Publikationen der Arbeitsgruppe Jacob



  1. M.J. Nasim, M.M. Zuraik, A.Y. Abdin, Y. Ney, C. Jacob. Selenomethionine: A Pink Trojan Redox Horse with Implications in Aging and Various Age-Related Diseases. Antioxidants. 10(6):882 (2021). 
  2. A.Y. Abdin, C. Jacob, L. Kästner. The Enigmatic Metallothioneins: A Case of Upward-Looking Research. International Journal of Molecular Sciences. 22 (11), 5984 (2021).
  3. A.Y. Abdin, M.J. Nasim, Y. Ney, C. Jacob.The Pioneering Role of Sci in Post Publication Public Peer Review (P4R). Publications,9, 13 (2021).
  4. A. Kaczor, K. Witek, S. Podlewska, V. Sinou, J. Czekajewska, E. Żesławska, A. Doroz-Płonka, A. Lubelska, G. Latacz, W. Nitek, M. Bischoff, S. Alibert, J-M. Pagès, C. Jacob, E. Karczewska, J-M. Bolla, J. Handzlik. Molecular Insights into an Antibiotic Enhancer Action of New Morpholine-Containing 5-Arylideneimidazolones in the Fight against MDR Bacteria. International Journal of Molecular Sciences.22(4):2062 (2021).
  5. A.K. Darkal, M.M. Zuraik, Y. Ney, M.J. Nasim, C. Jacob . Unleashing the Biological Potential of Fomes fomentarius via Dry and Wet Milling. Antioxidants. 10(2):303 (2021).
  6. T.G. Sad, I. Djafaridze, A. Kalandia, M. Vanidze, K. Smilkov, C. Jacob. Antioxidant Properties of Western Georgia Native Khechechuri Pear. Sci. 1(2), 44 (2021).
  7. K. Khairan, R. Idroes, T. E. Tallei, M. J. Nasim, C. Jacob. Bioactive Compounds from Medicinal Plants and Their Possible Effect as Therapeutic Agents against COVID-19: A Review.  Current Nutrition & Food Science 17: 1 (2021). 


  8. M.A. Marć, A. Kincses, B. Rácz, M.J. Nasim, M. Sarfraz, C. Lázaro-Milla, E. Domínguez-Álvarez E, C. Jacob, G. Spengler, P. Almendros. Antimicrobial, Anticancer and Multidrug-Resistant Reversing Activity of Novel Oxygen-, Sulfur- and Selenoflavones and Bioisosteric Analogues. Pharmaceuticals. 13(12):453 (2020).
  9. A. Al Ghanem, M. J. Nasim, F. Alnahas, Y. Ney, A.V. Weiss, M. Koch, M. Schneider, C. Jacob. Incredible edible selenium nanoparticles produced by food-grade microorganisms. Current Nutraceuticals. 1: 1(2020).
  10. M. Vaso, W. Ali, M. I. Masood, M. J. Nasim, R. Lilischkis, Karl-Herbert Schäfer, M. Schneider, V. T. Papajani, C. Jacob. Nanosizing Nigella: A Cool Alternative to Liberate Biological Activity. Current Nutraceuticals. 1: 1. (2020).
  11. S. O. Azubuike-Osu, I. C. Ohanenye, C. Jacob, C. E.C.C. Ejike, C.C. Udenigwe. Beneficial Role of Vitexin and Isovitexin Flavonoids in the Vascular Endothelium and Cardiovascular System. Current Nutraceuticals. 1:1. (2020).
  12. A.M. Abraham, R.M. Alnemari, C. Jacob, C.M. Keck. PlantCrystals—Nanosized Plant Material for Improved Bioefficacy of Medical Plants. Materials. 13(19):4368 (2020).
  13. D. A. Yassin, M. J. Nasim, A. M. Abraham, C. M. Keck, C. Jacob. Upcycling Culinary Organic Waste: Production of Plant Particles from Potato and Carrot Peels to Improve Antioxidative Capacity. Current Nutraceuticals.1: 1. (2020).
  14. S. Hambardzumyan, N. Sahakyan, M. Petrosyan, M.J. Nasim, C. Jacob, A. Trchounian. Origanum vulgare L. extract-mediated synthesis of silver nanoparticles, their characterization and antibacterial activities. AMB Express. 10(1):162. (2020).
  15. A. Kharma, C. Jacob, Í.A.O. Bozzi, G.A.M. Jardim, A.L. Braga, K. Salomão, C.C. Gatto, M.F.S. Silva, C. Pessoa, M. Stangier, L. Ackermann, E.N. da Silva Júnior. Electrochemical Selenation/Cyclization of Quinones: A Rapid, Green and Efficient Access to Functionalized Trypanocidal and Antitumor Compounds. European. Journal of  Organic Chemistry. 4474-4486. (2020).
  16. P. Yeboah, A.D. Forkuo, O.K.O. Amponsah, N.O. Adomako, A.Y. Abdin, M.J. Nasim, P. Werner, A.B. Panyin, E. Emrich, C. Jacob . Antimalarial Drugs in Ghana: A Case Study on Personal Preferences. Sci. 2(3):49. (2020).
  17. N. Sahakyan, A. Bartoszek, C. Jacob, M. Petrosyan, A. Trchounian. Bioavailability of Tannins and Other Oligomeric Polyphenols: a Still to Be Studied Phenomenon. Current Pharmacology Reports. 6, 131–136 (2020).
  18. W. Ali, G. Spengler, A. Kincses, M. Nové, C. Battistelli, G. Latacz, M. Starek, M. Dąbrowska, E. Honkisz-Orzechowska, A. Romanelli, M. M. Rasile, E. Szymańska, C. Jacob, C. Zwergel, J. Handzlik. Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma. European Journal of Medicinal Chemistry. 200, 112435 (2020).
  19. M. Sarfraz, M.J. Nasim, C. Jacob, Claus; C.H.M. Gruhlke. Efficacy of Allicin against Plant Pathogenic Fungi and Unveiling the Underlying Mode of Action Employing Yeast Based Chemogenetic Profiling Approach. Applied Sciences. 10, 7. (2020).
  20. E.N. da Silva Júnior, R.L. de Carvalho, R.G. Almeida, L.G. Rosa, F. Fantuzzi, T. Rogge, P.M.S. Costa, C. Pessoa, C. Jacob, L. Ackermann. Ruthenium(II)-Catalyzed Double Annulation of Quinones: Step-Economical Access to Valuable Bioactive Compounds. Chemistry. (2020).
  21. A.Y. Abdin, C. Jacob, L. Kästner. Disambiguating "Mechanisms" in Pharmacy: Lessons from Mechanist Philosophy of Science. International Journal of Environmental Research and Public Health. 17(6) (2020).
  22. W. Salman, Y. Ney, M. J. Nasim, T. Bohn, C. Jacob. Turning Apparent Waste into New Value: Up-Cycling Strategies Exemplified by Brewer’s Spent Grains (BSG). Current Nutraceuticals, 1: 6. (2020).
  23. A. Y. Abdin, P. Yeboah, C. Jacob. Chemical Impurities: An Epistemological Riddle with Serious Side Effects International Journal of Environmental Research and Public Health. 17(3): 1030. (2020).


  24. E. Y. Efe, A. Mazumder, J. Lee, A. Gaigneaux, F. Radogna, M. J. Nassim, C. Christov, C. Jacob, K. Kim, D. Mario, P. Chaimbault, C. Cerella, M. Diederich. Les polysulfides anticancéreux induisent l’apoptose des cellules issues de cancers colorectaux par arrêt de la division cellulaire et du flux autophagique. Morphologie, 103(342), 69-70 (2019).
  25. M. Sarfraz, M. J. Nasim, C. Jacob, M. C.H. Gruhlke. Yeast Chemogenetic Screening as a Tool to Unravel the Antifungal Mode of Action of Two Selected Selenocyanates. Appl. Sci.-Basel. (2019).
  26. N. Sahakyan, M. Petrosyan, I. Koss-Mikołajczyk, A. Bartoszek, T. G. Sad, M. J. Nasim, M. Vanidze, A. Kalandia, C. Jacob, A. Trchounian. The Caucasian flora: a still-to-be-discovered rich source of antioxidants. Free Radical Research (2019).
  27.  M. J. Nasim, K. Witek, A. Kincses, A. Y. Abdin, E. Żesławska, M. A. Marć, M. Gajdács, G. Spengler, W. Nitek, G. Latacz, E. Karczewska, K. Kieć-Kononowicz, J. Handzlik, C. Jacob. Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria. New Journal of Chemistry, 43, 6021-6031 (2019).
  28. S.L. Wadgaonkar, Y.V. Nancharaiah, C. Jacob, G. Esposito, P.N.L. Lens. Microbial transformation of Se oxyanions in cultures of Delftia lacustris grown under aerobic conditions. Journal of Microbiology, 57(5):362-371 (2019).
  29. C. Jacob, M. Rittman, F. Vazquez, A:Y.  Abdin. Evolution of Sci's Community-Driven Post-Publication Peer-Review. Sci, 1, 16 (2019).
  30. A. Kharma, M. Grman, A. Misak, E. Domínguez-Álvarez, M.J. Nasim, K. Ondrias, M. Chovanec, C. Jacob. Inorganic Polysulfides and Related Reactive Sulfur–Selenium Species from the Perspective of Chemistry. Molecules, 24, 1359 (2019).
  31. R. Alhasan, M. J. Nasim, C. Jacob, C. Gaucher. Selenoneine: a Unique Reactive Selenium Species From the Blood of Tuna With Implications for Human Diseases. Current Pharmacology Reports, 5: 163 (2019).
  32. K. Khairan,  L.A. Ba, T. Burkholz,M.Leroch, M.Hahn, T. Schwab, M.Klotz, K-H. Schaefer, C. Jacob. Electrochemical Potential-Biological Activity Relationships of Cyclic Sulfur-Containing Molecules Against Steinernema feltiae, Botrytis cinerea, and Neuro 2a Cell Line. Current Pharmacology Reports, 5: 174 (2019).
  33. C.Aloke, I.I.Ezeigbo, I.C. Ohanenye, C.C.Udenigwe, C. Jacob, C.E.C.C. Ejike. A Small Green Red-Ox Carries a Bright Medical Future for Sub-Saharan Africa. Current Pharmacology Reports, 5: 245 (2019).
  34. M.J. Nasim; R. Alhasan, A.Y. Abdin, F. Alnahas; C. Jacob. Inspired by Nature: Redox Modulators and Natural Nanoparticles. Proceedings, 11, 24 (2019).
  35. N.K.Tittikpina, L.  P.Sandjo, F. Nana, V. Vaillant, S. Fontanaya, S. Philippot, Y. M.Dioph, K. Batawila, K. Akpagana, G. Kirsch, R. E. Duval, C. Jacob, P. Chaimbault. Investigation of the antifungal activity of Pterocarpus erinaceus led to the identification of two new diarylpropanoids from its roots. Phytochemistry Letters, 32, 110-114 (2019).
  36. E.N. da Silva Júnior, G.A.M. Jardim, C. Jacob, U. Dhawa, L. Ackermann, S.L. de Castro. Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones. European Journal of Medicinal Chemistry ;179:863-915 (2019).
  37. A.Y. Abdin, D. Auker-Howlett, J. Landes, G. Mulla, C. Jacob, B. Osimani. Reviewing the mechanistic evidence assessors E-Synthesis and EBM+: A case study of amoxicillin and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). Current Pharmaceutical Design, 25(16):1866-1880 (2019).
  38. A. Kharma, A. Misak, M. Grman, V. Brezova, L. Kurakova, P. Baráth,  C. Jacob, M. Chovanec, K. Ondrias,  E. Domínguez-Álvarez. Release of reactive selenium species from phthalic selenoanhydride in the presence of hydrogen sulfide and glutathione with implications for cancer research. New Journal of Chemistry, 43, 11771-11783 (2019).
  39. D. Kołodziejski, I. Koss-Mikołajczyk, A.Y. Abdin, C. Jacob, A. Bartoszek. Chemical aspects of biological activity of isothiocyanates and indoles, the products of glucosinolate decomposition. Current Pharmaceutical Design, 25(15):1717-1728 (2019).
  40. R. Alhasan, A. Kharma, P. Leroy, C. Jacob, C. Gaucher. Selenium donors at the junction of inflammatory diseases. Current Pharmaceutical Design, 25(15):1707-1716 (2019).
  41. N.E.B. Saidu, N. Kavian, K. Leroy, C. Jacob , C. Nicco, F. Batteux, J. Alexandre. Dimethyl fumarate, a two-edged drug: Current status and future directions. Medicinal Research Reviews; 39(5):1923-1952 (2019).
  42.  N. Hamdi, S. Chaouch, I. da Silva, M. Ezahri, M. Lachkar, R. Alhasan, A. Y. Abdin, C. Jacob, B. El Bali. Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (C4N2H14)Co(H2PO3)4·2H2O. Sci, 1(1), 13 (2019).
  43.  J. A. Tur, C. Jacob, P. Chaimbault, M. Tadayyon, E. Richling, N. Hermans, C. N. dos Santos, M. Diederich, L. Giblin, M. Elhabiri, C. Gaucher, P. Andreoletti, A. Fernandes, M. Davies, A. Bartoszek, M. Cherkaoui-Malki. Personalized nutrition in ageing society: redox control of major-age related diseases through the NutRedOx Network (COST Action CA16112). Free Radical Research, 53(sup1):1163-1170 (2019).
  44. G. G. Dias, T. A. do Nascimento,  A. K. A. de Almeida, A. C. S. Bombaça, R. F. S. Menna‐Barreto, C. Jacob, S. Warratz, E.N. da Silva Júnior, L. Ackermann, Ruthenium(II)-Catalyzed C-H Alkenylation of Quinones: Diversity-Oriented Strategy for Trypanocidal Compounds. European Journal of Organic Chemistry,2019(13), 2344-2353 (2019).


  45. R. Alhasan, A. Kharma, M. J. Nasim, A. Y. Abdin, J. Bonetti, P. Giummelli, C. E.C.C. Ejike, P. Leroy, C. Gaucher, C. Jacob, Flush with a flash: Natural three-component antimicrobial combinations based on S-nitrosothiols, controlled superoxide formation and “domino” reactions leading to peroxynitrite. Medicinal. Chemistry. Communications, 9(12), 1994-1999 (2018).
  46. G.G. Dias, T. Rogge , R. Kuniyil, C. Jacob, R.F.S. Menna-Barreto, E.N. da Silva Júnior, L. Ackermann, Ruthenium-catalyzed C-H oxygenation of quinones by weak O-coordination for potent trypanocidal agents. Chemistry Communications, 13;54(91):12840-12843 (2018).
  47. R. Kurczab, W. Ali, D. Łażewska, M. Kotańska, M. Jastrzębska-Więsek, G. Satała, M. Więcek, A. Lubelska, G. Latacz, A. Partyka, M. Starek, M. Dąbrowska, A. Wesołowska, C. Jacob, KI. Kieć-Kononowicz , J .Handzlik, Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT₆ Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo. Molecules, 23(10), 2529 (2018).
  48.  M. J. Nasim, P. Denezhkin, M. Sarfraz, R. Leontiev, Y. Ney, A. Kharma, S. Griffin, M. I. Masood, C. Jacob, The Small Matter of a Red Ox, a Particularly Sensitive Pink Cat, and the Quest for the Yellow Stone of Wisdom. Current. Pharmacology. Reports, 4:380–396 (2018).
  49.  K. Khairan, J. Vincent, C. Jacob, Study Cytotoxicity of Haarlem Oil by Crystal Violet Staining Assay. Research Journal of Chemistry and Environment, 22, 198-202 (2018).
  50. S. Shaaban, D. Vervandier-Fasseur,P. Andreoletti, A. Zarrouk, P. Richard, A. Negm, G. Manolikakes, ,C. Jacob, M. Cherkaoui-Malki, Cytoprotective and antioxidant properties of organic selenides for the myelin-forming cells, oligodendrocytes. Bioorganic Chemistry, 80, 43-56 (2018).
  51. Y. Ney, M. J. Nasim, A. Kharma, L. A. Youssef, C. Jacob,  Small Molecule Catalysts with Therapeutic Potential. Molecules;23(4), 765 (2018). 
  52. R. Leontiev, N. Hohaus, C. Jacob, M. C. H. Gruhlke,  A. J. Slusarenko, A Comparison of the Antibacterial and Antifungal Activities of Thiosulfinate Analogues of Allicin. Scientific Reports, 8, 6763 (2018).
  53. S. Griffin, M. Sarfraz, S. F. Hartmann, S. R. Pinnapireddy, M. J. Nasim, U. Bakowsky, M. C. M. Keck, C. Jacob, Resuspendable Powders of Lyophilized Chalcogen Particles with Activity against Microorganisms. Antioxidants;7(2), 23 (2018).
  54. M. Sarfraz, S. Griffin, T. G. Sad, R. Alhasan, M. J. Nasim, M. I. Masood, K. H. Schäfer, C. E.C.C. Ejike, C. M. Keck ,C. Jacob, A. P. Ebokaiwe,  Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Into antimicrobial Materials. Antioxidants; 7(4), 60 (2018).
  55. S. Griffin, M. Sarfraz, V. Farida, M: J. Nasim, A. P. Ebokaiwe,C. M. Keck, C. Jacob,  No time to waste organic waste: Nanosizing converts remains of food processing into refined materials, J Environ Manage, 210, 114-121 (2018).
  56. G. A .M. Jardim, E. H. G. da Cruz, W. O. Valença, D. J. B. Lima, B. C. Cavalcanti, C. Pessoa, J. Rafique, A. L. Braga, C. Jacob, E. N. da Silva Júnior.  Synthesis of Selenium-Quinone Hybrid Compounds with Potential Antitumor Activity via Rh-Catalyzed C-H Bond Activation and Click Reactions. Molecules. ;23(1) (2018).
  57. S. Griffin, M. I. Masood , M. J. Nasim, M. Sarfraz, A. P.  Ebokaiwe, K-H. Schäfer, C. M. Keck, C. Jacob, Natural Nanoparticles: A Particular Matter Inspired by Nature. Antioxidants.;7(1) (2018).
  58. M. J. Nasim, W. Ali, ,E. Dominguez-Álvarez, E. N. da Silva Júnior, R. S. Z. Saleem, C. Jacob. Reactive Selenium Species: Redox Modulation, Antioxidant, Antimicrobial and Anticancer Activities. In book:  Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments. Royal Society of Chemistry, 277-302  (2018).
  59. N.K. Tittikpina, F. Nana, S. Fontanay, S. Philippot, K. Batawila, K. Akpagana, G. Kirsch, P. Chaimbault, C. Jacob, R.E. Duval, Antibacterial activity and cytotoxicity of Pterocarpus erinaceus Poir extracts, fractions and isolated compounds. J Ethnopharmacol.212, 200-207 (2018).


  60. K. Witek, M. J. Nasim, M. Bischoff, R. Gaupp, P. Arsenyan, J. Vasiljeva, M. A. Marć , A. Olejarz, G. Latacz, K. Kieć-Kononowicz, J. Handzlik, C.  Jacob, Selenazolinium Salts as "Small Molecule Catalysts" with High Potency against ESKAPE Bacterial Pathogens. Molecules.;22(12) (2017)
  61. E. Y. Efe A. Mazumder, J. Lee,  A. Gaigneaux F. Radogna, M. J. Nasim, Christo Christov , Claus Jacob, K. Kim, M. Dicato, P. Chaimbault, C. Cerella, M. Diederich. Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal cancer. Cancer Letters, 410, 139-157 (2017).
  62. N. Koko Tittikpina, F. Nana, S. Fontanay, S. Philippot, K. Batawila, K. Akpagana, G. Kirsch, P. Chaimbault, C. Jacob, R. Emmanuel Duval, Antibacterial activity and cytotoxicity of Pterocarpus erinaceus Poir extracts, fractions and isolated compounds, Journal of Ethnopharmacology, (2017).
  63. N. K. Tittikpina, W. Atakpama, H. Pereki, M. J. Nasim, W. Ali, S. Fontanay, F. Nana, C. E. C. C.  Ejike, G. Kirsch, R. E. Duval, P. Chaimbault, S. D. Karou, K. Batawila, K. Akpagana, C. Jacob ‘Capiture’ plants with interesting biological activities: a case to go. Open chemistry, 15, 1-11 (2017).
  64. E. Jabeen, N. K. Janjua,  S. Ahmed, E. Domínguez-Álvarez, C. Jacob. A selective and sensitive monitoring of the OH radical using flavonoid-modified electrodes. Electrochimica Acta,  258 (20) , 228-235 ( 2017).
  65. F. Albrecht, R. Leontiev, C. Jacob, A.J. Slusarenko, An Optimized Facile Procedure to Synthesize and Purify Allicin, Molecules, 22, (2017).
  66. E.C. Estevam, S. Griffin, M.J. Nasim, P. Denezhkin, R. Schneider, R. Lilischkis, E. Dominguez-Alvarez, K. Witek, G. Latacz, C. Keck, K.H. Schafer, K. Kie-Kononowicz, J. Handzlik, C. Jacob, Natural selenium particles from Staphylococcus carnosus: Hazards or particles with particular promise?, Journal of Hazardous Materials, 324,  22-30, (2017).
  67. W.O. Valenca, T.V. Baiju, F.G. Brito, M.H. Araujo, C. Pessoa, B.C. Cavalcanti, C.A. de Simone, C. Jacob, I.N.N. Namboothiri, E.N. da Silva, Synthesis of Quinone-Based N-Sulfonyl-1,2,3-triazoles: Chemical Reactivity of Rh(II) Azavinyl Carbenes and Antitumor Activity, Chemistry select, 2 4301-4308, (2017).
  68. S. Griffin, R. Alkhayer, S. Mirzoyan, A. Turabyan, P. Zucca, M. Sarfraz, M. J. Nasim, A. Trchounian, A. Rescigno, C. M. Keck, C. Jacob, Nanosizing Cynomorium: Thumbs up for Potential Antifungal Applications. Inventions, 2(3), 24 1-10, (2017).
  69. G.I. Giles, M.J. Nasim, W. Ali, C. Jacob, The Reactive Sulfur Species Concept: 15 Years On. Antioxidants, 6(2):38, 1-29, (2017).
  70. J. Rendeková, D. Vlasáková, P. Arsenyan, J. Vasiljeva, M. J. Nasim, K. Witek, E. Domínguez-Álvarez, E. Żesławska, D. Mániková, W. Tejchman, R. S. Z. Saleem, K. Rory, J. Handzlik, M. Chovanec, The Selenium-Nitrogen Bond as Basis for Reactive Selenium Species with Pronounced Antimicrobial Activity, Current Organic Synthesis, 14, (2017).
  71. M. Grman, M. J. Nasim, R. Leontiev, A. Misak, V. Jakusova, K. Ondrias, C. Jacob, Inorganic Reactive Sulfur-Nitrogen Species: Intricate Release Mechanisms or Cacophony in Yellow, Blue and Red?, Antioxidants, 6(1), (2017).
  72. L. Faulstich, S. Griffin, M.J. Nasim, M.I. Masood, W. Ali, S. Alhamound, Y. Omran, H. Kim, A. Kharma, K.H. Schaefer, R. Lilischkis, M. Montenarh, C. Keck, C. Jacob, Nature's Hat-trick: Can we use sulfur springs as ecological source for materials with agricultural and medical applications?, International . Biodeterioration and  Biodegradation, 119, 678-686, (2017).
  73. C. Zwergel, B. Czepukojc, E. Evain-Bana, Z. Xu, G. Stazi, M. Mori,  A. Patsilinakos, A. Mai, B. Botta, R. Ragno, D. Bagrel, G. Kirsch , P. Meiser, C. Jacob,  M. Montenarh,  S. Valente, Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells, European Journal of  Medicinal. Chemistry, 134, 316-333,  ( 2017).


  74. S. Griffin, N. K. Tittikpina, A. Al-marby, R. Alkhayer, P. Denezhkin, K. Witek K. A. Gbogbo, K. Batawila, R. E. Duval, M. J. Nasim, N. A. Awadh-Ali, G. Kirsch, P. Chaimbault, K-H. Schäfer, C. M. Keck, J. Handzlik, C. Jacob,  Turning Waste into Value: Nanosized Natural Plant Materials of Solanum incanum L. and Pterocarpus erinaceus Poir with Promising Antimicrobial Activities, Pharmaceutics, 8(2): 11, (2016).
  75. E. C. Estevam, L. Faulstich, S. Griffin, T. Burkholz, C. Jacob. Polysulfides in Biology: From Intricate Chemistry to an Astonishing Yet Hidden Biological Activity.  Current Organic Chemistry, 20(2) : 211 – 217, (2016).
  76. E. Domínguez-Álvarez, M. Gajdács, G. Spengler, J.A. Palop, M.A. Marć,  K. Kieć-Kononowicz,  L. Amaral, J. Molnár, C. Jacob, J. Handzlik, C. Sanmartín, Identification of selenocompounds with promising properties to reverse cancer multidrug resistance, Bioorganic and Medicinal Chemistry Letters 26(12):2821-4, (2016).
  77. O. Talhi, L. Brodziak-Jarosz, J. Panning, B. Orlikova, C. Zwergel, T. Tzanova, S. Philippot, D.C. G. A. Pinto, F. A. A. Paz, C. Gerhäuser, T. P. Dick, C. Jacob, M. Diederich, D. Bagrel, G. Kirsch, A. M. S. Silva, One-Pot Synthesis of Benzopyran-4-ones with Cancer Preventive and Therapeutic Potential. European Journal of  Organic Chemistry, 5, 965–975, (2016).
  78. A. Al-Marby, C.E.C.C. Ejike, M.J. Nasim, N.A. Awadh-Ali, R.A. Al-badani, G.M.A. Alghamdi , C. Jacob, Nematicidal and antimicrobial activities of methanol extracts of 17 plants, of importance in ethnopharmacology, obtained from the Arabian Peninsula, Journal of  Intercultural  Ethnopharmacology, 5(1): 1-6, (2016).
  79. N.K. Tittikpina, C.E.C.C. Ejike, E. Castelluci Estevam, M.J. Nasim, S. Griffin, P. Chaimbault, G. Kirsch, W. Atakpama, K. Batawila, C. Jacob, Togo to go: Products and compounds derived from local plants for the treatment of diseases endemic in sub-Saharan Africa, African Journal of Traditional Complementary and  Alternative Medicine, 13(1):85-94, (2016).


  80. E. Castellucci Estevam, S. Griffin, M.J. Nasim, D. Zieliński, J. Aszyk, M. Osowicka, N. Dawidowska, R. Idroes, A. Bartoszek, C. Jacob, Inspired by Nature: The Use of Plant-derived Substrate/Enzyme Combinations to Generate Antimicrobial Activity in situ, Natural Product Communication, 10(10), 1733-1738, (2015).
  81. D. Rezk Allah, L. Schwind, I. Abu Asali, J. Nasim, C. Jacob, C. Götz, M. Montenarh, A scent of therapy: Synthetic polysulfanes with improved physico-chemical properties induce apoptosis in human cancer cells, International  Journal of  Oncology, 47 (3), 991-1000, (2015).
  82. C. Zwergel, S. Valente, C. Jacob, A. Mai, Emerging approaches for histone deacetylase inhibitor drug discovery, Expert Opinion on Drug Discovery, 10 (6), (2015).
  83. M. Grman, E. Ondriasova, J. Nasim, C. Jacob, K. Ondrias, Decomposition of S-nitrosoglutathione by interaction with organic polysulfides and reduced thiols, Nitric Oxide, 47, (2015).
  84. E. Castellucci Estevam , K. Witek , L. Faulstich , M.J. Nasim , G. Latacz  , E. Domínguez-Álvarez  , K. Kieć-Kononowicz , M. Demasi , J. Handzlik, C. Jacob, Aspects of a Distinct Cytotoxicity of Selenium Salts and Organic Selenides in Living Cells with Possible Implications for Drug Design, Molecules, 20, 13894-13912, (2015).
  85. A.K.K. Bhasin, C. Jacob, F. Sasse, K. Karaghiosoff , K.K. Bhasin, S.K. Mehta, Alka Sharma, Rishu, Design, synthesis and characterization of picoline based organoselenium compounds, 1,2-bis(pyridine-2/3/4-yl)methyl diselanes: X-ray crystal structure of 1,2-bis(pyridine-3-y1) methyldiselane, Journal of Organometallic Chemistry, 785, 19-25, (2015).


  86. E. Domínguez, D. Plano, M. Font, A. Calvo, C. Prior, C. Jacob, J.A. Palop, C. Sanmartín, Synthesis and antiproliferative activity of novel selenoester derivative, European Journal of Medicinal Chemistry, 73, 153-166 (2014).
  87. O. Talhi, M. Schnekenburger, J. Panning, D.G.C. Pinto, J.A. Fernandes, F.A. Almeida Paz, C. Jacob, M. Diederich, A.M.S. Silva, Bis(4-hydroxy-2H-chromen-2-one): Synthesis and effects on leukemic cell lines proliferation and NF-jB regulation, Bioorganic & Medicinal Chemistry, 22, 3008–3015 (2014).
  88. A. Nucci, F.M. Merlo, M. De Nisco, S. Pedatella, F. Rossi, C. Jacob, R. Caputo, A. Mastino, Se-(2-aminoalkyl)selenocysteines as biochemical redox agents. A tool to contrast cell injury induced by aflatoxin B1 in HepG2 cells, Amino Acids, 46(2), 459-470 (2014).
  89. B. Czepukojc, A.K. Baltes, M. Kelkel, C. Cerella, U.M. Viswanathan, F. Salm, T. Burkholz, C. Schneider, M. Montenarh, M. Diederich, C. Jacob, Towards pharmaceutically useful, redox-modulating polysulfanes based on naturally occurring garlic compounds, Food and Chemical Toxicology, 64, 249–257 (2014).
  90. P. Du, U.M. Viswanathan, K. Khairan, T. Buric, N.E.B. Saidu, Z. Xu, B. Hanf, I. Bazukyan, A. Trchounian, F. Hannemann, I. Bernhardt, T. Burkholz, B. Diesel, A.K. Kiemer, K.-H. Schaefer, M. Montenarh, G. Kirsch, C. Jacob, Synthesis of amphiphilic, chalcogen-based redox modulators with in vitro cytotoxic activity against cancer cells, macrophages and microbes, Med.Chem.Comm., 5, 25-31 (2014).
  91. P. Du, U.M. Viswanathan, Z. Xu, H. Ebrahimnejad, B. Hanf, T. Burkholz, M. Schneider, I. Bernhardt, G. Kirsch, M. Montenarh, C. Jacob, Synthesis and biological activity of amphiphilic seleninic acid derivatives with considerable activity against membranes, cancer cells and certain pathogenic microbes, Journal of Hazardous Materials, 269, 74–82 (2014).
  92. P. Du, N.E:B. Saidu, J. Intemann, C. Jacob, M. Montenarh, A new tellurium-containing amphiphilic molecule induces apoptosis in HCT116 colon cancer cells, Biochim Biophys Acta, 1840(6), 1808-16 (2014).
  93. T. Burkholz, M. Egert, C. Jacob, Elektrochemische Dekontamination von leitenden Oberflächen: Von grundlegenden Ideen zu neuen Ansätzen, WOMAG Oberflächen, Ausgabe 6/2014.
  94. O. Talhi, M. Schnekenburger, J. Panning, D.G.C. Pinto, J.A. Fernandes, F.A. Almeida Paz, C. Jacob, M. Diederich, A.M.S. Silva, Bis(4-hydroxy-2H-chromen-2-one): Synthesis and effects on leukemic cell lines proliferation and NF-κB regulation, Bioorganic & Medicinal Chemistry, 22 (11), 3008–3015 (2014).
  95. V. Jamier, W. Marut, S. Valente, C. Chéreau, S. Chouzenoux, C. Nicco, H. Lemaréchal, B. Weill, G. Kirsch, C. Jacob, F. Batteux, Chalcone-Coumarin Derivatives as Potential Anti-Cancer Drugs: An in vitro and in vivo Investigation, Anti-Cancer Agents in Medicinal Chemistry, 14(7), 963-74 (2014).
  96. D. Mániková, L.M. Letavayová, D. Vlasáková, P. Košík, E. Castellucci Estevam, M.J. Nasim, M. Gruhlke, A. Slusarenko, T. Burkholz, C. Jacob, M. Chovanec, Intracellular Diagnostics: Hunting for the Mode of Action of Redox-Modulating Selenium Compounds in Selected Model Systems, Molecules, 19(8), 12258-12279 (2014).
  97. C. Jacob, Special Issue: Redox Active Natural Products and Their Interaction with Cellular Signalling Pathways, Molecules, 19, 19588-19593 (2014).
  98. L.-O. Klotz, X. Hou, C. Jacob, 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling, Molecules, 19, 14902-14918 (2014).
  99. S. Shaaban, F. Sasse, T. Burkholz, C. Jacob, Sulfur, selenium and tellurium pseudopeptides: Synthesis and biological evaluation, Bioorganic & Medicinal Chemistry, 22, 3610–3619 (2014).
  100. C. Jacob, G. Kirsch, A. Slusarenko, P.G. Winyard, T. Burkholz (eds.), Recent Advances in Redox Active Plant and Microbial Products: From basic chemistry to widespread applications in Medicine and Agriculture, Springer Science, ISBN: 978-9401789523 (2015).
  101. T. Burkholz, C. Jacob, A word on redox activity, in: C. Jacob, G. Kirsch, A. Slusarenko, P.G. Winyard, T. Burkholz (eds.), Recent Advances in Redox Active Plant and Microbial Products: From basic chemistry to widespread applications in Medicine and Agriculture, Springer Science (2015).
  102. H. Ebrahimnejad, T. Burkholz, C. Jacob, Treasures along the oligomeric road from flavonoids to polyphenols and tannins, in: C. Jacob, G. Kirsch, A. Slusarenko, P.G. Winyard, T. Burkholz (eds.), Recent Advances in Redox Active Plant and Microbial Products: From basic chemistry to widespread applications in Medicine and Agriculture, Springer Science (2015).
  103. L.S. Sargsyan, K.R. Grigoryan, T. Burkholz, S.A. Markarian, C. Jacob, Fluorescence characterisation of human haemoglobin binding binding with tannic acid, Chemical Journal of Armenia, 67(2-3), 181-187 (2014).
  104. C. Jacob, L. Faulstich, M.J Nasim, T. Burkholz, Von der Natur inspiriert: Redox-aktive Nahrungsbestandteile (Metabolite) mit vielseitigen Anwendungen in der Medizin und Landwirtschaft, Magazin Forschung, Ausgabe 2/2014 (2014).


  105. W. Marut, V. Jamier, N. Kavian, A. Servettaz, P. Winyard, P. Eggleton, A. Anwar, C. Nicco, C. Jacob, C. Chéreau, B. Weill, F. Batteux, The Natural Organosulfur compound Dipropyltetrasulfide Prevents HOCl-Induced Systemic Sclerosis in the Mouse, Arthritis Research & Therapy, 15. 167 (2013).
  106. L. Dejon, H. Mohammed, P. Du, C. Jacob, A. Speicher, Synthesis of tetrahydrochromenoindole derivatives from Robinia pseudoacacia, Med. Chem. Commun., (2013), DOI: 10.1039/C3MD00213F.
  107. B. Czepukojc, M. Leroch, F. Salm, U.M. Viswanathan, T. Burkholz, M. Hahn, C. Jacob, Antifungal activity of tetrasulfanes against Botrytis cinerea, Natural Product Communications, 8(11), 1599-1603 (2013).
  108. N.E.B. Saidu, I.A. Asali, B. Czepukojc, B. Seitz, C. Jacob, M. Montenarh, Comparison between the effects of diallyl tetrasulfide on human retina pigment epithelial cells (ARPE-19) and HCT116 cells, Biochimica et Biophysica Acta, 1830(11), 5267-5276 (2013).
  109. Y. Yu, B. Czepukojc, C. Jacob, Y. Jiang, M. Zeller, C. Brückner, J.-L. Zhang, Porphothionolactones: Synthesis, structure, physical, and chemical properties of a chemodosimeter for hypochlorite, Organic & Biomolecular Chemistry, 11(28), 4613-21 (2013).
  110. T. Burkholz, C. Jacob, Tellurium in Nature, in: R.H. Kretsinger, V.N. Uversky, E.A. Permyakov, (eds.), Encyclopaedia of Metalloproteins, 2163-2174 (2013).
  111. M. Grman, A. Misak, C. Jacob, Z. Tomaskova, A. Bertova, T. Burkholz, P. Docolomansky, L. Habala, K. Ondrias, Low molecular thiols, pH and O2 modulate H2S induced NO release from S-nitrosoglutathione, General Physiology and Biophysics, 32, 429–441 (2013).
  112. B. Czepukojc, U.M. Viswanathan, A. Raza, S. Ali, T. Burkholz, C Jacob, Tetrasulfanes as Selective Modulators of the Cellular Thiolstat, Phosphorus, Sulfur, and Silicon and the related elements, 188(4), 446-453 (2013).
  113. S. Valente, Z. Xu, E. Bana, C. Zwergel, A. Mai, C. Jacob, P. Meiser, D. Bagrel, A.M.S. Silva, G. Kirsch, Reactivity of 4-Vinyl-2H-1-benzopyran-2-ones in Diels–Alder Cycloaddition Reactions: Access to Coumarin-Based Polycycles with Cdc25 Phosphatase-Inhibiting Activity, European Journal of Organic Chemistry, DOI: 10.1002/ejoc.201201736 (2013).
  114. U.M. Viswanathan, T. Burkholz and C. Jacob, Electrochemistry at the edge of reason: Chalcogen-based redox systems in biochemistry and drug design, Zeitschrift für Physikalische Chemie, 227(5), 691-706(2013).
  115. E. Domínguez Álvarez, U.M. Viswanathan, T. Burkholz, K. Khairan, C. Jacob, Bio-Electrochemistry and Chalcogens, Chapter 7, in M. Schlesinger (ed.), Applications of Electrochemistry in Medicine, Modern Aspects of Electrochemistry, 56, 249-282 (2013).
  116. N.E.B. Saidu, R. Touma, I.A. Asali, C. Jacob, M. Montenarh, Diallyl tetrasulfane activates both the eIF2α and Nrf2/HO-1 pathways, Biochimica et Biophysica Acta, 1830, 2214–2225 (2013).
  117. P. Du, U.M. Viswanathan, Z. Xu, H. Ebrahimnejad, B. Hanf, T. Burkholz, M. Schneider, I. Bernhardt, G. Kirsch, M. Montenarh, C. Jacob, Emerging Biological Applications of Chalcogens: Amphiphilic Selenic Acids with Multiple Impact on Living Cells. in E.R. Rene, P. Kijjanapanich, P.N.L. Lens (eds.), Proceedings of the 3rd International Conference on Research Frontiers in Chalcogen Cycle Science & Technology, Delft, The Netherlands, May 27-28, 59-68 (2013).
  118. A.K.K. Bhasin, E. Arora, B. Hinkelmann, F. Sasse, A. Raja, Y. Muthukumar, K.K. Bhasin, S.K. Mehta, T. Burkholz, C. Jacob, Synthesis, Structural Elucidation and Anticarcinogenic Potential of a New Selenium-incorporated Tricyclic Quinoline. in E.R. Rene, P. Kijjanapanich, P.N.L. Lens (eds.), Proceedings of the 3rd International Conference on Research Frontiers in Chalcogen Cycle Science & Technology, Delft, The Netherlands, May 27-28, 3-10 (2013).
  119. C. Jacob, T. Burkholz, Emerging biological applications of chalcogens: From the trivial to the more exotic. in E.R. Rene, P. Kijjanapanich, P.N.L. Lens (eds.), Abstract book from the 3rd International Conference on Research Frontiers in Chalcogen Cycle Science & Technology, Delft, The Netherlands, May 27-28, 37-38 (2013).
  120. A.K.K. Bhasin, F. Sasse, C. Jacob, E. Arora, S.K. Mehta, K.K. Bhasin, Design, synthesis and characterisation of novel quinolone-based selenium compounds: X-ray structure of 3H-[1,2]diselenolo[3,4b]quinoline. in E.R. Rene, P. Kijjanapanich, P.N.L. Lens (eds.), Abstract book from the 3rd International Conference on Research Frontiers in Chalcogen Cycle Science & Technology, Delft, The Netherlands, May 27-28, 37-38 (2013).
  121. K.K. Bhasin, Ekta Arora, Alka S. Grover, Jyoti, H. Singh, S.K. Mehta, A.K.K. Bhasin, C. Jacob, Synthesis and characterization of new 2-pyrimidyl chalcogen (S, Se, Te) compounds: X-ray crystal structure of bis(4,6-dimethyl-2-pyrimidyl)diselenide and 4,6-dimethyl-2-(phenylselanyl)pyrimidine, Journal of Organometallic Chemistry, 732, 137-141 (2013).


  122. M. Doering, B. Diesel, M.C.H. Gruhlke, U.M. Viswanathan, T. Burkholz, A. Slusarenko, A.K. Kiemer and C. Jacob, Selenium- and Tellurium-Containing Redox Modulators with Distinct Activity against Macrophages: Possible Implications for the Treatment of Inflammatory Diseases, Tetrahedron, 68, 10577-10585 (2012).
  123. S. Shaaban, R. Diestel, B. Hinkelmann, Y. Muthukumar, R.P. Verma, F. Sasse, C. Jacob, Novel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents, European Journal of Medicinal Chemistry, 58, 192-205 (2012).
  124. T. Schneider, Y. Muthukumar, B. Hinkelmann, R. Franke, M. Döring, C. Jacob, F. Sasse, Deciphering intracellular targets of organochalcogen based redox catalysts, Med. Chem. Commun., 3, 784 (2012).
  125. B. Czepukojc, T. Schneider, T. Burkholz, V. Jamier, C. Jacob, Natural Sulfur Products as Redox Modulators and Selective Inducers of Cell Death, in M. Diederich, K. Noworyta (eds.), Natural compounds as inducers of cell death: 1, Springer Science, 293-327 (2012).
  126. M. Kelkel, C. Cerella, F. Mack, T. Schneider, C. Jacob, M. Schumacher, M. Dicato, M. Diederich, ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis, Carcinogenesis, 33(11), 2162–2171 (2012).
  127. W. Marut, N. Kavian, A. Servettaz, C. Nicco, L.A. Ba, M. Doering, C. Chereau, C. Jacob, B. Weill, F. Batteux, The Organotelluride Catalyst (PHTE)(2)NQ Prevents HOCl-Induced Systemic Sclerosis in Mouse, Journal of Investigative Dermatology, 132, 1125-1132 (2012).
  128. L.A. Ba, T. Burkholz, T. Schneider, C. Jacob, The Role of Cysteine in Amino Acids, Peptides and Proteins in Organic Chemistry, in A.B. Hughes (ed.), Amino Acids, Peptides and Proteins in Organic Chemistry: Analysis and Function of Amino Acids and Peptides, 5, Wiley-VCH (2012).
  129. C. Jacob, E. Battaglia, T. Burkholz, D. Peng, D. Bagrel, M. Montenarh, Control of oxidative posttranslational cysteine modifications: from intricate chemistry to widespread biological and medical applications, Chemical Research in Toxicology, 25, 588-604 (2012).
  130. Z. Xu, P. Du, P. Meiser and C. Jacob, Proanthocyanidins: Oligomeric Structures with Unique Biochemical Properties and Great Therapeutic Promise, Natural Product Communications, 7(3), 381-388 (2012).
  131. N. Arshad, N.K. Janjua, A.Y. Khan, A. Yaqub, T. Burkholz, C. Jacob, Natural Flavonoids Interact with Dinitrobenzene System in Aprotic Media: An Electrochemical Probing, Natural Product Communications, 7(3), 311-315 (2012).
  132. P.K. Agrawal, T. Burkholz and C. Jacob, Revisit to 25R/25S Stereochemical Analysis of Spirostane-type Steroidal Sapogenins and Steroidal Saponins via 1H NMR Chemical Shift Data, Natural Product Communications, 7(6), 709-711 (2012).


  133. C. Jacob, Redox signalling via the cellular thiolstat, Biochemical Society Transactions, 39(5):1247-53 (2011).
  134. R. Coriat, W. Marut, M. Leconte, L.A. Ba, A. Vienne, C. Chéreau, J. Alexandre, B. Weill, M. Doering, C. Jacob, C. Nicco, F. Batteux, The organotelluride catalyst LAB027 prevents colon cancer growth in the mice, Cell Death and Disease, 2, 191 (2011).
  135. C. Jacob, V. Jamier and L.A. Ba, Redox Active Secondary Metabolites, Current Opinion in Chemical Biology, 15, 149-155 (2011).
  136. N. Lilienthal, C. Prinz, A.A. Peer-Zada, M. Doering, L.A. Ba, M. Hallek, C. Jacob, M. Herling, Targeting the disturbed redox equilibrium in chronic lymphocytic leukemia by novel reactive oxygen species-catalytic ‘sensor/effector’ compounds, Leukemia & Lymphoma, 52(7), 1407–1411 (2011).
  137. H.A. Mohammed, L.A. Ba, T. Burkholz, E. Schumann, B. Diesel, J. Zapp, A.K. Kiemer, C. Ries, R.W. Hartmann, M. Hosny and C. Jacob, Facile Synthesis of Chrysin-derivatives with Promising Activities as Aromatase Inhibitors, Natural Product Communications, 6(1), 31-34 (2011).
  138. E. Viry, A.Anwar, G. Kirsch, C.Jacob, M. Diederich, D. Bagrel, Antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatases, International Journal of Oncology, 38(4), 1103-1111 (2011).
  139. T. Schneider, A. Baldauf, L.A. Ba, V. Jamier, K. Yusuf, M.-B. Sarakbi, N. Reum, M. Schneider, A. Röseler, K. Becker, T. Burkholz, P. G. Winyard, M. Kelkel, M. Diederich and C. Jacob, Selective antimicrobial activity associated with sulfur nanoparticles, Journal of Biomedical Nanotechnology, 7, 395-405 (2011).
  140. T. Schneider, T., L.A. Ba, K. Khairan, C. Zwergel, N.D. Bach, I. Bernhardt, W. Brandt, L. Wessjohann, M. Diederich, C. Jacob, Interactions of polysulfanes with components of red blood cells, Med. Chem. Commun., 2, 196-200 (2011).
  141. C. Jacob, L.A. Ba, Open season for hunting and trapping posttranslational cysteine modifications in proteins and enzymes, ChemBioChem, 12, 841-844 (2011).
  142. C. Cerella, M. Dicato, C. Jacob, M. Diederich, Chemical Properties and Mechanisms Determining the Anti-Cancer Action of Garlic-Derived Organic Sulfur Compounds, Anti-Cancer Agents in Medicinal Chemistry, 5, 267-271 (2011).
  143. N.K. Janjua, A. Shaheen, A. Yaqub, F. Perveen, S. Sabahat, M. Mumtaz, C. Jacob, L.A. Ba, H.A. Mohammed, Flavonoid–DNA binding studies and thermodynamic parameters, Spectrochimica ActaPart A, 79, 1600–1604 (2011).


  144. M.C.H. Gruhlke, D. Portz, M. Stitz, A. Anwar, T. Schneider, C. Jacob, N.L. Schlaich, A.J. Slusarenko, Allicin disrupts the cell's electrochemical potential and induces apoptosis in yeast, Free Radical Biology and Medicine, 49, 1916-1924 (2010).
  145. M. Kelkel, C. Jacob, M. Dicato and M. Diederich, Potential of the dietary antioxidants resveratrol and curcumin in prevention and treatment of hematologic molecules, Molecules, 15, 7035-7074 (2010).
  146. M. Doering, L.A. Ba, N. Lilienthal, C. Nicco, C. Scherer, M. Abbas, A.A. Peer Zada, R. Coriat, T. Burkholz, L. Wessjohann, M. Diederich, F. Batteux, M. Herling and C. Jacob, Synthesis and selective anti-cancer activity of novel organotellurium based redox catalysts, Journal of Medicinal Chemistry, 53, 6954-6963 (2010).
  147. V. Jamier, L.A. Ba and C. Jacob, Selenium- and Tellurium-containing Multifunctional Redox Agents, Chemistry - A European Journal, 16, 10920-10928 (2010).
  148. L.A. Ba, V. Jamier, M. Doering and C. Jacob, Tellurium: An element with great potency and potential, Organic & Biomolecular Chemistry, 8, 4203-4216 (2010), Invited Emerging Area manuscript.
  149. C. Busch, C. Jacob, A. Anwar, T. Burkholz, L.A. Ba, C. Cerella, M. Diederich, W. Brandt, L. Wessjohann and M. Montenarh, Diallylpolysulfides induce growth arrest and apoptosis, International Journal of Oncology, 36(3), 743-749 (2010).
  150. C. Scherer, C. Jacob, M. Dicato and M. Diederich, Allylsulfides as bioactive compounds with chemotherapeutic and/or chemopreventive effects, in: I. Rasooli (ed.) Phytochemicals - Bioactivities and Impact on Health, ISBN 978-953-307-424-5, InTech (2010).


  151. C. Scherer, C. Jacob, M. Dicato and M. Diederich, Potential role of organic sulfur compounds from Allium species in cancer prevention and therapy. Phytochemistry Reviews, 8, 349–368 (2009).
  152. C. Jacob, M. Doering and T. Burkholz, The chemical basis of biological redox-control, in: C. Jacob and P.G. Winyard (eds.), Redox Signaling and Regulation in Biology and Medicine, Wiley-VCH, Weinheim (2009).
  153. Redox Signaling and Regulation in Biology and Medicine, C. Jacob and P.G. Winyard (eds.), Wiley-VCH, Weinheim (2009).
  154. S. Mecklenburg, S. Shaaban, L.A. Ba, T. Burkholz, T. Schneider, B. Diesel, A.K. Kiemer, A. Röseler, K. Becker, J. Reichrath, A. Stark, W. Tilgen, M. Abbas, L.A. Wessjohann, F. Sasse, C. Jacob, Exploring synthetic avenues for the effective synthesis of selenium- and tellurium-containing multifunctional redox agents, Organic & Biomolecular Chemistry, 7, 4753–4762 (2009).
  155. S. Shabaan, L.A. Ba, M. Abbas, T. Burkholz, A. Denkert, A. Gohr, L.A. Wessjohann, F. Sasse, W. Weberd and C. Jacob, Multicomponent reactions for the synthesis of multifunctional agents with activity against cancer cells, Chemical Communications, 31, 4702–4704 (2009).
  156. C. Cerella, C. Scherer, S. Cristofanon, E. Henry, A. Anwar, C. Busch, M. Montenarh, M. Dicato, C. Jacob and M. Diederich, Cell cycle arrest in early mitosis and induction of caspase-dependent apoptosis in U937 cells by diallyltetrasulfide (Al2S4), Apoptosis, 14, 641–654 (2009).
  157. K.K. Bhasin, R. Kumar, S.K. Mehta, P. Raghavaiah, C. Jacob and T.M. Klapötke, Synthesis and characterization of 5,5′-dibromo-2,2′-dipyridyl disulfide and some of its derivatives: X-ray structure of 5,5′-dibromo-2,2′-dipyridyl disulfide and bis(5-bromopyridine-2-ylthio) methane, Inorganica Chimica Acta, 362(7), 2386-2390 (2009).
  158. C. Jacob and A. Anwar, Sulfides in Allium Vegetables, in Chemoprevention of cancer and DNA damage by dietary factors, S. Knasmüller, D. DeMarini, I.T. Johnson, C. Gerhäuser (Eds.), Weinheim: Wiley-VCH, 663-684 (2009).
  159. L.A. Ba, M. Doering, T. Burkholz and C. Jacob, Metal trafficking: from maintaining the metal homeostasis to future drug design, Metallomics, 1, 292–311 (2009).


  160. S. Mecklenburg, C.A. Collins, M. Doering, T. Burkholz, M. Abbas, F.H. Fry, C. Pourzand and C. Jacob, The Design of Multifunctional Antioxidants Against the Damaging Ingredients of Oxidative Stress, Phosphorus, Sulfur, andSilicon and the related elements, 183, 863-888 (2008).
  161. C. Jacob and A. Anwar, The chemistry behind redox regulation with a focus on sulphur redox systems, Physiologia Plantarum, 133, 469–480 (2008).
  162. A. Anwar, T. Burkholz, C. Scherer, M. Abbas, C.M. Lehr, M. Diederich and C. Jacob, Naturally Occurring Reactive Sulfur Species, their Implications for Cancer Therapy and Possible Modes of Biochemical Action, Journal of Sulfur Chemistry, 29, 251-268 (2008).
  163. C. Jacob, A. Anwar and T. Burkholz, Perspective on recent developments on sulfur containing agents and hydrogen sulfide signalling, Planta Medica, 74, 1580-1592 (2008). Invited perspective.


  164. U. Muenchberg, A. Anwar, S. Mecklenburg and C. Jacob, Polysulfides as biologically active ingredients of garlic, Organic & Biomolecular Chemistry, 5, 1505-1518 (2007).
  165. C. Jacob, S. Mecklenburg, U. Muenchberg, Intelligente Wirkstoffe zwischen Küche und Klinik, Saarländisches Ärzteblatt, 07/2007.


  166. C. Jacob, A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms, Natural Product Reports, 23, 851-863 (2006).
  167. C. Jacob, I. Knight and P.G. Winyard, Aspects of the biological redox chemistry of cysteine: from simple redox responses to sophisticated signalling pathways, Biological Chemistry, 387, 1385-1397 (2006).
  168. F.H. Fry and C. Jacob, Sensor/Effector Drug Design with Potential Relevance to Cancer, Current Pharmaceutical Design, 12, 4479-4499 (2006).


  169. F.H. Fry, A.L. Holme, N.M. Giles, G.I. Giles, C. Collins, K. Holt, S. Pariagh, T. Gelbrich, M.B. Hursthouse, N.J. Gutowski and C. Jacob, Multifunctional redox catalysts as selective enhancers of oxidative stress, Organic & Biomolecular Chemistry, 3, 2579-2587 (2005).
  170. C.A. Collins, F.H. Fry, A.L. Holme, A. Yiakouvaki, A. Al-Qenaei, C. Pourzand and C. Jacob, Towards multifunctional antioxidants: synthesis, electrochemistry, in vitro and cell culture evaluation of compounds with ligand/catalytic properties, Organic & Biomolecular Chemistry, 3, 1541-1546 (2005).
  171. S. Pariagh, K.M. Tasker, F.H. Fry, A.L. Holme, C.A. Collins, N. Okarter, N.J. Gutowski and C. Jacob, Asymmetric organotellurides as potent antioxidants and building blocks of protein conjugates, Organic & Biomolecular Chemistry, 3, 975-980 (2005).
  172. F.H. Fry, N. Okarter, C. Baynton-Smith, M.J. Kershaw, N.J. Talbot and C. Jacob, The use of a substrate/alliinase combination to generate anti-fungal activity in situ, Journal of Agricultural and Food Chemistry, 53, 574-580 (2005).
  173. P.G. Winyard, C.J. Moody and C. Jacob, Oxidative activation of antioxidant defence, Trends in Biochemical Sciences, 30, 453-461 (2005).


  174. S.L. Tucker, C.R. Thornton, K. Tasker, C. Jacob, G. Giles, M. Egan and N.J. Talbot, A fungal metallothionein is required for pathogenicity of Magnaphorte grisea, Plant Cell, 16, 1575-1588 (2004).
  175. C. Jacob, The logical structure of chemical statements - past and present, Scientific Proceedings of Riga Technical University, 8, 78-83 (2004).
  176. C. Jacob, A.L. Holme and F.H. Fry, The Sulfinic Acid Switch in Proteins, Organic & Biomolecular Chemistry, 2, 1953-1956 (2004).
  177. C. Jacob, Critical Thinking in the Chemistry Classroom and Beyond, Journal of Chemical Education, 81, 1216-1223 (2004).
  178. C. Jacob, Some Remarks on Chemical Arguments, Studia Philosophica IV, 40, 37-52 (2004).
  179. C. Jacob, The Use of Philosophy in Chemistry: Logical Aspects of Scientific Arguments in Everyday Research, in: D. Sobczynska, P. Zeidler, E. Zielonacka-Lis (eds.) Chemistry in the Philosophical Melting Pot, Peter Lang Verlag, Frankfurt/M., 117-139 (2004).


  180. G.I. Giles, N.M. Giles, C.A. Collins, K. Holt, F.H. Fry, P.A.S. Lowden, N.J. Gutowski and C. Jacob, Electrochemical, in vitro and cell culture analysis of integrated redox catalysts: implications for cancer therapy, Chemical Communications, 16, 2030-2031 (2003).
  181. N.M. Giles, N.J. Gutowski, G.I. Giles and C. Jacob, Redox catalysts as sensitisers towards oxidative stress, FEBS Letters, 535, 179-182 (2003).
  182. G.I. Giles, K.M. Tasker, C. Peers, K.N. Green, L.-O. Klotz, H. Sies and C. Jacob, Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potential, Organic & Biomolecular Chemistry, 1, 4317-4322 (2003).
  183. N.M. Giles, G.I. Giles, N.J. Gutowski, J. Holley and C. Jacob, Targeting Oxidative Stress-Related Diseases: Organochalcogen Catalysts as Redox Sensitizers, Biochemical Pharmacology: Chemotherapy and Metabolic inhibitors, 66, 2021-2028 (2003).
  184. G.I. Giles, C.A. Collins, T.W. Stone and C. Jacob, Electrochemical and in vitro evaluation of the redox-properties of kynurenine species, Biochemical and Biophysical Research Communications, 300, 719-724 (2003).
  185. C.A. Collins and C. Jacob, Oxidative stress and redox catalysis, Free Radical Research, 37, 107 (2003). (conference contribution, not peer reviewed)
  186. C.A. Collins, N.M. Giles, G.I. Giles, F.H. Fry, A.L. Holme and C. Jacob, Oxidative Stress and Redox Sensitisers, in: D. Galaris (ed.) Free Radicals and Oxidative Stress: Chemistry, Biochemistry and Pathophysiological Implications, Monduzzi Editore, Bologna, 171-175 (2003).
  187. C. Jacob, Statement Analysis in Chemistry, Annals of the New York Academy of Sciences, 988, 239-244 (2003).
  188. G. Jones and C. Jacob, Teaching Philosophy of Chemistry at the University of Exeter, HYLE - International Journal for Philosophy of Chemistry, 9, 133-134 (2003).
  189. C. Jacob, G.I. Giles, N.M. Giles and H. Sies, Sulfur and Selenium: The Role of Oxidation State in Protein Structure and Function, Angewandte Chemie International Edition, 42, 4742-4758 (2003).
  190. N.M. Giles, A. Watts, G.I. Giles, F.H. Fry, J.A. Littlechild and C. Jacob, Metal and Redox Modulation of Cysteine Protein Function, Chemistry & Biology, 10, 677-93 (2003).
  191. N.M. Giles, G.I. Giles and C. Jacob, The Role of Cysteine in Biocatalysis, Biochemical and Biophysical Research Communications, 300, 1-4 (2003).


  192. G.I. Giles, K.M. Tasker, C. Collins, N.M. Giles, E. O’Rourke and C. Jacob, Reactive Sulfur Species: an in vitro investigation of the oxidation properties of disulfide-S-oxides, Biochemical Journal, 364, 579-585 (2002).
  193. G.I. Giles, K.M. Tasker and C. Jacob, Oxidation of Biological Thiols by Highly Reactive Disulfide-S-oxides, General Physiology and Biophysics, 21, 65-72 (2002).
  194. N.M. Giles, G.I. Giles, C.A. Collins, K.M. Tasker and C. Jacob, Synthetic GPx mimics as antioxidants towards Reactive Sulfur Species, The Microcirculation and Vascular Biology, 1, 253-256 (2002).
  195. A.E.J. Harle and C. Jacob, Historical and Epistemological Aspects of Optical Isomerism on Trivalent Sulfur and Nitrogen Atoms, Ambix, 49, 127-147 (2002).
  196. G.I. Giles and C. Jacob, Reactive Sulfur Species: An emerging Concept in Oxidative Stress, Biological Chemistry, 383, 375-388 (2002).
  197. C. Jacob, Philosophy and Biochemistry: Research at the Interface between Chemistry and Biology, Foundations of Chemistry, 4, 97-125 (2002).


  198. G.I. Giles, K.M. Tasker and C. Jacob, Hypothesis: The Role of Reactive Sulfur Species in Oxidative Stress, Free Radical Biology and Medicine, 31, 1279-1283 (2001).
  199. G.I. Giles, K.M. Tasker, R.J.K. Johnson, C. Jacob, K.N. Green and C. Peers, Electrochemistry of chalcogen compounds: prediction of antioxidant activity, Chemical Communications, 23, 2490-2491 (2001).
  200. C. Jacob, Oxidative Stress and Antioxidant Therapy, National Newsletter of the Alzheimer’s Society (UK) June 2001.
  201. C. Jacob, Analysis and Synthesis, Interdependent Operations in Chemical Language and Practice, HYLE - International Journal for Philosophy of Chemistry, 7, 31-50 (2001).


  202.   C. Jacob, G.E. Arteel, T. Kanda, L. Engman and H. Sies, Water-soluble organotellurium compounds: catalytic protection against peroxynitrite and release of zinc from metallothionein, Chemical Research in Toxicology, 13, 3-9 (2000).


  203. C. Jacob, W. Maret and B.L. Vallee, Selenium redox biochemistry of zinc-sulfur coordination sites in proteins and enzymes, Proceedings of the National Academy of Sciences of the United States of America, 96, 1910-1914 (1999).
  204. W. Maret, C. Jacob, B.L. Vallee and E.H. Fischer, Inhibitory sites in enzymes: Zinc removal and reactivation by thionein, Proceedings of the National Academy of Sciences of the United States of America, 96, 1936-1940 (1999).


  205. C. Jacob, W. Maret and B.L. Vallee, Control of zinc transfer between thionein, metallothionein and zinc proteins, Proceedings of the National Academy of Sciences of the United States of America, 95, 3489-3494 (1998).
  206. C. Jacob, W. Maret and B.L. Vallee, Ebselen, a selenium-containing redox drug, releases zinc from metallothionein, Biochemical and Biophysical Research Communications, 248, 569-573 (1998).
  207. J. J. Davis, H.A.O. Hill, A. Kurz, C. Jacob, W. Maret and B.L. Vallee, A scanning tunneling microscopy study of rabbit metallothionein, PhysChemComm, 2, (1998).


  208. C. Jacob, A.Y. Safronov, S.K. Wilson, H.A.O. Hill and T.F. Booth, Investigations of a novel, Vesicles and “Rosettes” forming ferrocene-containing Lipid by Cyclic Voltammetry and Cryogenic Transmission Electron Microscopy, Journal of Electroanalytical Chemistry, 431, 7-10 (1997).
  209. C. Jacob, A.Y. Safronov, S.K. Wilson, H.A.O. Hill, T.F. Booth and S.K. Chapman, Redox active Lipid incorporating Proteins as a novel Immobilisation Technique, Journal of Electroanalytical Chemistry, 430, 119-125 (1997).
  210. C. Jacob, A.Y. Safronov, S.K. Wilson, H.A.O. Hill and T.F. Booth, Synthesis, Characterisation and Electrochemistry of a Novel Ruthenocene Surfactant, Journal of Electroanalytical Chemistry, 427, 161-167 (1997).
  211. K. di Gleria, C.M. Halliwell, C. Jacob and H.A.O. Hill, Site-specific introduction of an electroactive label into a non-electroactive enzyme (β-lactamase I), FEBS Letters, 400, 155-157 (1997).


  212. C. Jacob, H.-T. Yang and H.A.O. Hill, Electrochemical investigations of a novel ferrocene surfactant, Journal of Electroanalytical Chemistry, 416, 83-88 (1996).


  213. C. Haliwell, K. di Gleria, C. Jacob and H.A.O. Hill, Site-directed introduction of analytically responsive groups into non-redox active enzymes, Journal of Inorganic Biochemistry, 59, 356 (1995). (conference contribution, not peer reviewed)


  214. C. Jacob, Bildung des Wundcallus an Keimblättern der Sojabohne durch Auxineinwirkung (Formation of callus growth on leaves of the soy bean plant stimulated by auxin), Junge Wissenschaft, 19, 40-46 (1990).
  • Patent applications
  1. C. Jacob and F.H. Fry, “Apparatus and process for removing destroying or reducing the growth of organic material.,” in World Intellectual Property Organization. GB: Exeter Antioxidant Therapeutics LTD [GB/GB], WO2006111771A2, 2006.
  2. C. Jacob, F.H. Fry and A.L. Holme, “Method of decontaminating, disinfecting or sterilizing of an article by means of an electrolytic system or by reactive oxygen species.,” in World Intellectual Property Organization: Exeter Antioxidant Therapeutics LTD [GB/GB], WO2005039653 A1, 2005.
  3. C. Jacob, G.I. Giles and F.H. Fry, “Organoselenium and organotellurium compound glutathione peroxidase mimic therapeutic oxidation catalysts.,” in World Intellectual Property Organization: Exeter Antioxidant Therapeutics Ltd. [GB/GB], 2004.