Inflammation, macrophages, ageing

Selected publications

  • Schymik HS, Dahlem C, Barghash A, Kiemer AK. 2022. Comment on: The m6A reader IGF2BP2 regulates macrophage phenotypic activation and inflammatory diseases by stabilizing TSC1 and PPARγ. Adv Sci 2104372
  • Köhler N, Höring M, Czepukojc B, Rose TD, Buechler C, Kröhler T, Hayback J, Liebisch G, Pauling J, Kessler SM, Kiemer AK.2022. Kupffer cells are protective in alcoholic steatosis. Biochim Biophys Acta Mol Basis Dis 1868:166398
  • Lapuhs P, Heinrich E, Garcia R, Goes A, Frank N, Bollenbach L, Stibane V, Kuhn T, Koch M, Kiemer AK, Müller R, Fuhrmann K, Fuhrmann G. 2022. The inherent antibiotic activity of myxobacteria-derived autofluorescent outer membrane vesicles is switched on and off by light stimulation. Nanoscale 14:17534-17542
  • Huck BC, Thiyagarajan D, Bali A, Boese A, Besecke KFW, Hozsa C, Gieseler RK, Furch M, Carvalho-Wodarz C, Waldow F, Schwudke D, Metelkrina O, Titz A, Huwer H, Schwarzkopf K, Hoppstädter J, Kiemer AK, Koch M, Loretz B, Lehr CM. 2022. Nano-in-microparticles for aerosol delivery of antibiotic-loaded, fucose-derivatized and macrophage-targeted liposomes to combat mycobacterial infections: in vitro deposition, pulmonary barrier interactions, and targeted delivery. Adv Healthc Mater 2102117
  • Mehanny M, Boese A, Bornamehr B, Hoppstädter J, Presser V, Kiemer AK, Lehr CM, Fuhrmann G. 2022. Spray-dried pneumococcal membrane vesicles are promising candidates for pulmonary immunization. Int J Pharm 621:121794 
  • Mehanny M, Kroniger T, Koch M, Hoppstädter J, Becher D, Kiemer AK, Lehr CM, Fuhrmann G. 2021. Yield and immunomodulatory effects of pneumococcal membrane vesicles change with bacterial growth phase. Adv Healthc Mater 2101151
  • Valbuena Perez JV, Linnenberger R, Dembek A, Bruscoli S, Riccardi C, Schulz MH, Meyer MR, Kiemer AK, Hoppstädter J. 2020. Altered glucocorticoid metabolism represents a feature of macroph-aging. Aging Cell 19:e13156
  • Kiemer AK. 2020. Blockade of an innate immune amplifier to fight immune hyperactivation in COVID-19? eBioMedicine, Commentary 61:103086
  • Kessler SM, Hoppstädter J, Hosseini K, Laggai S, Haybaeck J, Kiemer AK. 2019. Lack of Kupffer cell depletion in diethylnitrosamine-induced hepatic inflammation. J Hepatol 70:175-177
  • Hoppstädter J, Dembek A, Linnenberger R, Dahlem C, Barghash A, Fecher-Trost C, Fuhrmann G, Koch M, Kraegeloh A, Huwer H, Kiemer AK. 2019. Toll-like receptor 2 release by macrophages: an anti-inflammatory program induced by glucocorticoids and lipopolysaccharide. Front Immunol 10:1634
  • Hoppstädter J, Diesel B, Hachenthal N, Minet M, Leidinger P, Backes C, Grässer F, Meese E, Bruscoli S, Riccardi C, Huwer H, Kiemer AK. 2019. Amplified host defense by Toll-like receptor-mediated downregulation of the glucocorticoid-induced leucine zipper (GILZ) in macrophages. Front Immunol 9:3111
  • Seif M, Hoppstädter J, Breinig F, Kiemer AK. 2017. Yeast-mediated mRNA delivery polarizes immuno-suppressive macrophages towards an immuno-stimulatory phenotype. Eur J Pharm Biopharm 117:1-13
  • Hoppstädter J, Hachenthal N, Valbuena-Perez JV, Lampe S, Astanina K, Kunze MM, Bruscoli S, Riccardi C, Schmid T, Diesel B, Kiemer AK. 2016. Induction of glucocorticoid-induced leucine zipper (GILZ) contributes to anti-inflammatory effects of the natural product curcumin in macrophages. J Biol Chem 291:22949-22960
  • Hoppstädter J, Kiemer AK. 2015. Glucocorticoid-induced leucine zipper (GILZ) in immunosuppression: master regulator or bystander? Oncotarget 6:38446-38457
  • Hoppstädter J, Kessler SM, Bruscoli S, Huwer H, Riccardi C, Kiemer AK. 2015. Glucocorticoid-induced leucine zipper (GILZ): a critical factor in macrophage endotoxin tolerance. J Immunol 194:6057-6067
  • Hoppstädter J, Seif M, Dembek A, Cavelius C, Huwer H, Kraegeloh A, Kiemer AK. 2015. M2 polarization enhances silica nanoparticle uptake by macrophages. Front Pharmacol 6:55
  • Hoppstädter J, Diesel B, Eifler LK, Schmid T, Brüne B, Kiemer AK. 2012. Glucocorticoid-Induced Leucine Zipper is downregulated in human alveolar macrophages upon Toll-like receptor activation. Eur J Immunol 42:1-13