Frühere Artikel


  • Hoppstaedter J, Kiemer AK. 2015. Glucocorticoid-induced leucine zipper (GILZ) in immuno suppression: master regulator or bystander? Oncotarget 6:38446-38457
  • Kessler SM, Laggai S, Barghash A, Schultheiß CS, Lederer E, Art M, Helms V, Haybaeck J, Kiemer AK. 2015. IMP2/p62 induces genomic instability and an aggressive HCC phenotype. Cell Death Dis6:e1894
  • Hoppstädter J, Kessler SM, Bruscoli S, Huwer H, Riccardi C, Kiemer AK. 2015. Glucocorticoid-induced leucine zipper (GILZ): a critical factor in macrophage endotoxin tolerance. J Immunol 194:6057-6067
  • Astanina K, Koch M, Jüngst C, Zumbusch A, Kiemer AK. 2015. Lipid droplets as a novel cargo of tunneling nanotubles in endothelial celles. Sci Rep 5:11453
  • Kessler SM, Barghash A, Laggai S, Helms V, Kiemer AK. 2015. Hepatic hepcidin expression is decreased in cirrhosis and HCC. J Hepatol 62:977-979
  • Hoppstädter J, Seif M, Dembek A, Cavelus C, Huwer H, Kraegeloh A, Kiemer AK. 2015. M2 polarization enhances silica nanoparticle uptake by macrophages. Front Pharmacol 6:55
  • Barghash A, Helms V, Kessler SM.2015. Overexpression of IGF2 mRNA-Binding Protein 2 (IMP2/p62) as a feature of basal-like breast cancer correlates with short survival. Scand J Immunol 82:142-143
  • Ziaei A, Hoppstädter J, Kiemer AK, Ramezani M, Amirghofran Z, Diesel B. 2015. Inhibitory effects of teuclatriol, a sesquiterpene from Salvia mirzayanii, on nuclear factor-kappaB activation and expression of inflammatory mediators. J Ethnopharmacol 160:94-100
  • Stiedl P, McMahon R, Blaas L, Stanek V, Svinka J, Grabner B, Zollner G, Kessler SM, Claudel T, Müller M, Mikulits W, Bilban M, Esterbauer H, Eferl R, Haybaeck J, Trauner M, Casanova E. 2015. Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis. Hepatology 61:613-626
  • Lepeltier E, Loretz B, Desmaele D, Zapp J, Herrmann J, Couvreur P, Lehr C-M. 2015. Squalenoylation of chitosan: a platform for drug delivery? Biomacromolecules 16:2930-2939
  • Kiss FM, Khatri Y, Schmitz D, Zapp J, Bernhardt R. 2015. Identification of new substrates for the CYP106A1-​mediated 11-​oxidation and investigation of the reaction mechanism. FEBS Lett 589:2320-2326
  • Mosa A, Hutter MC, Zapp J, Bernhardt R. Hannemann F. 2015. Regioselective acetylation of C21 hydroxysteroids by the bacterial chloramphenicol acetyltransferase I. ChemBioChem 16:1670-1679
  • Kiss FM, Schmitz D, Zapp J, Dier TKF, Volmer DA, Bernhardt R. 2015. Comparison of CYP106A1 and CYP106A2 from Bacillus megaterium - identification of a novel 11-​oxidase activity. App Microbiol Biotechnol 99:8495-8514
  • Meyer GMJ, Wink CSD, Zapp J, Maurer HH. 2015 GC-MS, LC-MSn, LC-high resolution-MSn, and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkalois of the legal high "Kanna" isolated from Sceletium tortuosum. Anal Bioanal Chem 407:761-778
  • Wink CSD, Meyer GMJ, Zapp J, Maurer HH. 2015. Lefetamine, a controlled drug and pharmaceutical lead of new designer drugs: synthesis, metabolism, and detectability in urine and human liver preparations using GC-MS, LC-MSn, and LC-high resolution-MS/MS. Anal Bioanal Chem 407:1545-1557
  • Kiss FM, Lundemo MT, Zapp J, Woodley JM, Bernhardt R. 2015. Process develoment for the production of 15ß-hydroxycyproterone acetate using Bacillus megaterium expressing CYP106A2 as whole-cell biocatalyst. Microb Cell Fact 14:1-13
  • Mosa A, Neunzig J, Gerber A, Zapp J, Hannemann F, Pilak P, Bernhardt R. 2015. 2ß- and 16ß-hydroxylase activity of CYP11A1 and direct stimulatory effect of estrogens on pregnenolone formation. Steroid Biochem 150:1-10
  • Schifrin A, Ly TTB, Guennewich N, Zapp J, Thiel V, Schulz S, Hannemann F, Khatri Y, Bernhardt R. 2015. Chraracterization of the gene cluster CYP264B1-geoA from Sorangium cellulosum So ce56: Biosynthesis of (+)-Eremophilene and its hydroxylation. ChemBioChem 16: 337-344


  • Kessler SM, Laggai S, Barghash A, Helms V, Kiemer AK. 2014. Lipid metabolism signatures in NASH-associated HCC - Letter. Cancer Res 74:2903-2904
  • Simon Y, Kessler SM, Bohle RM, Haybaeck J, Kiemer AK. 2014. The insulin-like growth factor 2 (IGF2) mRNA binding protein p62/IMP2-2/ IGF2BP2-2 as a promoter of NAFLD and HCC? Gut 63:861-863
  • Laggai S, Kessler SM, Boettcher S, Lebrun V, Gemperlein K, Lederer E, Leclercq IA, Mueller R, Hartmann RW, Haybaeck J, Kiemer AK. 2014. The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis. J Lipid Res 55:1087-1097
  • Hahn RT, Hoppstädter J, Hirschfelder K, Hachenthal N, Diesel B, Kessler SM, Huwer H, Kiemer AK. 2014. Downregulation of the glucocorticoid-induced leucine zipper (GILZ) promotes vascular inflammation. Atherosclerosis 234:391-400
  • Astanina K, Simon Y, Cavelius C, Petry S, Kraegeloh A, Kiemer AK. 2014. Superparamagnetic iron oxide nanoparticles impair endothelial integrity and inhibit nitric oxide production. Acta Biomater 10:4896-4911
  • Abdel-Halim M, Diesel B, Kiemer AK, Abadi A, Hartmann RW, Engel M. 2014. Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C zeta. J Med Chem 57:6513-6530
  • Simon Y, Kessler SM, Gemperlein K, Bohle RM, Müller R, Haybaeck J, Kiemer AK. 2014. Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis. World J Gastroenterol 20:17839-178350
  • Kessler SM, Simon Y, Gemperlein K, Gianmoena K, Cadenas C, Zimmer V, Pokorny J, Barghash A, Helms V, van Rooijen N, Bohle RM, Lammert F, Hengstler JG, Müller R, Haybaeck J, Kiemer AK. 2014. Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma. Int J Mol Sci 15:5762-5773
  • Du P, Viswanathan UM, Khairan K, Buric T, Saidu NEB, Xu Z, Hanf B, Bazukyan I, Trchounian A, Hannemann F, Bernhardt B, Burkholz T, Diesel B, Kiemer AK, Schäfer K-H, Montenarh M, Kirsch G, Jacob C. 2014. Synthesis of amphiphilic, chalcogen-based redox modulators with in vitro cytotoxic activity against cancer celles, macrophages and microbes. Med Chem Commun 5:25-31
  • Schmitz D, Zapp J, Bernhardt R. 2014. Steroid conversion with CYP106A2-production of pharmaceutically interesting DHEA metabolites. Microbial Cell Fact 13:1-13
  • Böse K, Koch M, Cavelius C, Kiemer AK, Kraegeloh A. 2014. Correlative analysis of gold nanoparticles internalized by A549 cells. Part Part Syst Char 31:439-448
  • Trierbach S, Bui N, Zapp J, Chhabra SR, Kappl R, Fetzner S. 2014 Substrate-assisted O2 activation in a cofactor-independent dioxygenese. Chem Biol 21:217-225.
  • Brill E, Hannemann F, Zapp J, Bruening G, Jauch J, Bernhardt R. 2014. A new cytochrome P450 system from Bacillus megaterium DSM319 for the hydroxylation of 11-keto-ß-boswellic acid (KBA) Appl Microbiol Biotechnol 98:1703-1717.


  • Kessler SM, Pokorny J, Zimmer V, Laggai S, Lammert F, Bohle RM, Kiemer AK. 2013. The lgf2-mRNA binding protein p62 in hepatocellular carcinoma: anti-apoptotic action is independent of lgf2/PI3-K signalling. Am J Physiol Gastrointest Liver Physiol 304:G328-G336
  • Diesel B, Hoppstädter J, Hachenthal N, Zarboc R, Cavelius C, Wahl B, Thewes N, Jacobs K, Kraegeloh A, Kiemer AK. 2013. Activation of Rac1 GTPase by nanoparticulate structures in human macrophages. Eur J Pharm Biopharm 84:315-324
  • Laggai L, Simon Y, Ranssweiler T, Kiemer AK, Kessler SM. 2013. Rapid chromatographic method to decipher distinct alterations in lipid classes in NAFLD/NASH. World J Hepatol 304:G328-G336
  • Janocha S, Zapp J, Hutter M, Kleser M, Bohlmann J, Bernhardt R. 2013. Resin Acid Conversion with CYP105A1: An Enzyme with potenial for the production of pharmaceutically relevant diterpenoids. ChemBioChem 14:467-473
  • Meyer GMJ, Meyer MR, Wink CSD, Zapp J, Maurer HH. 2014. Studies on the in vivo contribution of human cytochrome P450s to the hepatic metabolism of glaucine, a new drug of abuse. Biochem Pharmacol 86:1497-1506.
  • Ringle M, Khatri Y, Zapp J, Hannemann F, Bernhardt R. 2014. Application of a new versatile electron transfer system for cytochrome P450-based Escherichia coli whole-cell bioconversions. Appl Microbiol Biotechnol 97:7741-7754.
  • Pirildar S, Unsal Gurer C, Kocyigit M, Zapp J, Kiemer AK, Meriçli AH. 2013. Alkaloids from the roots of Aconitum anthora and aerial parts of Delphinium kurdicum. Chem Natl Compd 48:1-2


  • Hoppstädter J, Diesel B, Eifler LK, Schmid T, Brüne B, Kiemer AK. 2012. Glucocorticoid-induced leucine zipper is downregulated in human alveolar macrophages upon Toll-like receotor activation. Eur J Immunol 42:1282-1293
  • Diesel B, Ripoche N, Risch RT, Tierling S, Walter J, Kiemer AK. 2012. Inflammation-induced upregulation of TLR2 expression in human endothelial cells is independent of differential methylation in the TLR2 promoter CpG island. Innate Immun 18:112-123
  • Doering M, Diesel B, Gruhlke M, viswanathan UM, Mániková D, Chovanec M, Burkholz T, Slusarenko A, Kiemer AK, Jacob C. 2012. Selenium- and Tellurium- containing redox modulators with distinct activity against macrophages: possible implications for the treatment of inflammatory diseases. Tetrahedron 68:10577-10585
  • Pirildar S, Ünsal-Gürer C, Koçyigit M, Kiemer AK, Meriçli AH. 2012. Norditerpenoid alkaloids from Delphinium flexuosum Bieb. Z Naturforsch C 67C:541-544
  • Meriçli AH, Yazici S, Eroglu- Ozkan E, Sen B, Kurtoglu S, Ozcelik H, Zapp J, Kiemer AK, Meriçli F. 2012. Nodditerpeniod alkaloids from Consolida thirkeana and Consolida sulpuhurea. Chem Nat Compd 48:525-526
  • Ardzivian-El Nar A, Diesel B, Desor F, Bouayed J, Kiemer AK, Soulimani R. 2012. Neurodevelopmental and behavioral toxicity of lactational exposure to the sum of six indicator non-dioxin-like-polychlorobiphenyls (∑6 NDL-PCBs) in offspring mice. Toxicology 299:44-54
  • Kurtoǧlu S, Şen B, Meligoǧlu G, Becker H, Zapp J, Kiemer AK, Meriçli F, Meriçli AH. 2012. Diterdenoid alkaloids of Aconitum vulparia Rchb. Z Naturforsch C 67:103-107
  • Bouayed J, Bohn T, Tybl E, Kiemer AK, Soulimani R. 2012. Benzo(α)pyrene -induced antidepressive-like behaviour in adult female mice: role of monoaminergic systems. Basic Clin Pharmacol Toxicol 110:544-550
  • Meriçli AH, Çağal-Yurdusever N, Özçelik H, Zapp J, Kiemer AK. 2012. A new diterpenoid alkaloid from the roots of a white-flowering Aconitum orientale sample. Helv Chim Acta 95:314-319
  • Ly TTB, Khatri Y, Zapp J, Hutter MC, Bernhardt R. 2012. CYP264B1 from Sorangium cellulosum So ce56: a fascinating norisoprenoid and sesquiterpene hydroxylase. App Microbiol Biotechnol 95:123-133
  • Schmitz D, Zapp J, Bernhardt R. 2012 Hydroxylation of the triterpenoid dipterocarpol with CYP106A2 from Bacillus megaterium. FEBS J 279:1663-1674
  • Schwaninger AE, Meyer MR, Zapp J, Maurer HH. 2012. Investigations on the stereoselectivity of the phase II metabolism of the 3,4-methylenedioxyethylamphetaminem (MDEA) metabolites 3,4-dihydroxyethylamphetamine (DHEA) and 4-hydroxy-3-methoxyethylamphetamine (HMEA). Toxicol Lett 212:38-47.
  • Kleser M, Hannemann F, Hutter M, Zapp J, Bernhardt R. 2012. CYP105A1 mediated 3-hydroxylation of glimepiride and glibenclamide using a recombinant Bacillus megaterium whole-cell catalyst. Biotechnol 157:405– 412
  • Bleif, S, Hannemann F, Zapp, J, Hartmann, D, Jauch, J, Bernhardt, R. 2012. A new Bacillus megaterium whole-cell catalyst for the hydroxylation of the pentacyclic triterpene 11-keto-β-boswellic acid (KBA) based on a recombinant cytochrome P450 system. Appl Microbiol and Biotechnol 93:1135-1146
  •  Ly TTB, Khatri Y, Zapp J., Hutter MC, Bernhardt R. 2012. CYP264B1 from Sorangium cellulosum So ce56: a fascinating norisoprenoid and sesquiterpene hydroxylase. Appl Microbiol Biotechnol 95:123-133
  • Meyer MR, Dinger J, Schwaninger AE, Wissenbach DK, Zapp J, Fritschi G, Maurer HH. 2012. Qualitative studies on the metabolism and the toxicological detection of the fentanyl-derived designer drugs 3-methylfentanyl and isofentanyl in rats using liquid chromatography-linear ion trap-mass spectrometry (LC-MSn). Anal Bioanal Chem 402:1249-1255


  • Tybl E, Shi F-D, Kessler SM, Tierling S, Walter J, Bohle RM, Wieland S, Zhang J, Tan EM, Kiemer AK. 2011. Overexpression of the lgf2-mRNA binding protein p62 in transgenic mice induces a steatotic phenotype. J Hepatol 54:994-1001
  • Mohammed HA, Baa LA, Burkholz T, Schumann E, Diesel B, Zapp J, Kiemer AK, Ries C, Hartmann RW, Hosny M, Jacob C. 2011. Facile Synthesis of Chrysin-derivatives with Promising Activities as Aromatase Inhibitors. Nat Prod Commun 6:31-34
  • Ziaei A, Amirghofran Z, Zapp J, Ramezani M. 2011. Immunoinhibitory effect of teuclatriol a guaiane sesquiterpene from Salvia mirzayanii. Iran J lmmunol 8:226-235
  • Philipp AA, Wissenbach DK, Weber AA, Zapp J, Maurer HH. 2011. Metabolism studies of the Kratom alkaloids mitraciliatine and isopaynantheine, diastereomers of the main alkaloids mitragynine and paynantheine, in rat and human urine using liquid chromatography-linear ion trap-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 879:1049-1055
  • Parr MK, Opfermann G, Geyer H, Westphal F, Soennichsen FD, Zapp J, Kwiatkowska, D, Schaenzer W. 2011. Seized designer supplement named "1-Androsterone": Identification as 3β-hydroxy-5α-androst-1-en-17-one and its urinary elimination. Steroids 76:540-547
  • Schwaninger AE, Meyer MR, Zapp J, Maurer HH. 2011. Sulfation of the 3,4-methylenedioxymethamphetamine (MDMA) metabolites 3,4-dihydroxymethamphetamine (DHMA) and 4-hydroxy-3-methoxymethamphetamine (HMMA) and their capability to inhibit human sulfotransferases. Toxicol Lett 202:120-128
  • Dragan C-A, Peters FT, Bour P, Schwaninger AE, Schwaan SM, Neunzig I, Widjaja M, Zapp J, Kraemer T, Maurer HH. 2011. Convenient gram-scale metabolite Synthesis by Engineered Fission Yeast Strains Expressing Functional Human P450 Systems. Appl Biochem Biotechnol 163:965-980
  • Bleif S, Hannemann F, Lisurek M, von Kries JP, Zapp J, Dietzen M, Antes I, Bernhart R. 2011. Identification of CYP106A2 as a Regioselective Allylic Bacteriadl Diterpene Hydroxylase. ChemBioChem 12:576-582
  • Philipp AA, Wissenbach DK, Weber AA, Zapp J, Maurer HH, 2011, Metabolism studies of the Kratom alkaloid speciociliatine, a diastereomer of the main alkaloid mitragynime, in rat and human urine using liquid chromatography-linear ion trap mass spectrometry. Anal Bioanal Chem 399(8), 2747-2753


  • Hoppstädter J, Diesel B, Zarbock R, Breinig T, Monz D, Koch M, Meyerhans A, Gortner L, Lehr CM, Huwer H, Kiemer AK. 2010. Differential cell reaction upon Toll-like receptor 4 and 9 activation in human alveolar and lung interstitial macrophages. Resp Res 11:124
  • Friedl AM, Oedendorfer K, Kitzer S, Reznicek G, Sladek G, Heuberger E. 2010. Comparison of liquid-liquid partition, HS-SPME and static HS GC/MS analysis for the quantification of (–)-linalool in human whole blood samples. Nat Prod Commun 5:1447-1452
  • Scher JM, Andreas Schinkovitz A, Zapp J, Wang Y, Franzblau SG, Becker H, Lankin DC, Pauli GF. 2010. Structure and Anti-TB Activity of Trachylobanes from the Liverwort Jungermannia exsertifolia ssp. Cordifolia. J Nat Prod 73:656-663
  • Philipp AA, Wissenbach DK, Weber AA, Zapp J, Zoerntlein SW, Kanogsunthornrat J, Maurer HH 2010. Use of liquid chromatography coupled to low- and high-resolution linear ion trap mass spectrometry for studying the metabolism of paynantheine, an alkaloid of the herbal drug Kratom in rat and human urine. Anal Bioanal Chem 396:2379-2391


  • Kiemer AK, Senaratne RH, Hoppstädter J, Diesel B, Riley LW, Tabeta K, Bauer S, Beutler B, Zuraw BL. 2009. Attenuated activation of macrophage TLR9 by DNA from virulent mycobacteria. J Innate Immun 1:29-45
  • Mecklenburg S, Shaaban S, Ba LA, Burkholz T, Schneider T, Diesel B, Kiemer AK, Röseler A, Becker K, Reichrath J, Stark A, Tilgen W, Abbas M, Wessjohann LA, Jacob C. 2009. Exploring synthetic avenues for the effective synthesis of selenium and tellurium containing multifunctional redox agents. Org Biomol Chem 7:4753-4762
  • Bouayed J, Desor F, Rammal H, Kiemer AK, Tybl E, Schroeder H, Rychen G, Soulimani R. 2009. Effects of lactational exposure to benzo[α]pyrene (B[α]P) on postnatal neurodevelopment, neuronal receptor gene expression and behaviour in mice. Toxicology 259:97-106
  • Schwaninger AE, Meyer MR, Zapp J, Maurer HH. 2009. The role of human UDP-glucuronyltransferases on the formation of the methylenedioxymethamphetamine (ecstasy) phase II metabolites R- and S-3-methoxymethamphetamine 4-O-glucuronides. Drug Metab Dispos 37:2212-2220
  • Speicher A, Groh M, Zapp J, Schaumloeffel A, Knauer M, Bringmann G. 2009. A synthesis-driven structure revision of plagiochin E, a highly bioactive bisbibenzyl. Synlett 11:1852-1858
  • Suzgec S, Bitiş L, Sozer U, Ozcelik H, Zapp J, Kiemer AK, Meriçli F, Meriçli AH. 2009. Alkaloids from the aerial parts of Consolida anthoroidea and Delphinium linearilobumChem Nat Compd 45:287-289
  • Peters FT, Dragan CA, Kauffels A, Schwaninger AE, Zapp J, Bureik M, Maurer HH. 2009. Biotechnological synthesis of the designer drug metabolite 4'-hydroxymethyl-ALPHA-pyrrolidinohexanophenone in fission yeast heterologously expressing human cytochrome P450 2D6-A versatile alternative to multistep hemical synthesis. J Anal Toxicol 33:190-197
  • Kroll U, Reif K, Lederer I, Foerster G, Zapp J. 2009. Kaempferol-3,4'-di-O-b-glucopyranoside-7-O-alpha-rhamnopyranoside as a new flavonoid from Iberis amara L. Pharmazie 64:142-144
  • Peters FT, Dragan CA, Schwaninger AE, Sauer C, Zapp J, Bureik M, Maurer HH. 2009. Use of fission yeast heterologously expressing human cytochrome P450 2B6 in biotechnological synthesis of the designer drug metabolite N-(1-phenylcyclohexyl)-2-hydroxyethanamine. Forensic Sci Int. 184:69-73


  • Dünschede F, Tybl E, Kiemer AK, Dutkowski P, Erbes K, Kircher A, Gockel I, Zechner U, Schad A, Lang H, Junginger T, Kempski O. 2008. Bcl-2 upregulation after 3-nitropropionic acid preconditioning in warm rat liver ischemia. Shock 30:699-704
  • Bohr G, Klimo K, Zapp J, Becker H, Gerhaeuser C. 2008. Cancer chemopreventive potential of humulones and isohumulones (hops alpha- and iso- alpha -acids): induction of NAD(P)H:quinone reductase as a novel mechanism. Nat Prod Commun 3:1971-1976
  • Zapp H, Orth K, Zapp J, Connolly JD, Becker H. 2008. 21, 28-epoxy-18b, 21b-dihydroxbaccharan-3-one and other terpenoids from the liverwort Lepidozia chordulifera T. Taylor. Nat Prod Commun 3:1755-1758
  • Taetz S, Muerdter TE, Zapp J, Boettcher S, Baldes C, Kleideiter E, Piotrowska K, Schaefer UF, Klotz U, Lehr C-M. 2008. Decomposition of the telomere-targeting agent BRACO19 in physiological media results in products with decreased inhibitory potential. Int J Pharm 357:6-14


  • Diesel B, Kulhanek-Heinze S, Höltje M, Brandt B, Höltje H-D, Vollmar AM, Kiemer AK. 2007. alpha-lipoic acid as a directly binding activator of the insulin receptor - protection from hepatocyte apoptosis. Biochemistry 46:2146-2155
  • Ladetzki-Baehs K, Keller M, Kiemer AK, Koch E, Zahler S, Wendel A, Vollmar AM. 2007. Atrial Natriuretic Peptide (ANP) - a regulator of NF-kappaB activation in vivoEndocrinology 148:332-336
  • Fürst R, Schroeder T, Eilken HM, Bubik MF, Kiemer AK, Zahler S, Vollmar AM. 2007. MAPK phosphatase-1 represents a novel anti-inflammatory target of glucocorticoids in the human endothelium. FASEB J 21:74-80s
  • Bitiş L, Suzgec S, Sozer U, Ozcelik H, Zapp J, Kiemer AK, Meriçli F, Meriçli AH. Diterpenoid alkaloids of Delphinium buschianum. 2007. GROSSH. Helvetica Chimica Acta 90:2217-2221
  • Duenschede F, Erbes K, Kircher A, Westermann S, Schad A, Riegler N, Ewald P, Dutkowski P, Kiemer AK, Kempski O, Junginger T. 2007. Protection from hepatic ischemia/reperfusion injury and improvement of liver regeneration by alpha-lipoic acid. Shock 27:644-651
  • Duenschede F, Westermann S, Miesner I, Albrecht-Schock S, Kneist W, Korenkov M, Schad A, Dutkowski P, Kiemer AK, Junginger T. 2007. Hepatocellular injury of non-ischemic liver tissue after selective clamping in rats - protective action by pharmacological pretreatment with lipoic acid. Eur Surg Res 9:325-331
  • Duenschede F, Erbes K, Riegler N, Ewald P, Kircher A, Westermann S, Schad A, Miesmer I, Albrecht-Schöck A, Gockel I, Kiemer AK, Junginger T. 2007. Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 minutes of hepatic ischemia in a rat model. World J Gastroenterol 13:3692-3698
  • Szwajgier D, Wasko A, Zapp J, Targonski Z. 2007. An attempt to identify the low molecular feruloylated oligosaccharides in beer. J Inst Brew 113:185-195
  • Meriçli AH, Ulusoylu DM, Meriçli F, Ozcelik H, Zapp J, Becker H. 2007. Norditerpenoid alkaloids from Delphinium cinereumChem Nat Compd 43:364-366
  • Peters FT, Dragan CA, Wilde DR, Meyer MR, Zapp J, Bureik M, Maurer HH. 2007. Biotechnological synthesis of drug metabolites using human cytochrome P450 2D6 heterologously expressed in fission yeast exemplified for the designer drug metabolite 4'-hydroxymethyl-alpha -pyrrolidinobutyrophenone. Biochem Pharmacol 74:511-520
  • Parr MK, Zapp J, Becker M, Opfermann G, Bartz U, Schaenzer W. 2007. Steroidal isomers with uniform mass spectra of their per-TMS derivatives: Synthesis of 17-hydroxyandrostan-3-ones, androst-1-, and -4-ene-3,17-diols. Steroids 72:545-551


  • Fürst R, Blumenthal SB, Kiemer AK, Zahler S, Vollmar AM. 2006. Nuclear Factor kappaB-independent anti-inflammatory action of salicylate in human endothelial cells: induction of heme oxygenase by the JNK/AP-1 pathway. J Pharmacol Exp Ther 318: 389-394
  • Dünschede F, Erbes K, Kircher A, Westermann S, Seifert J, Schad A, Kempski O, Kiemer AK, Junginger T. 2006. Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by alpha-lipoic acid in humans. World J Gastroenterol 12:6812-6817
  • Dünschede F, Westermann S, Riegler N, Miesner I, Erbes K, Ewald P, Kircher A, Schaefer H, Schneider J, Schad A, Dutkowski P, Kiemer AK, Junginger T. 2006. Different protection mechanisms after pretreatment with glycine or alpha-lipoic acid in a rat model of warm hepatic ischemia. Eur Surg Res 38:503-512
  • Grützner U, Keller M, Bach M, Kiemer AK, Meißner H, Bilzer M, Zahler S, Gerbes AL, Vollmar AM. 2006. PI 3-kinase-pathway is responsible for antiapoptotic effects of Atrial Natriuretic Peptide (ANP) in rat liver transplantation. World J Gastroenterol 12:1049-1055
  • Arroniz-Crespo M, Nunez-Olivera E, Martinez-Abaigar J, Becker H. Scher J, Zapp J, Tomas R, Beaucourt N. 2006. Physiological changes and UV protection in the aquatic liverwort Jungermannia exsertifolia subsp. cordifolia along an altitudinal gradient of UV-B radiation. Funct Plant Biol 33:1025-1036
  • Weiss B, Schaefer UF, Zapp J, Lamprecht A, Stallmach A, Lehr CM. 2006. Nanoparticles made of fluorescence-labelled poly(L-lactide-co-glycolide): preparation, stability and biocompatibility. J Nanosci Nanotechnol 6:3048-3056
  • Simunovic V, Zapp J, Rachid S, Krug D, Meiser P, Mueller R. 2006. Myxovirescin A biosynthesis is directed by hybrid polyketide synthases/nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl-CoA synthases, and trans-acting acyl-transferases. ChemBioChem 7:1206-1220
  • Bitiş L, Suzgec S, Meriçli F, Ozcelik H, Zapp J, Becker H, Meriçli A. H. 2006. Alkaloids from Consolida olopetala. Pharm Biol 44:244-246
  • Meriçli AH, Süzgec S, Bitis L, Meriçli F, Oczelik H, Zapp J, Becker H. 2006. Diterpenoid alkaloids from the roots of Aconitum cochlearePharmazie 61:483-485
  • Suzgec S, Bitis L, Pirildar S, Ozcelik H, Zapp J, Becker H, Meriçli F, Meriçli AH. 2006. Diterpenoid alkaloids of Delphinium schmalhausenii. Chem Nat Compd 42:75-78
  • Meriçli AH, Pirildar S, Suzgec S, Bitis L, Meriçli F, Ozcelik H, Zapp J, Becker H. 2006. Norditerpenoid alkaloids from the aerial parts of Aconitum cochleare WoroschinHelv Chim Acta 89:210-217
  • Radermacher J, Diesel B, Seifert M, Tilgen W, Reichrath J, Fischer U, Meese E. 2006. Expression analysis of CYP27B1 in tumor biopsies and cell cultures. Anticancer Res 26:2683-2686


  • Fürst R, Kuebler WM, Brueckl C, Zahler S, Krötz F, Görlach A, Vollmar AM, Kiemer AK. 2005. Atrial Natriuretic Peptide induces mitogen-activated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD(P)H oxidase/Nox2 activation. Circ Res 96:43-53
  • Blumenthal SB, Kiemer AK, Tiegs G, Seyfried S, Höltje M, Brandt B, Höltje H-D, Zahler S, Vollmar AM. 2005. Metalloporphyrins inactivate caspase-3 and -8. FASEB J 19:1272-1279
  • Kable EPW, Kiemer AK. 2005. Non-invasive live cell measurement of changes in macrophage NAD(P)H by two-photon microscopy. Immunol Lett 96:33-38
  • Keller M, Gerbes AL, Kulhanek-Heinze S, Gerwig T, Grützner U, Vollmar AM, Kiemer AK. 2005. The hepatocyte cytoskeleton during ischemia and reperfusion – influence of ANP-mediated p38 MAPK activation. World J Gastroenterol 11:7418-7429
  • Bohr G, Gerhaeuser C, Knauft J, Zapp J, Becker H. 2005. Anti-inflammatory acyl­phloroglucinol derivatives from hops (Humulus lupulus). J Nat Prod 68:1545-1548
  • Becker H, Scher JM, Speakman JB, Zapp J. 2005. Bioactivity guided isolation of antimicrobial compounds from Lythrum salicariaFitoterapia 76:580-584
  • Berwanger S, Zapp J, Becker H. 2005. 13C-labelling of xanthohumol in hop cones (Humulus lupulus). Planta Med 71:530-534
  • Feld H, Hertewich UM, Zapp J, Becker H. 2005. Sacculatane diterpenoids from axenic cultures of the liverwort Fossombronia wondraczekiiPhytochemistry 66:1094-1099
  • Diesel B, Radermacher J, Bureik M, Bernhardt R, Seifert M, Reichrath J, Fischer U, Meese E. 2005. Vitamin D3 Metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol and effect of calcitriol. Clin Cancer Res 11: 5370-5380


  • Kulhanek-Heinze S, Gerbes AL, Gerwig T, Vollmar AM, Kiemer AK. 2004. Protein kinase A signalling mediates anti-apoptotic effects of the Atrial Natriuretic Peptide in ischemia reperfusion injury. J Hepatol 41:414-420
  • Kiemer AK, Förnges AC, Pantopoulos K, Bilzer M, Andriopoulos B, Gerwig T, Kenngott S, Gerbes AL, Vollmar AM. 2004. ANP-induced decrease of iron regulatory protein activity is independent of HO-1 induction. Am J Physiol Gastrointest Liver Physiol 287:G518-G526
  • Scher JM, Zapp J, Becker H, Kather N, Kolz J, Speicher A, Dreyer M, Maksimenka K, Bringmann G. 2004. Optically active bisbibenzyls from Bazzania trilobata: isolation and stereochemical analysis by chromatographic, chiroptical, and computational methods. Tetrahedron 60:9877-9881
  • Scher JM, Speakman JB, Zapp J, Becker H. 2004. Bioactivity guided isolation of antifungal compounds from the liverwort Bazzania trilobata (L.) S. F. Gray. Phytochemistry 65:2583-2588
  • Umlauf D, Zapp J, Becker H, Adam KP. 2004. Biosynthesis of the irregular monoterpene artemisia ketone, the sesquiterpene germacrene D and other isoprenoids in Tanacetum vulgare L. (Asteraceae). Phytochemistry 65:2463-2470
  • Feld H, Zapp J, Connolly JD, Becker, H. 2004. Terpenoids from the liverwort Blepharostoma trichophyllumPhytochemistry 65:2357-2362
  • Feld H, Rycroft DS, Zapp J. 2004. Chromenes and prenylated benzoic acid derivatives from the liverwort Pedinophyllum interruptumZeitschrift fuer Naturforschung. B: Chemical Sciences 59:825-828
  • Hillenbrand M, Zapp J, Becker H. 2004. Depsides from the petals of Papaver rhoeasPlanta Med 70:380-382
  • Blaes B, Zapp J, Becker H. 2004. Ent-Clerodane diterpenes and other constituents from the liverwort Adelanthus lindenbergianus (Lehm.) Mitt. Phytochemistry 65:127-137
  • Mitschele T, Diesel B, Friedrich M, Meineke V, Maas RM, Gärtner BC, Kamradt J, Meese E, Tilgen W, Reichrath J. 2004. Analysis of the vitamin D system in basal cell carcinomas (BCC`s). Lab Invest 84: 693-702


  • Kiemer AK, Hartung T, Huber C, Vollmar AM. 2003. Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kappaB pathway. J Hepatol 38:289-297
  • Kiemer AK, Bildner N, Weber NC, Vollmar AM. 2003. Characterization of heme oxygenase 1 (hsp 32) induction by the Atrial Natriuretic Peptide in human endothelial cells. Endocrinology 144:802-812
  • Schümann J, Mühlen K, Kiemer AK, Vollmar AM, Tiegs G. 2003. Parenchymal, but not leukocyte, TNF receptor 2 mediates T cell-dependent hepatitis in mice. J Immunol 170:2129-2137
  • Bang R, Sass G, Kiemer AK, Vollmar AM, Neuhuber WL, Tiegs G. 2003. Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. J Pharmacol Exp Ther 305:31-39
  • Schümann J, Prockl J, Kiemer AK, Vollmar AM, Bang R, Tiegs G. 2003. Silibinin protects mice from T cell-dependent liver injury. J Hepatol 39:333-340
  • Gerwig T, Meißner H, Bilzer M, Kiemer AK, Arnholdt H, Vollmar AM, Gerbes AL. 2003. ANP preconditioning protects against hepatic preservation injury by attenuating apoptotic and necrotic cell death. J Hepatol 39:341-348
  • Kiemer AK, Gerwig T, Gerbes AL, Meißner H, Bilzer M, Vollmar AM. 2003. Kupffer-cell specific induction of heme oxygenase 1 (HSP32) by the Atrial Natriuretic Peptide – role of cGMP. J Hepatol 38:490-498
  • Müller C, Dünschede F, Koch E, Vollmar AM, Kiemer AK. 2003. alpha-lipoic acid preconditioning reduces ischemia/reperfusion injury of the rat liver via the PI-3 kinase/Akt pathway. Am J Physiol Gastrointest Liver Physiol 285:G769-G778
  • Weber NC, Blumenthal SB, Hartung T, Vollmar AM, Kiemer AK. 2003. ANP inhibits TNF-alpha-induced endothelial MCP-1 expression – involvement of p38 MAPK and MKP-1. J Leukoc Biol 74:932-941
  • Abou-Douh AM, Zapp J, Desoky EE, El-Baga NaY, El-Khrisy EA, Becker H. 2003. A cycloartane triterpene and phytosterols from the fruit of Ficus vogeliiRev Lat Am Quim 31:58-65
  • Feld H, Zapp J, Becker H. 2003. Secondary metabolites from the liverwort Tylimanthus renifoliusPhytochemistry 64:1335-1340
  • Scher JM, Zapp J, Schmidt A, Becker H. 2003. Bazzanins L-R, chlorinated macrocyclic bisbibenzyls from the liverwort Lepidozia incurvataPhytochemistry 64:791-796
  • Hertewich UM, Zapp J, Becker H. 2003. Secondary metabolites from the liverwort Jamesoniella colorata. Phytochemistry. 63:227-233
  • Scher JM, Zapp J, Becker H. 2003. Lignan derivatives from the liverwort Bazzania trilobataPhytochemistry 62:769-777


  • Kiemer AK, Baron A, Gerbes AL, Bilzer M, Vollmar AM. 2002. The Atrial Natriuretic Peptide as a regulator of Kupffer cell functions. Shock 17:365-371
  • Kiemer AK, Weber NC, Vollmar AM. 2002. Induction of IkappaB: Atrial natriuretic peptide as a regulator of the NF-kappaB pathway. Biochem Biophys Res Commun 295:1068-1076
  • Kiemer AK, Kulhanek-Heinze S, Gerwig T, Gerbes AL, Vollmar AM. 2002. Stimulation of p38 MAPK by hormonal preconditioning with Atrial Natriuretic Peptide. World J Gastroenterol 8:707-711
  • Kiemer AK, Müller C, Vollmar AM. 2002. Inhibition of LPS-induced NO and TNF-alpha production by alpha-lipoic acid in rat Kupffer cells and in RAW 264.7 murine macrophages. Immunol Cell Biol 80:550-557
  • Kiemer AK, Gerbes AL, Bilzer M, Vollmar AM, 2002. The Atrial Natriuretic Peptide and cGMP – novel activators of the heat shock response in rat livers. Hepatology 35:88-94
  • Kiemer AK, Lehner MD, Hartung T, Vollmar AM. 2002. Inhibition of Cyclooxygenase-2 by Natriuretic Peptides. Endocrinology 143:846-852
  • Kiemer AK, Weber NC, Fürst R, Bildner N, Kulhanek-Heinze S, Vollmar AM. 2002. Inhibition of p38 MAPK activation via induction of MKP-1: Atrial Natriuretic Peptide reduces TNF-alpha-induced actin polymerization and endothelial permeability. Circ Res 90:874-881
  • Koerber K, Sass G, Kiemer AK, Vollmar AM, Tiegs G. 2002. In vivo regulation of inducible NO synthase in immune-mediated liver injury. Hepatology 36:1061-1069
  • Kouokam JC, Zapp J, Becker H. 2002. Oxygen-containing sulfur-rich compounds from the bark of the tropical garlic tree Scorodophloeus zenkeri Harms. Phytochemistry 60:403-407


  • Wolf D, Schümann J, Koerber K, Kiemer AK, Vollmar AM, Sass G, Papadopoulos T, Bang R, Klein SD, Brüne B, Tiegs G. 2001. Low-molecular-weight hyaluronic acid induces nuclear factor-kappaB-dependent resistance against tumor necrosis factor alpha-mediated liver injury in mice. Hepatology 34:535-547
  • Kiemer AK, Vollmar AM. 2001. Elevation of intracellular calcium levels contributes to the inhibition of nitric oxide production by atrial natriuretic peptide. Immunol Cell Biol 79:11-17
  • Kiemer AK, Vollmar AM. 2001. Induction of L-arginine transport is inhibited by ANP: a peptide hormone as a novel regulator of iNOS substrate availability. Mol Pharmacol 60:421-426
  • Kiemer AK, Takeuchi K, Quinlan MP. 2001. Identification of genes involved in epithelial-mesenchymal transition and tumor progression. Oncogene 20:6679-6688
  • Hertewich U, Zapp J, Becker H, Adam KP. 2001. Biosynthesis of a hopane triterpene and three diterpenes in the liverwort Fossombronia alaskanaPhytochemistry 58:1049-1054
  • Hannemann F, Rottmann M, Schiffler B, Zapp J, Bernhardt R. 2001. The loop region covering the iron-sulfur cluster in bovine adrenodoxin comprises a new interaction site for redox partners. J Biol Chem 276:1369-1375
  • Maas RM, Reus K, Diesel B, Steudel WI, Feiden W, Fischer U, Meese E. 2001. Amplification and expression of splice variants of the gene encoding the p450 cytochrome 25-hydroxyvitamin D3 1, alpha-hydroxylase (CYP27B1) in human malignant glioma. Clin Cancer Res 7: 868-875


  • Kiemer AK, Hartung T, Vollmar AM. 2000. cGMP-mediated inhibition of TNF-alpha production by the atrial natriuretic peptide in murine macrophages. J Immunol 165:175-181
  • Kiemer AK, Vollmar AM, Bilzer M, Gerwig T, Gerbes AL. 2000. Atrial Natriuretic Peptide reduces expression of TNF-alpha mRNA during reperfusion of the rat liver upon decreased activation of NF-kappaB and AP-1. J Hepatol 33:236-246
  • Liu HL, Wu CL, Becker H, Zapp J. 2000. Sesquiterpenoids and diterpenoids from the chilean liverwort Lepicolea ochroleucaPhytochemistry 53:845-849


  • Adam KP, Thiel R, Zapp J. 1999. Incorporation of 1-[1-13C] deoxy-D-xylulose in chamomile sesquiterpenes. Arch Biochem Biophys 369:127-132
  • Ulubelen A, Meriçli AH, Meriçli F, Ozcelik H, Sener B, Becker H, Zapp J, Choudhary I, Atta-Ur-Rahman. 1999. Norditerpene and diterpene alkaloids from Consolida hohenackeriPhytochemistry 50:909-912


  • Kiemer AK, Vollmar AM. 1998. Autocrine regulation of inducible nitric oxide synthase in macrophages by Atrial Natriuretic Peptide. J Biol Chem 273:13444-13451
  • Gerbes AL, Vollmar AM, Kiemer AK, Bilzer M. 1998. The guanylate cyclase-coupled natriuretic peptide receptor: a new target for prevention of cold ischemia-reperfusion damage of the rat liver. Hepatology 28:1309-1317
  • Tiegs G, Küsters S, Künstle G, Hentze H, Kiemer AK, Wendel A. 1998. Ebselen protects mice against T cell-dependent, TNF-mediated apoptotic liver injury. J Pharmacol Exp Ther 287:1098-1104
  • Dirsch VM, Kiemer AK, Wagner H, Vollmar AM. 1998. Effects of allicin and ajoene, two compounds of garlic, on the inducible nitric oxide synthase. Atherosclerosis 139:333-339
  • Martini U, Zapp J, Becker H. 1998. Studies on the chemistry and biology of mosses. Part 121. Lignans from the liverwort Bazzania trilobataPhytochemistry 49:1139-1146
  • Bungert M, Gabler J, Adam K-P, Zapp J, Becker H. 1998. Pinguisane sesquiterpenes from the liverwort Porella navicularisPhytochemistry 49:1079-1083
  • Adam KP, Zapp J. 1998. Biosynthesis of the isoprene units of chamomile sesquiterpenes. Phytochemistry 48:953-959
  • Adam KP, Thiel R, Zapp J, Becker, H. 1998. Involvement of the mevalonic acid pathway and the glyceraldehyde-pyruvate pathway in terpenoid biosynthesis of the liverworts Ricciocarpos natans and Conocephalum conicumArch Biochem Biophys 354:181-187
  • Knoess W, Zapp J. 1998. Accumulation of furan labdane diterpenes in Marrubium vulgare and Leonurus cardiacaPlanta Med 64:357-361


  • Kiemer AK, Vollmar AM. 1997. Effects of different natriuretic peptides on nitric oxide synthesis in macrophages. Endocrinology 138:4282-4290
  • Dirsch VM, Kiemer AK, Wagner H, Vollmar AM. 1997. The triterpinoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages. Eur J Pharmacol 336:211-217
  • Martini U, Zapp J, Becker H. 1997. Studies on the chemistry and biology of mosses. Part 112. Chlorinated macrocyclic bisbibenzyls from the liverwort Bazzania trilobataPhytochemistry (Volume Date 1998) 47:89-96
  • Knoss W, Reuter B, Zapp J. 1997. Biosynthesis of the labdane diterpene marrubiin in Marrubium vulgare via a non-mevalonate pathway. Biochem. J 326:449-454
  • Thiel R, Adam KP, Zapp J, Becker H. 1997. Isopentenyl diphosphate biosynthesis in liverworts. Pharmaceut Pharmacol Lett 7:103-105


  • Valcic S, Zapp J, Becker H. 1996. Plagiochilines and other sesquiterpenoids from Plagiochila (Hepaticae). Phytochemistry (Volume Date 1997) 44:89-99
  • Cullmann F, Adam KP, Zapp J, Becker H. 1996. Pelliatin, a macrocyclic lignan derivative from Pellia epiphyllaPhytochemistry 41:611-615


  • Liu J, Zapp J, Becker, H. 1995. Comparative phytochemical investigation of Salvia miltiorrhiza and Salvia trilobaPlanta Med 61:453-455
  • Liu J, Becker H, Zapp J, Wu D. 1995. Four sesquiterpenes from the insecticidal plant Celastrus angulatusPhytochemistry 40:841-846
  • Tazaki H, Zapp J, Becker H. 1995. Diterpenes from in vitro cultures of the liverwort Jamesoniella autumnalisPhytochemistry 39:859-868


  • Zapp J, Burkhardt G, Becker H. 1994. Sphenolobane and fusicoccane diterpenoids from the liverwort Anastrophyllum auritumPhytochemistry 37:787-793