Christina Kovar

Field of research

Physiologically based pharmacokinetic (PBPK) modeling
Population pharmacokinetic (PopPK) modeling

Curriculum vitae

Since 01/2020: Doctoral student Clinical Pharmacy, Saarland University, Saarbrücken

12/2019: Licensed as pharmacist

05/2019 – 10/2019: Practical year, Stengel-Apotheke, Saarbrücken

11/2018 – 04/2019: Practical year, Hospital pharmacy, Klinikum Hanau GmbH

04/2018 – 10/2018: Practical year, InfectoPharm Arzneimittel und Consilium GmbH, Heppenheim

04/2014 – 04/2018: Pharmacy studies, Goethe-Universität, Frankfurt am Main

07/2013: Abitur, Marienschule, Offenbach am Main

Publications

Manuscripts

Kovar C, Loer HLH, Rüdesheim S, Fuhr LM, Marok FZ, Selzer D, Schwab M, Lehr T. A physiologically-based pharmacokinetic precision dosing approach to manage dasatinib drug-drug interactions. CPT Pharmacometrics Syst Pharmacol. 2024. doi:10.1002/psp4.13146

Loer HLH, Kovar C, Rüdesheim S, Marok FZ, Fuhr LM, Selzer D, Schwab M, Lehr T. Physiologically based pharmacokinetic modeling of imatinib and N-desmethyl imatinib for drug-drug interaction predictions. CPT Pharmacometrics Syst Pharmacol. 2024;00:1-15.

Kovar C, Kovar L, Rüdesheim S, Selzer D, Ganchev B, Kröner P, Igel S, Kerb R, Schaeffeler E, Mürdter TE, Schwab M, Lehr T. Prediction of drug–drug–gene interaction scenarios of (E)-clomiphene and its metabolites using physiologically based pharmacokinetic modeling. Pharmaceutics 2022;14(12):2604.

Schräpel C, Kovar L, Selzer D, Hofmann U, Tran F, Reinisch W, Schwab M, Lehr T. External model performance evaluation of twelve infliximab population pharmacokinetic models in patients with inflammatory bowel disease. Pharmaceutics 2021;13(9):1368.

Kovar L, Schräpel C, Selzer D, Kohl Y, Bals R, Schwab M, Lehr T. Physiologically-based pharmacokinetic (PBPK) modeling of buprenorphine in adults, children and preterm neonates. Pharmaceutics 2020;12(6):578.

Kovar L, Wojtyniak JG, Schräpel C, Lehr T. Pharmakometrie erklärt: Wie verändert sie die moderne Pharmazie? PZ Prisma 2019;26:217-230.

Posters

Schräpel C, Kovar L, Rüdesheim S, Selzer D, Ganchev B, Kröner P, Igel S, Kerb R, Mürdter TE, Schwab M, Lehr T. Physiologically based pharmacokinetic (PBPK) modeling of (E)-clomiphene drug-drug-gene interactions with CYP2D6 and clarithromycin. 29th Population Approach Group Europe (PAGE) meeting, 2021, virtual meeting.

Schräpel C, Kovar L, Hofmann U, Reinisch W, Schwab M, Lehr T. Predictive Model Performance of Population Pharmacokinetic (popPK) and Physiologically Based Pharmacokinetic (PBPK) Models for Infliximab Concentrations. e:Med Kick-off Meeting, 2020, virtual meeting.