Publications

2023

Fielden, L.F., Busch, J.D., Merkt, S.G., Ganesan, I., Steiert, C., Hasselblatt, H.B., Busto, J.V., Wirth, C., Zufall, N., Jungbluth, S., Noll, K., Dung, J.M., Butenko, L., von der Malsburg,, K., Koch, H.G., Hunte, C., van der Laan, M.*, and Wiedemann, N.* (2023). Central role of Tim17 in mitochondrial presequence protein translocation. Nature, online ahead of print, (* corresponding authors) doi:10.1038/s41586-023-06477-8.

von der Malsburg, A., Sapp, G.M., Zuccaro, K.E., von Appen, A., Moss, F.R., Kalia, R., Bennett, J.A., Abriata, L.A., Dal Reraro, M., van der Laan, M., Frost, A., and Aydin, H. (2023). Structural mechanism of mitochondrial membrane remodelling by human OPA1. Nature 620, 1101-1108.  doi.org/10.1038/s41586-023-06441-6

2022

Bock-Bierbaum, T., Funck, K., Wollweber, F., Lisicki, E., von der Malsburg, K., von der Malsburg, A., Laborenz, J., Noel, J.K., Hessenberger, M., Jungbluth, S., Bernert, C., Kunz, S., Riedel, D., Lilie, H., Jakobs, S., van der Laan, M., and Daumke, O. (2022). Structural insights into crista junctions formation by the Mic60-Mic19 complex. Science Advances 8: eabo4946. doi: 10.1126/sciadv.abo4946. Epub 2022 Aug 31. https://www.science.org/doi/10.1126/sciadv.abo4946

Rampelt, H., Wollweber, F., Licheva, M., de Boer, R., Perschil, I., Steidle, L., Becker, T., Bohnert, M., van der Klei, I., Kraft, C., van der Laan, M.*, and Pfanner     N.* (2022). Dual role of Mic10 in mitochondrial cristae organization and ATP synthase-linked metabolic adaptation and respiratory growth. Cell Rep. 38, 110290. (* corresponding authors)   doi:10.1016/j.celrep.2021.110290.

Priesnitz, C., Böttinger, L., Zufall, N., Gebert, M., Guiard, B., van der Laan, M., and Becker, T. (2022). Coupling to Pam16 differentially controls the dual role of Pam18 in protein import and respiratory chain formation. Cell Rep. 39, 110619.
doi:10.1016/j.celrep.2022.110619.

2021

Bertero, E., Nickel, A., Kohlhaas, M., Hohl, M., Sequira, V., Brune, C., Schwemmlein, J., Abeßer, M., Schuh, K., Kutschka, I., Carlein, C., Münker, K., Atighetchi, S., Müller, A., Kazakov, A., Kappl, R., von der Malsburg, K., van der Laan, M., Schiuma, A.F., Böhm, M., Laufs, U., Hoth, M., Rehling, P., Kuhn, M., Dudek, J., von der Malsburg, A., Prates Roma, L., and Maack, C. (2021). Loss of mitochondrial Ca2+ uniporter limits inotropic reserve and provides trigger and substrate for arrhythmias in Barth syndrome cardiomyopathy. Circulation 144, 1694-1713.
doi:10.1161/CIRCULATIONAHA.121.053755.

Kurokin, I., Lauer, A.A., Janitschke, D., Winkler, J., Theiss, E.L., Griebsch, L.V., Pilz, S.M., Matschke, V., van der Laan, M., Grimm, H.S., Hartmann, T., and Grimm, M.O. (2021). Targeted lipidomics of mitochondria in a cellular Alzheimer's disease model. Biomedicines 9, 1062. doi:10.3390/biomedicines9081062.

Lauterwasser, J., Fimm-Todt, F., Oelgeklaus, A., Schreiner, A., Funk, K., Falquez-Medina, H., Klesse, R., Jahreis, G., Zerbes R.M., O'Neill, K., van der Laan, M., Luo, X., and Edlich, F. (2021). Hexokinases inhibit death-receptor-dependent apoptosis on the mitochondria. Proc. Natl. Acad. Sci. USA 118, e2021175118.
doi:10.1073/pnas.2021175118.

2020

Caumont-Sarcos, A., Moulin, C., Poinot, L., Guiard, B., van der Laan, M.*, and Ieva, R.* (2020). Transmembrane coordination of preprotein recognition and motor coupling by the mitochondrial presequence receptor Tim50. Cell Rep., 30: 3092-3104.e4. (* corresponding authors). doi: 10.1016/j.celrep.2020.02.031.

Rampelt, H., Sucec, I., Bersch, B., Horten, P., Perschil, I., Martinou J.-C., van der Laan, M., Wiedemann, N., Schanda, P., and Pfanner, N. (2020). The mitochondrial carrier pathway transports non-canonical substrates with an odd number of transmembrane segments. BMC Biol. 18, 2.  doi:10.1186/s12915-019-0733-6

Lee, S., Lee, H., Yoo, S., Ieva, R., van der Laan, M., von Heijne, G., and Kim, H. (2020). The Mgr2 subunit of the TIM23 complex regulates membrane insertion of marginal stop-transfer signals in the mitochondrial inner membrane. FEBS Lett. 594, 1081-1087.  doi:10.1002/1873-3468.13692.

2019

Faelber, K., Dietrich, L., Noel, J.K., Wollweber, F., Pfitzner, A.-K., Mühleip, A., Sánchez, R., Kudryashev, M., Chiaruttini, N.,  Lilie, H., Schlegel, J., Rosenbaum, E., Hessenberger, M., Matthaeus, C,.  Kunz, S., von der Malsburg, A., Noé, F.,  Roux, A.,  van der Laan, M., Kühlbrandt, W. & Daumke, O. (2019). Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1. Nature 571, 429-433. doi 10.1038/s41586-019-1372-3

Boos, F., Krämer, L., Groh, C., Jung, F., Haberkant, P., Stein, F., Wollweber, F., Gackstatter, A., Zöller, E., van der Laan, M., Savitski, M.M., Benes, V., and Herrmann, J.M. (2019). Mitochondrial protein-induced stress trigger a global adaptive transcriptional programme. Nat. Cell Biol. 21, 442-451. doi:10.1038/s41556-019-0294-5.

2018

Rampelt, H., Wollweber, F., Gerke C., de Boer, R., van der Klei, I., Bohnert, M.,Pfanner, N., and van der Laan, M. (2018). Assembly of the mitochondrial cristae organizer Mic10 is regulated by Mic26-Mic27 antagonism and cardiolipin. J. Mol. Biol. 430, 1883-1890. doi:10.1016/j.jmb.2018.04.037

Muench, S.P., and van der Laan, M. (2018). No longer hidden secrets of proton pumping: The resolution revolution enlightens V-ATPases. Mol. Cell 69, 921-922. doi:10.1016/j.molcel.2018.02.031

Gonzalez-Montoro, A., Auffarth, K., Hönscher, C., Bohnert, M., Becker, T., Warscheid, B., Reggiori, F., van der Laan, M., Fröhlich, F., and Ungermann, C. (2018). Vps39 interacts with Tom40 to establish one of two functionally distinct vacuole-mitochondria contact sites. Dev. Cell 45, 621-636. doi: 10.1016/j.devcel.2018.05.011

Schorr, S. and van der Laan, M. (2018). Integrative functions of the mitochondrial contact site and cristae organizing system. Semin. Cell Dev. Biol. 76, 191-200. doi:10.1016/j.semcdb.2017.09.021

2017

Wollweber, F., von der Malsburg, K., and van der Laan, M. (2017). Mitochondrial contact site and cristae organizing system: A central player in membrane shaping and crosstalk. Biochim. Biophys. Acta 1864, 1481-1489. doi:10.1016/j.bbamcr.2017.05.004

Hessenberger, M., Zerbes, R.M., Rampelt, H., Kunz, S., Xavier, A.H., Purfürst, B., Lilie, H., Pfanner, N., van der Laan, M.*, and Daumke, O.* (2017). Regulated membrane remodelling by Mic60 controls formation of mitochondrial crista junctions. Nat. Commun. 8, 15258. (* corresponding authors)  doi:10.1038/ncomms15258

Rampelt, H. and van der Laan, M. (2017) The Yin & Yang of mitochondrial architecture - Interplay of MICOS and F₁F_o-ATP synthase in cristae formation. Microb. Cell 4, 236-239. doi:10.15698/mic2017.08.583

Cakir, Z., Funk, K., Lauterwasser, J., Todt, F., Zerbes, R.M., Oelgeklaus, A., Tanaka, A., van der Laan., M., and Edlich F. (2017). Parkin promotes proteasomal degradation of misregulated BAX. J. Cell Sci. 130, 2903-2913. doi:10.1242/jcs.200162

Morgenstern, M., Stiller, S.B., Lübbert, P., Peikert, C.D., Dannenmaier, S., Drepper, F., Weill, U., Höß, P., Feuerstein, R., Gebert, M., Bohnert, M., van der Laan, M., Schuldiner, M., Schütze, C., Oeljeklaus, S., Pfanner, N., Wiedemann, N., and Warscheid, B. (2017). Definition of a high confidence mitochondrial proteome at quantitative scale. Cell Rep. 19, 2836-2852. doi:10.1016/j.celrep.2017.06.014

Rampelt, H., Bohnert, M., Zerbes, R.M., Horvath, S.E., Warscheid, B., Pfanner, N., and van der Laan, M. (2017). Mic10, a core subunit of the mitochondrial contact site and cristae organizing system interacts with the dimeric F₁F_o-ATP synthase. J. Mol. Biol. 429, 1162-1170. doi: 10.1016/j.jmb.2017.03.006

Rampelt, H., Zerbes, R.M., van der Laan, M., and Pfanner, N. (2017). Role of the mitochondrial contact site and cristae organizing system in membrane architecture and dynamics. Biochim. Biophys. Acta 1864, 737-746. doi: 10.1016/j.bbamcr.2016.05.020

Dumit, V.I., Zerbes, R.M., Kaeser-Pebernard, S., Rackiewicz, M., Wall, M.T., Gretzmeier, C., Küttner, V., van der Laan, M., Braun, R.J., Dengjel, J. (2017). Respiratory status determines the effect of emodin on cell viability. Oncotarget 8, 37478-37490. doi: 10.18632/oncotarget.16396

Highlighted in:Kolitsida, P, and Abeliovich, H. (2017) Selective emodin toxicity in cancer cells. Oncotarget, doi:10.18632/oncotarget.16611.

Gold, V.A., Brandt, T., Cavellini, L., Cohen, M.M., Ieva, I., and van der Laan, M. (2017). Analysis of mitochondrial membrane protein complexes by electron cryo-tomography. Methods Mol. Biol., 1567, 315-336. doi: 10.1007/978-1-4939-6824-4_19

Schendzielorz, A.B., Schulz, C., Lytovchenko, O., Clancy, A., Guiard, B., Ieva, R., van der Laan, M., and Rehling, P. (2017). Two distinct membrane potential-dependent steps drive mitochondrial matrix protein translocation. J. Cell Biol. 216, 83-92. doi:10.1083/jcb.201607066

2016

van der Laan, M., Horvath, S.E., and Pfanner, N. (2016). Mitochondrial contact site and cristae organizing system. Curr. Opin. Cell Biol. 41, 33-42. doi: 10.1016/j.ceb.2016.03.013

Zerbes, R.M., Höß, P., Pfanner, N.*, van der Laan, M.*, and Bohnert, M. (2016). Distinct roles of Mic12 and Mic27 in the mitochondrial contact site and cristae organizing system. J. Mol. Biol. 428, 1485-1492. (* corresponding authors) doi: 10.1016/j.jmb.2016.02.031

Lauterwasser, J., Todt, F., Zerbes, R.M., Nguyen, T., Craigen, W., Lazarou, M., van der Laan, M., and Edlich, F. (2016). The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation. Sci. Rep. 6, 32994. doi: 10.1038/srep32994

Ramesh, A., Peleh, V., Martinez-Caballero, S., Wollweber, F., Sommer, F., van der Laan, M., Schroda, M., Alexander R.T., Campo, M.L., and Herrmann, J.L. (2016). A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import. J. Cell Biol. 214, 417-431. doi: 10.1083/jcb.201602074

Stiller, S.B., Höpker, J., Oeljeklaus, S., Schütze, C., Schrempp, S.G., Vent-Schmidt, J., Horvath, S.E., Frazier, A.E., Gebert, N., van der Laan, M., Bohnert, M., Warscheid, B., Pfanner, N., and Wiedemann, N. (2016). Major role of OXA translocase in biogenesis of mitochondria inner membrane proteins. Cell Metab. 23, 901-908. doi: 10.1016/j.cmet.2016.04.005

Turakhiya, U., von der Malsburg, K., Gold, V.A., Guiard, B., Chacinska, A., van der Laan, M., and Ieva, R. (2016). Protein import by the mitochondrial presequence translocase in the absence of a membrane potential. J. Mol. Biol. 428, 1041-1052. doi: 10.1016/j.jmb.2016.01.020

2015

Bohnert, M., Zerbes, R.M., Davies, K.M., Mühleip, A.W., Rampelt, H., Horvath, S.E., Boenke, T., Kram, A., Perschil, I., Veenhuis, M., Kühlbrandt, W., van der Klei, I.J., Pfanner, N., and van der Laan, M. (2015). Central role of Mic10 in the mitochondrial contact site and cristae organizing system. Cell Metab. 21, 747-755. doi: 10.1016/j.cmet.2015.04.007

Highlighted in: Milenkovic, D., and Larsson, N.G. (2015). Mic10 oligomerization pinches off mitochondrial cristae. Cell Metab. 21, 660-661.

Bohnert, M., Pfanner, N., and van der Laan, M. (2015). Mitochondrial machineries for insertion of membrane proteins. Curr. Opin. Struct. Biol. 33, 92-102. doi: 10.1016/j.sbi.2015.07.013

Wenz, L.S., Ellenrieder, L., Qiu, J., Bohnert, M., Zufall, F., van der Laan, M., Pfanner, N., Wiedemann, N., and Becker, T. (2015). Crucial role of Sam37 in forming the mitochondrial TOM-SAM supercomplex promoting β-Barrel biogenesis. J. Cell Biol. 210, 1047-1054. doi: 10.1083/jcb.201504119

Rampelt, H., and van der Laan, M. (2015). Metabolic remodelling: a pyruvate transport affair. EMBO J. 34, 835-837. doi: 10.15252/embj.201591228

Vögtle, F.N., Keller, M., Taskin A.A., Horvath, S.E., Guan, X.L., Prinz, C., Opalinska, M., Zorzin, C., van der Laan, M., Wenk, M.R., Schubert, R., Wiedemann, N., Holzer, M., Meisinger, C. (2015). Mitochondrial dynamics: The fusogenic lipid phosphatidic acid promotes Ugo1 biogenesis. J. Cell Biol. 210, 951-960. doi: 10.1083/jcb.201506085

Schrempp, S.G., and van der Laan, M. (2015). Get ready for fusion: Insights into Mgm1-mediated membrane remodelling. J. Mol. Biol. 427, 2595-2598. doi: 10.1016/j.jmb.2015.06.003

Bode, M., Woellhaf, M.W., Bohnert, M., van der Laan, M., Sommer, F., Jung, M., Zimmermann, R., Schroda, M., and Herrmann, J.M. (2015). Redox-regulated dynamic interplay between Cox19 and the copper-binding protein Cox11 in the intermembrane space of mitochondria facilitates biogenesis of cytchrome c oxidase. Mol. Biol. Cell 26, 2835-2401. doi: 10.1091/mbc.E14-11-1526

Horvath, S., Rampelt, H., Oeljeklaus, S., Warscheid, B., van der Laan, M., and Pfanner, N. (2015). Role of membrane contact sites in protein import into mitochondria. Protein Sci. 24, 277-297. doi: 10.1002/pro.2625

2014

Ieva, R., Schrempp, S.G., Opalinski, L., Wollweber, F., Höß, P., Heißwolf, A.K., Gebert, M., Zhang, Y., Guiard, B., Rospert, S., Becker, T., Chacinska, A., Pfanner, N., and van der Laan, M. (2014). Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane. Mol. Cell 56, 641-652. doi: 10.1016/j.molcel.2014.10.010

Highlighted in: Steffen, J., and Koehler, C.M. (2014). The great escape: Mgr2 of the mitochondrial TIM23 translocon is a gatekeeper tasked with releasing Membrane proteins. Mol. Cell 56, 613-614.

Aiyar, R.S., Bohnert, M., Duvezin-Caubet, S., Voisset, C., Gagneur, J., Fritsch, E.S., Couplan, E., von der Malsburg, K., Funaya, C., Soubigou, F., Courtin, F., Suresh, S., Kucharczyk, R., Evrard, J., Antony, C., St. Onge, R.P., Blondel, M., di Rago, J.P., van der Laan, M.*, and Steinmetz, L.M.* (2014). Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders. Nat. Commun. 5, 5585. (* corresponding authors) doi: 10.1038/ncomms6585

Lytovchenko, O., Naumenko, N., Oeljeklaus, S., Schmidt, B., von der Malsburg, K., Deckers, M., Warscheid, B., van der Laan, M.*, and Rehling, P.* (2014). The INA complex facilitates assembly of the peripheral stalk of the mitochondrial F₁F_o-ATP synthase. EMBO J. 33, 1624-1638. (* corresponding authors) doi: 10.15252/embj.201488076

Highlighted in: Stroud, D.A., and Ryan, M.T. (2014). Stalking the mitochondrial ATP synthase: Ina found guilty by association. EMBO J. 33, 1617-1618.

Mehnert, C.S., Rampelt, H., Gebert, M., Oeljeklaus, S., Schrempp, S.G., Kochbeck, L., Guiard, B., Warscheid, B., and van der Laan, M. (2014). Mitochondrial ADP/ATP carrier associates with the inner membrane presequence translocase in a stoichiometric manner. J. Biol. Chem. 289, 27352-27362. doi: 10.1074/jbc.M114.556498.

Wenz, L.S., Opalinski, L., Schuler, M.H., Ellenrieder, L., Ieva, R., Böttinger, L., Qiu, J. , van der Laan, M., Wiedemann, N., Guiard, B., Pfanner, N., and Becker T. (2014). The presequence pathway is involved in protein sorting to the mitochondrial outer membrane. EMBO Rep. 15, 678-685. doi: 10.1002/embr.201338144

Hönscher, C., Mari, M., Auffarth, K., Bohnert, M., Griffith, J., Geerts, W., van der Laan, M., Cabrera, M., Reggiori, F., Ungermann, C. (2014). Cellular metabolism regulates contact sites between vacuoles and mitochondria. Dev. Cell 30, 86-94. doi: 10.1016/j.devcel.2014.06.006

Highlighted in: Klecker, T., and Westermann, B. (2014). Mitochondria are clamped to vacuoles for lipid transport. Dev. Cell 30, 1-2.

Pfanner, N., van der Laan, M., Amati, P., Capaldi, R.A., Caudy, A.A., Chacinska, A., Darshi, M., Deckers, M., Hoppins, S., Icho, T., Jakobs, S., Ji, J., Kozjak-Pavlovic, V., Meisinger, C., Odgren P.R., Park, S.K., Rehling, P., Reichert, A.S., Sheikh, M.S, Taylor, S.S., Tsuchida, N., van der Bliek, A.M., van der Klei, I.J., Weissman, J.S., Westermann, B., Zha, J., Neupert, W., and Nunnari, J. (2014). Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J. Cell Biol. 204, 1083-1086. doi: 10.1083/jcb.201401006

Gold, V.A., Ieva, R., Walter, A., Pfanner, N., van der Laan, M., and Kühlbrandt, W. (2014). Visualizing active membrane protein complexes by electron cryo-tomography. Nat. Commun. 5, 4129. doi: 10.1038/ncomms5129

2013

Ieva, R., Heißwolf, A.K., Gebert, M., Vögtle, F.N., Wollweber, F., Mehnert, C.S., Oeljeklaus, S., Warscheid, B., Meisinger, C., van der Laan, M.*, and Pfanner, N.* (2013). Mitochondrial inner membrane protease promotes assembly of presequence translocase by removing a carboxy-terminal targeting sequence. Nat. Commun. 4, 2853. (* corresponding authors) doi: 10.1038/ncomms3853

Qiu, J., Wenz, L.S., Zerbes, R.M., Oeljeklaus, S., Bohnert, M., Stroud, D.A., Wirth, C., Ellenrieder, L., Thornton, N., Kutik, S., Wiese, S., Schulze-Specking, A., Zufall, N., Chacinska, A., Guiard, B., Hunte, C., Warscheid, B., van der Laan, M., Pfanner, N., Wiedemann, N., and Becker, T. (2013). Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation. Cell 154, 596-608. doi: 10.1016/j.cell.2013.06.033

van der Laan, M., Zerbes, R.M., and van der Does, C. (2013). Reconstitution of mitochondrial presequence translocase into proteoliposomes. Methods Mol. Biol. 1033, 325-344.doi: 10.1007/978-1-62703-487-6_21

van der Laan, M., Schrempp, S.G., and Pfanner, N. (2013). Voltage-coupled conformational dynamics of mitochondrial protein-import channel. Nat. Struct. Mol. Biol. 20, 915-197. doi: 10.1038/nsmb.2643

Lewrenz, I., Rietzschel, N, Guiard, B., Lill, R., van der Laan, M., and Voos, W. (2013). The functional interaction of mitochondrial Hsp70s with the escort protein Zim17 is critical for Fe/S biogenesis and substrate interaction at the inner membrane preprotein translocase. J. Biol. Chem. 288, 30931-30943. doi: 10.1074/jbc.M113.465997

Schleiff, E., and van der Laan, M. (2013). What comes around goes around: Protein import and quality control in mitochondria and plastids. Biochim. Biophys. Acta 1833, 243-244. doi: 10.1016/j.bbamcr.2012.11.002

Dudek, J., Rehling, P., and van der Laan, M. (2013). Mitochondrial protein import: Common principles and physiological networks. Biochim. Biophys. Acta 1833, 274-285. doi: 10.1016/j.bbamcr.2012.05.028

Böttinger, L., Guiard, B., Oeljeklaus, S., Kulawiak, B., Zufall, N., Wiedemann, N., Warscheid, B., van der Laan, M., and Becker, T. (2013). A complex of Cox4 and mitochondrial Hsp70 plays an important role in the assembly of the cytochrome c oxidase. Mol. Biol. Cell 24, 2609-2619. doi: 10.1091/mbc.E13-02-0106

2012

Bohnert, M., Wenz, L.-S., Zerbes, R.M., Horvath, S.E., Stroud, D.A., von der Malsburg, K., Müller, J.M., Oeljeklaus, S., Perschil, I., Warscheid, B., Chacinska, A., Veenhuis, M., van der Klei, I.J., Wiedemann, N., Becker, T., Pfanner, N., and van der Laan, M. (2012). Role of MINOS in protein biogenesis of the mitochondrial outer membrane. Mol. Biol. Cell 23, 3948-3956. doi: 10.1091/mbc.E12-04-0295

Gebert, M., Schrempp, S.G., Mehnert, C.S., Heißwolf, A.K., Oeljeklaus, S., Ieva, R., Bohnert, M., von der Malsburg, K., Wiese, S., Kleinschroth, T., Hunte, C., Meyer, H.E., Haferkamp, I., Guiard, B., Warscheid, B., Pfanner, N., and van der Laan, M. (2012). Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes. J. Cell Biol. 197, 595-604.  doi: 10.1083/jcb.201110047

Zerbes, R.M., Bohnert, M., Stroud, D.A., von der Malsburg, K., Kram, A., Oeljeklaus, S., Warscheid, B., Becker, T., Wiedemann, N., Veenhuis, M., van der Klei, I.J., Pfanner, N., and van der Laan, M. (2012). Role of MINOS in mitochondrial membrane architecture: Cristae morphology and outer membrane interactions differentially depend on mitofilin domains. J. Mol. Biol. 422, 183-191. doi: 10.1016/j.jmb.2012.05.004

Highlighted in: Gabriel, K. (2012). Connecting the points: revealing the bigger picture. J. Mol. Biol. 422, 181-182.

van der Laan, M., Bhnert, M., Wiedemann, N., and Pfanner, N. (2012). Role of MINOS in mitochondrial membrane architecture and biogenesis. Trends Cell Biol. 22, 185-192. doi: 10.1016/j.tcb.2012.01.004

Stojanovski, D., Bohnert, M., Pfanner, N., and van der Laan. M. (2012). Mechanisms of protein sorting in mitochondria. Cold Spring Harb. Perspect. Biol., doi:10.1101/cshperspect.a011320.

Reinhold, R., Krüger, V., Meinecke, M., Schulz, C., Schmidt, B., Grunau, S.D., Guiard, B., Wiedemann, N., van der Laan, M., Wagner, R., Rehling, P., and Dudek, J. (2012). The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner. Mol. Cell. Biol. 32, 5009-5021. doi: 10.1128/MCB.00843-12

Krüger, V., Deckers, M., Hildenbeutel, M., van der Laan, M., Hellmers, M., Dreker, C., Preuss, M., Herrmann, J.M., Rehling, P., Wagner, R., and Meinecke, M. (2012). The mitochondrial oxidase assembly protein 1 (Oxa1) insertase forms a membrane pore in lipid bilayers. J. Biol. Chem. 287, 33314-33326. doi: 10.1074/jbc.M112.387563

Zerbes, R.M., van der Klei, I.J., Veenhuis, M., Pfanner, N., van der Laan, M., and Bohnert, M. (2012). Mitofilin complexes: Conserved organizers of mitochondrial membrane architecture. Biol. Chem. 393, 1247–1261. doi: 10.1515/hsz-2012-0239

2011

von der Malsburg, K., Müller, J.M., Bohnert, M., Oeljeklaus, S., Kwiatkowska, P., Becker, T., Loniewska-Lwowska, A., Wiese, S., Rao, S., Milenkovic, D., Hutu, D.P., Zerbes, R.M., Schulze-Specking, A., Meyer, H.E., Martinou, J.C., Rospert, S., Rehling, P., Meisinger, C., Veenhuis, M., Warscheid, B., van der Klei, I.J., Pfanner, N., Chacinska, A., and van der Laan, M. (2011). Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev. Cell 21, 694-707. doi: 10.1016/j.devcel.2011.08.026

Highlighted in: Herrmann, J.M. (2011). MINOS is plus: a mitofilin complex for mitochondrial membrane contacts. Dev. Cell 21, 599-600

Gebert, N., Gebert, M., Oeljeklaus, S., von der Malsburg, K., Stroud, D.A., Kulawiak, B., Wirth, C., Zahedi, R.P., Dolezal, P., Wiese, S., Simon, O., Schulze-Specking, A., Truscott, T.N., Sickmann, A., Rehling, P., Guiard, B., Hunte, C., Warscheid, B., van der Laan, M., Pfanner, N., and Wiedemann, N. (2011). Dual role of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membrane. Mol. Cell 44, 811-818. doi: 10.1016/j.molcel.2011.09.025

Stroud, D.A., Oeljeklaus, S., Wiese, S., Bohnert, M., Lewandrowski, U., Sickmann, A., Guiard, B., van der Laan, M., Warscheid, B., and Wiedemann, N. (2011). Composition and topology of the Endoplasmic Reticulum-Mitochondria Encounter Structure. J. Mol. Biol. 413, 743-750. doi: 10.1016/j.jmb.2011.09.012

Kaufenstein, M., van der Laan, M., and Graumann P.L. (2011). The three-layered DNA uptake machinery at the cell pole of competent Bacillus subtilis cells is a stable complex. J. Bacteriol. 193, 1633-1642. doi: 10.1128/JB.01128-10

Qian, X., Gebert, M., Höpker, J., Yan, M., Li, J., Wiedemann, N., van der Laan, M., Pfanner, N., and Sha, B. (2011). Structural basis for the function of Tim50 in the mitochondrial presequence translocase. J. Mol. Biol. 411, 513-519. doi: 10.1016/j.jmb.2011.06.020

2010

Wagner, K., Perschil, I., Fichter, C.D., and van der Laan, M. (2010). Stepwise assembly of dimeric F₁F_o-ATP synthase in mitochondria involves the small F_o-subunits k and i. Mol. Biol. Cell 21, 1494-1504. doi: 10.1091/mbc.E09-12-1023

Bohnert, M., Rehling, P., Guiard, B., Herrmann, J.M., Pfanner, N., and van der Laan, M. (2010). Cooperation of stop-transfer and conservative sorting mechanisms in mitochondrial protein transport. Curr. Biol. 20, 1227-1232. doi: 10.1016/j.cub.2010.05.058

Highlighted in: Webb, C.T., and Lithgow, T. (2010). Mitochondrial biogenesis: sorting mechanisms cooperate in ABC transporter assembly. Curr. Biol. 20, R564-567.

van der Laan, M., Hutu, D.P., and Rehling, P. (2010). On the mechanism of preprotein import by the mitochondrial presequence translocase. Biochim. Biophys. Acta 1803, 732-739. doi: 10.1016/j.bbamcr.2010.01.013

van der Laan, M. (2010). Mitochondrien – Kraftwerke des Lebens. eta green 06/10, 16-18.

Chacinska, A., van der Laan, M., Mehnert, C.S., Guiard, B., Mick, D.U., Hutu, D.P., Truscott, K.N., Wiedemann, N., Meisinger, C., Pfanner, N., and Rehling, P. (2010). Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting. Mol. Cell. Biol. 30, 307-318. doi: 10.1128/MCB.00749-09

2009

Becker, T., Gebert, M., Pfanner, N., and van der Laan, M. (2009). Biogenesis of mitochondrial membrane proteins. Curr. Opin. Cell Biol. 21, 484-493. doi: 10.1016/j.ceb.2009.04.002

Wagner, K., Rehling, P., Sanjuán Szklarz, L.K., Taylor, R.D., Pfanner, N., and van der Laan, M. (2009). Mitochondrial F₁F_o-ATP synthase: the small subunits e and g associate with monomeric complexes to trigger dimerization. J. Mol. Biol. 392, 855-861. doi: 10.1016/j.jmb.2009.07.059

Wiedemann, N., van der Laan, M., and Pfanner, N. (2009). SnapShot: Import and sorting of mitochondrial proteins. Cell 138, 808-808.e1. doi: 10.1016/j.cell.2009.08.004

2008

Hutu, D., Guiard, B., Chacinska, A., Becker, D., Pfanner, N., Rehling, P., and van der Laan, M. (2008). Mitochondrial protein import motor: Differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase. Mol. Biol. Cell 19, 2642-2649. doi: 10.1091/mbc.E07-12-1226

2007

van der Laan, M., Meinecke, M., Dudek, J., Hutu, D.P., Lind, M., Perschil, I., Guiard, B., Wagner, R., Pfanner, N., and Rehling, P. (2007). Motor-free mitochondrial presequence translocase drives membrane integration of preproteins. Nat. Cell Biol. 9, 1152-1159. doi: 10.1038/ncb1635

Wiedemann, N.*, van der Laan, M.*, Hutu, D.P., Rehling, P., and Pfanner, N. (2007). Sorting switch of mitochondrial presequence translocase involves coupling of motor module to respiratory chain.  J. Cell Biol. 179, 1115-1122. (* equal contribution) doi: 10.1083/jcb.200709087

Bohnert, M., Pfanner N., and van der Laan, M. (2007). A dynamic machinery for import of mitochondrial precursor proteins. FEBS Lett. 581, 2802-2810. doi: 10.1016/j.febslet.2007.03.004

Mick, D.U., Wagner, K., van der Laan, M., Frazier A.E., Perschil, I., Pawlas, M., Meyer, H.E., Warscheid, B., and Rehling, P. (2007). Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly. EMBO J. 26, 4347-4358. doi: 10.1038/sj.emboj.7601862

de Keyzer, J., van der Laan, M., and Driessen, A.J. (2007). Membrane protein insertion and secretion in bacteria. Methods Mol. Biol. 390, 17-32.

Reinders, J., Wagner, K., Zahedi, R.P., Stojanovski, D., Eyrich, B, van der Laan, M., Rehling, P., Sickmann, A., Pfanner, N., and Meisinger, C. (2007). Profiling phospho-proteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol. Cell. Proteomics 6, 1896-1906. doi: 10.1074/mcp.M700098-MCP200

2006

van der Laan, M., Wiedemann, N., Mick, D.U., Guiard, B., Rehling, P., and Pfanner, N. (2006). A role for Tim21 in membrane potential-dependent preprotein sorting in mitochondria. Curr. Biol. 16, 2271-2276. doi: 10.1016/j.cub.2006.10.025

Kol, S., Turrell, B.R., de Keyzer, J., van der Laan, M., Nouwen, N., and Driessen, A.J. (2006). YidC mediates membrane insertion of assembly mutants of subunit c of the F₁F₀ ATPase. J. Biol. Chem. 281, 29762-29768. doi: 10.1074/jbc.M605317200

van der Laan, M., Rissler, M. and Rehling, P. (2006). Presequence translocase of the inner mitochondrial membrane – an intricate and highly dynamic molecular machine. FEMS Yeast Res. 6, 849-861. doi: 10.1111/j.1567-1364.2006.00134.x

2005

van der Laan, M., Chacinska, A., Lind, M., Perschil, I., Sickmann, A., Meyer, H.E., Guiard, B., Meisinger, C., Pfanner, N., and Rehling, P. (2005). Pam17 is required for the architecture and translocation activity of the mitochondrial protein import motor. Mol. Cell. Biol. 25, 7449-7458. doi: 10.1128/MCB.25.17.7449-7458.2005

van der Laan, M., Nouwen, N., and Driessen, A.J. (2005). YidC – an evolutionary conserved device for the assembly of energy-transducing membrane protein complexes. Curr. Opin. Microbiol. 8, 182-187. doi: 10.1016/j.mib.2005.02.004

Sanjuàn Szklarz, L.K., Guiard, B., Rissler, M., Wiedemann, N., Kozjak, V., van der Laan, M., Lohaus, C., Markus, K., Meyer, H.E., Chacinskia, A., Pfanner, N., and Meisinger C. (2005). Inactivation of the mitochondrial heat shock protein Zim17 leads to aggregation of matrix Hsp70s followed by pleiotropic effects on morphology and protein biogenesis. J. Mol. Biol. 351, 206-218. doi: 10.1016/j.jmb.2005.05.068

Earlier publications (1999-2004)

van der Laan, M., Bechtluft, P., Kol, S., Nouwen, N., and Driessen, A.J. (2004). F₁F₀ ATP synthase subunit c is a substrate of the novel YidC pathway for membrane protein biogenesis. J. Cell Biol. 165, 213-222. doi: 10.1083/jcb.200402100

van der Laan, M., Nouwen, N., and Driessen, A.J. (2004). SecYEG proteoliposomes catalyze the Dy-dependent membrane insertion of FtsQ. J. Biol. Chem. 279, 1659-1664. doi: 10.1074/jbc.M306527200

van der Laan, M., Urbanus, M.L., Ten Hagen-Jongman, C.M., Nouwen, N., Oudega, B., Harms, N., Driessen, A.J., and Luirink, J. (2003). A conserved function of YidC in the biogenesis of respiratory chain complexes. Proc. Natl. Acad. Sci. USA 100, 5801-5806. doi: 10.1073/pnas.0636761100

van der Does, C., de Keyzer, J., van der Laan, M., and Driessen, A.J. (2003). Reconstitution of purified bacterial preprotein translocase in liposomes. Methods Enzymol. 372, 86-99.

van der Laan, M., Gassel, M., and Altendorf K. (2002). Characterization of amino acid substitutions in KdpA, the K⁺-binding and -translocating subunit of the KdpFABC complex of Escherichia coli. J. Bacteriol. 184, 5491-5494. doi: 10.1128/JB.184.19.5491-5494.2002

Houben, E.N., Urbanus, M.L., van der Laan, M., Ten Hagen-Jongman, C.M., Driessen, A.J., Brunner, J., Oudega, B., and Luirink, J. (2002). YidC and SecY mediate membrane insertion of a Type I transmembrane domain. J. Biol. Chem. 277, 35880-35886. doi: 10.1074/jbc.M205556200

van Dalen, A., van der Laan, M., Driessen, A.J., Killian J.A., and de Kruijff, B. (2002). Components required for membrane assembly of newly synthesized K⁺ channel KcsA. FEBS Lett. 511, 51-58. doi: 10.1016/S0014-5793(01)03278-1

Nouwen, N., van der Laan, M., and Driessen, A.J. (2001). SecDFyajC is not required for the maintenance of the proton motive force. FEBS Lett. 508, 103-106. doi: 10.1016/S0014-5793(01)03033-2

van der Laan, M., Houben, E.N., Nouwen, N., Luirink, J., and Driessen, A.J. (2001). Reconstitution of Sec-dependent membrane protein insertion: nascent FtsQ interacts with YidC in a SecYEG-dependent manner. EMBO Rep. 2, 519-523. doi: 10.1093/embo-reports/kve106

Tjaden, J., Winkler, H.H., Schwöppe, C., van der Laan, M., Möhlmann, T., and Neuhaus, H.E. (1999). Two nucleotide transport proteins in Chlamydia trachomatis, one for net nucleoside triphosphate uptake and the other for transport of energy. J. Bacteriol. 181, 1196-1202.