Dr. Dominik Selzer

Forschungsgebiet

 
  • Mathematische Modellierung biologischer Barrieren                                                                                           
 

Lebenslauf

Seit 04/2019: Postdoktorand Klinische Pharmazie, Universität des Saarlandes

01/2014 - 02/2019: Bioinformatiker, Scientific Consilience GmbH, Saarbrücken

06/2010 - 09/2013: Promotion in der Biopharmazie und Pharmazeutischen Biotechnologie, Universität des Saarlandes, Saarbrücken

10/2003 - 05/2010: Studium der Bioinformatik, Universität des Saarlandes, Saarbrücken

08/2002 - 05/2003: Zivildienst, Waldschule Saarwellingen

06/2002: Abitur, Johannes-Kepler-Gymnasium, Lebach

Publikationen

Manuskripte

Fuhr LM, Marok FZ, Hanke N, Selzer D, Lehr T. Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and its drug-drug interaction potential: a physiologically based pharmacokinetic modeling approach. Pharmaceutics 2021;13(2):270.

Rüdesheim S, Wojtyniak JG, Selzer D, Hanke N, Mahfoud F, Schwab M, Lehr T. Physiologically based pharmacokinetic modeling of metoprolol enantiomers and α-hydroxymetoprolol to describe CYP2D6 drug-gene interactions. Pharmaceutics 2020;12(12):1200.

Wojtyniak JG, Selzer D, Schwab M, Lehr T. Physiologically based precision dosing approach for drug-drug-gene interactions: a simavastatin network analysis. Clin Pharmacol Ther 2020; Epub: 10.1002/cpt.2111.

Kovar L, Weber A, Zemlin M, Kohl Y, Bals R, Meibohm B, Selzer D, Lehr T. Physiologically-based pharmacokinetic (PBPK) modeling providing insights into fentanyl pharmacokinetics in adults and pediatric patients. Pharmaceutics 2020;12(10):908.

Kovar L, Schräpel C, Selzer D, Kohl Y, Bals R, Schwab M, Lehr T. Physiologically-based pharmacokinetic (PBPK) modeling of buprenorphine in adults, children and preterm neonates. Pharmaceutics 2020;12(6):578.

Hanke N, Türk D, Selzer D, Wiebe S, Fernandez É, Stopfer P, Nock V, Lehr T. A mechanistic, enantioselective, physiologically based pharmacokinetic model of verapamil and norverapamil, built and evaluated for drug-drug interaction studies. Pharmaceutics 2020;12(6):556.

Wojtyniak JG, Britz H, Selzer D, Schwab M, Lehr T. Data digitizing: accurate and precise data extraction for quantitative systems pharmacology and physiologically‐based pharmacokinetic modeling. CPT Pharmacometrics Syst Pharmacol 2020;9(6):322-331.

Hanke N, Türk D, Selzer D, Ishiguro N, Ebner T, Wiebe S, Müller F, Stopfer P, Nock V, Lehr T. A comprehensive whole-body physiologically based pharmacokinetic drug-drug-gene interaction model of metformin and cimetidine in healthy adults and renally impaired individuals. Clin Pharmacokinet 2020;Epub:10.1007/s40262-020-00896-w.

Kovar L, Selzer D, Britz H, Benowitz N, St. Helen G, Kohl Y, Bals R, Lehr T. Comprehensive parent-metabolite PBPK/PD modeling insights into nicotine replacement therapy strategies. Clin Pharmacokinet 2020;59(9):1119-1134.

Mathes C, Melero A, Conrad P, Vogt T, Rigo L, Selzer D, Prado WA, De Rossi C, Garrigues TM, Hansen S, Guterres SS, Pohlmann AR, Beck RCR, Lehr CM, Schaefer UF. Nanocarriers for optimizing the balance between interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverse effects. J Control Release. 2016;223:207-214.

Raesch SS, Tenzer S, Storck W, Rurainski A, Selzer D, Ruge CA, Perez-Gil J, Schaefer UF, Lehr CM. Proteomic and Lipidomic Analysis of Nanoparticle Corona upon Contact with Lung Surfactant Reveals Differences in Protein, but Not Lipid Composition. ACS Nano. 2015;9(12):11872-85.

Selzer D, Neumann D, Schaefer UF. Mathematical models for dermal drug absorption. Expert Opin Drug Metab Toxicol. 2015;11(10):1567-83.  

Selzer D, Neumann D, Neumann H, Kostka KH, Lehr CM, Schaefer UF. A strategy for in-silico prediction of skin absorption in man. Eur J Pharm Biopharm. 2015;95(Pt A):68-76.  

Selzer D, Hahn T, Naegel A, Heisig M, Kostka KH, Lehr CM, Neumann D, Schaefer UF, Wittum G. Finite dose skin mass balance including the lateral part: comparison between experiment, pharmacokinetic modeling and diffusion models. J Control Release. 2013;165(2):119-28.  

Franzen L, Selzer D, Fluhr JW, Schaefer UF, Windbergs M. Towards drug quantification in human skin with confocal Raman microscopy. Eur J Pharm Biopharm. 2013;84(2):437-44.  

Selzer D, Abdel-Mottaleb MM, Hahn T, Schaefer UF, Neumann D. Finite and infinite dosing: difficulties in measurements, evaluations and predictions. Adv Drug Deliv Rev. 2013;65(2):278-94.  

Hahn T, Selzer D, Neumann D, Kostka KH, Lehr CM, Schaefer UF. Influence of the application area on finite dose permeation in relation to drug type applied. Exp Dermatol. 2012;21(3):233-5.

Hansen S, Selzer D, Schaefer UF, Kasting GB. An extended database of keratin binding. J Pharm Sci. 2011;100(5):1712-26. 

 

Kontakt

Dr. Dominik Selzer

Klinische Pharmazie
Universität des Saarlandes
Campus C4 1, Zimmer -1.10
66123 Saarbrücken 

T: +49/681/302-70246
F: +49/681/302-70258

dominik.selzer[at]uni-saarland.de