Abou-Douh AM, Zapp J, Desoky EE, El-Baga NaY, El-Khrisy EA, Becker H. 2003. A cycloartane triterpene and phytosterols from the fruit of Ficus vogeliiRev Lat Am Quim 31:58-65

 

Feld H, Zapp J, Becker H. 2003. Secondary metabolites from the liverwort Tylimanthus renifoliusPhytochemistry 64:1335-1340

 

Scher JM, Zapp J, Schmidt A, Becker H. 2003. Bazzanins L-R, chlorinated macrocyclic bisbibenzyls from the liverwort Lepidozia incurvataPhytochemistry 64:791-796

 

Hertewich UM, Zapp J, Becker H. 2003. Secondary metabolites from the liverwort Jamesoniella colorata. Phytochemistry. 63:227-233

 

Scher JM, Zapp J, Becker H. 2003. Lignan derivatives from the liverwort Bazzania trilobataPhytochemistry 62:769-777

2002

Kiemer AK, Baron A, Gerbes AL, Bilzer M, Vollmar AM. 2002. The Atrial Natriuretic Peptide as a regulator of Kupffer cell functions. Shock 17:365-371

 

Kiemer AK, Weber NC, Vollmar AM. 2002. Induction of IkappaB: Atrial natriuretic peptide as a regulator of the NF-kappaB pathway. Biochem Biophys Res Commun 295:1068-1076

 

Kiemer AK, Kulhanek-Heinze S, Gerwig T, Gerbes AL, Vollmar AM. 2002. Stimulation of p38 MAPK by hormonal preconditioning with Atrial Natriuretic Peptide. World J Gastroenterol 8:707-711

 

Kiemer AK, Müller C, Vollmar AM. 2002. Inhibition of LPS-induced NO and TNF-alpha production by alpha-lipoic acid in rat Kupffer cells and in RAW 264.7 murine macrophages. Immunol Cell Biol 80:550-557

 

Kiemer AK, Gerbes AL, Bilzer M, Vollmar AM, 2002. The Atrial Natriuretic Peptide and cGMP – novel activators of the heat shock response in rat livers. Hepatology 35:88-94

 

 Kiemer AK, Lehner MD, Hartung T, Vollmar AM. 2002. Inhibition of Cyclooxygenase-2 by Natriuretic Peptides. Endocrinology 143:846-852

 

Kiemer AK, Weber NC, Fürst R, Bildner N, Kulhanek-Heinze S, Vollmar AM. 2002. Inhibition of p38 MAPK activation via induction of MKP-1: Atrial Natriuretic Peptide reduces TNF-alpha-induced actin polymerization and endothelial permeability. Circ Res 90:874-881

 

Koerber K, Sass G, Kiemer AK, Vollmar AM, Tiegs G. 2002. In vivo regulation of inducible NO synthase in immune-mediated liver injury. Hepatology 36:1061-1069

 

Kouokam JC, Zapp J, Becker H. 2002. Oxygen-containing sulfur-rich compounds from the bark of the tropical garlic tree Scorodophloeus zenkeri Harms. Phytochemistry 60:403-407

2001

Wolf D, Schümann J, Koerber K, Kiemer AK, Vollmar AM, Sass G, Papadopoulos T, Bang R, Klein SD, Brüne B, Tiegs G. 2001. Low-molecular-weight hyaluronic acid induces nuclear factor-kappaB-dependent resistance against tumor necrosis factor alpha-mediated liver injury in mice. Hepatology 34:535-547

 

Kiemer AK, Vollmar AM. 2001. Elevation of intracellular calcium levels contributes to the inhibition of nitric oxide production by atrial natriuretic peptide. Immunol Cell Biol 79:11-17

 

Kiemer AK, Vollmar AM. 2001. Induction of L-arginine transport is inhibited by ANP: a peptide hormone as a novel regulator of iNOS substrate availability. Mol Pharmacol 60:421-426

 

Kiemer AK, Takeuchi K, Quinlan MP. 2001. Identification of genes involved in epithelial-mesenchymal transition and tumor progression. Oncogene 20:6679-6688

 

Hertewich U, Zapp J, Becker H, Adam KP. 2001. Biosynthesis of a hopane triterpene and three diterpenes in the liverwort Fossombronia alaskanaPhytochemistry 58:1049-1054

 

Hannemann F, Rottmann M, Schiffler B, Zapp J, Bernhardt R. 2001. The loop region covering the iron-sulfur cluster in bovine adrenodoxin comprises a new interaction site for redox partners. J Biol Chem 276:1369-1375

 

Maas RM, Reus K, Diesel B, Steudel WI, Feiden W, Fischer U, Meese E. 2001. Amplification and expression of splice variants of the gene encoding the p450 cytochrome 25-hydroxyvitamin D3 1, alpha-hydroxylase (CYP27B1) in human malignant glioma. Clin Cancer Res 7: 868-875

2000

Kiemer AK, Hartung T, Vollmar AM. 2000. cGMP-mediated inhibition of TNF-alpha production by the atrial natriuretic peptide in murine macrophages. J Immunol 165:175-181

 

Kiemer AK, Vollmar AM, Bilzer M, Gerwig T, Gerbes AL. 2000. Atrial Natriuretic Peptide reduces expression of TNF-alpha mRNA during reperfusion of the rat liver upon decreased activation of NF-kappaB and AP-1. J Hepatol 33:236-246

 

Liu HL, Wu CL, Becker H, Zapp J. 2000. Sesquiterpenoids and diterpenoids from the chilean liverwort Lepicolea ochroleucaPhytochemistry 53:845-849

1994-1999

1999

Adam KP, Thiel R, Zapp J. 1999. Incorporation of 1-[1-13C] deoxy-D-xylulose in chamomile sesquiterpenes. Arch Biochem Biophys 369:127-132

 

Ulubelen A, Meriçli AH, Meriçli F, Ozcelik H, Sener B, Becker H, Zapp J, Choudhary I, Atta-Ur-Rahman. 1999. Norditerpene and diterpene alkaloids from Consolida hohenackeriPhytochemistry 50:909-912

 

1998

Kiemer AK, Vollmar AM. 1998. Autocrine regulation of inducible nitric oxide synthase in macrophages by Atrial Natriuretic Peptide. J Biol Chem 273:13444-13451

 

Gerbes AL, Vollmar AM, Kiemer AK, Bilzer M. 1998. The guanylate cyclase-coupled natriuretic peptide receptor: a new target for prevention of cold ischemia-reperfusion damage of the rat liver. Hepatology 28:1309-1317

 

Tiegs G, Küsters S, Künstle G, Hentze H, Kiemer AK, Wendel A. 1998. Ebselen protects mice against T cell-dependent, TNF-mediated apoptotic liver injury. J Pharmacol Exp Ther 287:1098-1104

 

Dirsch VM, Kiemer AK, Wagner H, Vollmar AM. 1998. Effects of allicin and ajoene, two compounds of garlic, on the inducible nitric oxide synthase. Atherosclerosis 139:333-339

 

Martini U, Zapp J, Becker H. 1998. Studies on the chemistry and biology of mosses. Part 121. Lignans from the liverwort Bazzania trilobataPhytochemistry 49:1139-1146

 

Bungert M, Gabler J, Adam K-P, Zapp J, Becker H. 1998. Pinguisane sesquiterpenes from the liverwort Porella navicularisPhytochemistry 49:1079-1083

 

Adam KP, Zapp J. 1998. Biosynthesis of the isoprene units of chamomile sesquiterpenes. Phytochemistry 48:953-959

 

Adam KP, Thiel R, Zapp J, Becker, H. 1998. Involvement of the mevalonic acid pathway and the glyceraldehyde-pyruvate pathway in terpenoid biosynthesis of the liverworts Ricciocarpos natans and Conocephalum conicumArch Biochem Biophys 354:181-187

 

Knoess W, Zapp J. 1998. Accumulation of furan labdane diterpenes in Marrubium vulgare and Leonurus cardiacaPlanta Med 64:357-361

 

1997

Kiemer AK, Vollmar AM. 1997. Effects of different natriuretic peptides on nitric oxide synthesis in macrophages. Endocrinology 138:4282-4290

 

Dirsch VM, Kiemer AK, Wagner H, Vollmar AM. 1997. The triterpinoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages. Eur J Pharmacol 336:211-217

 

Martini U, Zapp J, Becker H. 1997. Studies on the chemistry and biology of mosses. Part 112. Chlorinated macrocyclic bisbibenzyls from the liverwort Bazzania trilobataPhytochemistry (Volume Date 1998) 47:89-96

 

Knoss W, Reuter B, Zapp J. 1997. Biosynthesis of the labdane diterpene marrubiin in Marrubium vulgare via a non-mevalonate pathway. Biochem. J 326:449-454

 

Thiel R, Adam KP, Zapp J, Becker H. 1997. Isopentenyl diphosphate biosynthesis in liverworts. Pharmaceut Pharmacol Lett 7:103-105

 

1996

Valcic S, Zapp J, Becker H. 1996. Plagiochilines and other sesquiterpenoids from Plagiochila (Hepaticae). Phytochemistry (Volume Date 1997) 44:89-99

 

Cullmann F, Adam KP, Zapp J, Becker H. 1996. Pelliatin, a macrocyclic lignan derivative from Pellia epiphyllaPhytochemistry 41:611-615

 

1995

Liu J, Zapp J, Becker, H. 1995. Comparative phytochemical investigation of Salvia miltiorrhiza and Salvia trilobaPlanta Med 61:453-455

 

Liu J, Becker H, Zapp J, Wu D. 1995. Four sesquiterpenes from the insecticidal plant Celastrus angulatusPhytochemistry 40:841-846

 

Tazaki H, Zapp J, Becker H. 1995. Diterpenes from in vitro cultures of the liverwort Jamesoniella autumnalisPhytochemistry 39:859-868

 

1994

Zapp J, Burkhardt G, Becker H. 1994. Sphenolobane and fusicoccane diterpenoids from the liverwort Anastrophyllum auritumPhytochemistry 37:787-793