Getting Started with PK-Sim

Our video series “Getting Started with PK-Sim” is a beginner-friendly introduction to whole-body PBPK modelling with PK-Sim for students and scientists. The eight videos take you from installing the software to running your first simulation, using midazolam as the running example. Each video focuses on one PK-Sim building block and takes less than 10 minutes.

The series covers:

Installing PK-Sim and linking the template and gene expression databases
Creating individuals with custom anatomy, physiology and expression profiles
Building compounds with physicochemical properties and clearance processes
Adding formulations and administration protocols
Importing observed data and setting up simulations for intravenous and oral dosing

You can also watch all videos as a playlist on our YouTube channel. The series was created by the PBPK Tutorial Team of Clinical Pharmacy at Saarland University.

1. Introduction – Getting Started with PK-Sim

2. How to install PK-Sim?

3. How to add individuals and expression profiles in PK-Sim?

4. How to add a compound in PK-Sim?

5. How to add a formulation in PK-Sim?

6. How to add an administration protocol in PK-Sim?

7. How to add observed data in PK-Sim?

8. How to set up a simulation in PK-Sim?

Getting Started with PK-Sim

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