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The Linares-Otoya Lab seeks to understand and engineer interbacterial and bacterial-host interactions. The group focuses primarily on members of the Bacteroidota phylum across environmental and human-associated microbiomes. The lab integrates biochemistry, synthetic biology, microbiology, structural biology, and bioinformatics to connect molecular mechanisms with community- and ecosystem-level functions, with implications for microbiome engineering, biotechnology, and human health.lab focuses on the computational modeling of cell identity.
The group is particularly interested in:
- Discovering and characterizing novel microbial chemical languages and defining their ecological roles
- Uncovering the “dark matter” of the human microbiome secretome and determining its molecular and biological functions
- Developing synthetic-biology approaches that harness microbial communication systems and their effectors to build new biological circuits and functional parts
- Understanding the molecular and evolutionary mechanisms that enable bacteria to transition between ecological niches
Homepage of the group