PBPK Resources

OSP Software, User Forum, Documentation, News:

http://www.open-systems-pharmacology.org

Selected Saarland University PBPK Publications:

  • Physiologically based pharmacokinetic models for prediction of complex CYP2C8 and OATP1B1 (SLCO1B1) drug-drug-gene interactions: a modeling network of gemfibrozil, repaglinide, pioglitazone, rifampicin, clarithromycin and itraconazole. 
    https://doi.org/10.1007/s40262-019-00777-x

  • A comprehensive whole-body physiologically based pharmacokinetic model of dabigatran etexilate, dabigatran and dabigatran glucuronide in healthy adults and renally impaired patients.
    https://doi.org/10.1007/s40262-019-00776-y

  • Physiologically-based pharmacokinetic models for CYP1A2 drug-drug interaction prediction: a modeling network of fluvoxamine, theophylline, caffeine, rifampicin, and midazolam.
    https://doi.org/10.1002/psp4.12397 

  • PBPK models for CYP3A4 and P‐gp DDI prediction: a modeling network of rifampicin, itraconazole, clarithromycin, midazolam, alfentanil, and digoxin
    https://doi.org/10.1002/psp4.12343 

  • A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model of the histone deacetylase (HDAC) inhibitor vorinostat for pediatric and adult patients and its application for dose specification. 
    https://doi.org/10.1007/s00280-017-3447-x