Publikationsliste 2015-2011


201   J. Gorges, U. Kazmaier, "BEt3-initiated thiol-en-click reactions as a versatile tool to modify sensitive substrates", Eur. J. Org. Chem. 2015, 8011–8017.

200   P. Barbie, U. Kazmaier, "Synthesis of fully protected, reverse N-prenylated (2S,3R)-3-hydroxytryptophan, a unique building block of the cyclomarins", Org. Biomol. Chem. 2015, 13, 9267–9275.

199   A. Kiefer, D. Gawas, U. Kazmaier, "A flexible Route towards α-Hydroxyesters via Pd-catalyzed allylic alkylations", Eur. J. Org. Chem. 2015, 5810–5816.

198   P. Servatius, U. Kazmaier, "A straightforward approach towards functionalized amino acids and pipecolinic acids via Ru-catalyzed allylic alkylation", Synlett 201526, 2001–2005.

197   K. Huwig, K. Schultz, U. Kazmaier, "Regio- und stereoselektive Modifizierung chiraler α-Aminoketone durch Pd-katalysierte allylische Alkylierung", Angew. Chem. 2015, 127, 9248–9251; Angew. Chem. Int. Ed. 2015, 54, 9120–9123.

196   D. Becker, U. Kazmaier, "Synthesis and biological evaluation of new dichlorinated chondramide derivatives", Eur. J. Org. Chem. 2015, 4198-4213.

195   J. Hoffmann, U. Kazmaier, "Development of a new photolabile protecting group suitable for cyclizations via ring closing metathesis", Curr. Org. Synth. 2015, 12, 475-483.

194   J. Hoffmann, J. Gorges, L. Junk, U. Kazmaier, "Synthesis of Pretubulysin-Derivatives via the TubUgi-Approach", Org. Biomol. Chem. 2015, 13, 6010-6020.

193   D. Becker, U. Kazmaier, "Synthesis of Simplified Halogenated Chondramide Derivatives as new Actin-binding Agents", Eur. J. Org. Chem. 2015, 2541–2748.

192   L. Karmann, K. Schulz, J. Herrmann, R. Müller, U. Kazmaier, "Totalsynthese und biologische Evaluierung von Miuraenamiden", Angew. Chem. 2015, 127, 4585–4590; Angew. Chem. Int. Ed. 2015, 127, 4502–4507.

191   D. S. Zurabishvili, T. J. Bukia, M. O. Lomidze, M. V. Trapaidze, E. N. Elizbarashvili, S. A. Samsoniya, T. V. Doroshenko, U. Kazmaier, Chem. Heterocycl. Comp. 2015, 51, 139–145.

190   Y. Tang, S. Frewert, K. Harmrolfs, J. Herrmann, L. Karmann, U. Kazmaier, L. Xia, Y. Zhang, R. Müller, "Heterologous expression of an orphan NRPS gene cluster from Paenibacillus larvae in E. coli revealed production of sevadicin", J. Biotechnol. 2015, 194, 122-124.

189   J. Hoffmann, U. Kazmaier, "Synthesis of Cyclic Peptides via Ring Closing Metathesis of Photolabile Protecting groups", Synthesis 2015, 47, 411-420.


188   J. Eirich, S. Braig, L. Schyschka, P. Servatius, J. Hoffmann, S. Fulda, S. Zahler, U. Kazmaier, S. A. Sieber, A. M. Vollmar, "Discovery and promotion of a new class of chemosensitizer reversibly inhibiting protein disulfide isomerase", Angew. Chem. 2014, 126, 13174–13179; Angew. Chem. Int. Ed. 2014, 53, 12960–12965.

187   J. Hoffmann, U. Kazmaier, "Ein einfacher Zugang zu cyclischen, photoschaltbaren Tubulysin-Derivaten", Angew. Chem. 2014, 126, 11538–11542; Angew. Chem. Int. Ed. 2014, 53, 11356–11360.

186   A. Bayer, U. Kazmaier, "Ruthenium-catalyzed Allylic Alkylations of Chelated Enolates using Vinyl Dioxolanon-2-ones", J. Org. Chem. 2014, 79, 8498−8504.

185   A. Bayer, U. Kazmaier, "Selective Peptide Modifications via Ruthenium-catalyzed Allylic Alkylations", J. Org. Chem. 2014, 79, 8491–8497.

184   A. Bayer, U. Kazmaier, "[(p-cymene)RuCl2]2, an Efficient Catalyst for Highly Regioselective Allylic Alkylations of Chelated Amino Acid Ester Enolates", Chem. Eur. J. 2014, 20, 10484–10491.

183   S. Firdous, U. Kazmaier, "Syntheses of Functionalized Allylamines via Lithiated Intermediates", Eur. J. Org. Chem. 2014, 3182–3187.

182   R. Kubisch, M. von Gamm, S. Braig, A. Ullrich, J. L Burkhart, L. Colling, J. Hermann, R. Müller, U. Kazmaier, A. M. Vollmar, "Simplified pretubulysin-derivatives and their  biological effects on cancer cells", J. Nat. Prod. 2014, 77, 536-542.

181   S. Thies, U. Kazmaier, "Synthesis of a-Amino-g-lactones via Pd-catalyzed intramolecular allylic alkylation of sarcosine allyl amides", Eur. J. Org. Chem. 2014, 1695-1707.

180   R. Chaudhuri, U. Kazmaier, "Stereoselective Formation of (E)-β-Alkoxy Acrylates from Fischer Carbene Complexes and Chelated Amino Acid Ester Enolates", Synlett 2014, 25, 693-695.

179   S. Braig, R. M. Wiedmann, J. Liebl, M. Singer, R. Kubisch, L. Schreiner, B. A. Abhari, E. Wagner, U. Kazmaier, S. Fulda, A. M. Vollmar, "Pretubulysin – a new option for the treatment of metastatic cancer", Cell Death Disease 2014, 5, e1001.

178   V. K. Kretzschmann, D. Gellrich, A. Ullrich, S. Zahler, A. M. Vollmar, U. Kazmaier, R. Fürst, "The novel tubulin antagonist pretubulysin exhibits profound tumor vessel disrupting properties in vitro and in vivo", Arterioscl. Thromb. Vasc. Biol. 2014, 34, 294–303.


177   P. Maity, M. Klos, U. Kazmaier, "Syntheses of α-stannylated and α-iodinated enamides via molybdenum-catalyzed hydrostannation", Org. Lett. 2013, 15, 6246-6249.

176   U. Kazmaier, A. Ullrich, J. Hoffmann, "Synthetic Approaches towards Tubulysins and their Derivatives", Open Nat. Prod. J. 2013, 6, 12-30.

175   R. Chaudhuri, U. Kazmaier, "Synthesis of 2,3-Disubstituted Pyrrols Initiated by 1,4-Addition of Chelated Enolates onto Alkynyl Carbene Complexes", Organometalllics 2013, 32, 5546-5550.

174   L. Karmann, U. Kazmaier, "Thiol-Ene Click Reactions – Versatile Tools for the Modification of Unsaturated Amino Acids and Peptides", Eur. J. Org. Chem. 2013, 7101-7109.

173   J. Gorges, A. Ullrich, U. Kazmaier, "A Straightforward Approach towards Ferrocenyl Amino Acids and Peptides via Allylic Alkylation", Eur. J. Org. Chem. 2013, 4372-4378.

172   U. Kazmaier, A. Bayer, J. Deska, "Palladium-catalyzed Allylic Alkylations as Versatile Tool in Amino Acid and Peptide Modifications", Synthesis 2013, 45, 1462-1468.

171   F. Maurer, U. Kazmaier, "Isolation of an s-alkyl iridium hydride complex, formed in the (semi)hydrogenation of an β-enamidoketone", J. Org. Chem. 2013, 78, 3425-3428.

170   M. Klos, U. Kazmaier, "A Catalyst-Economic One-Pot Protocol for the Synthesis and Conversion of Functionalized Vinylstannanes", Eur. J. Org. Chem. 2013, 1726-1731.

169   D. Becker, U. Kazmaier, "The Ireland-Claisen rearrangement as a key step in the synthesis of tubuphenylalanines", J. Org. Chem. 2013, 78, 59-65.



168   P. Barbie, L. Huo, R. Müller, U. Kazmaier, "Stereoselective Synthesis of Deuterium-labeld (2S)-Cyclohexenylalanine, a Biosynthetic Intermediate of the Cinnabaramides", Org. Lett. 2012, 14, 6064-6067.

167   S. Ackermann, H.-G. Lerchen, D. Häbich, A. Ullrich, U. Kazmaier, "Synthetic studies towards Bottromycin", Beilstein J. Org. Chem. 2012, 8, 1652-1656.

166   S. Datta, A. Bayer, U. Kazmaier, "Highly Stereoselective Modifications of Peptides via Pd-catalyzed Allylic Alkylation of Internal Peptide Amide Enolates", Org. Biomol. Chem. 2012, 10, 8268-8275.

165   S. Rath, J. Liebl, R. Fürst, A. Ullrich, J. L. Burkhart, U. Kazmaier, J. Herrmann, R. Müller, M. Günther, L. Schreiner, E. Wagner, A. M. Vollmar, S. Zahler, "Anti-angiogenic effects of the tubulysin precursor pretubulysin and of simplified pretubulysin derivatives", Brit. J. Pharmacol. 2012, 167, 1048-1061.

164   J. Eirich, J. L. Burkhart, A. Ullrich, A. Vollmar, S. Zahler, U. Kazmaier, S. A. Sieber, "Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy", Mol. BioSyst. 2012, 8, 2067-2075.

163   J. Herrmann, R. M. Wiedmann, Y. A. Elnakady, A. Ullrich, M. Rohde, U. Kazmaier, A. M. Vollmar, R. Müller, "Pretubulysins: from a hypothetical biosynthetic intermediate to potential lead in tumor therapie", PLoS One 2012, 7, e37416, 1-12.

162   L. Yin, S. Lucas, F. Maurer, U. Kazmaier, Q. Hu, R. W. Hartmann, "Novel Imidazol-1-ylmethyl Substituted 1,2,5,6-Tetrahydro-pyrrolo[3,2,1-ij]quinolin-4-ones as Potent and Selective CYP11B1 Inhibitors for the Treatment of Cushing’s Syndrome", J. Med. Chem. 2012, 55, 6629-6633.

161   F. Maurer, V. Huch, A. Ullrich, U. Kazmaier, "Development of catalysts for the stereoselective hydrogenation of α,β-unsaturated ketones", J. Org. Chem. 2012, 77, 5139-5143.

160   L. Wirtz, D. Auerbach, G. Jung, U. Kazmaier, "Fluorescence Labeling of Amino Acids and Peptides with 7-Aminocoumarins", Synthesis 2012, 44, 2005-2012.

159   J. L. Burkhart, U. Kazmaier, "A Click Approach towards Tubulysin-Analogues and Tubulysin-Dolastatin Chimera", RSC Advances 2012, 3785-3790.

158   K. Schultz, L. Stief, U. Kazmaier, "A Straightforward Approach towards α-Amino-β-keto esters via Acylation of Chelates Amino Acid Ester Enolates", Synthesis 2012, 600-604.

157   J. L. Burkhart, B. Diehl, M. J. Schmitt, U. Kazmaier, "A straightforward approach towards MMP-2 and MMP-9 inhibitors based on chelate Claisen rearrangements", Eur. J. Org. Chem. 2012, 567-576.


156   S. Samsonia, M. V. Trapaidze, N. N. Nikoleushvili, K. G. Japaridze, J. P. Maisuradze, U. Kazmaier, "New condensed Indoline bis-spiropyrans", Chem. Heterocycl. Comp. 2011, 47, 1098-1104.

155   J. L. Burkhart, U. Kazmaier, "A straightforward approach towards protected (S)-dolaphenine (Doe), the unusual amino acid of dolastatin 10", Synthesis 2011, 4033-4036.

154   B. Diehl, T. M. Hoffmann, N. C. Müller, J. L. Burkhart, U. Kazmaier, M. J. Schmitt, "A novel yeast bioassay for high-throughput screening of matrix metalloproteinase inhibitors", Appl. Environ. Microbiol. 2011, 8573-8577.

153   L. Wirtz, U. Kazmaier, "A mild titanium-catalyzed synthesis of functionalized amino coumarines as fluorescence labels", Eur. J. Org. Chem. 2011, 7062-7065.

152   A. F. Zahoor, S. Thies, U. Kazmaier, "A straightforward approach towards combined a-amino- and a-hydroxy acids based on Passerini reactions", Beilstein J. Org. Chem. 20117, 1299-1303.

151   A. F. Zahoor, U. Kazmaier, "A Straightforward Approach towards Functionalized γ-Hydroxy and Heterocyclic Amino Acids", Synthesis 2011, 3020-3026.

150   J. Deska, S. Hähn, U. Kazmaier, "Stereoselective synthesis of deuterated β-cyclohexenyl­serine, a biosynthetic intermediate of the salinosporamides", Org. Lett. 2011, 13, 3210-3213.

149   S. Hähn, U. Kazmaier, "Chemoselective Rh-Catalyzed Allylic Alkylations of Chelated Enolates using Dienylcarbonates", Eur. J. Org. Chem. 2011, 4931-4939.

148   L. Wirtz, U. Kazmaier, "A Straightforward Approach towards Isoxazoline Amino Acids via Domino Michael Addition / Nitrile Oxide Cycloaddition", Eur. J. Org. Chem. 2011, 3467-3474.

147   J. L. Burkhart, R. Müller, U. Kazmaier, "Syntheses and Evaluation of Simplified Pretubulysin Analogues", Eur. J. Org. Chem. 2011, 3050-3059.

146   C. Bukovec, U. Kazmaier, "Stannylated allyl carbonates as versatile building blocks for the diversity oriented synthesis of allylic amines and amides", Org. Biomol. Chem. 2011, 9, 2743-2750.

145   D. Pistorius, A. Ullrich, S. Lucas, R. W. Hartmann, U. Kazmaier, R. Müller, "Biosynthesis of 2-alkyl-4(1H)-quinolones in Pseudomonas auruginosa: Potential for interference with pathogenicity", ChemBioChem 2011, 850-853.

144   A. F. Zahoor, U. Kazmaier, "A Straightforward Approach towards β-Substituted Phenyl­alanines via Ring Opening of Aryl Epoxides", Synthesis 2011, 1059-1066.

143   C. Bukovec, A. O. Wesquet, U. Kazmaier, "Insights into the Reaction Behaviour of Stannylated Allylic Substrates", Eur. J. Org. Chem. 2011, 1047-1056.

142   U. Kazmaier, A. F. Zahoor, "Regioselective Ringopening of Epoxides by Chelated Amino Acid Ester Enolates", Arkivoc 2011, IV, 6-16.

141   B. V. Lakshmi, U. K. Wefelscheid, U. Kazmaier, "Synthesis of Arylstannanes from Silyl Triflates via Aryne Intermediates", Synlett 2011, 345-348.

140   S. Datta, U. Kazmaier, "Stereoselective palladium-catalyzed allylic alkylations of peptide amide enolates", Org. Biomol. Chem. 2011, 9, 872-880.