Dosing regimen optimization is therefore important to obtain the best compromise between efficacy and toxicity, but also to prevent antibiotic resistance. Traditionally, antibiotic dosing regimen optimization relies on PK/PD (Pharmacokinetics/Pharmacodynamics) indexes derived from the minimum inhibitory concentration (MIC), distinguishing
between time-dependent and concentration-dependent antibiotics (T>MIC, fAUC/MIC, Cmax/MIC). However, these traditional PK/PD approaches, based on MIC present serious limitations.
The main approach of the U1070 unit to overcome the MIC limitation to use semi-mechanical PK/PD models, which is a recent development of PK/PD integrating the phenomena of bacterial susceptibility changes. Another approach used to avoid antibiotic resistance is to consider the infectious microenvironment. Bacteria behave significantly differently under standard laboratory conditions than they do in real-world infections. The infectious microenvironment can cause susceptible bacteria to lose their sensitivity to antibiotics, which can be assessed using molecular biology tools and relevant in vitro and in vivo models that resemble real infectious microenvironments.
After a presentation of the unit, a description of the complementary (formulation, in vitro and in vivo PK/PD, PK/PD modelling and study of resistance mechanisms) and transversal (preclinical and clinical) skills of the unit will be proposed through a presentation of studies developed or in progress.
“PK/PD of Antimicrobial Agents and Antibiotic resistance: Beyond the MIC”
Speakers: Prof. Sandrine Marchand, Assoc. Prof. Fédéric Tewes & Assoc. Prof. Julien Buyck
INSERM U1070 “Pharmacology of antimicrobial agents”,
Prof. Dr. Claus-Michael Lehr
Guests are welcome online!
University of Poitiers, France Prof. Dr. Marchand © Université de Poitiers