Abgeschlossene Projekte

Abgeschlossene Projekte der Klinischen Pharmazie, sortiert nach Laufzeit, mit ausgewählten Publikationen.

Medication Management Center für mehr Arzneimittelsicherheit bei Polymedikation
06/2022 bis 08/2026, EU Horizon Europe (Koordination)

Gepp SC, Schera F, Marok F, … Lehr T, Kiefer S. The SafePolyMed Medication Management Center: A patient-centered platform for improving safety in polypharmacy. Curr Dir Biomed Eng. 2026;12(1):163-166. doi:10.1515/cdbme-2026-0142
Rüdesheim S, Loer HLH, Feick D, … Schwab M, Lehr T. A comprehensive CYP2D6 drug-drug-gene interaction network for application in precision dosing and drug development. Clin Pharmacol Ther. 2025;117(6):1718-1731. doi:10.1002/cpt.3604
Kovar C, Loer HLH, Rüdesheim S, … Schwab M, Lehr T. A physiologically-based pharmacokinetic precision dosing approach to manage dasatinib drug-drug interactions. CPT Pharmacometrics Syst Pharmacol. 2024;13(7):1144-1159. doi:10.1002/psp4.13146

Modellierungsnetzwerk für Arzneimittel-Gen-Interaktionen
10/2020 bis 09/2023, BMBF (ERACoSysMed)

Rüdesheim S, Loer HLH, Feick D, … Schwab M, Lehr T. A Comprehensive CYP2D6 Drug-Drug-Gene Interaction Network for Application in Precision Dosing and Drug Development. Clin Pharmacol Ther. 2025;117(6):1718-1731. doi:10.1002/cpt.3604
Loer HLH, Feick D, Rüdesheim S, … Swen JJ, Lehr T. Physiologically based pharmacokinetic modeling of tacrolimus for food-drug and CYP3A drug-drug-gene interaction predictions. CPT Pharmacometrics Syst Pharmacol. 2023;12(5):724-738. doi:10.1002/psp4.12946
Feick D, Rüdesheim S, Marok FZ, … Schwab M, Lehr T. Physiologically-based pharmacokinetic modeling of quinidine to establish a CYP3A4, P-gp, and CYP2D6 drug-drug-gene interaction network. CPT Pharmacometrics Syst Pharmacol. 2023;12(8):1143-1156. doi:10.1002/psp4.12981

Open-Source-Modellierungs- und Simulationsplattform
04/2019 bis 2023, BMBF (CompLS)

Marok FZ, Fuhr LM, Hanke N, Selzer D, Lehr T. Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network. Pharmaceutics. 2021;13(3):331. doi:10.3390/pharmaceutics13030331
Fuhr LM, Marok FZ, Hanke N, Selzer D, Lehr T. Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach. Pharmaceutics. 2021;13(2):270. doi:10.3390/pharmaceutics13020270
Hanke N, Türk D, Selzer D, … Nock V, Lehr T. A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug-Drug Interaction Studies. Pharmaceutics. 2020;12(6):556. doi:10.3390/pharmaceutics12060556

Modellierung des Pandemieverlaufs
04/2020 bis 02/2023

Dings C, Götz KM, Och K, … Selzer D, Lehr T. Model-Based Analysis of SARS-CoV-2 Infections, Hospitalization and Outcome in Germany, the Federal States and Districts. Viruses. 2022;14(10):2114. doi:10.3390/v14102114

Arzneimitteltherapiesicherheit in Pflegeeinrichtungen
04/2018 bis 03/2022, G-BA Innovationsfonds

Tönnies L, Zimmer V, Piotrowski A, Lehr T, Laag S, Köberlein-Neu J. Effects of an interprofessional care concept in nursing homes evaluated in the SaarPHIR project: A cluster-randomized controlled trial. PLoS One. 2025;20(5):e0321118. doi:10.1371/journal.pone.0321118
Piotrowski A, Meyer M, Burkholder I, … Manderscheid L, Köberlein-Neu J. Effect of an interprofessional care concept on the hospitalization of nursing home residents: study protocol for a cluster-randomized controlled trial. Trials. 2020;21(1):411. doi:10.1186/s13063-020-04325-y

Evaluierung der COVID-19-Impfung bei Kindern und Jugendlichen im Landkreis Siegen-Wittgenstein
07/2021 bis 02/2022

Rothoeft T, Brinkmann F, Maier C, … Lehr T, Lücke T. Motivations for Adolescent COVID-19 Vaccination: A Comparative Study of Adolescent and Caregiver Perspectives in Germany. Children (Basel). 2023;10(12):1890. doi:10.3390/children10121890
Hussong J, Möhler E, Kühn A, … Rothoeft T, Lehr T. Mental Health and Health-Related Quality of Life in German Adolescents after the Third Wave of the COVID-19 Pandemic. Children (Basel). 2022;9(6):780. doi:10.3390/children9060780
Paulus FW, Joas J, Gerstner I, … Lehr T, Möhler E. Problematic Internet Use among Adolescents 18 Months after the Onset of the COVID-19 Pandemic. Children (Basel). 2022;9(11):1724. doi:10.3390/children9111724

Ubiquitous Pharmacogenomics
01/2016 bis 12/2021, EU Horizon 2020 (Kooperation)

Swen JJ, van der Wouden CH, Manson LE, … Toffoli G, Guchelaar HJ. A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study. Lancet. 2023;401(10374):347-356. doi:10.1016/s0140-6736(22)01841-4
Wojtyniak JG, Selzer D, Schwab M, Lehr T. Physiologically Based Precision Dosing Approach for Drug-Drug-Gene Interactions: A Simvastatin Network Analysis. Clin Pharmacol Ther. 2021;109(1):201-211. doi:10.1002/cpt.2111
Türk D, Hanke N, Wolf S, … Schwab M, Lehr T. Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug-Drug-Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole. Clin Pharmacokinet. 2019;58(12):1595-1607. doi:10.1007/s40262-019-00777-x

Mikrofluidisches System als Alternative zu Tierversuchen
06/2019 bis 05/2021, BMBF

Reinhold S, Herr C, Yao Y, … Beisswenger C, Bals R. Modeling of lung-liver interaction during infection in a human fluidic organ-on-a-chip. Sci Rep. 2025;15(1):35241. doi:10.1038/s41598-025-22682-z
Kovar L, Wien L, Selzer D, Kohl Y, Bals R, Lehr T. In Vitro-In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier. Pharmaceuticals (Basel). 2022;15(2):250. doi:10.3390/ph15020250
Kovar L, Selzer D, Britz H, … Bals R, Lehr T. Comprehensive Parent-Metabolite PBPK/PD Modeling Insights into Nicotine Replacement Therapy Strategies. Clin Pharmacokinet. 2020;59(9):1119-1134. doi:10.1007/s40262-020-00880-4

Prädiktive Modellierung in der Onkologie
03/2016 bis 02/2021, BMBF (i:DSem)

Götz KM, Turki AT, Och K, … Bittenbring J, Lehr T. Model-Based Prediction of Clinically Relevant Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation. Clin Pharmacol Ther. 2025;117(5):1413-1426. doi:10.1002/cpt.3580
Och K, Turki AT, Götz KM, … Bittenbring J, Lehr T. A dynamic time-to-event model for prediction of acute graft-versus-host disease in patients after allogeneic hematopoietic stem cell transplantation. Cancer Med. 2024;13(1):e6833. doi:10.1002/cam4.6833
Weiler G, Schwarz U, Rauch J, … Bittenbring J, Graf N. XplOit: An Ontology-Based Data Integration Platform Supporting the Development of Predictive Models for Personalized Medicine. Stud Health Technol Inform. 2018;247:21-25. doi:10.3233/978-1-61499-852-5-21

Prävention des Zervixkarzinoms
04/2017 bis 03/2020, G-BA Innovationsfonds

Sternjakob-Marthaler A, Berkó-Göttel B, Rissland J, … Wagenpfeil S, Smola S. Human papillomavirus vaccination of girls in the German model region Saarland: Insurance data-based analysis and identification of starting points for improving vaccination rates. PLoS One. 2022;17(9):e0273332. doi:10.1371/journal.pone.0273332

Infektionsgeschehen in saarländischen Schulen und Kitas
Ministerium für Bildung und Kultur Saarland

Optimierung der Übersichtlichkeit und Verständlichkeit

Arzneimitteltherapiesicherheit nach Stammzelltransplantation