Makrophagenaktivierung, Alterungsprozesse

Ausgewählte Publikationen

  • Kiemer AK. 2020. Blockade of an innate immune amplifier to fight immune hyperactivation in COVID-19? eBioMedicine, Commentary 61:103086
  • Valbuena Perez JV, Linnenberger R, Dembek A, Bruscoli S, Riccardi C, Schulz MH, Meyer MR, Kiemer AK, Hoppstädter J. 2020. Altered glucocorticoid metabolism represents a feature of macroph-aging. Aging Cell 19:e13156
  • Hoppstädter J, Dembek A, Linnenberger R, Dahlem C, Barghash A, Fecher-Trost C, Fuhrmann G, Koch M, Kraegeloh A, Huwer H, Kiemer AK. 2019. Toll-like receptor 2 release by macrophages: an anti-inflammatory program induced by glucocorticoids and lipopolysaccharide. Front Immunol 10:1634
  • Hoppstädter J, Diesel B, Hachenthal N, Minet M, Leidinger P, Backes C, Grässer F, Meese E, Bruscoli S, Riccardi C, Huwer H, Kiemer AK. 2019. Amplified host defense by Toll-like receptor-mediated downregulation of the glucocorticoid-induced leucine zipper (GILZ) in macrophages. Front Immunol 9:3111
  • Seif M, Hoppstädter J, Breinig F, Kiemer AK. 2017. Yeast-mediated mRNA delivery polarizes immuno-suppressive macrophages towards an immuno-stimulatory phenotype. Eur J Pharm Biopharm 117:1-13
  • Hoppstädter J, Hachenthal N, Valbuena-Perez JV, Lampe S, Astanina K, Kunze MM, Bruscoli S, Riccardi C, Schmid T, Diesel B, Kiemer AK. 2016. Induction of glucocorticoid-induced leucine zipper (GILZ) contributes to anti-inflammatory effects of the natural product curcumin in macrophages. J Biol Chem 291:22949-22960
  • Hoppstädter J, Kiemer AK. 2015. Glucocorticoid-induced leucine zipper (GILZ) in immunosuppression: master regulator or bystander? Oncotarget 6:38446-38457
  • Hoppstädter J, Kessler SM, Bruscoli S, Huwer H, Riccardi C, Kiemer AK. 2015. Glucocorticoid-induced leucine zipper (GILZ): a critical factor in macrophage endotoxin tolerance. J Immunol 194:6057-6067
  • Hoppstädter J, Seif M, Dembek A, Cavelius C, Huwer H, Kraegeloh A, Kiemer AK. 2015. M2 polarization enhances silica nanoparticle uptake by macrophages. Front Pharmacol 6:55
  • Hoppstädter J, Diesel B, Eifler LK, Schmid T, Brüne B, Kiemer AK. 2012. Glucocorticoid-Induced Leucine Zipper is downregulated in human alveolar macrophages upon Toll-like receptor activation. Eur J Immunol 42:1-13
  • Kiemer AK, Senaratne RH, Hoppstädter J, Diesel B, Riley LW, Tabeta K, Bauer S, Beutler B, Zuraw BL. 2009. Attenuated activation of macrophage TLR9 by DNA from virulent mycobacteria. J Innate Immun 1:29-45